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Items: 1 to 50 of 208

1.

Involvement of plasma miRNAs, muscle miRNAs and mitochondrial miRNAs in the pathophysiology of frailty.

Rusanova I, Fernández-Martínez J, Fernández-Ortiz M, Aranda-Martínez P, Escames G, García-García FJ, Mañas L, Acuña-Castroviejo D.

Exp Gerontol. 2019 Jun 11:110637. doi: 10.1016/j.exger.2019.110637. [Epub ahead of print] Review.

PMID:
31199979
2.

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy.

Fernandez-Gil BI, Guerra-Librero A, Shen YQ, Florido J, Martínez-Ruiz L, García-López S, Adan C, Rodríguez-Santana C, Acuña-Castroviejo D, Quiñones-Hinojosa A, Fernández-Martínez J, Abdel Moneim AE, López LC, Rodríguez Ferrer JM, Escames G.

Oxid Med Cell Longev. 2019 Feb 28;2019:7187128. doi: 10.1155/2019/7187128. eCollection 2019.

3.

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease.

Barriocanal-Casado E, Hidalgo-Gutiérrez A, Raimundo N, González-García P, Acuña-Castroviejo D, Escames G, López LC.

EBioMedicine. 2019 Apr;42:511-523. doi: 10.1016/j.ebiom.2019.03.025. Epub 2019 Mar 18.

4.

Lack of NLRP3 inflammasome activation reduces age-dependent sarcopenia and mitochondrial dysfunction, favoring the prophylactic effect of melatonin.

Sayed RKA, Fernández-Ortiz M, Diaz-Casado ME, Aranda-Martínez P, Fernández-Martínez J, Guerra-Librero A, Escames G, López LC, Alsaadawy RM, Acuña-Castroviejo D.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14. pii: glz079. doi: 10.1093/gerona/glz079. [Epub ahead of print]

PMID:
30869745
5.

Impact of Daylight Saving Time on circadian timing system: An expert statement.

Meira E Cruz M, Miyazawa M, Manfredini R, Cardinali D, Madrid JA, Reiter R, Araujo JF, Agostinho R, Acuña-Castroviejo D.

Eur J Intern Med. 2019 Feb;60:1-3. doi: 10.1016/j.ejim.2019.01.001. Epub 2019 Jan 5. Review. No abstract available.

PMID:
30617016
6.

Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders.

Wang Z, Hu W, Lu C, Ma Z, Jiang S, Gu C, Acuña-Castroviejo D, Yang Y.

Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2765-2779. doi: 10.1161/ATVBAHA.118.311916.

PMID:
30571177
7.

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice.

Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC.

EMBO Mol Med. 2019 Jan;11(1). pii: e9466. doi: 10.15252/emmm.201809466.

8.

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.

Rodríguez-Hidalgo M, Luna-Sánchez M, Hidalgo-Gutiérrez A, Barriocanal-Casado E, Mascaraque C, Acuña-Castroviejo D, Rivera M, Escames G, López LC.

Sci Rep. 2018 Sep 18;8(1):14013. doi: 10.1038/s41598-018-32190-y.

9.

Cardiometabolic impact of changing internal time during daylight saving time: a window for a deleterious role within sleep-related breathing disorders.

Meira E Cruz M, Acuña-Castroviejo D.

Intern Emerg Med. 2018 Dec;13(8):1345-1346. doi: 10.1007/s11739-018-1934-7. Epub 2018 Aug 27. No abstract available.

PMID:
30151816
10.

Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3.

Reiter RJ, Tan DX, Rosales-Corral S, Galano A, Jou MJ, Acuna-Castroviejo D.

Int J Mol Sci. 2018 Aug 18;19(8). pii: E2439. doi: 10.3390/ijms19082439. Review.

11.

Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans.

Rusanova I, Diaz-Casado ME, Fernández-Ortiz M, Aranda-Martínez P, Guerra-Librero A, García-García FJ, Escames G, Mañas L, Acuña-Castroviejo D.

