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Items: 1 to 50 of 193

1.

Is leptin resistance the cause or the consequence of diet-induced obesity?

de Git KCG, Peterse C, Beerens S, Luijendijk MCM, van der Plasse G, la Fleur SE, Adan RAH.

Int J Obes (Lond). 2018 May 22. doi: 10.1038/s41366-018-0111-4. [Epub ahead of print]

PMID:
29789721
2.

The role of genetic variation of human metabolism for BMI, mental traits and mental disorders.

Hebebrand J, Peters T, Schijven D, Hebebrand M, Grasemann C, Winkler TW, Heid IM, Antel J, Föcker M, Tegeler L, Brauner L, Adan RAH, Luykx JJ, Correll CU, König IR, Hinney A, Libuda L.

Mol Metab. 2018 Jun;12:1-11. doi: 10.1016/j.molmet.2018.03.015. Epub 2018 Apr 3.

3.

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states.

Verharen JPH, de Jong JW, Roelofs TJM, Huffels CFM, van Zessen R, Luijendijk MCM, Hamelink R, Willuhn I, den Ouden HEM, van der Plasse G, Adan RAH, Vanderschuren LJMJ.

Nat Commun. 2018 Feb 21;9(1):731. doi: 10.1038/s41467-018-03087-1.

4.

Microbiota in obesity: interactions with enteroendocrine, immune and central nervous systems.

Mulders RJ, de Git KCG, Schéle E, Dickson SL, Sanz Y, Adan RAH.

Obes Rev. 2018 Apr;19(4):435-451. doi: 10.1111/obr.12661. Epub 2018 Jan 23. Review.

PMID:
29363272
5.

Emotion-driven impulsiveness and snack food consumption of European adolescents: Results from the I.Family study.

Coumans JMJ, Danner UN, Intemann T, De Decker A, Hadjigeorgiou C, Hunsberger M, Moreno LA, Russo P, Stomfai S, Veidebaum T, Adan RAH, Hebestreit A; I.Family Consortium.

Appetite. 2018 Apr 1;123:152-159. doi: 10.1016/j.appet.2017.12.018. Epub 2017 Dec 19.

PMID:
29269316
6.

Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake.

Romero-Picó A, Sanchez-Rebordelo E, Imbernon M, González-Touceda D, Folgueira C, Senra A, Fernø J, Blouet C, Cabrera R, van Gestel M, Adan RA, López M, Maldonado R, Nogueiras R, Diéguez C.

Neuropharmacology. 2018 Mar 1;130:62-70. doi: 10.1016/j.neuropharm.2017.11.040. Epub 2017 Dec 2.

PMID:
29191753
7.

Enhancing excitability of dopamine neurons promotes motivational behaviour through increased action initiation.

Boekhoudt L, Wijbrans EC, Man JHK, Luijendijk MCM, de Jong JW, van der Plasse G, Vanderschuren LJMJ, Adan RAH.

Eur Neuropsychopharmacol. 2018 Jan;28(1):171-184. doi: 10.1016/j.euroneuro.2017.11.005. Epub 2017 Nov 17.

PMID:
29153928
8.

The association of emotion-driven impulsiveness, cognitive inflexibility and decision-making with weight status in European adolescents.

Coumans JMJ, Danner UN, Ahrens W, Hebestreit A, Intemann T, Kourides YA, Lissner L, Michels N, Moreno LA, Russo P, Stomfai S, Veidebaum T, Adan RAH.

Int J Obes (Lond). 2018 Apr;42(4):655-661. doi: 10.1038/ijo.2017.270. Epub 2017 Nov 1.

PMID:
29089612
9.

Considering healthiness promotes healthier choices but modulates medial prefrontal cortex differently in children compared with adults.

van Meer F, van der Laan LN, Viergever MA, Adan RAH, Smeets PAM; I.Family Consortium.

Neuroimage. 2017 Oct 1;159:325-333. doi: 10.1016/j.neuroimage.2017.08.007. Epub 2017 Aug 4.

PMID:
28827095
10.

A novel approach to map induced activation of neuronal networks using chemogenetics and functional neuroimaging in rats: A proof-of-concept study on the mesocorticolimbic system.

Roelofs TJM, Verharen JPH, van Tilborg GAF, Boekhoudt L, van der Toorn A, de Jong JW, Luijendijk MCM, Otte WM, Adan RAH, Dijkhuizen RM.

