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Items: 1 to 50 of 142

1.

Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity.

Duke-Cohan JS, Ishikawa Y, Yoshizawa A, Choi YI, Lee CN, Acuto O, Kissler S, Reinherz EL.

Sci Signal. 2018 Jun 12;11(534). pii: eaan8799. doi: 10.1126/scisignal.aan8799.

PMID:
29895617
2.

ProteoSign: an end-user online differential proteomics statistical analysis platform.

Efstathiou G, Antonakis AN, Pavlopoulos GA, Theodosiou T, Divanach P, Trudgian DC, Thomas B, Papanikolaou N, Aivaliotis M, Acuto O, Iliopoulos I.

Nucleic Acids Res. 2017 Jul 3;45(W1):W300-W306. doi: 10.1093/nar/gkx444.

3.

The T cell IFT20 interactome reveals new players in immune synapse assembly.

Galgano D, Onnis A, Pappalardo E, Galvagni F, Acuto O, Baldari CT.

J Cell Sci. 2017 Mar 15;130(6):1110-1121. doi: 10.1242/jcs.200006. Epub 2017 Feb 2.

4.

TCR Signal Strength and T Cell Development.

Gascoigne NR, Rybakin V, Acuto O, Brzostek J.

Annu Rev Cell Dev Biol. 2016 Oct 6;32:327-348. Review.

PMID:
27712102
5.

SHP1-ing thymic selection.

Gascoigne NR, Brzostek J, Mehta M, Acuto O.

Eur J Immunol. 2016 Sep;46(9):2091-4. doi: 10.1002/eji.201646582.

6.

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination.

Pageon SV, Tabarin T, Yamamoto Y, Ma Y, Nicovich PR, Bridgeman JS, Cohnen A, Benzing C, Gao Y, Crowther MD, Tungatt K, Dolton G, Sewell AK, Price DA, Acuto O, Parton RG, Gooding JJ, Rossy J, Rossjohn J, Gaus K.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5454-63. doi: 10.1073/pnas.1607436113. Epub 2016 Aug 29. Erratum in: Proc Natl Acad Sci U S A. 2016 Oct 17;:.

7.

Corrigendum: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.

Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR.

Nature. 2016 May 5;533(7601):130. doi: 10.1038/nature16968. Epub 2016 Jan 20. No abstract available.

PMID:
26789242
8.

DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.

Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR.

Nature. 2015 Dec 24;528(7583):517-22. doi: 10.1038/nature16193. Epub 2015 Dec 16. Erratum in: Nature. 2016 May 5;533(7601):130. Rigo, Frank W [Corrected to Rigo, Frank]..

9.

Expanding the yeast protein arginine methylome.

Plank M, Fischer R, Geoghegan V, Charles PD, Konietzny R, Acuto O, Pears C, Schofield CJ, Kessler BM.

Proteomics. 2015 Sep;15(18):3232-43. doi: 10.1002/pmic.201500032. Epub 2015 Jul 2.

PMID:
26046779
10.

Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signalling.

Geoghegan V, Guo A, Trudgian D, Thomas B, Acuto O.

Nat Commun. 2015 Apr 7;6:6758. doi: 10.1038/ncomms7758.

11.

THEMIS: a critical TCR signal regulator for ligand discrimination.

Gascoigne NR, Acuto O.

Curr Opin Immunol. 2015 Apr;33:86-92. doi: 10.1016/j.coi.2015.01.020. Epub 2015 Feb 18. Review.

PMID:
25700024
12.

Membrane nanodomains in T-cell antigen receptor signalling.

Nika K, Acuto O.

Essays Biochem. 2015;57:165-75. doi: 10.1042/bse0570165.

PMID:
25658352
13.

A THEMIS:SHP1 complex promotes T-cell survival.

Paster W, Bruger AM, Katsch K, Grégoire C, Roncagalli R, Fu G, Gascoigne NR, Nika K, Cohnen A, Feller SM, Simister PC, Molder KC, Cordoba SP, Dushek O, Malissen B, Acuto O.

EMBO J. 2015 Feb 3;34(3):393-409. doi: 10.15252/embj.201387725. Epub 2014 Dec 22.

14.

The late endosomal transporter CD222 directs the spatial distribution and activity of Lck.

Pfisterer K, Forster F, Paster W, Supper V, Ohradanova-Repic A, Eckerstorfer P, Zwirzitz A, Donner C, Boulegue C, Schiller HB, Ondrovičová G, Acuto O, Stockinger H, Leksa V.

J Immunol. 2014 Sep 15;193(6):2718-32. doi: 10.4049/jimmunol.1303349. Epub 2014 Aug 15.

15.

Fine-tuning T cell receptor signaling to control T cell development.

Fu G, Rybakin V, Brzostek J, Paster W, Acuto O, Gascoigne NR.

Trends Immunol. 2014 Jul;35(7):311-8. doi: 10.1016/j.it.2014.05.003. Epub 2014 Jun 17. Review.

