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Items: 1 to 50 of 173

1.

Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response.

Donoghue JF, Kerr LT, Alexander NW, Greenall SA, Longano AB, Gottardo NG, Wang R, Tabar V, Adams TE, Mischel PS, Johns TG.

Cancers (Basel). 2018 Jul 25;10(8). pii: E243. doi: 10.3390/cancers10080243.

2.

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.

Bandala-Sanchez E, G Bediaga N, Goddard-Borger ED, Ngui K, Naselli G, Stone NL, Neale AM, Pearce LA, Wardak A, Czabotar P, Haselhorst T, Maggioni A, Hartley-Tassell LA, Adams TE, Harrison LC.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7783-7788. doi: 10.1073/pnas.1722056115. Epub 2018 Jul 11.

3.

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3.

Greenall SA, Donoghue J, Johns TG, Adams TE.

Transl Oncol. 2018 Aug;11(4):971-978. doi: 10.1016/j.tranon.2018.05.011. Epub 2018 Jun 22.

4.

C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response.

Ambrose RL, Liu YC, Adams TE, Bean AGD, Stewart CR.

J Biol Chem. 2018 Jul 6;293(27):10561-10573. doi: 10.1074/jbc.RA117.001491. Epub 2018 May 25.

PMID:
29802199
5.

Electrostatic Interactions between Hendra Virus Matrix Proteins Are Required for Efficient Virus-Like-Particle Assembly.

Liu YC, Grusovin J, Adams TE.

J Virol. 2018 Jun 13;92(13). pii: e00143-18. doi: 10.1128/JVI.00143-18. Print 2018 Jul 1.

PMID:
29695428
6.

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

Newman J, Sharp JA, Enjapoori AK, Bentley J, Nicholas KR, Adams TE, Peat TS.

Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):39-45. doi: 10.1107/S2053230X17017708. Epub 2018 Jan 1.

PMID:
29372906
7.

CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation.

Rashidi M, Bandala-Sanchez E, Lawlor KE, Zhang Y, Neale AM, Vijayaraj SL, O'Donoghue R, Wentworth JM, Adams TE, Vince JE, Harrison LC.

Cell Death Differ. 2018 Feb;25(2):392-405. doi: 10.1038/cdd.2017.173. Epub 2017 Dec 15.

PMID:
29244050
8.

Development of an anti-ferret CD4 monoclonal antibody for the characterisation of ferret T lymphocytes.

Layton DS, Xiao X, Bentley JD, Lu L, Stewart CR, Bean AG, Adams TE.

J Immunol Methods. 2017 May;444:29-35. doi: 10.1016/j.jim.2017.02.009. Epub 2017 Feb 16.

PMID:
28216237
9.

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells.

O'Brien CM, Chy HS, Zhou Q, Blumenfeld S, Lambshead JW, Liu X, Kie J, Capaldo BD, Chung TL, Adams TE, Phan T, Bentley JD, McKinstry WJ, Oliva K, McMurrick PJ, Wang YC, Rossello FJ, Lindeman GJ, Chen D, Jarde T, Clark AT, Abud HE, Visvader JE, Nefzger CM, Polo JM, Loring JF, Laslett AL.

Stem Cells. 2017 Mar;35(3):626-640. doi: 10.1002/stem.2558. Epub 2017 Jan 19.

10.

Design and characterization of an APC-specific serpin for the treatment of hemophilia.

Polderdijk SG, Adams TE, Ivanciu L, Camire RM, Baglin TP, Huntington JA.

Blood. 2017 Jan 5;129(1):105-113. doi: 10.1182/blood-2016-05-718635. Epub 2016 Oct 27.

11.

Genome-wide siRNA Screening at Biosafety Level 4 Reveals a Crucial Role for Fibrillarin in Henipavirus Infection.

Deffrasnes C, Marsh GA, Foo CH, Rootes CL, Gould CM, Grusovin J, Monaghan P, Lo MK, Tompkins SM, Adams TE, Lowenthal JW, Simpson KJ, Stewart CR, Bean AG, Wang LF.

PLoS Pathog. 2016 Mar 24;12(3):e1005478. doi: 10.1371/journal.ppat.1005478. eCollection 2016 Mar.

12.

Incomplete target neutralization by the anti-cancer antibody rilotumumab.

Greenall SA, Adams TE, Johns TG.