Neuroimage. 2017 Aug 1;156:109-118. doi: 10.1016/j.neuroimage.2017.05.021. Epub 2017 May 11.

PMID:
28502844
11.

Genetic predisposition to obesity affects behavioural traits including food reward and anxiety-like behaviour in rats.

Vogel H, Kraemer M, Rabasa C, Askevik K, Adan RAH, Dickson SL.

Behav Brain Res. 2017 Jun 15;328:95-104. doi: 10.1016/j.bbr.2017.02.037. Epub 2017 Apr 5.

12.

Exploration of large, rare copy number variants associated with psychiatric and neurodevelopmental disorders in individuals with anorexia nervosa.

Yilmaz Z, Szatkiewicz JP, Crowley JJ, Ancalade N, Brandys MK, van Elburg A, de Kovel CGF, Adan RAH, Hinney A, Hebebrand J, Gratacos M, Fernandez-Aranda F, Escaramis G, Gonzalez JR, Estivill X; Genetic Consortium for Anorexia Nervosa, Wellcome Trust Case Control Consortium 3, Zeggini E, Sullivan PF, Bulik CM.

Psychiatr Genet. 2017 Aug;27(4):152-158. doi: 10.1097/YPG.0000000000000172.

PMID:
28368970
13.

Role of leptin in energy expenditure: the hypothalamic perspective.

Pandit R, Beerens S, Adan RAH.

Am J Physiol Regul Integr Comp Physiol. 2017 Jun 1;312(6):R938-R947. doi: 10.1152/ajpregu.00045.2016. Epub 2017 Mar 29. Review.

14.

Does activation of midbrain dopamine neurons promote or reduce feeding?

Boekhoudt L, Roelofs TJM, de Jong JW, de Leeuw AE, Luijendijk MCM, Wolterink-Donselaar IG, van der Plasse G, Adan RAH.

Int J Obes (Lond). 2017 Jul;41(7):1131-1140. doi: 10.1038/ijo.2017.74. Epub 2017 Mar 21.

PMID:
28321131
15.

The determinants of food choice.

Leng G, Adan RAH, Belot M, Brunstrom JM, de Graaf K, Dickson SL, Hare T, Maier S, Menzies J, Preissl H, Reisch LA, Rogers PJ, Smeets PAM.

Proc Nutr Soc. 2017 Aug;76(3):316-327. doi: 10.1017/S002966511600286X. Epub 2016 Dec 1. Review.

PMID:
27903310
16.

Developmental differences in the brain response to unhealthy food cues: an fMRI study of children and adults.

van Meer F, van der Laan LN, Charbonnier L, Viergever MA, Adan RA, Smeets PA; I.Family Consortium.

Am J Clin Nutr. 2016 Dec;104(6):1515-1522. Epub 2016 Nov 2. Erratum in: Am J Clin Nutr. 2017 Mar;105(3):772.

PMID:
27806979
17.

Chemogenetic Activation of Midbrain Dopamine Neurons Affects Attention, but not Impulsivity, in the Five-Choice Serial Reaction Time Task in Rats.

Boekhoudt L, Voets ES, Flores-Dourojeanni JP, Luijendijk MC, Vanderschuren LJ, Adan RA.

Neuropsychopharmacology. 2017 May;42(6):1315-1325. doi: 10.1038/npp.2016.235. Epub 2016 Oct 17.

18.

Chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats.

Boekhoudt L, Omrani A, Luijendijk MC, Wolterink-Donselaar IG, Wijbrans EC, van der Plasse G, Adan RA.

Eur Neuropsychopharmacol. 2016 Nov;26(11):1784-1793. doi: 10.1016/j.euroneuro.2016.09.003. Epub 2016 Oct 4.

PMID:
27712862
19.

Ventral Tegmental Area Dopamine Cell Activation during Male Rat Sexual Behavior Regulates Neuroplasticity and d-Amphetamine Cross-Sensitization following Sex Abstinence.

Beloate LN, Omrani A, Adan RA, Webb IC, Coolen LM.

J Neurosci. 2016 Sep 21;36(38):9949-61. doi: 10.1523/JNEUROSCI.0937-16.2016.

20.

Associations between neural correlates of visual stimulus processing and set-shifting in ill and recovered women with anorexia nervosa.

Sultson H, van Meer F, Sanders N, van Elburg AA, Danner UN, Hoek HW, Adan RA, Smeets PA.

