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Integrated thermodynamic analysis of electron bifurcating [FeFe]-hydrogenase to inform anaerobic metabolism and H2 production.

Jay ZJ, Hunt KA, Chou KJ, Schut GJ, Maness PC, Adams MWW, Carlson RP.

Biochim Biophys Acta Bioenerg. 2020 Jan 1;1861(1):148087. doi: 10.1016/j.bbabio.2019.148087. Epub 2019 Nov 8.


Quantitative fermentation of unpretreated transgenic poplar by Caldicellulosiruptor bescii.

Straub CT, Khatibi PA, Wang JP, Conway JM, Williams-Rhaesa AM, Peszlen IM, Chiang VL, Adams MWW, Kelly RM.

Nat Commun. 2019 Aug 7;10(1):3548. doi: 10.1038/s41467-019-11376-6.


The biology and biotechnology of the genus Caldicellulosiruptor: recent developments in 'Caldi World'.

Lee LL, Crosby JR, Rubinstein GM, Laemthong T, Bing RG, Straub CT, Adams MWW, Kelly RM.

Extremophiles. 2019 Jul 29. doi: 10.1007/s00792-019-01116-5. [Epub ahead of print] Review.


Characterization of thiosulfate reductase from Pyrobaculum aerophilum heterologously produced in Pyrococcus furiosus.

Haja DK, Wu CH, Poole FL 2nd, Sugar J, Williams SG, Jones AK, Adams MWW.

Extremophiles. 2019 Jul 5. doi: 10.1007/s00792-019-01112-9. [Epub ahead of print]


Nitrate-Utilizing Microorganisms Resistant to Multiple Metals from the Heavily Contaminated Oak Ridge Reservation.

Thorgersen MP, Ge X, Poole FL 2nd, Price MN, Arkin AP, Adams MWW.

Appl Environ Microbiol. 2019 Aug 14;85(17). pii: e00896-19. doi: 10.1128/AEM.00896-19. Print 2019 Sep 1.


The thermophilic biomass-degrading bacterium Caldicellulosiruptor bescii utilizes two enzymes to oxidize glyceraldehyde 3-phosphate during glycolysis.

Scott IM, Rubinstein GM, Poole FL 2nd, Lipscomb GL, Schut GJ, Williams-Rhaesa AM, Stevenson DM, Amador-Noguez D, Kelly RM, Adams MWW.

J Biol Chem. 2019 Jun 21;294(25):9995-10005. doi: 10.1074/jbc.RA118.007120. Epub 2019 May 16.


Optimizing electron transfer from CdSe QDs to hydrogenase for photocatalytic H2 production.

Sanchez MLK, Wu CH, Adams MWW, Dyer RB.

Chem Commun (Camb). 2019 May 9;55(39):5579-5582. doi: 10.1039/c9cc01150a.


Lignocellulose solubilization and conversion by extremely thermophilic Caldicellulosiruptor bescii improves by maintaining metabolic activity.

Straub CT, Khatibi PA, Otten JK, Adams MWW, Kelly RM.

Biotechnol Bioeng. 2019 Aug;116(8):1901-1908. doi: 10.1002/bit.26993. Epub 2019 May 21.


Extreme thermophiles as emerging metabolic engineering platforms.

Crosby JR, Laemthong T, Lewis AM, Straub CT, Adams MW, Kelly RM.

Curr Opin Biotechnol. 2019 Oct;59:55-64. doi: 10.1016/j.copbio.2019.02.006. Epub 2019 Mar 12. Review.


The catalytic mechanism of electron-bifurcating electron transfer flavoproteins (ETFs) involves an intermediary complex with NAD<sup/>.

Schut GJ, Mohamed-Raseek N, Tokmina-Lukaszewska M, Mulder DW, Nguyen DMN, Lipscomb GL, Hoben JP, Patterson A, Lubner CE, King PW, Peters JW, Bothner B, Miller AF, Adams MWW.

J Biol Chem. 2019 Mar 1;294(9):3271-3283. doi: 10.1074/jbc.RA118.005653. Epub 2018 Dec 19.


Cytoplasmic and membrane-bound hydrogenases from Pyrococcus furiosus.

Wu CH, Haja DK, Adams MWW.

Methods Enzymol. 2018;613:153-168. doi: 10.1016/bs.mie.2018.10.009. Epub 2018 Nov 23.