MAbs. 2016;8(2):246-52. doi: 10.1080/19420862.2015.1122149.

13.

Structural and functional characterisation of ferret interleukin-2.

Ren B, McKinstry WJ, Pham T, Newman J, Layton DS, Bean AG, Chen Z, Laurie KL, Borg K, Barr IG, Adams TE.

Dev Comp Immunol. 2016 Feb;55:32-8. doi: 10.1016/j.dci.2015.10.007. Epub 2015 Oct 22.

PMID:
26472619
14.

Structural transitions during prothrombin activation: On the importance of fragment 2.

Adams TE, Huntington JA.

Biochimie. 2016 Mar;122:235-42. doi: 10.1016/j.biochi.2015.09.013. Epub 2015 Sep 10.

15.

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase.

Suryadinata R, Seabrook SA, Adams TE, Nuttall SD, Peat TS.

Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1505-13. doi: 10.1107/S1399004715009219. Epub 2015 Jun 30.

16.

FMRI hypoactivation during verbal learning and memory in former high school football players with multiple concussions.

Terry DP, Adams TE, Ferrara MS, Miller LS.

Arch Clin Neuropsychol. 2015 Jun;30(4):341-55. doi: 10.1093/arclin/acv020. Epub 2015 Apr 22.

PMID:
25903375
17.

Blood-based protein biomarker panel for the detection of colorectal cancer.

Fung KY, Tabor B, Buckley MJ, Priebe IK, Purins L, Pompeia C, Brierley GV, Lockett T, Gibbs P, Tie J, McMurrick P, Moore J, Ruszkiewicz A, Nice E, Adams TE, Burgess A, Cosgrove LJ.

PLoS One. 2015 Mar 20;10(3):e0120425. doi: 10.1371/journal.pone.0120425. eCollection 2015.

18.

LRIG1 extracellular domain: structure and function analysis.

Xu Y, Soo P, Walker F, Zhang HH, Redpath N, Tan CW, Nicola NA, Adams TE, Garrett TP, Zhang JG, Burgess AW.

J Mol Biol. 2015 May 22;427(10):1934-48. doi: 10.1016/j.jmb.2015.03.001. Epub 2015 Mar 9.

19.

Notch ligand delta-like1: X-ray crystal structure and binding affinity.

Kershaw NJ, Church NL, Griffin MD, Luo CS, Adams TE, Burgess AW.

Biochem J. 2015 May 15;468(1):159-66. doi: 10.1042/BJ20150010.

PMID:
25715738
20.

EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications.

Greenall SA, Donoghue JF, Van Sinderen M, Dubljevic V, Budiman S, Devlin M, Street I, Adams TE, Johns TG.

Oncogene. 2015 Oct 8;34(41):5277-87. doi: 10.1038/onc.2014.448. Epub 2015 Feb 9.

PMID:
25659577
21.

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.

Boersma YL, Newman J, Adams TE, Cowieson N, Krippner G, Bozaoglu K, Peat TS.

Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3320-9. doi: 10.1107/S1399004714022767. Epub 2014 Nov 28.

PMID:
25478849
22.

Effect of time and dose of recombinant follicle stimulating hormone agonist on the superovulatory response of sheep.

Rutigliano HM, Adams BM, Jablonka-Shariff A, Boime I, Adams TE.

Theriogenology. 2014 Aug;82(3):455-60. doi: 10.1016/j.theriogenology.2014.05.010. Epub 2014 May 20.

PMID:
24938801
23.

Effect of single-chain ovine gonadotropins with dual activity on ovarian function in sheep.

Rutigliano HM, Adams BM, Jablonka-Shariff A, Boime I, Adams TE.

Reproduction. 2014 Aug;148(2):129-36. doi: 10.1530/REP-14-0063. Epub 2014 May 7.

PMID:
24811780
24.

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo.

Greenall SA, Donoghue JF, Gottardo NG, Johns TG, Adams TE.

Oncogene. 2015 Mar 26;34(13):1658-66. doi: 10.1038/onc.2014.106. Epub 2014 Apr 21.

PMID:
24747966
25.

Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling.

Baer S, Nigro J, Madej MP, Nisbet RM, Suryadinata R, Coia G, Hong LP, Adams TE, Williams CC, Nuttall SD.

Org Biomol Chem. 2014 May 7;12(17):2675-85. doi: 10.1039/c3ob42325e.

