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Hypothalamic transcriptome of tame and aggressive silver foxes (Vulpes vulpes) identifies gene expression differences shared across brain regions.

Rosenfeld CS, Hekman JP, Johnson JL, Lyu Z, Ortega MT, Joshi T, Mao J, Vladimirova AV, Gulevich RG, Kharlamova AV, Acland GM, Hecht EE, Wang X, Clark AG, Trut LN, Behura SK, Kukekova AV.

Genes Brain Behav. 2019 Oct 11. doi: 10.1111/gbb.12614. [Epub ahead of print]


Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes).

Wang X, Pipes L, Trut LN, Herbeck Y, Vladimirova AV, Gulevich RG, Kharlamova AV, Johnson JL, Acland GM, Kukekova AV, Clark AG.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10398-10403. doi: 10.1073/pnas.1800889115. Epub 2018 Sep 18.


Author Correction: Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours.

Kukekova AV, Johnson JL, Xiang X, Feng S, Liu S, Rando HM, Kharlamova AV, Herbeck Y, Serdyukova NA, Xiong Z, Beklemischeva V, Koepfli KP, Gulevich RG, Vladimirova AV, Hekman JP, Perelman PL, Graphodatsky AS, O'Brien SJ, Wang X, Clark AG, Acland GM, Trut LN, Zhang G.

Nat Ecol Evol. 2018 Sep;2(9):1514. doi: 10.1038/s41559-018-0664-6.


Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours.

Kukekova AV, Johnson JL, Xiang X, Feng S, Liu S, Rando HM, Kharlamova AV, Herbeck Y, Serdyukova NA, Xiong Z, Beklemischeva V, Koepfli KP, Gulevich RG, Vladimirova AV, Hekman JP, Perelman PL, Graphodatsky AS, O'Brien SJ, Wang X, Clark AG, Acland GM, Trut LN, Zhang G.

Nat Ecol Evol. 2018 Sep;2(9):1479-1491. doi: 10.1038/s41559-018-0611-6. Epub 2018 Aug 6. Erratum in: Nat Ecol Evol. 2018 Aug 13;:.


Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes.

Hekman JP, Johnson JL, Edwards W, Vladimirova AV, Gulevich RG, Ford AL, Kharlamova AV, Herbeck Y, Acland GM, Raetzman LT, Trut LN, Kukekova AV.

G3 (Bethesda). 2018 Mar 2;8(3):859-873. doi: 10.1534/g3.117.300508.


Genetics of Interactive Behavior in Silver Foxes (Vulpes vulpes).

Nelson RM, Temnykh SV, Johnson JL, Kharlamova AV, Vladimirova AV, Gulevich RG, Shepeleva DV, Oskina IN, Acland GM, Rönnegård L, Trut LN, Carlborg Ö, Kukekova AV.

Behav Genet. 2017 Jan;47(1):88-101. doi: 10.1007/s10519-016-9815-1. Epub 2016 Oct 18.


Genotyping-By-Sequencing (GBS) Detects Genetic Structure and Confirms Behavioral QTL in Tame and Aggressive Foxes (Vulpes vulpes).

Johnson JL, Wittgenstein H, Mitchell SE, Hyma KE, Temnykh SV, Kharlamova AV, Gulevich RG, Vladimirova AV, Fong HW, Acland GM, Trut LN, Kukekova AV.

PLoS One. 2015 Jun 10;10(6):e0127013. doi: 10.1371/journal.pone.0127013. eCollection 2015.


IQCB1 and PDE6B mutations cause similar early onset retinal degenerations in two closely related terrier dog breeds.

Goldstein O, Mezey JG, Schweitzer PA, Boyko AR, Gao C, Bustamante CD, Jordan JA, Aguirre GD, Acland GM.

Invest Ophthalmol Vis Sci. 2013 Oct 25;54(10):7005-19. doi: 10.1167/iovs.13-12915.


A non-stop S-antigen gene mutation is associated with late onset hereditary retinal degeneration in dogs.

Goldstein O, Jordan JA, Aguirre GD, Acland GM.

Mol Vis. 2013 Aug 27;19:1871-84. eCollection 2013.


Genomic deletion of CNGB3 is identical by descent in multiple canine breeds and causes achromatopsia.

Yeh CY, Goldstein O, Kukekova AV, Holley D, Knollinger AM, Huson HJ, Pearce-Kelling SE, Acland GM, Komáromy AM.

BMC Genet. 2013 Apr 20;14:27. doi: 10.1186/1471-2156-14-27.