Comparative Biochemical and Structural Analysis of Novel Cellulose Binding Proteins (Tāpirins) from Extremely Thermophilic Caldicellulosiruptor Species.

Lee LL, Hart WS, Lunin VV, Alahuhta M, Bomble YJ, Himmel ME, Blumer-Schuette SE, Adams MWW, Kelly RM.

Appl Environ Microbiol. 2019 Jan 23;85(3). pii: e01983-18. doi: 10.1128/AEM.01983-18. Print 2019 Feb 1.


Improved production of the NiFe-hydrogenase from Pyrococcus furiosus by increased expression of maturation genes.

Wu CH, Ponir CA, Haja DK, Adams MWW.

Protein Eng Des Sel. 2018 Sep 1;31(9):337-344. doi: 10.1093/protein/gzy025.


Iron- and aluminium-induced depletion of molybdenum in acidic environments impedes the nitrogen cycle.

Ge X, Vaccaro BJ, Thorgersen MP, Poole FL 2nd, Majumder EL, Zane GM, De León KB, Lancaster WA, Moon JW, Paradis CJ, von Netzer F, Stahl DA, Adams PD, Arkin AP, Wall JD, Hazen TC, Adams MWW.

Environ Microbiol. 2019 Jan;21(1):152-163. doi: 10.1111/1462-2920.14435. Epub 2018 Nov 21.


A synthetic enzymatic pathway for extremely thermophilic acetone production based on the unexpectedly thermostable acetoacetate decarboxylase from Clostridium acetobutylicum.

Zeldes BM, Straub CT, Otten JK, Adams MWW, Kelly RM.

Biotechnol Bioeng. 2018 Dec;115(12):2951-2961. doi: 10.1002/bit.26829. Epub 2018 Oct 23.


Characterization of membrane-bound sulfane reductase: A missing link in the evolution of modern day respiratory complexes.

Wu CH, Schut GJ, Poole FL 2nd, Haja DK, Adams MWW.

J Biol Chem. 2018 Oct 26;293(43):16687-16696. doi: 10.1074/jbc.RA118.005092. Epub 2018 Sep 4.


A new era for electron bifurcation.

Peters JW, Beratan DN, Bothner B, Dyer RB, Harwood CS, Heiden ZM, Hille R, Jones AK, King PW, Lu Y, Lubner CE, Minteer SD, Mulder DW, Raugei S, Schut GJ, Seefeldt LC, Tokmina-Lukaszewska M, Zadvornyy OA, Zhang P, Adams MW.

Curr Opin Chem Biol. 2018 Dec;47:32-38. doi: 10.1016/j.cbpa.2018.07.026. Epub 2018 Aug 1. Review.


Engineering redox-balanced ethanol production in the cellulolytic and extremely thermophilic bacterium, Caldicellulosiruptor bescii.

Williams-Rhaesa AM, Rubinstein GM, Scott IM, Lipscomb GL, Poole Ii FL, Kelly RM, Adams MWW.

Metab Eng Commun. 2018 May 28;7:e00073. doi: 10.1016/j.mec.2018.e00073. eCollection 2018 Dec.


Parsing in vivo and in vitro contributions to microcrystalline cellulose hydrolysis by multidomain glycoside hydrolases in the Caldicellulosiruptor bescii secretome.

Conway JM, Crosby JR, McKinley BS, Seals NL, Adams MWW, Kelly RM.

Biotechnol Bioeng. 2018 Oct;115(10):2426-2440. doi: 10.1002/bit.26773. Epub 2018 Aug 1.


Biotechnology of extremely thermophilic archaea.

Straub CT, Counts JA, Nguyen DMN, Wu CH, Zeldes BM, Crosby JR, Conway JM, Otten JK, Lipscomb GL, Schut GJ, Adams MWW, Kelly RM.

FEMS Microbiol Rev. 2018 Sep 1;42(5):543-578. doi: 10.1093/femsre/fuy012. Review.


Native xylose-inducible promoter expands the genetic tools for the biomass-degrading, extremely thermophilic bacterium Caldicellulosiruptor bescii.

Williams-Rhaesa AM, Awuku NK, Lipscomb GL, Poole FL, Rubinstein GM, Conway JM, Kelly RM, Adams MWW.

Extremophiles. 2018 Jul;22(4):629-638. doi: 10.1007/s00792-018-1023-x. Epub 2018 May 24.