Oxid Med Cell Longev. 2018 Jul 18;2018:7671850. doi: 10.1155/2018/7671850. eCollection 2018.

12.

The Melatonin Analog IQM316 May Induce Adult Hippocampal Neurogenesis and Preserve Recognition Memories in Mice.

Figueiro-Silva J, Antequera D, Pascual C, de la Fuente Revenga M, Volt H, Acuña-Castroviejo D, Rodríguez-Franco MI, Carro E.

Cell Transplant. 2018 Mar;27(3):423-437. doi: 10.1177/0963689717721217.

13.

The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes.

Sayed RKA, Fernández-Ortiz M, Diaz-Casado ME, Rusanova I, Rahim I, Escames G, López LC, Mokhtar DM, Acuña-Castroviejo D.

J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1330-1338. doi: 10.1093/gerona/gly059.

PMID:
29562315
14.

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation.

Shen YQ, Guerra-Librero A, Fernandez-Gil BI, Florido J, García-López S, Martinez-Ruiz L, Mendivil-Perez M, Soto-Mercado V, Acuña-Castroviejo D, Ortega-Arellano H, Carriel V, Diaz-Casado ME, Reiter RJ, Rusanova I, Nieto A, López LC, Escames G.

J Pineal Res. 2018 Apr;64(3). doi: 10.1111/jpi.12461. Epub 2018 Jan 9.

PMID:
29247557
15.

In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.

Díaz-Casado ME, Rusanova I, Aranda P, Fernández-Ortiz M, Sayed RKA, Fernández-Gil BI, Hidalgo-Gutiérrez A, Escames G, López LC, Acuña-Castroviejo D.

Zebrafish. 2018 Feb;15(1):15-26. doi: 10.1089/zeb.2017.1479. Epub 2017 Nov 29.

PMID:
29185873
16.

Effect of Melatonin Supplementation on Antioxidant Status and DNA Damage in High Intensity Trained Athletes.

Ortiz-Franco M, Planells E, Quintero B, Acuña-Castroviejo D, Rusanova I, Escames G, Molina-López J.

Int J Sports Med. 2017 Dec;38(14):1117-1125. doi: 10.1055/s-0043-119881. Epub 2017 Nov 17.

PMID:
29165732
17.

Melatonin Treatment Reduces Oxidative Damage and Normalizes Plasma Pro-Inflammatory Cytokines in Patients Suffering from Charcot-Marie-Tooth Neuropathy: A Pilot Study in Three Children.

Chahbouni M, López MDS, Molina-Carballo A, de Haro T, Muñoz-Hoyos A, Fernández-Ortiz M, Guerra-Librero A, Acuña-Castroviejo D.

Molecules. 2017 Oct 14;22(10). pii: E1728. doi: 10.3390/molecules22101728.

18.

Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs).

Sugden WW, Leonardo-Mendonça RC, Acuña-Castroviejo D, Siekmann AF.

PLoS One. 2017 Aug 17;12(8):e0183433. doi: 10.1371/journal.pone.0183433. eCollection 2017.

19.

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.

López A, Ortiz F, Doerrier C, Venegas C, Fernández-Ortiz M, Aranda P, Díaz-Casado ME, Fernández-Gil B, Barriocanal-Casado E, Escames G, López LC, Acuña-Castroviejo D.

PLoS One. 2017 Aug 11;12(8):e0183090. doi: 10.1371/journal.pone.0183090. eCollection 2017.

20.

Melatonin, clock genes and mitochondria in sepsis.

Acuña-Castroviejo D, Rahim I, Acuña-Fernández C, Fernández-Ortiz M, Solera-Marín J, Sayed RKA, Díaz-Casado ME, Rusanova I, López LC, Escames G.

Cell Mol Life Sci. 2017 Nov;74(21):3965-3987. doi: 10.1007/s00018-017-2610-1. Epub 2017 Aug 7. Review.