16.

Themis sets the signal threshold for positive and negative selection in T-cell development.

Fu G, Casas J, Rigaud S, Rybakin V, Lambolez F, Brzostek J, Hoerter JA, Paster W, Acuto O, Cheroutre H, Sauer K, Gascoigne NR.

Nature. 2013 Dec 19;504(7480):441-5. doi: 10.1038/nature12718. Epub 2013 Nov 13.

17.

Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation.

Salek M, McGowan S, Trudgian DC, Dushek O, de Wet B, Efstathiou G, Acuto O.

PLoS One. 2013 Oct 30;8(10):e77423. doi: 10.1371/journal.pone.0077423. eCollection 2013.

18.

QuaNCAT: quantitating proteome dynamics in primary cells.

Howden AJ, Geoghegan V, Katsch K, Efstathiou G, Bhushan B, Boutureira O, Thomas B, Trudgian DC, Kessler BM, Dieterich DC, Davis BG, Acuto O.

Nat Methods. 2013 Apr;10(4):343-6. doi: 10.1038/nmeth.2401. Epub 2013 Mar 10.

19.

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.

Paster W, Brockmeyer C, Fu G, Simister PC, de Wet B, Martinez-Riaño A, Hoerter JA, Feller SM, Wülfing C, Gascoigne NR, Acuto O.

J Immunol. 2013 Apr 1;190(7):3749-56. doi: 10.4049/jimmunol.1203389. Epub 2013 Mar 4.

20.

Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells.

Deswal S, Meyer A, Fiala GJ, Eisenhardt AE, Schmitt LC, Salek M, Brummer T, Acuto O, Schamel WW.

J Immunol. 2013 Mar 1;190(5):1927-35. doi: 10.4049/jimmunol.1200653. Epub 2013 Jan 28.

21.

Quantitative dynamics of phosphoproteome: the devil is in the details.

Salek M, Acuto O.

Anal Chem. 2012 Oct 16;84(20):8431-6. doi: 10.1021/ac301833k. Epub 2012 Oct 4.

22.

A method for large-scale identification of protein arginine methylation.

Uhlmann T, Geoghegan VL, Thomas B, Ridlova G, Trudgian DC, Acuto O.

Mol Cell Proteomics. 2012 Nov;11(11):1489-99. doi: 10.1074/mcp.M112.020743. Epub 2012 Aug 3.

23.

A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.

Girard T, El-Far M, Gaucher D, Acuto O, Beaulé G, Michel F, Mourad W, Sékaly RP.

Biochem Biophys Res Commun. 2012 Jun 29;423(2):301-7. doi: 10.1016/j.bbrc.2012.05.116. Epub 2012 May 30.

PMID:
22659416
24.

Lymphocyte signaling: a Tuscan affair.

Baldari CT, Acuto O, Batista F, Koretzky G, Weiss A.

Nat Immunol. 2011 Dec 16;13(1):3-6. doi: 10.1038/ni.2185. No abstract available.

PMID:
22179269
25.

Comparative evaluation of label-free SINQ normalized spectral index quantitation in the central proteomics facilities pipeline.

Trudgian DC, Ridlova G, Fischer R, Mackeen MM, Ternette N, Acuto O, Kessler BM, Thomas B.

Proteomics. 2011 Jul;11(14):2790-7. doi: 10.1002/pmic.201000800. Epub 2011 Jun 8.

PMID:
21656681
26.

Molecular T cell biology -- basic and translational challenges in the twenty-first century.

Reinherz EL, Acuto O.

Front Immunol. 2011 Feb 7;2:3. doi: 10.3389/fimmu.2011.00003. eCollection 2011. No abstract available.

27.

T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.

Brockmeyer C, Paster W, Pepper D, Tan CP, Trudgian DC, McGowan S, Fu G, Gascoigne NR, Acuto O, Salek M.

J Biol Chem. 2011 Mar 4;286(9):7535-47. doi: 10.1074/jbc.M110.201236. Epub 2010 Dec 28.

28.

Proteomic characterization of plasma membrane-proximal T cell activation responses.

de Wet B, Zech T, Salek M, Acuto O, Harder T.

J Biol Chem. 2011 Feb 11;286(6):4072-80. doi: 10.1074/jbc.M110.165415. Epub 2010 Dec 2.

29.

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.

Nika K, Soldani C, Salek M, Paster W, Gray A, Etzensperger R, Fugger L, Polzella P, Cerundolo V, Dushek O, Höfer T, Viola A, Acuto O.

Immunity. 2010 Jun 25;32(6):766-77. doi: 10.1016/j.immuni.2010.05.011. Epub 2010 Jun 11.

30.

Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue.

Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N.

J Biol Chem. 2010 Aug 20;285(34):26506-18. doi: 10.1074/jbc.M110.111104. Epub 2010 Jun 9.