Psychiatry Res Neuroimaging. 2016 Sep 30;255:35-42. doi: 10.1016/j.pscychresns.2016.07.004. Epub 2016 Jul 9.

PMID:
27518327
21.

Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress.

Imbernon M, Sanchez-Rebordelo E, Romero-Picó A, Kalló I, Chee MJ, Porteiro B, Al-Massadi O, Contreras C, Fernø J, Senra A, Gallego R, Folgueira C, Seoane LM, van Gestel M, Adan RA, Liposits Z, Dieguez C, López M, Nogueiras R.

Hepatology. 2016 Oct;64(4):1086-104. doi: 10.1002/hep.28716. Epub 2016 Aug 9.

22.

Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.

Pandit R, Omrani A, Luijendijk MC, de Vrind VA, Van Rozen AJ, Ophuis RJ, Garner K, Kallo I, Ghanem A, Liposits Z, Conzelmann KK, Vanderschuren LJ, la Fleur SE, Adan RA.

Neuropsychopharmacology. 2016 Aug;41(9):2241-51. doi: 10.1038/npp.2016.19. Epub 2016 Feb 8.

23.

Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets.

van den Heuvel JK, Eggels L, van Rozen AJ, Fliers E, Kalsbeek A, Adan RA, la Fleur SE.

Front Behav Neurosci. 2015 Dec 24;9:358. doi: 10.3389/fnbeh.2015.00358. eCollection 2015.

24.

Diet-induced neuropeptide expression: feasibility of quantifying extended and highly charged endogenous peptide sequences by selected reaction monitoring.

Schmidlin T, Boender AJ, Frese CK, Heck AJ, Adan RA, Altelaar AF.

Anal Chem. 2015 Oct 6;87(19):9966-73. doi: 10.1021/acs.analchem.5b03334.

PMID:
26376940
25.

Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin.

van der Plasse G, van Zessen R, Luijendijk MC, Erkan H, Stuber GD, Ramakers GM, Adan RA.

Int J Obes (Lond). 2015 Dec;39(12):1742-9. doi: 10.1038/ijo.2015.131. Epub 2015 Jul 17.

26.

Overview of genetic research in anorexia nervosa: The past, the present and the future.

Brandys MK, de Kovel CG, Kas MJ, van Elburg AA, Adan RA.

Int J Eat Disord. 2015 Nov;48(7):814-25. doi: 10.1002/eat.22400. Epub 2015 Jul 14. Review.

PMID:
26171770
27.

Central melanocortins regulate the motivation for sucrose reward.

Pandit R, van der Zwaal EM, Luijendijk MC, Brans MA, van Rozen AJ, Oude Ophuis RJ, Vanderschuren LJ, Adan RA, la Fleur SE.

PLoS One. 2015 Mar 26;10(3):e0121768. doi: 10.1371/journal.pone.0121768. eCollection 2015.

28.

Altered food-cue processing in chronically ill and recovered women with anorexia nervosa.

Sanders N, Smeets PA, van Elburg AA, Danner UN, van Meer F, Hoek HW, Adan RA.

Front Behav Neurosci. 2015 Feb 27;9:46. doi: 10.3389/fnbeh.2015.00046. eCollection 2015.

29.

Reducing Ventral Tegmental Dopamine D2 Receptor Expression Selectively Boosts Incentive Motivation.

de Jong JW, Roelofs TJ, Mol FM, Hillen AE, Meijboom KE, Luijendijk MC, van der Eerden HA, Garner KM, Vanderschuren LJ, Adan RA.

Neuropsychopharmacology. 2015 Aug;40(9):2085-95. doi: 10.1038/npp.2015.60. Epub 2015 Mar 4.

30.

Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation.

de Git KC, Adan RA.

Obes Rev. 2015 Mar;16(3):207-24. doi: 10.1111/obr.12243. Epub 2015 Jan 14. Review.

PMID:
25589226
31.

FTO knockdown in rat ventromedial hypothalamus does not affect energy balance.

van Gestel MA, Sanders LE, de Jong JW, Luijendijk MC, Adan RA.

Physiol Rep. 2014 Dec 11;2(12). pii: e12152. doi: 10.14814/phy2.12152. Print 2014 Dec 1.

32.

What you see is what you eat: an ALE meta-analysis of the neural correlates of food viewing in children and adolescents.

van Meer F, van der Laan LN, Adan RA, Viergever MA, Smeets PA.

