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Items: 45


Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.

Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D'Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Slukvin I, Ryu BY, Sorrentino BP, Adair JE, Snyder SA, Compton AA, Torbett BE.

Blood. 2019 Aug 15. pii: blood.2019000040. doi: 10.1182/blood.2019000040. [Epub ahead of print]


Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates.

Humbert O, Radtke S, Samuelson C, Carrillo RR, Perez AM, Reddy SS, Lux C, Pattabhi S, Schefter LE, Negre O, Lee CM, Bao G, Adair JE, Peterson CW, Rawlings DJ, Scharenberg AM, Kiem HP.

Sci Transl Med. 2019 Jul 31;11(503). pii: eaaw3768. doi: 10.1126/scitranslmed.aaw3768.


Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants.

Peterson CW, Adair JE, Wohlfahrt ME, Deleage C, Radtke S, Rust B, Norman KK, Norgaard ZK, Schefter LE, Sghia-Hughes GM, Repetto A, Baldessari A, Murnane RD, Estes JD, Kiem HP.

Stem Cell Reports. 2019 Jul 9;13(1):91-104. doi: 10.1016/j.stemcr.2019.05.016. Epub 2019 Jun 13.


Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations.

Shahbazi R, Sghia-Hughes G, Reid JL, Kubek S, Haworth KG, Humbert O, Kiem HP, Adair JE.

Nat Mater. 2019 Oct;18(10):1124-1132. doi: 10.1038/s41563-019-0385-5. Epub 2019 May 27.


What the Gene Therapy Community Should Do About Sexual Harassment.

Adair JE, Flotte TR.

Hum Gene Ther. 2019 Mar;30(3):249-251. doi: 10.1089/hum.2019.028. No abstract available.


Minimal conditioning in Fanconi anemia promotes multi-lineage marrow engraftment at 10-fold lower cell doses.

Haworth KG, Ironside C, Ramirez MA, Weitz S, Beard BC, Schwartz JD, Adair JE, Kiem HP.

J Gene Med. 2018 Oct;20(10-11):e3050. doi: 10.1002/jgm.3050. Epub 2018 Oct 1.


UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.

Ngom M, Imren S, Maetzig T, Adair JE, Knapp DJHF, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RK.

Mol Ther Methods Clin Dev. 2018 Jul 5;10:156-164. doi: 10.1016/j.omtm.2018.06.009. eCollection 2018 Sep 21.


HIV infection results in clonal expansions containing integrations within pathogenesis-related biological pathways.

Haworth KG, Schefter LE, Norgaard ZK, Ironside C, Adair JE, Kiem HP.

JCI Insight. 2018 Jul 12;3(13). pii: 99127. doi: 10.1172/jci.insight.99127.


Novel lineage depletion preserves autologous blood stem cells for gene therapy of Fanconi anemia complementation group A.

Adair JE, Chandrasekaran D, Sghia-Hughes G, Haworth KG, Woolfrey AE, Burroughs LM, Choi GY, Becker PS, Kiem HP.

Haematologica. 2018 Nov;103(11):1806-1814. doi: 10.3324/haematol.2018.194571. Epub 2018 Jul 5.


Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy.

Humbert O, Chan F, Rajawat YS, Torgerson TR, Burtner CR, Hubbard NW, Humphrys D, Norgaard ZK, O'Donnell P, Adair JE, Trobridge GD, Scharenberg AM, Felsburg PJ, Rawlings DJ, Kiem HP.

Blood Adv. 2018 May 8;2(9):987-999. doi: 10.1182/bloodadvances.2018016451.


Driving CARs Across New Borders.

Turtle CJ, Adair JE.

Hum Gene Ther. 2018 May;29(5):529. doi: 10.1089/hum.2018.29065.cjt. No abstract available.


An Interview with Michel Sadelain, MD, PhD.

Adair JE.

Hum Gene Ther. 2018 May;29(5):530-533. doi: 10.1089/hum.2018.29063.msa. No abstract available.


A distinct hematopoietic stem cell population for rapid multilineage engraftment in nonhuman primates.

Radtke S, Adair JE, Giese MA, Chan YY, Norgaard ZK, Enstrom M, Haworth KG, Schefter LE, Kiem HP.

Sci Transl Med. 2017 Nov 1;9(414). pii: eaan1145. doi: 10.1126/scitranslmed.aan1145.


Hematopoietic Stem Cell Approaches to Cancer.

Adair JE, Kubek SP, Kiem HP.

Hematol Oncol Clin North Am. 2017 Oct;31(5):897-912. doi: 10.1016/j.hoc.2017.06.012. Review.


In Vivo Murine-Matured Human CD3+ Cells as a Preclinical Model for T Cell-Based Immunotherapies.

Haworth KG, Ironside C, Norgaard ZK, Obenza WM, Adair JE, Kiem HP.

Mol Ther Methods Clin Dev. 2017 May 17;6:17-30. doi: 10.1016/j.omtm.2017.05.004. eCollection 2017 Sep 15.


Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.

Gori JL, Butler JM, Kunar B, Poulos MG, Ginsberg M, Nolan DJ, Norgaard ZK, Adair JE, Rafii S, Kiem HP.