Structure of an Ancient Respiratory System.

Yu H, Wu CH, Schut GJ, Haja DK, Zhao G, Peters JW, Adams MWW, Li H.

Cell. 2018 Jun 14;173(7):1636-1649.e16. doi: 10.1016/j.cell.2018.03.071. Epub 2018 May 10.


On the nature of organic and inorganic centers that bifurcate electrons, coupling exergonic and endergonic oxidation-reduction reactions.

Peters JW, Beratan DN, Schut GJ, Adams MWW.

Chem Commun (Camb). 2018 Apr 19;54(33):4091-4099. doi: 10.1039/c8cc01530a.


The diversity and specificity of the extracellular proteome in the cellulolytic bacterium Caldicellulosiruptor bescii is driven by the nature of the cellulosic growth substrate.

Poudel S, Giannone RJ, Basen M, Nookaew I, Poole FL 2nd, Kelly RM, Adams MWW, Hettich RL.

Biotechnol Biofuels. 2018 Mar 23;11:80. doi: 10.1186/s13068-018-1076-1. eCollection 2018.


Novel Bioengineered Cassava Expressing an Archaeal Starch Degradation System and a Bacterial ADP-Glucose Pyrophosphorylase for Starch Self-Digestibility and Yield Increase.

Ligaba-Osena A, Jones J, Donkor E, Chandrayan S, Pole F, Wu CH, Vieille C, Adams MWW, Hankoua BB.

Front Plant Sci. 2018 Feb 26;9:192. doi: 10.3389/fpls.2018.00192. eCollection 2018.


Genus-Wide Assessment of Lignocellulose Utilization in the Extremely Thermophilic Genus Caldicellulosiruptor by Genomic, Pangenomic, and Metagenomic Analyses.

Lee LL, Blumer-Schuette SE, Izquierdo JA, Zurawski JV, Loder AJ, Conway JM, Elkins JG, Podar M, Clum A, Jones PC, Piatek MJ, Weighill DA, Jacobson DA, Adams MWW, Kelly RM.

Appl Environ Microbiol. 2018 Apr 16;84(9). pii: e02694-17. doi: 10.1128/AEM.02694-17. Print 2018 May 1.


Microbial Functional Gene Diversity Predicts Groundwater Contamination and Ecosystem Functioning.

He Z, Zhang P, Wu L, Rocha AM, Tu Q, Shi Z, Wu B, Qin Y, Wang J, Yan Q, Curtis D, Ning D, Van Nostrand JD, Wu L, Yang Y, Elias DA, Watson DB, Adams MWW, Fields MW, Alm EJ, Hazen TC, Adams PD, Arkin AP, Zhou J.

MBio. 2018 Feb 20;9(1). pii: e02435-17. doi: 10.1128/mBio.02435-17.


Cluster-Dependent Charge-Transfer Dynamics in Iron-Sulfur Proteins.

Mao Z, Liou SH, Khadka N, Jenney FE Jr, Goodin DB, Seefeldt LC, Adams MWW, Cramer SP, Larsen DS.

Biochemistry. 2018 Feb 13;57(6):978-990. doi: 10.1021/acs.biochem.7b01159. Epub 2018 Jan 24.


Artemether Does Not Turn α Cells into β Cells.

van der Meulen T, Lee S, Noordeloos E, Donaldson CJ, Adams MW, Noguchi GM, Mawla AM, Huising MO.

Cell Metab. 2018 Jan 9;27(1):218-225.e4. doi: 10.1016/j.cmet.2017.10.002. Epub 2017 Nov 2.


Applications of Photogating and Time Resolved Spectroscopy to Mechanistic Studies of Hydrogenases.

Greene BL, Vansuch GE, Chica BC, Adams MWW, Dyer RB.

Acc Chem Res. 2017 Nov 21;50(11):2718-2726. doi: 10.1021/acs.accounts.7b00356. Epub 2017 Oct 30. Review.


H/D exchange mass spectrometry and statistical coupling analysis reveal a role for allostery in a ferredoxin-dependent bifurcating transhydrogenase catalytic cycle.

Berry L, Poudel S, Tokmina-Lukaszewska M, Colman DR, Nguyen DMN, Schut GJ, Adams MWW, Peters JW, Boyd ES, Bothner B.