Neuroimage. 2015 Jan 1;104:35-43. doi: 10.1016/j.neuroimage.2014.09.069. Epub 2014 Oct 5. Review.

PMID:
25285373
33.

The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas.

Boender AJ, van Gestel MA, Garner KM, Luijendijk MC, Adan RA.

Physiol Rep. 2014 Jul 30;2(7). pii: e12083. doi: 10.14814/phy2.12083. Print 2014 Jul 1.

34.

The neuroanatomical function of leptin in the hypothalamus.

van Swieten MM, Pandit R, Adan RA, van der Plasse G.

J Chem Neuroanat. 2014 Nov;61-62:207-20. doi: 10.1016/j.jchemneu.2014.05.004. Epub 2014 Jul 4. Review.

PMID:
25007719
35.

Pharmacological manipulations in animal models of anorexia and binge eating in relation to humans.

van Gestel MA, Kostrzewa E, Adan RA, Janhunen SK.

Br J Pharmacol. 2014 Oct;171(20):4767-84. doi: 10.1111/bph.12789. Epub 2014 Sep 5. Review.

36.

Recombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood.

van Gestel MA, Boender AJ, de Vrind VA, Garner KM, Luijendijk MC, Adan RA.

PLoS One. 2014 May 23;9(5):e97639. doi: 10.1371/journal.pone.0097639. eCollection 2014.

37.

Combined use of the canine adenovirus-2 and DREADD-technology to activate specific neural pathways in vivo.

Boender AJ, de Jong JW, Boekhoudt L, Luijendijk MC, van der Plasse G, Adan RA.

PLoS One. 2014 Apr 15;9(4):e95392. doi: 10.1371/journal.pone.0095392. eCollection 2014.

38.

Cannabinoid, melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum.

Oude Ophuis RJ, Boender AJ, van Rozen AJ, Adan RA.

Front Neuroanat. 2014 Mar 26;8:14. doi: 10.3389/fnana.2014.00014. eCollection 2014.

39.

AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior.

Boender AJ, Koning NA, van den Heuvel JK, Luijendijk MC, van Rozen AJ, la Fleur SE, Adan RA.

PLoS One. 2014 Apr 7;9(4):e94159. doi: 10.1371/journal.pone.0094159. eCollection 2014.

40.

Neuropeptide Y and leptin sensitivity is dependent on diet composition.

van den Heuvel JK, Eggels L, van Rozen AJ, Luijendijk MC, Fliers E, Kalsbeek A, Adan RA, la Fleur SE.

J Neuroendocrinol. 2014 Jun;26(6):377-85. doi: 10.1111/jne.12155.

PMID:
24698502
41.

The vital role of constitutive GPCR activity in the mesolimbic dopamine system.

Meye FJ, Ramakers GM, Adan RA.

Transl Psychiatry. 2014 Feb 11;4:e361. doi: 10.1038/tp.2013.130. Review.

42.

A genome-wide association study of anorexia nervosa.