PMID:
28785808
21.

Oral Mucositis: Melatonin Gel an Effective New Treatment.

Abdel Moneim AE, Guerra-Librero A, Florido J, Shen YQ, Fernández-Gil B, Acuña-Castroviejo D, Escames G.

Int J Mol Sci. 2017 May 7;18(5). pii: E1003. doi: 10.3390/ijms18051003. Review.

22.

Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.

Mendivil-Perez M, Soto-Mercado V, Guerra-Librero A, Fernandez-Gil BI, Florido J, Shen YQ, Tejada MA, Capilla-Gonzalez V, Rusanova I, Garcia-Verdugo JM, Acuña-Castroviejo D, López LC, Velez-Pardo C, Jimenez-Del-Rio M, Ferrer JM, Escames G.

J Pineal Res. 2017 Sep;63(2). doi: 10.1111/jpi.12415. Epub 2017 May 18.

PMID:
28423196
23.

Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.

Reiter RJ, Rosales-Corral SA, Tan DX, Acuna-Castroviejo D, Qin L, Yang SF, Xu K.

Int J Mol Sci. 2017 Apr 17;18(4). pii: E843. doi: 10.3390/ijms18040843. Review.

24.

Melatonin protects rats from radiotherapy-induced small intestine toxicity.

Fernández-Gil B, Moneim AE, Ortiz F, Shen YQ, Soto-Mercado V, Mendivil-Perez M, Guerra-Librero A, Acuña-Castroviejo D, Molina-Navarro MM, García-Verdugo JM, Sayed RK, Florido J, Luna JD, López LC, Escames G.

PLoS One. 2017 Apr 12;12(4):e0174474. doi: 10.1371/journal.pone.0174474. eCollection 2017.

25.

Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.

Rahim I, Djerdjouri B, Sayed RK, Fernández-Ortiz M, Fernández-Gil B, Hidalgo-Gutiérrez A, López LC, Escames G, Reiter RJ, Acuña-Castroviejo D.

J Pineal Res. 2017 Aug;63(1). doi: 10.1111/jpi.12410. Epub 2017 Apr 29.

PMID:
28370493
26.

The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes.

Leonardo-Mendonça RC, Ocaña-Wilhelmi J, de Haro T, de Teresa-Galván C, Guerra-Hernández E, Rusanova I, Fernández-Ortiz M, Sayed RKA, Escames G, Acuña-Castroviejo D.

Appl Physiol Nutr Metab. 2017 Jul;42(7):700-707. doi: 10.1139/apnm-2016-0677. Epub 2017 Feb 13.

PMID:
28192673
27.

Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.

García JA, Ortiz F, Miana J, Doerrier C, Fernández-Ortiz M, Rusanova I, Escames G, García JJ, Acuña-Castroviejo D.

J Physiol Biochem. 2017 May;73(2):235-244. doi: 10.1007/s13105-017-0548-2. Epub 2017 Jan 21.

PMID:
28110436
28.

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.

Luna-Sánchez M, Hidalgo-Gutiérrez A, Hildebrandt TM, Chaves-Serrano J, Barriocanal-Casado E, Santos-Fandila Á, Romero M, Sayed RK, Duarte J, Prokisch H, Schuelke M, Distelmaier F, Escames G, Acuña-Castroviejo D, López LC.

EMBO Mol Med. 2017 Jan;9(1):78-95. doi: 10.15252/emmm.201606345.

29.

Prophylactic Role of Oral Melatonin Administration on Neurogenesis in Adult Balb/C Mice during REM Sleep Deprivation.

López-Armas G, Flores-Soto ME, Chaparro-Huerta V, Jave-Suarez LF, Soto-Rodríguez S, Rusanova I, Acuña-Castroviejo D, González-Perez O, González-Castañeda RE.

Oxid Med Cell Longev. 2016;2016:2136902. doi: 10.1155/2016/2136902. Epub 2016 Aug 7.