Genetics of behavior in the silver fox.

Kukekova AV, Temnykh SV, Johnson JL, Trut LN, Acland GM.

Mamm Genome. 2012 Feb;23(1-2):164-77. doi: 10.1007/s00335-011-9373-z. Epub 2011 Nov 23. Review.


Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies.

Miyadera K, Acland GM, Aguirre GD.

Mamm Genome. 2012 Feb;23(1-2):40-61. doi: 10.1007/s00335-011-9361-3. Epub 2011 Nov 8. Review.


Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina.

Berta ÁI, Boesze-Battaglia K, Genini S, Goldstein O, O'Brien PJ, Szél Á, Acland GM, Beltran WA, Aguirre GD.

PLoS One. 2011;6(9):e24074. doi: 10.1371/journal.pone.0024074. Epub 2011 Sep 30.


Sequence comparison of prefrontal cortical brain transcriptome from a tame and an aggressive silver fox (Vulpes vulpes).

Kukekova AV, Johnson JL, Teiling C, Li L, Oskina IN, Kharlamova AV, Gulevich RG, Padte R, Dubreuil MM, Vladimirova AV, Shepeleva DV, Shikhevich SG, Sun Q, Ponnala L, Temnykh SV, Trut LN, Acland GM.

BMC Genomics. 2011 Oct 3;12:482. doi: 10.1186/1471-2164-12-482.


On the origin of a domesticated species: Identifying the parent population of Russian silver foxes (Vulpes vulpes).

Statham MJ, Trut LN, Sacks BN, Kharlamova AV, Oskina IN, Gulevich RG, Johnson JL, Temnykh SV, Acland GM, Kukekova AV.

Biol J Linn Soc Lond. 2011 May;103(1):168-175.


Structural organization and expression pattern of the canine RPGRIP1 isoforms in retinal tissue.

Kuznetsova T, Zangerl B, Goldstein O, Acland GM, Aguirre GD.

Invest Ophthalmol Vis Sci. 2011 May 6;52(6):2989-98. doi: 10.1167/iovs.10-6094.


Mapping Loci for fox domestication: deconstruction/reconstruction of a behavioral phenotype.

Kukekova AV, Trut LN, Chase K, Kharlamova AV, Johnson JL, Temnykh SV, Oskina IN, Gulevich RG, Vladimirova AV, Klebanov S, Shepeleva DV, Shikhevich SG, Acland GM, Lark KG.

Behav Genet. 2011 Jul;41(4):593-606. doi: 10.1007/s10519-010-9418-1. Epub 2010 Dec 14.


Differential genetic regulation of canine hip dysplasia and osteoarthritis.

Zhou Z, Sheng X, Zhang Z, Zhao K, Zhu L, Guo G, Friedenberg SG, Hunter LS, Vandenberg-Foels WS, Hornbuckle WE, Krotscheck U, Corey E, Moise NS, Dykes NL, Li J, Xu S, Du L, Wang Y, Sandler J, Acland GM, Lust G, Todhunter RJ.

PLoS One. 2010 Oct 11;5(10):e13219. doi: 10.1371/journal.pone.0013219.


Exonic SINE insertion in STK38L causes canine early retinal degeneration (erd).

Goldstein O, Kukekova AV, Aguirre GD, Acland GM.

Genomics. 2010 Dec;96(6):362-8. doi: 10.1016/j.ygeno.2010.09.003. Epub 2010 Sep 29.


An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9.

Goldstein O, Mezey JG, Boyko AR, Gao C, Wang W, Bustamante CD, Anguish LJ, Jordan JA, Pearce-Kelling SE, Aguirre GD, Acland GM.

Mol Vis. 2010 Aug 11;16:1549-69.


COL9A2 and COL9A3 mutations in canine autosomal recessive oculoskeletal dysplasia.

Goldstein O, Guyon R, Kukekova A, Kuznetsova TN, Pearce-Kelling SE, Johnson J, Aguirre GD, Acland GM.

Mamm Genome. 2010 Aug;21(7-8):398-408. doi: 10.1007/s00335-010-9276-4. Epub 2010 Aug 5.


Identification of genetic variation and haplotype structure of the canine ABCA4 gene for retinal disease association studies.

Zangerl B, Lindauer SJ, Acland GM, Aguirre GD.

Mol Genet Genomics. 2010 Oct;284(4):243-50. doi: 10.1007/s00438-010-0560-5. Epub 2010 Jul 27.


Genome-wide association identifies a deletion in the 3' untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy.