Boraska V, Franklin CS, Floyd JA, Thornton LM, Huckins LM, Southam L, Rayner NW, Tachmazidou I, Klump KL, Treasure J, Lewis CM, Schmidt U, Tozzi F, Kiezebrink K, Hebebrand J, Gorwood P, Adan RA, Kas MJ, Favaro A, Santonastaso P, Fernández-Aranda F, Gratacos M, Rybakowski F, Dmitrzak-Weglarz M, Kaprio J, Keski-Rahkonen A, Raevuori A, Van Furth EF, Slof-Op 't Landt MC, Hudson JI, Reichborn-Kjennerud T, Knudsen GP, Monteleone P, Kaplan AS, Karwautz A, Hakonarson H, Berrettini WH, Guo Y, Li D, Schork NJ, Komaki G, Ando T, Inoko H, Esko T, Fischer K, Männik K, Metspalu A, Baker JH, Cone RD, Dackor J, DeSocio JE, Hilliard CE, O'Toole JK, Pantel J, Szatkiewicz JP, Taico C, Zerwas S, Trace SE, Davis OS, Helder S, Bühren K, Burghardt R, de Zwaan M, Egberts K, Ehrlich S, Herpertz-Dahlmann B, Herzog W, Imgart H, Scherag A, Scherag S, Zipfel S, Boni C, Ramoz N, Versini A, Brandys MK, Danner UN, de Kovel C, Hendriks J, Koeleman BP, Ophoff RA, Strengman E, van Elburg AA, Bruson A, Clementi M, Degortes D, Forzan M, Tenconi E, Docampo E, Escaramís G, Jiménez-Murcia S, Lissowska J, Rajewski A, Szeszenia-Dabrowska N, Slopien A, Hauser J, Karhunen L, Meulenbelt I, Slagboom PE, Tortorella A, Maj M, Dedoussis G, Dikeos D, Gonidakis F, Tziouvas K, Tsitsika A, Papezova H, Slachtova L, Martaskova D, Kennedy JL, Levitan RD, Yilmaz Z, Huemer J, Koubek D, Merl E, Wagner G, Lichtenstein P, Breen G, Cohen-Woods S, Farmer A, McGuffin P, Cichon S, Giegling I, Herms S, Rujescu D, Schreiber S, Wichmann HE, Dina C, Sladek R, Gambaro G, Soranzo N, Julia A, Marsal S, Rabionet R, Gaborieau V, Dick DM, Palotie A, Ripatti S, Widén E, Andreassen OA, Espeseth T, Lundervold A, Reinvang I, Steen VM, Le Hellard S, Mattingsdal M, Ntalla I, Bencko V, Foretova L, Janout V, Navratilova M, Gallinger S, Pinto D, Scherer SW, Aschauer H, Carlberg L, Schosser A, Alfredsson L, Ding B, Klareskog L, Padyukov L, Courtet P, Guillaume S, Jaussent I, Finan C, Kalsi G, Roberts M, Logan DW, Peltonen L, Ritchie GR, Barrett JC; Wellcome Trust Case Control Consortium 3, Estivill X, Hinney A, Sullivan PF, Collier DA, Zeggini E, Bulik CM.

Mol Psychiatry. 2014 Oct;19(10):1085-94. doi: 10.1038/mp.2013.187. Epub 2014 Feb 11.

43.

Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food.

Pandit R, Luijendijk MC, Vanderschuren LJ, la Fleur SE, Adan RA.

Obesity (Silver Spring). 2014 May;22(5):1216-9. doi: 10.1002/oby.20718. Epub 2014 Feb 19.

44.

Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet.

van den Heuvel JK, Eggels L, Fliers E, Kalsbeek A, Adan RA, la Fleur SE.

PLoS One. 2014 Jan 31;9(1):e87729. doi: 10.1371/journal.pone.0087729. eCollection 2014.

45.

shRNA-induced saturation of the microRNA pathway in the rat brain.

van Gestel MA, van Erp S, Sanders LE, Brans MA, Luijendijk MC, Merkestein M, Pasterkamp RJ, Adan RA.

Gene Ther. 2014 Feb;21(2):205-11. doi: 10.1038/gt.2013.76. Epub 2014 Jan 2.

PMID:
24385145
46.

Feelings about food: the ventral tegmental area in food reward and emotional eating.

Meye FJ, Adan RA.

Trends Pharmacol Sci. 2014 Jan;35(1):31-40. doi: 10.1016/j.tips.2013.11.003. Epub 2013 Dec 11. Review.

PMID:
24332673
47.

Longitudinal changes in the physical activity of adolescents with anorexia nervosa and their influence on body composition and leptin serum levels after recovery.

Kostrzewa E, van Elburg AA, Sanders N, Sternheim L, Adan RA, Kas MJ.

PLoS One. 2013 Oct 21;8(10):e78251. doi: 10.1371/journal.pone.0078251. eCollection 2013.

48.

Modelling olanzapine-induced weight gain in rats.

van der Zwaal EM, Janhunen SK, la Fleur SE, Adan RA.

Int J Neuropsychopharmacol. 2014 Jan;17(1):169-86. doi: 10.1017/S146114571300093X. Epub 2013 Oct 8. Review.

PMID:
24103788
49.

Low control over palatable food intake in rats is associated with habitual behavior and relapse vulnerability: individual differences.

de Jong JW, Meijboom KE, Vanderschuren LJ, Adan RA.

PLoS One. 2013 Sep 10;8(9):e74645. doi: 10.1371/journal.pone.0074645. eCollection 2013.

50.

The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns.

la Fleur SE, Luijendijk MC, van der Zwaal EM, Brans MA, Adan RA.

Int J Obes (Lond). 2014 May;38(5):643-9. doi: 10.1038/ijo.2013.159. Epub 2013 Aug 27.

PMID:
23979221

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