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Items: 1 to 50 of 81

1.

Long-Acting and Selective Oxytocin Peptide Analogs Show Antidiabetic and Antiobesity Effects in Male Mice.

Snider B, Geiser A, Yu XP, Beebe EC, Willency JA, Qing K, Guo L, Lu J, Wang X, Yang Q, Efanov A, Adams AC, Coskun T, Emmerson PJ, Alsina-Fernandez J, Ai M.

J Endocr Soc. 2019 May 16;3(7):1423-1444. doi: 10.1210/js.2019-00004. eCollection 2019 Jul 1.

2.

Vagal nerve stimulation for intractable hiccups is not a panacea: a case report and review of the literature.

Grewal SS, Adams AC, Van Gompel JJ.

Int J Neurosci. 2018 Dec;128(12):1114-1117. doi: 10.1080/00207454.2018.1486307. Epub 2018 Jul 3. Review.

PMID:
29882681
3.

Eccentric exercise increases circulating fibroblast activation protein α but not bioactive fibroblast growth factor 21 in healthy humans.

Parmar B, Lewis JE, Samms RJ, Ebling FJP, Cheng CC, Adams AC, Mallinson J, Cooper S, Taylor T, Ghasemi R, Stephens FB, Tsintzas K.

Exp Physiol. 2018 Jun;103(6):876-883. doi: 10.1113/EP086669.

PMID:
29663541
4.

Cholic Acid Supplementation of a High-Fat Obesogenic Diet Suppresses Hepatic Triacylglycerol Accumulation in Mice via a Fibroblast Growth Factor 21-Dependent Mechanism.

Ippagunta SM, Kharitonenkov A, Adams AC, Hillgartner FB.

J Nutr. 2018 Apr 1;148(4):510-517. doi: 10.1093/jn/nxy022.

PMID:
29659970
5.

CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis.

Prentice KJ, Wendell SG, Liu Y, Eversley JA, Salvatore SR, Mohan H, Brandt SL, Adams AC, Serena Wang X, Wei D, FitzGerald GA, Durham TB, Hammond CD, Sloop KW, Skarke C, Schopfer FJ, Wheeler MB.

EBioMedicine. 2018 Jan;27:200-213. doi: 10.1016/j.ebiom.2017.12.019. Epub 2017 Dec 19.

6.

Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice.

Xia JY, Sun K, Hepler C, Ghaben AL, Gupta RK, An YA, Holland WL, Morley TS, Adams AC, Gordillo R, Kusminski CM, Scherer PE.

Diabetologia. 2018 Apr;61(4):932-941. doi: 10.1007/s00125-017-4516-8. Epub 2017 Dec 9.

7.

Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.

Desai BN, Singhal G, Watanabe M, Stevanovic D, Lundasen T, Fisher FM, Mather ML, Vardeh HG, Douris N, Adams AC, Nasser IA, FitzGerald GA, Flier JS, Skarke C, Maratos-Flier E.

Mol Metab. 2017 Nov;6(11):1395-1406. doi: 10.1016/j.molmet.2017.08.004. Epub 2017 Aug 19.

8.

Discrepancies between ClinicalTrials.gov recruitment status and actual trial status: a cross-sectional analysis.

Jones CW, Safferman MR, Adams AC, Platts-Mills TF.

BMJ Open. 2017 Oct 11;7(10):e017719. doi: 10.1136/bmjopen-2017-017719.

9.

Antibody-Mediated Targeting of the FGFR1c Isoform Increases Glucose Uptake in White and Brown Adipose Tissue in Male Mice.

Lewis JE, Samms RJ, Cooper S, Luckett JC, Perkins AC, Dunbar JD, Smith DP, Emmerson PJ, Adams AC, Ebling FJP, Tsintzas K.

Endocrinology. 2017 Oct 1;158(10):3090-3096. doi: 10.1210/en.2017-00591.

10.

FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans.

Samms RJ, Lewis JE, Norton L, Stephens FB, Gaffney CJ, Butterfield T, Smith DP, Cheng CC, Perfield JW 2nd, Adams AC, Ebling FJP, Tsintzas K.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3806-3813. doi: 10.1210/jc.2017-01257.

11.

Clinical Reasoning: A 54-year-old woman with dementia, myoclonus, and ataxia.

Ali F, Murray JA, Adams AC, Flanagan EP.

Neurology. 2017 Jul 11;89(2):e7-e12. doi: 10.1212/WNL.0000000000004093. No abstract available.

PMID:
28696937
12.

Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster.

Lewis JE, Samms RJ, Cooper S, Luckett JC, Perkins AC, Adams AC, Tsintzas K, Ebling FJP.

Sci Rep. 2017 Jun 26;7(1):4238. doi: 10.1038/s41598-017-03607-x.

13.

Precise stimulation location optimizes speech outcomes in essential tremor.

Matsumoto JY, Fossett T, Kim M, Duffy JR, Strand E, McKeon A, Lee KH, Stead M, Burnett M, Adams AC, Klassen BT.

Parkinsonism Relat Disord. 2016 Nov;32:60-65. doi: 10.1016/j.parkreldis.2016.08.017. Epub 2016 Aug 25.

PMID:
27595548
14.

Fibroblast growth factor 21 has no direct role in regulating fertility in female mice.

Singhal G, Douris N, Fish AJ, Zhang X, Adams AC, Flier JS, Pissios P, Maratos-Flier E.

Mol Metab. 2016 May 18;5(8):690-698. doi: 10.1016/j.molmet.2016.05.010. eCollection 2016 Aug.

15.

FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency.

Dollet L, Levrel C, Coskun T, Le Lay S, Le May C, Ayer A, Venara Q, Adams AC, Gimeno RE, Magré J, Cariou B, Prieur X.

Diabetes. 2016 Nov;65(11):3410-3417. Epub 2016 Aug 23.

16.

Fibroblast Growth Factor 21-Null Mice Do Not Exhibit an Impaired Response to Fasting.

Antonellis PJ, Hayes MP, Adams AC.

Front Endocrinol (Lausanne). 2016 Jun 30;7:77. doi: 10.3389/fendo.2016.00077. eCollection 2016.

17.

The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling.

Jager J, Wang F, Fang B, Lim HW, Peed LC, Steger DJ, Won KJ, Kharitonenkov A, Adams AC, Lazar MA.

J Biol Chem. 2016 May 13;291(20):10867-75. doi: 10.1074/jbc.M116.719120. Epub 2016 Mar 21.

18.

Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity.

Samms RJ, Cheng CC, Kharitonenkov A, Gimeno RE, Adams AC.

Endocrinology. 2016 Apr;157(4):1467-80. doi: 10.1210/en.2015-1722. Epub 2016 Feb 22.

PMID:
26901091
19.

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas.

Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS, Maratos-Flier E.

PLoS One. 2016 Feb 12;11(2):e0148252. doi: 10.1371/journal.pone.0148252. eCollection 2016.

20.

The Sweetest Thing: Regulation of Macronutrient Preference by FGF21.

Adams AC, Gimeno RE.

Cell Metab. 2016 Feb 9;23(2):227-8. doi: 10.1016/j.cmet.2016.01.013.

21.

Antibody-Mediated Inhibition of the FGFR1c Isoform Induces a Catabolic Lean State in Siberian Hamsters.

Samms RJ, Lewis JE, Lory A, Fowler MJ, Cooper S, Warner A, Emmerson P, Adams AC, Luckett JC, Perkins AC, Wilson D, Barrett P, Tsintzas K, Ebling FJ.

Curr Biol. 2015 Nov 16;25(22):2997-3003. doi: 10.1016/j.cub.2015.10.010. Epub 2015 Nov 5.

22.

Dual effects of fibroblast growth factor 21 on hepatic energy metabolism.

Samms RJ, Murphy M, Fowler MJ, Cooper S, Emmerson P, Coskun T, Adams AC, Kharitonenkov A, Ebling FJ, Tsintzas K.

J Endocrinol. 2015 Oct;227(1):37-47. doi: 10.1530/JOE-15-0334. Epub 2015 Aug 20.

PMID:
26294388
23.

Melanin-concentrating hormone is necessary for olanzapine-inhibited locomotor activity in male mice.

Chee MJ, Douris N, Forrow AB, Monnard A, Lu S, Flaherty SE 3rd, Adams AC, Maratos-Flier E.

Eur Neuropsychopharmacol. 2015 Oct;25(10):1808-16. doi: 10.1016/j.euroneuro.2015.05.010. Epub 2015 Jun 3.

24.

The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis.

Carracedo A, Rousseau D, Douris N, Fernández-Ruiz S, Martín-Martín N, Weiss D, Webster K, Adams AC, Vazquez-Chantada M, Martinez-Chantar ML, Anty R, Tran A, Maratos-Flier E, Gual P, Pandolfi PP.