Biochim Biophys Acta Gen Subj. 2018 Jan;1862(1):9-17. doi: 10.1016/j.bbagen.2017.10.002. Epub 2017 Oct 6.


Functional Analysis of the Glucan Degradation Locus in Caldicellulosiruptor bescii Reveals Essential Roles of Component Glycoside Hydrolases in Plant Biomass Deconstruction.

Conway JM, McKinley BS, Seals NL, Hernandez D, Khatibi PA, Poudel S, Giannone RJ, Hettich RL, Williams-Rhaesa AM, Lipscomb GL, Adams MWW, Kelly RM.

Appl Environ Microbiol. 2017 Dec 1;83(24). pii: e01828-17. doi: 10.1128/AEM.01828-17. Print 2017 Dec 15.


Advanced water splitting for green hydrogen gas production through complete oxidation of starch by in vitro metabolic engineering.

Kim JE, Kim EJ, Chen H, Wu CH, Adams MWW, Zhang YP.

Metab Eng. 2017 Nov;44:246-252. doi: 10.1016/j.ymben.2017.09.015. Epub 2017 Sep 30.


A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea.

Martinez-Pastor M, Lancaster WA, Tonner PD, Adams MWW, Schmid AK.

Nucleic Acids Res. 2017 Sep 29;45(17):9990-10001. doi: 10.1093/nar/gkx662.


Mechanisms of Chromium and Uranium Toxicity in Pseudomonas stutzeri RCH2 Grown under Anaerobic Nitrate-Reducing Conditions.

Thorgersen MP, Lancaster WA, Ge X, Zane GM, Wetmore KM, Vaccaro BJ, Poole FL 2nd, Younkin AD, Deutschbauer AM, Arkin AP, Wall JD, Adams MWW.

Front Microbiol. 2017 Aug 10;8:1529. doi: 10.3389/fmicb.2017.01529. eCollection 2017.


Impact of growth mode, phase, and rate on the metabolic state of the extremely thermophilic archaeon Pyrococcus furiosus.

Khatibi PA, Chou CJ, Loder AJ, Zurawski JV, Adams MWW, Kelly RM.

Biotechnol Bioeng. 2017 Dec;114(12):2947-2954. doi: 10.1002/bit.26408. Epub 2017 Oct 6.


Defining Electron Bifurcation in the Electron-Transferring Flavoprotein Family.

Garcia Costas AM, Poudel S, Miller AF, Schut GJ, Ledbetter RN, Fixen KR, Seefeldt LC, Adams MWW, Harwood CS, Boyd ES, Peters JW.

J Bacteriol. 2017 Oct 3;199(21). pii: e00440-17. doi: 10.1128/JB.00440-17. Print 2017 Nov 1.


The Physiological Functions and Structural Determinants of Catalytic Bias in the [FeFe]-Hydrogenases CpI and CpII of Clostridium pasteurianum Strain W5.

Therien JB, Artz JH, Poudel S, Hamilton TL, Liu Z, Noone SM, Adams MWW, King PW, Bryant DA, Boyd ES, Peters JW.

Front Microbiol. 2017 Jul 12;8:1305. doi: 10.3389/fmicb.2017.01305. eCollection 2017.


Biological iron-sulfur storage in a thioferrate-protein nanoparticle.

Vaccaro BJ, Clarkson SM, Holden JF, Lee DW, Wu CH, Poole Ii FL, Cotelesage JJH, Hackett MJ, Mohebbi S, Sun J, Li H, Johnson MK, George GN, Adams MWW.

Nat Commun. 2017 Jul 20;8:16110. doi: 10.1038/ncomms16110.


Two functionally distinct NADP+-dependent ferredoxin oxidoreductases maintain the primary redox balance of Pyrococcus furiosus.

Nguyen DMN, Schut GJ, Zadvornyy OA, Tokmina-Lukaszewska M, Poudel S, Lipscomb GL, Adams LA, Dinsmore JT, Nixon WJ, Boyd ES, Bothner B, Peters JW, Adams MWW.

J Biol Chem. 2017 Sep 1;292(35):14603-14616. doi: 10.1074/jbc.M117.794172. Epub 2017 Jul 13.


Reduction Potentials of [FeFe]-Hydrogenase Accessory Iron-Sulfur Clusters Provide Insights into the Energetics of Proton Reduction Catalysis.