31.

CPFP: a central proteomics facilities pipeline.

Trudgian DC, Thomas B, McGowan SJ, Kessler BM, Salek M, Acuto O.

Bioinformatics. 2010 Apr 15;26(8):1131-2. doi: 10.1093/bioinformatics/btq081. Epub 2010 Feb 25.

PMID:
20189941
32.

Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.

Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR.

Nat Immunol. 2009 Aug;10(8):848-56. doi: 10.1038/ni.1766. Epub 2009 Jul 13.

33.

Tailoring T-cell receptor signals by proximal negative feedback mechanisms.

Acuto O, Di Bartolo V, Michel F.

Nat Rev Immunol. 2008 Sep;8(9):699-712. doi: 10.1038/nri2397. Review.

PMID:
18728635
34.

A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.

Di Bartolo V, Montagne B, Salek M, Jungwirth B, Carrette F, Fourtane J, Sol-Foulon N, Michel F, Schwartz O, Lehmann WD, Acuto O.

J Exp Med. 2007 Mar 19;204(3):681-91. Epub 2007 Mar 12.

35.

T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2.

Dong S, Corre B, Foulon E, Dufour E, Veillette A, Acuto O, Michel F.

J Exp Med. 2006 Oct 30;203(11):2509-18. Epub 2006 Oct 16.

36.

Protein arginine methylation: a new frontier in T cell signal transduction.

Schurter BT, Blanchet F, Acuto O.

Adv Exp Med Biol. 2006;584:189-206. Review. No abstract available.

PMID:
16802608
37.

Protein arginine methylation in lymphocyte signaling.

Blanchet F, Schurter BT, Acuto O.

Curr Opin Immunol. 2006 Jun;18(3):321-8. Epub 2006 Apr 17. Review.

PMID:
16616479
38.

Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.

Martín-Cófreces NB, Sancho D, Fernández E, Vicente-Manzanares M, Gordón-Alonso M, Montoya MC, Michel F, Acuto O, Alarcón B, Sánchez-Madrid F.

J Immunol. 2006 Apr 1;176(7):4201-7.

39.

CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.

Marquez ME, Ellmeier W, Sanchez-Guajardo V, Freitas AA, Acuto O, Di Bartolo V.

J Immunol. 2005 Dec 1;175(11):7388-97.

40.

Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.

Rohrlich PS, Fazilleau N, Ginhoux F, Firat H, Michel F, Cochet M, Laham N, Roth MP, Pascolo S, Nato F, Coppin H, Charneau P, Danos O, Acuto O, Ehrlich R, Kanellopoulos J, Lemonnier FA.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12855-60. Epub 2005 Aug 25.

41.

CD28 costimulatory signal induces protein arginine methylation in T cells.

Blanchet F, Cardona A, Letimier FA, Hershfield MS, Acuto O.

J Exp Med. 2005 Aug 1;202(3):371-7.

42.

Sequence tag scanning: a new explorative strategy for recognition of unexpected protein alterations by nanoelectrospray ionization-tandem mass spectrometry.

Salek M, Di Bartolo V, Cittaro D, Borsotti D, Wei J, Acuto O, Rappsilber J, Lehmann WD.

Proteomics. 2005 Feb;5(3):667-74.

PMID:
15714472
43.

Antigen receptor signaling: the Tuscan chronicles.

Baldari CT, Koretzky G, Telford JL, Acuto O.

Nat Immunol. 2005 Jan;6(1):3-5. No abstract available.

PMID:
15611771
44.

Large-scale screening for genes involved in T-cell signaling: do we know all the players now?

Di Bartolo V, Acuto O.

Trends Immunol. 2004 Aug;25(8):399-402. Review. No abstract available.

PMID:
15275636
45.

Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.

Setterblad N, Blancheteau V, Delaguillaumie A, Michel F, Bécart S, Lombardi G, Acuto O, Charron D, Mooney N.

J Leukoc Biol. 2004 Jun;75(6):1036-44. Epub 2004 Feb 24.

PMID:
14982950
46.

Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis.

Le Bras S, Foucault I, Foussat A, Brignone C, Acuto O, Deckert M.

J Biol Chem. 2004 Apr 9;279(15):15550-60. Epub 2004 Jan 16.

47.

CD28-mediated co-stimulation: a quantitative support for TCR signalling.

Acuto O, Michel F.

Nat Rev Immunol. 2003 Dec;3(12):939-51. Review. No abstract available.

PMID:
14647476
48.

Proximal changes in signal transduction that modify CD8+ T cell responsiveness in vivo.

Guillaume S, Tuosto L, Tanchot C, Di Bartolo V, Acuto O, Rocha B.

Eur J Immunol. 2003 Sep;33(9):2551-6.

49.
50.

Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.

Acuto O, Mise-Omata S, Mangino G, Michel F.

Immunol Rev. 2003 Apr;192:21-31. Review.

PMID:
12670392

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