Int J Biol Sci. 2015 Apr 11;11(6):629-32. doi: 10.7150/ijbs.11615. eCollection 2015. No abstract available.

25.

Serum FGF21 levels are associated with brown adipose tissue activity in humans.

Hanssen MJ, Broeders E, Samms RJ, Vosselman MJ, van der Lans AA, Cheng CC, Adams AC, van Marken Lichtenbelt WD, Schrauwen P.

Sci Rep. 2015 May 18;5:10275. doi: 10.1038/srep10275.

26.

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.

Samms RJ, Smith DP, Cheng CC, Antonellis PP, Perfield JW 2nd, Kharitonenkov A, Gimeno RE, Adams AC.

Cell Rep. 2015 May 19;11(7):991-9. doi: 10.1016/j.celrep.2015.04.046. Epub 2015 May 5.

27.

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.

Douris N, Stevanovic DM, Fisher FM, Cisu TI, Chee MJ, Nguyen NL, Zarebidaki E, Adams AC, Kharitonenkov A, Flier JS, Bartness TJ, Maratos-Flier E.

Endocrinology. 2015 Jul;156(7):2470-81. doi: 10.1210/en.2014-2001. Epub 2015 Apr 29.

28.

Microglia in Glia-Neuron Co-cultures Exhibit Robust Phagocytic Activity Without Concomitant Inflammation or Cytotoxicity.

Adams AC, Kyle M, Beaman-Hall CM, Monaco EA 3rd, Cullen M, Vallano ML.

Cell Mol Neurobiol. 2015 Oct;35(7):961-75. doi: 10.1007/s10571-015-0191-9. Epub 2015 Apr 18.

PMID:
25894384
29.

Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21.

Assini JM, Mulvihill EE, Burke AC, Sutherland BG, Telford DE, Chhoker SS, Sawyez CG, Drangova M, Adams AC, Kharitonenkov A, Pin CL, Huff MW.

Endocrinology. 2015 Jun;156(6):2087-102. doi: 10.1210/en.2014-2003. Epub 2015 Mar 16.

PMID:
25774553
30.

Interplay between FGF21 and insulin action in the liver regulates metabolism.

Emanuelli B, Vienberg SG, Smyth G, Cheng C, Stanford KI, Arumugam M, Michael MD, Adams AC, Kharitonenkov A, Kahn CR.

J Clin Invest. 2015 Jan;125(1):458. doi: 10.1172/JCI80223. Epub 2015 Jan 2. No abstract available.

31.

Fibroblast growth factor 21 is not required for the reductions in circulating insulin-like growth factor-1 or global cell proliferation rates in response to moderate calorie restriction in adult mice.

Thompson AC, Bruss MD, Nag N, Kharitonenkov A, Adams AC, Hellerstein MK.

PLoS One. 2014 Nov 4;9(11):e111418. doi: 10.1371/journal.pone.0111418. eCollection 2014.

32.

Photoperiodic regulation of FGF21 production in the Siberian hamster.

Samms RJ, Fowler MJ, Cooper S, Emmerson P, Coskun T, Adams AC, Kharitonenkov A, Tsintzas K, Ebling FJ.

Horm Behav. 2014 Jun;66(1):180-5. doi: 10.1016/j.yhbeh.2014.03.013.

PMID:
24909854
33.

Inventing new medicines: The FGF21 story.

Kharitonenkov A, Adams AC.

Mol Metab. 2013 Dec 27;3(3):221-9. doi: 10.1016/j.molmet.2013.12.003. eCollection 2014 Jun. Review.

34.

Interplay between FGF21 and insulin action in the liver regulates metabolism.

Emanuelli B, Vienberg SG, Smyth G, Cheng C, Stanford KI, Arumugam M, Michael MD, Adams AC, Kharitonenkov A, Kahn CR.

J Clin Invest. 2014 Feb;124(2):515-27. doi: 10.1172/JCI67353. Epub 2014 Jan 9. Erratum in: J Clin Invest. 2015 Jan;125(1):458.

35.

Physiology and Endocrinology Symposium: FGF21: Insights into mechanism of action from preclinical studies.

Antonellis PJ, Kharitonenkov A, Adams AC.

J Anim Sci. 2014 Feb;92(2):407-13. doi: 10.2527/jas.2013-7076. Epub 2014 Jan 7.

PMID:
24398833
36.

Mood stability in Parkinson disease following deep brain stimulation: a 6-month prospective follow-up study.

Chopra A, Abulseoud OA, Sampson S, Lee KH, Klassen BT, Fields JA, Matsumoto JY, Adams AC, Stoppel CJ, Geske JR, Frye MA.