Stem Cells Transl Med. 2017 Mar;6(3):864-876. doi: 10.5966/sctm.2016-0240. Epub 2016 Oct 14.


Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia.

Adair JE, Sevilla J, Heredia CD, Becker PS, Kiem HP, Bueren J.

Curr Gene Ther. 2017;16(5):338-348. doi: 10.2174/1566523217666170119113029. Review.


Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.

Adair JE, Waters T, Haworth KG, Kubek SP, Trobridge GD, Hocum JD, Heimfeld S, Kiem HP.

Nat Commun. 2016 Oct 20;7:13173. doi: 10.1038/ncomms13173.


Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS.

Peterson CW, Haworth KG, Burke BP, Polacino P, Norman KK, Adair JE, Hu SL, Bartlett JS, Symonds GP, Kiem HP.

Mol Ther Methods Clin Dev. 2016 Feb 24;3:16007. doi: 10.1038/mtm.2016.7. eCollection 2016.


VISA--Vector Integration Site Analysis server: a web-based server to rapidly identify retroviral integration sites from next-generation sequencing.

Hocum JD, Battrell LR, Maynard R, Adair JE, Beard BC, Rawlings DJ, Kiem HP, Miller DG, Trobridge GD.

BMC Bioinformatics. 2015 Jul 7;16:212. doi: 10.1186/s12859-015-0653-6.


Plerixafor+G-CSF-mobilized CD34+ cells represent an optimal graft source for thalassemia gene therapy.

Karponi G, Psatha N, Lederer CW, Adair JE, Zervou F, Zogas N, Kleanthous M, Tsatalas C, Anagnostopoulos A, Sadelain M, Rivière I, Stamatoyannopoulos G, Yannaki E.

Blood. 2015 Jul 30;126(5):616-9. doi: 10.1182/blood-2015-03-629618. Epub 2015 Jun 18.


(211)Astatine-Conjugated Monoclonal CD45 Antibody-Based Nonmyeloablative Conditioning for Stem Cell Gene Therapy.

Burtner CR, Chandrasekaran D, Santos EB, Beard BC, Adair JE, Hamlin DK, Wilbur DS, Sandmaier BM, Kiem HP.

Hum Gene Ther. 2015 Jun;26(6):399-406. doi: 10.1089/hum.2015.021.


Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection.

Olszko ME, Adair JE, Linde I, Rae DT, Trobridge P, Hocum JD, Rawlings DJ, Kiem HP, Trobridge GD.

Gene Ther. 2015 Jul;22(7):591-5. doi: 10.1038/gt.2015.20. Epub 2015 Mar 19.


Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.

Gori JL, Butler JM, Chan YY, Chandrasekaran D, Poulos MG, Ginsberg M, Nolan DJ, Elemento O, Wood BL, Adair JE, Rafii S, Kiem HP.

J Clin Invest. 2015 Mar 2;125(3):1243-54. doi: 10.1172/JCI79328. Epub 2015 Feb 9.


Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients.

Adair JE, Johnston SK, Mrugala MM, Beard BC, Guyman LA, Baldock AL, Bridge CA, Hawkins-Daarud A, Gori JL, Born DE, Gonzalez-Cuyar LF, Silbergeld DL, Rockne RC, Storer BE, Rockhill JK, Swanson KR, Kiem HP.

J Clin Invest. 2014 Sep;124(9):4082-92. doi: 10.1172/JCI76739. Epub 2014 Aug 8.


Applying the speed-dating model and other approaches to foster future leaders for the American Society of Gene and Cell Therapy.

Adair JE, Weitzman MD.

Mol Ther. 2014 Aug;22(8):1397-1398. doi: 10.1038/mt.2014.119. No abstract available.


High-throughput genomic mapping of vector integration sites in gene therapy studies.

Beard BC, Adair JE, Trobridge GD, Kiem HP.

Methods Mol Biol. 2014;1185:321-44. doi: 10.1007/978-1-4939-1133-2_22.


Intravenous injection of a foamy virus vector to correct canine SCID-X1.

Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ, Kiem HP.

Blood. 2014 Jun 5;123(23):3578-84. doi: 10.1182/blood-2013-11-538926. Epub 2014 Mar 18.


Pigtailed macaques as a model to study long-term safety of lentivirus vector-mediated gene therapy for hemoglobinopathies.

Kiem HP, Arumugam PI, Burtner CR, Fox CF, Beard BC, Dexheimer P, Adair JE, Malik P.

Mol Ther Methods Clin Dev. 2014 Dec 17;1:14055. doi: 10.1038/mtm.2014.55. eCollection 2014.


CREB phosphorylation regulates striatal transcriptional responses in the self-administration model of methamphetamine addiction in the rat.

Krasnova IN, Chiflikyan M, Justinova Z, McCoy MT, Ladenheim B, Jayanthi S, Quintero C, Brannock C, Barnes C, Adair JE, Lehrmann E, Kobeissy FH, Gold MS, Becker KG, Goldberg SR, Cadet JL.