30.

Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice.

Sayed RK, de Leonardis EC, Guerrero-Martínez JA, Rahim I, Mokhtar DM, Saleh AM, Abdalla KE, Pozo MJ, Escames G, López LC, Acuña-Castroviejo D.

Exp Gerontol. 2016 Oct;83:22-30. doi: 10.1016/j.exger.2016.07.007. Epub 2016 Jul 18.

PMID:
27435496
31.

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network.

Díaz-Casado ME, Lima E, García JA, Doerrier C, Aranda P, Sayed RK, Guerra-Librero A, Escames G, López LC, Acuña-Castroviejo D.

J Pineal Res. 2016 Aug;61(1):96-107. doi: 10.1111/jpi.12332. Epub 2016 Apr 30.

PMID:
27064726
32.

Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network.

Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D.

Mitochondrion. 2016 Mar;27:56-63. doi: 10.1016/j.mito.2015.12.010. Epub 2015 Dec 31.

PMID:
26748191
33.

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.

Volt H, García JA, Doerrier C, Díaz-Casado ME, Guerra-Librero A, López LC, Escames G, Tresguerres JA, Acuña-Castroviejo D.

J Pineal Res. 2016 Mar;60(2):193-205. doi: 10.1111/jpi.12303. Epub 2016 Jan 13.

PMID:
26681113
34.

Influence of aging and growth hormone on different members of the NFkB family and IkB expression in the heart from a murine model of senescence-accelerated aging.

Forman K, Vara E, García C, Kireev R, Cuesta S, Acuña-Castroviejo D, Tresguerres JA.

Exp Gerontol. 2016 Jan;73:114-20. doi: 10.1016/j.exger.2015.11.005. Epub 2015 Nov 12.

PMID:
26581911
35.

The benefits of four weeks of melatonin treatment on circadian patterns in resistance-trained athletes.

Leonardo-Mendonça RC, Martinez-Nicolas A, de Teresa Galván C, Ocaña-Wilhelmi J, Rusanova I, Guerra-Hernández E, Escames G, Acuña-Castroviejo D.

Chronobiol Int. 2015;32(8):1125-34. doi: 10.3109/07420528.2015.1069830. Epub 2015 Sep 11.

PMID:
26361788
36.

Fluorination Effects on NOS Inhibitory Activity of Pyrazoles Related to Curcumin.

Nieto CI, Cabildo MP, Cornago MP, Sanz D, Claramunt RM, Torralba MC, Torres MR, Elguero J, García JA, López A, Acuña-Castroviejo D.

Molecules. 2015 Aug 28;20(9):15643-65. doi: 10.3390/molecules200915643.

37.

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice.

García JA, Volt H, Venegas C, Doerrier C, Escames G, López LC, Acuña-Castroviejo D.

FASEB J. 2015 Sep;29(9):3863-75. doi: 10.1096/fj.15-273656. Epub 2015 Jun 4.

PMID:
26045547
38.

Comment on "Serum melatonin levels are associated with mortality in severe septic patients" by Lorente et al., J Crit Care (2015), http://dx.doi.org/10.1016/j.jcrc.2015.03.023.

Acuña-Castroviejo D, Bueno-Laraño P.

J Crit Care. 2015 Oct;30(5):1133. doi: 10.1016/j.jcrc.2015.05.009. Epub 2015 May 19. No abstract available.

PMID:
26025099
39.

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.

Luna-Sánchez M, Díaz-Casado E, Barca E, Tejada MÁ, Montilla-García Á, Cobos EJ, Escames G, Acuña-Castroviejo D, Quinzii CM, López LC.

EMBO Mol Med. 2015 May;7(5):670-87. doi: 10.15252/emmm.201404632.

40.

Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats.

Abdel Moneim AE, Ortiz F, Leonardo-Mendonça RC, Vergano-Villodres R, Guerrero-Martínez JA, López LC, Acuña-Castroviejo D, Escames G.