Psychosomatics. 2014 Sep-Oct;55(5):478-84. doi: 10.1016/j.psym.2013.09.003. Epub 2013 Dec 21.

37.

Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.

Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M.

Gastroenterology. 2014 Feb;146(2):539-49.e7. doi: 10.1053/j.gastro.2013.10.059. Epub 2013 Nov 1.

38.

Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones.

Adams AC, Coskun T, Cheng CC, O Farrell LS, Dubois SL, Kharitonenkov A.

Mol Metab. 2013 May 29;2(3):205-14. doi: 10.1016/j.molmet.2013.05.005. eCollection 2013.

39.

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys.

Adams AC, Halstead CA, Hansen BC, Irizarry AR, Martin JA, Myers SR, Reynolds VL, Smith HW, Wroblewski VJ, Kharitonenkov A.

PLoS One. 2013 Jun 18;8(6):e65763. doi: 10.1371/journal.pone.0065763. Print 2013.

40.

FGF21 drives a shift in adipokine tone to restore metabolic health.

Adams AC, Kharitonenkov A.

Aging (Albany NY). 2013 Jun;5(6):386-7. No abstract available.

41.

An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice.

Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, Bauer SM, Wade M, Singhal E, Cheng CC, Volk K, Kuo MS, Gordillo R, Kharitonenkov A, Scherer PE.

Cell Metab. 2013 May 7;17(5):790-7. doi: 10.1016/j.cmet.2013.03.019.

42.

FGF21 requires βklotho to act in vivo.

Adams AC, Cheng CC, Coskun T, Kharitonenkov A.

PLoS One. 2012;7(11):e49977. doi: 10.1371/journal.pone.0049977. Epub 2012 Nov 27.

43.

Increased responses to the actions of fibroblast growth factor 21 on energy balance and body weight in a seasonal model of adiposity.

Murphy M, Samms R, Warner A, Bolborea M, Barrett P, Fowler MJ, Brameld JM, Tsintzas K, Kharitonenkov A, Adams AC, Coskun T, Ebling FJ.

J Neuroendocrinol. 2013 Feb;25(2):180-9. doi: 10.1111/j.1365-2826.2012.02383.x.

PMID:
22958332
44.

A metabolic prosurvival role for PML in breast cancer.

Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP.

J Clin Invest. 2012 Sep;122(9):3088-100. doi: 10.1172/JCI62129. Epub 2012 Aug 13.

45.

Fundamentals of FGF19 & FGF21 action in vitro and in vivo.

Adams AC, Coskun T, Rovira AR, Schneider MA, Raches DW, Micanovic R, Bina HA, Dunbar JD, Kharitonenkov A.

PLoS One. 2012;7(5):e38438. doi: 10.1371/journal.pone.0038438. Epub 2012 May 31.

46.

FGF21: The center of a transcriptional nexus in metabolic regulation.

Adams AC, Kharitonenkov A.

Curr Diabetes Rev. 2012 Jul 1;8(4):285-93. Review.

PMID:
22587513
47.

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue.

Adams AC, Yang C, Coskun T, Cheng CC, Gimeno RE, Luo Y, Kharitonenkov A.

Mol Metab. 2012 Aug 28;2(1):31-7. doi: 10.1016/j.molmet.2012.08.007. eCollection 2012.

48.

Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.

Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, Kharitonenkov A, Spiegelman BM, Maratos-Flier E.

Endocrinology. 2011 Aug;152(8):2996-3004. doi: 10.1210/en.2011-0281. Epub 2011 Jun 28.

49.

Ablation of the hypothalamic neuropeptide melanin concentrating hormone is associated with behavioral abnormalities that reflect impaired olfactory integration.

Adams AC, Domouzoglou EM, Chee MJ, Segal-Lieberman G, Pissios P, Maratos-Flier E.

Behav Brain Res. 2011 Oct 10;224(1):195-200. doi: 10.1016/j.bbr.2011.05.039. Epub 2011 Jun 6.

50.

Voltage-dependent mania after subthalamic nucleus deep brain stimulation in Parkinson's disease: a case report.

Chopra A, Tye SJ, Lee KH, Matsumoto J, Klassen B, Adams AC, Stead M, Sampson S, Kall BA, Frye MA.

Biol Psychiatry. 2011 Jul 15;70(2):e5-7. doi: 10.1016/j.biopsych.2010.12.035. Epub 2011 Mar 16. No abstract available.

PMID:
21414603

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