Neurobiol Dis. 2013 Oct;58:132-43. doi: 10.1016/j.nbd.2013.05.009. Epub 2013 May 30.


Efficient generation, purification, and expansion of CD34(+) hematopoietic progenitor cells from nonhuman primate-induced pluripotent stem cells.

Gori JL, Chandrasekaran D, Kowalski JP, Adair JE, Beard BC, D'Souza SL, Kiem HP.

Blood. 2012 Sep 27;120(13):e35-44. Epub 2012 Aug 16.


Cyclophosphamide promotes engraftment of gene-modified cells in a mouse model of Fanconi anemia without causing cytogenetic abnormalities.

Adair JE, Zhao X, Chien S, Fang M, Wohlfahrt ME, Trobridge GD, Taylor JA, Beard BC, Kiem HP, Becker PS.

J Mol Med (Berl). 2012 Nov;90(11):1283-94. doi: 10.1007/s00109-012-0905-0. Epub 2012 Jun 3.


Extended survival of glioblastoma patients after chemoprotective HSC gene therapy.

Adair JE, Beard BC, Trobridge GD, Neff T, Rockhill JK, Silbergeld DL, Mrugala MM, Kiem HP.

Sci Transl Med. 2012 May 9;4(133):133ra57. doi: 10.1126/scitranslmed.3003425.


Outside the box--novel therapeutic strategies for glioblastoma.

Mrugala MM, Adair JE, Kiem HP.

Cancer J. 2012 Jan-Feb;18(1):51-8. doi: 10.1097/PPO.0b013e318243f785. Review.


Safeguarding nonhuman primate iPS cells with suicide genes.

Zhong B, Watts KL, Gori JL, Wohlfahrt ME, Enssle J, Adair JE, Kiem HP.

Mol Ther. 2011 Sep;19(9):1667-75. doi: 10.1038/mt.2011.51. Epub 2011 May 17.


Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.

Tolar J, Adair JE, Antoniou M, Bartholomae CC, Becker PS, Blazar BR, Bueren J, Carroll T, Cavazzana-Calvo M, Clapp DW, Dalgleish R, Galy A, Gaspar HB, Hanenberg H, Von Kalle C, Kiem HP, Lindeman D, Naldini L, Navarro S, Renella R, Rio P, Sevilla J, Schmidt M, Verhoeyen E, Wagner JE, Williams DA, Thrasher AJ.

Mol Ther. 2011 Jul;19(7):1193-8. doi: 10.1038/mt.2011.78. Epub 2011 May 3. Review.


Efficient generation of nonhuman primate induced pluripotent stem cells.

Zhong B, Trobridge GD, Zhang X, Watts KL, Ramakrishnan A, Wohlfahrt M, Adair JE, Kiem HP.

Stem Cells Dev. 2011 May;20(5):795-807. doi: 10.1089/scd.2010.0343. Epub 2011 Feb 1.


Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice.

Matsuoka T, Adair JE, Lih FB, Hsi LC, Rubino M, Eling TE, Tomer KB, Yashiro M, Hirakawa K, Olden K, Roberts JD.

Br J Cancer. 2010 Oct 12;103(8):1182-91. doi: 10.1038/sj.bjc.6605881. Epub 2010 Sep 14.


Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.

Beard BC, Trobridge GD, Ironside C, McCune JS, Adair JE, Kiem HP.

J Clin Invest. 2010 Jul;120(7):2345-54. doi: 10.1172/JCI40767. Epub 2010 Jun 14.


Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding.

Adair JE, Stober V, Sobhany M, Zhuo L, Roberts JD, Negishi M, Kimata K, Garantziotis S.

J Biol Chem. 2009 Jun 19;284(25):16922-30. doi: 10.1074/jbc.M808560200. Epub 2009 Apr 24.


High-mobility group A1 proteins inhibit expression of nucleotide excision repair factor xeroderma pigmentosum group A.

Adair JE, Maloney SC, Dement GA, Wertzler KJ, Smerdon MJ, Reeves R.

Cancer Res. 2007 Jul 1;67(13):6044-52.


Gene-specific nucleotide excision repair is impaired in human cells expressing elevated levels of high mobility group A1 nonhistone proteins.

Maloney SC, Adair JE, Smerdon MJ, Reeves R.

DNA Repair (Amst). 2007 Sep 1;6(9):1371-9. Epub 2007 May 30.


Inhibition of nucleotide excision repair by high mobility group protein HMGA1.

Adair JE, Kwon Y, Dement GA, Smerdon MJ, Reeves R.

J Biol Chem. 2005 Sep 16;280(37):32184-92. Epub 2005 Jul 19.


Role of high mobility group (HMG) chromatin proteins in DNA repair.

Reeves R, Adair JE.

DNA Repair (Amst). 2005 Jul 28;4(8):926-38. Review.


Human KIT ligand promoter is positively regulated by HMGA1 in breast and ovarian cancer cells.

Treff NR, Dement GA, Adair JE, Britt RL, Nie R, Shima JE, Taylor WE, Reeves R.

Oncogene. 2004 Nov 4;23(52):8557-62.


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