Artz JH, Mulder DW, Ratzloff MW, Lubner CE, Zadvornyy OA, LeVan AX, Williams SG, Adams MWW, Jones AK, King PW, Peters JW.

J Am Chem Soc. 2017 Jul 19;139(28):9544-9550. doi: 10.1021/jacs.7b02099. Epub 2017 Jul 6.


Bioavailability of Carbohydrate Content in Natural and Transgenic Switchgrasses for the Extreme Thermophile Caldicellulosiruptor bescii.

Zurawski JV, Khatibi PA, Akinosho HO, Straub CT, Compton SH, Conway JM, Lee LL, Ragauskas AJ, Davison BH, Adams MWW, Kelly RM.

Appl Environ Microbiol. 2017 Aug 17;83(17). pii: e00969-17. doi: 10.1128/AEM.00969-17. Print 2017 Sep 1.


Equilibrium and ultrafast kinetic studies manipulating electron transfer: A short-lived flavin semiquinone is not sufficient for electron bifurcation.

Hoben JP, Lubner CE, Ratzloff MW, Schut GJ, Nguyen DMN, Hempel KW, Adams MWW, King PW, Miller AF.

J Biol Chem. 2017 Aug 25;292(34):14039-14049. doi: 10.1074/jbc.M117.794214. Epub 2017 Jun 14.


Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island.

Antranikian G, Suleiman M, Schäfers C, Adams MWW, Bartolucci S, Blamey JM, Birkeland NK, Bonch-Osmolovskaya E, da Costa MS, Cowan D, Danson M, Forterre P, Kelly R, Ishino Y, Littlechild J, Moracci M, Noll K, Oshima T, Robb F, Rossi M, Santos H, Schönheit P, Sterner R, Thauer R, Thomm M, Wiegel J, Stetter KO.

Extremophiles. 2017 Jul;21(4):733-742. doi: 10.1007/s00792-017-0938-y. Epub 2017 May 10.


Genome Stability in Engineered Strains of the Extremely Thermophilic Lignocellulose-Degrading Bacterium Caldicellulosiruptor bescii.

Williams-Rhaesa AM, Poole FL 2nd, Dinsmore JT, Lipscomb GL, Rubinstein GM, Scott IM, Conway JM, Lee LL, Khatibi PA, Kelly RM, Adams MWW.

Appl Environ Microbiol. 2017 Jun 30;83(14). pii: e00444-17. doi: 10.1128/AEM.00444-17. Print 2017 Jul 15.


Systems biology guided by XCMS Online metabolomics.

Huan T, Forsberg EM, Rinehart D, Johnson CH, Ivanisevic J, Benton HP, Fang M, Aisporna A, Hilmers B, Poole FL, Thorgersen MP, Adams MWW, Krantz G, Fields MW, Robbins PD, Niedernhofer LJ, Ideker T, Majumder EL, Wall JD, Rattray NJW, Goodacre R, Lairson LL, Siuzdak G.

Nat Methods. 2017 Apr 27;14(5):461-462. doi: 10.1038/nmeth.4260. No abstract available.


Mechanistic insights into energy conservation by flavin-based electron bifurcation.

Lubner CE, Jennings DP, Mulder DW, Schut GJ, Zadvornyy OA, Hoben JP, Tokmina-Lukaszewska M, Berry L, Nguyen DM, Lipscomb GL, Bothner B, Jones AK, Miller AF, King PW, Adams MWW, Peters JW.

Nat Chem Biol. 2017 Jun;13(6):655-659. doi: 10.1038/nchembio.2348. Epub 2017 Apr 10.


Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.

van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, Ackermann AM, Cáceres E, Hunter AE, Kaestner KH, Donaldson CJ, Huising MO.

Cell Metab. 2017 Apr 4;25(4):911-926.e6. doi: 10.1016/j.cmet.2017.03.017.


Reverse gyrase is essential for microbial growth at 95 °C.

Lipscomb GL, Hahn EM, Crowley AT, Adams MWW.

Extremophiles. 2017 May;21(3):603-608. doi: 10.1007/s00792-017-0929-z. Epub 2017 Mar 22.


Extremely thermophilic energy metabolisms: biotechnological prospects.

Straub CT, Zeldes BM, Schut GJ, Adams MW, Kelly RM.

Curr Opin Biotechnol. 2017 Jun;45:104-112. doi: 10.1016/j.copbio.2017.02.016. Epub 2017 Mar 16. Review.


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