Acta Trop. 2015 Mar;143:58-65. doi: 10.1016/j.actatropica.2014.12.007. Epub 2014 Dec 24.

PMID:
25542296
41.

Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry.

Doerrier C, García JA, Volt H, Díaz-Casado ME, Lima-Cabello E, Ortiz F, Luna-Sánchez M, Escames G, López LC, Acuña-Castroviejo D.

Life Sci. 2015 Jan 15;121:158-65. doi: 10.1016/j.lfs.2014.11.031. Epub 2014 Dec 10.

PMID:
25498899
42.

Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy.

Escames G, Díaz-Casado ME, Doerrier C, Luna-Sánchez M, López LC, Acuña-Castroviejo D.

Horm Mol Biol Clin Investig. 2013 Dec;16(2):91-100. doi: 10.1515/hmbci-2013-0026.

PMID:
25436750
43.

Beneficial effect of melatonin treatment on age-related insulin resistance and on the development of type 2 diabetes.

Tresguerres JA, Cuesta S, Kireev RA, Garcia C, Acuña-Castroviejo D, Vara E.

Horm Mol Biol Clin Investig. 2013 Dec;16(2):47-54. doi: 10.1515/hmbci-2013-0041.

PMID:
25436746
44.

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis.

Ortiz F, Acuña-Castroviejo D, Doerrier C, Dayoub JC, López LC, Venegas C, García JA, López A, Volt H, Luna-Sánchez M, Escames G.

J Pineal Res. 2015 Jan;58(1):34-49. doi: 10.1111/jpi.12191. Epub 2014 Dec 4.

PMID:
25388914
45.

Melatonin and metabolic regulation: a review.

Navarro-Alarcón M, Ruiz-Ojeda FJ, Blanca-Herrera RM, A-Serrano MM, Acuña-Castroviejo D, Fernández-Vázquez G, Agil A.

Food Funct. 2014 Nov;5(11):2806-32. doi: 10.1039/c4fo00317a. Review.

PMID:
25207999
46.

A review of the melatonin functions in zebrafish physiology.

Lima-Cabello E, Díaz-Casado ME, Guerrero JA, Otalora BB, Escames G, López LC, Reiter RJ, Acuña-Castroviejo D.

J Pineal Res. 2014 Aug;57(1):1-9. doi: 10.1111/jpi.12149. Epub 2014 Jul 3.

PMID:
24920150
47.

Redox status and antioxidant response in professional cyclists during training.

Leonardo-Mendonça RC, Concepción-Huertas M, Guerra-Hernández E, Zabala M, Escames G, Acuña-Castroviejo D.

Eur J Sport Sci. 2014;14(8):830-8. doi: 10.1080/17461391.2014.915345. Epub 2014 May 7.

PMID:
24803271
48.

Melatonin in the oral cavity: physiological and pathological implications.

Reiter RJ, Rosales-Corral SA, Liu XY, Acuna-Castroviejo D, Escames G, Tan DX.

J Periodontal Res. 2015 Feb;50(1):9-17. doi: 10.1111/jre.12176. Epub 2014 Mar 25. Review.

PMID:
24665831
49.

Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency.

García-Corzo L, Luna-Sánchez M, Doerrier C, Ortiz F, Escames G, Acuña-Castroviejo D, López LC.

Biochim Biophys Acta. 2014 Jul;1842(7):893-901. doi: 10.1016/j.bbadis.2014.02.008. Epub 2014 Feb 24.

50.

Extrapineal melatonin: sources, regulation, and potential functions.

Acuña-Castroviejo D, Escames G, Venegas C, Díaz-Casado ME, Lima-Cabello E, López LC, Rosales-Corral S, Tan DX, Reiter RJ.

Cell Mol Life Sci. 2014 Aug;71(16):2997-3025. doi: 10.1007/s00018-014-1579-2. Epub 2014 Feb 20. Review.

PMID:
24554058

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