PMID:
24643508
26.

Colorectal cancer biomarkers: to be or not to be? Cautionary tales from a road well travelled.

Fung KY, Nice E, Priebe I, Belobrajdic D, Phatak A, Purins L, Tabor B, Pompeia C, Lockett T, Adams TE, Burgess A, Cosgrove L.

World J Gastroenterol. 2014 Jan 28;20(4):888-98. doi: 10.3748/wjg.v20.i4.888. Review.

27.

Effect of phytoestrogens on basal and GnRH-induced gonadotropin secretion.

Arispe SA, Adams B, Adams TE.

J Endocrinol. 2013 Oct 28;219(3):243-50. doi: 10.1530/JOE-13-0158. Print 2013 Dec.

PMID:
24050980
28.

Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis.

Lechtenberg BC, Murray-Rust TA, Johnson DJ, Adams TE, Krishnaswamy S, Camire RM, Huntington JA.

Blood. 2013 Oct 17;122(16):2777-83. doi: 10.1182/blood-2013-06-511733. Epub 2013 Jul 18.

29.

Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation.

Heazlewood SY, Neaves RJ, Williams B, Haylock DN, Adams TE, Nilsson SK.

Stem Cell Res. 2013 Sep;11(2):782-92. doi: 10.1016/j.scr.2013.05.007. Epub 2013 May 28.

30.

Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2.

Epa VC, Dolezal O, Doughty L, Xiao X, Jost C, Plückthun A, Adams TE.

PLoS One. 2013;8(3):e59163. doi: 10.1371/journal.pone.0059163. Epub 2013 Mar 19.

31.

Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer.

Greenall SA, Bentley JD, Pearce LA, Scoble JA, Sparrow LG, Bartone NA, Xiao X, Baxter RC, Cosgrove LJ, Adams TE.

J Biol Chem. 2013 Jan 4;288(1):59-68. doi: 10.1074/jbc.M112.432013. Epub 2012 Nov 19.

32.

Ligand binding induces a conformational change in epidermal growth factor receptor dimers.

Walker F, Rothacker J, Henderson C, Nice EC, Catimel B, Zhang HH, Scott AM, Bailey MF, Orchard SG, Adams TE, Liu Z, Garrett TP, Clayton AH, Burgess AW.

Growth Factors. 2012 Dec;30(6):394-409. doi: 10.3109/08977194.2012.739619. Epub 2012 Nov 20.

PMID:
23163584
33.

A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation.

Koziolek EJ, Donoghue JF, Bentley JD, Lovrecz G, Dolezal O, Ward CW, Rothacker J, Nice EC, Burgess AW, Hafner M, Johns TG, Adams TE.

Growth Factors. 2012 Oct;30(5):310-9. Epub 2012 Aug 2.

PMID:
22856597
34.

Taking down the FLAG! How insect cell expression challenges an established tag-system.

Schmidt PM, Sparrow LG, Attwood RM, Xiao X, Adams TE, McKimm-Breschkin JL.

PLoS One. 2012;7(6):e37779. doi: 10.1371/journal.pone.0037779. Epub 2012 Jun 6.

35.

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.

Davydova N, Streltsov VA, Roufail S, Lovrecz GO, Stacker SA, Adams TE, Achen MG.

Protein Expr Purif. 2012 Mar;82(1):232-9. doi: 10.1016/j.pep.2012.01.001. Epub 2012 Jan 10.

PMID:
22261343
36.

Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by Sortase A-mediated protein ligation.

Madej MP, Coia G, Williams CC, Caine JM, Pearce LA, Attwood R, Bartone NA, Dolezal O, Nisbet RM, Nuttall SD, Adams TE.

Biotechnol Bioeng. 2012 Jun;109(6):1461-70. doi: 10.1002/bit.24407. Epub 2011 Dec 26.

PMID:
22170409
37.

Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin.

Hsieh YS, Taleski D, Wilkinson BL, Wijeyewickrema LC, Adams TE, Pike RN, Payne RJ.

Chem Commun (Camb). 2012 Feb 1;48(10):1547-9. doi: 10.1039/c1cc14773k. Epub 2011 Nov 23.

PMID:
22109100
38.

Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation.

Ymer SI, Greenall SA, Cvrljevic A, Cao DX, Donoghue JF, Epa VC, Scott AM, Adams TE, Johns TG.

Cancers (Basel). 2011 Apr 18;3(2):2032-49. doi: 10.3390/cancers3022032.

39.

A new crystal form of human vascular adhesion protein 1.

Ernberg K, McGrath AP, Peat TS, Adams TE, Xiao X, Pham T, Newman J, McDonald IA, Collyer CA, Guss JM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1572-8. doi: 10.1107/S1744309110041515. Epub 2010 Nov 16.

40.

Direct involvement of the TEN domain at the active site of human telomerase.

Jurczyluk J, Nouwens AS, Holien JK, Adams TE, Lovrecz GO, Parker MW, Cohen SB, Bryan TM.

Nucleic Acids Res. 2011 Mar;39(5):1774-88. doi: 10.1093/nar/gkq1083. Epub 2010 Nov 3.

41.

Thrombin inhibition by serpins disrupts exosite II.

Li W, Johnson DJ, Adams TE, Pozzi N, De Filippis V, Huntington JA.

J Biol Chem. 2010 Dec 3;285(49):38621-9. doi: 10.1074/jbc.M110.144964. Epub 2010 Oct 2.

42.

A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo.

Dransfield DT, Cohen EH, Chang Q, Sparrow LG, Bentley JD, Dolezal O, Xiao X, Peat TS, Newman J, Pilling PA, Phan T, Priebe I, Brierley GV, Kastrapeli N, Kopacz K, Martik D, Wassaf D, Rank D, Conley G, Huang Y, Adams TE, Cosgrove L.

Mol Cancer Ther. 2010 Jun;9(6):1809-19. doi: 10.1158/1535-7163.MCT-09-1134. Epub 2010 Jun 1.

43.

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.

Whitten AE, Smith BJ, Menting JG, Margetts MB, McKern NM, Lovrecz GO, Adams TE, Richards K, Bentley JD, Trewhella J, Ward CW, Lawrence MC.

J Mol Biol. 2009 Dec 18;394(5):878-92. doi: 10.1016/j.jmb.2009.10.011. Epub 2009 Oct 14.

PMID:
19835884
44.

Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.

Newman J, Cohen EH, Cosgrove L, Kopacz K, Dransfield DT, Adams TE, Peat TS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Sep 1;65(Pt 9):945-8. doi: 10.1107/S1744309109024932. Epub 2009 Aug 26.

45.

Molecular basis of thrombomodulin activation of slow thrombin.

Adams TE, Li W, Huntington JA.

J Thromb Haemost. 2009 Oct;7(10):1688-95. doi: 10.1111/j.1538-7836.2009.03563.x. Epub 2009 Jul 28.

46.

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo.

Adams TE, Koziolek EJ, Hoyne PH, Bentley JD, Lu L, Lovrecz G, Ward CW, Lee FT, Scott AM, Nash AD, Rothacker J, Nice EC, Burgess AW, Johns TG.

Growth Factors. 2009 Jun;27(3):141-54. doi: 10.1080/08977190902843565.

PMID:
19333814
47.

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.

Garrett TP, Burgess AW, Gan HK, Luwor RB, Cartwright G, Walker F, Orchard SG, Clayton AH, Nice EC, Rothacker J, Catimel B, Cavenee WK, Old LJ, Stockert E, Ritter G, Adams TE, Hoyne PA, Wittrup D, Chao G, Cochran JR, Luo C, Lou M, Huyton T, Xu Y, Fairlie WD, Yao S, Scott AM, Johns TG.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5082-7. doi: 10.1073/pnas.0811559106. Epub 2009 Mar 16.

48.

Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.

Adams TE, El Sous M, Hawkins BC, Hirner S, Holloway G, Khoo ML, Owen DJ, Savage GP, Scammells PJ, Rizzacasa MA.

J Am Chem Soc. 2009 Feb 4;131(4):1607-16. doi: 10.1021/ja808402e.

PMID:
19140688
49.

The expanding role of recombinant gonadotropins in assisted reproduction.

Adams TE, Boime I.

Reprod Domest Anim. 2008 Jul;43 Suppl 2:186-92. doi: 10.1111/j.1439-0531.2008.01160.x. Review.

PMID:
18638122
50.

Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.

Li W, Adams TE, Nangalia J, Esmon CT, Huntington JA.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4661-6. doi: 10.1073/pnas.0711055105. Epub 2008 Mar 24.

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