Meurs KM, Mauceli E, Lahmers S, Acland GM, White SN, Lindblad-Toh K.

Hum Genet. 2010 Sep;128(3):315-24. doi: 10.1007/s00439-010-0855-y. Epub 2010 Jul 2.


Transcriptional profile analysis of RPGRORF15 frameshift mutation identifies novel genes associated with retinal degeneration.

Genini S, Zangerl B, Slavik J, Acland GM, Beltran WA, Aguirre GD.

Invest Ophthalmol Vis Sci. 2010 Nov;51(11):6038-50. doi: 10.1167/iovs.10-5443. Epub 2010 Jun 23.


Gene therapy rescues cone function in congenital achromatopsia.

Komáromy AM, Alexander JJ, Rowlan JS, Garcia MM, Chiodo VA, Kaya A, Tanaka JC, Acland GM, Hauswirth WW, Aguirre GD.

Hum Mol Genet. 2010 Jul 1;19(13):2581-93. doi: 10.1093/hmg/ddq136. Epub 2010 Apr 8. Erratum in: Hum Mol Genet. 2011 Dec 15;20(24):5024.


CREB1/ATF1 activation in photoreceptor degeneration and protection.

Beltran WA, Allore HG, Johnson E, Towle V, Tao W, Acland GM, Aguirre GD, Zeiss CJ.

Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5355-63. doi: 10.1167/iovs.09-3741. Epub 2009 Jul 30.


An expressed fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs.

Parker HG, VonHoldt BM, Quignon P, Margulies EH, Shao S, Mosher DS, Spady TC, Elkahloun A, Cargill M, Jones PG, Maslen CL, Acland GM, Sutter NB, Kuroki K, Bustamante CD, Wayne RK, Ostrander EA.

Science. 2009 Aug 21;325(5943):995-8. doi: 10.1126/science.1173275. Epub 2009 Jul 16.


Chromosomal mapping of canine-derived BAC clones to the red fox and American mink genomes.

Kukekova AV, Vorobieva NV, Beklemisheva VR, Johnson JL, Temnykh SV, Yudkin DV, Trut LN, Andre C, Galibert F, Aguirre GD, Acland GM, Graphodatsky AS.

J Hered. 2009 Jul-Aug;100 Suppl 1:S42-53. doi: 10.1093/jhered/esp037. Epub 2009 Jun 21.


Using the NAFX to measure the effectiveness over time of gene therapy in canine LCA.

Jacobs JB, Dell'Osso LF, Wang ZI, Acland GM, Bennett J.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4685-92. doi: 10.1167/iovs.09-3387. Epub 2009 May 20.


Comparative genomic mapping of uncharacterized canine retinal ESTs to identify novel candidate genes for hereditary retinal disorders.

Zangerl B, Johnson JL, Pillardy J, Sun Q, André C, Galibert F, Acland GM, Aguirre GD.

Mol Vis. 2009 May 9;15:927-36.


Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass.

Munroe RJ, Prabhu V, Acland GM, Johnson KR, Harris BS, O'Brien TP, Welsh IC, Noden DM, Schimenti JC.

BMC Dev Biol. 2009 Apr 20;9:27. doi: 10.1186/1471-213X-9-27.


Age-dependent disease expression determines remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations.

Beltran WA, Acland GM, Aguirre GD.

Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3985-95. doi: 10.1167/iovs.08-3364. Epub 2009 Feb 28.


Steroids do not prevent photoreceptor degeneration in the light-exposed T4R rhodopsin mutant dog retina irrespective of AP-1 inhibition.

Gu D, Beltran WA, Pearce-Kelling S, Li Z, Acland GM, Aguirre GD.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3482-94. doi: 10.1167/iovs.08-3111. Epub 2009 Feb 21.


Canine RD3 mutation establishes rod-cone dysplasia type 2 (rcd2) as ortholog of human and murine rd3.

Kukekova AV, Goldstein O, Johnson JL, Richardson MA, Pearce-Kelling SE, Swaroop A, Friedman JS, Aguirre GD, Acland GM.

Mamm Genome. 2009 Feb;20(2):109-23. doi: 10.1007/s00335-008-9163-4. Epub 2009 Jan 9.


Development and use of DNA archives at veterinary teaching hospitals to investigate the genetic basis of disease in dogs.

Castelhano MG, Acland GM, Ciccone PA, Corey EE, Mezey JG, Schimenti JC, Todhunter RJ.

J Am Vet Med Assoc. 2009 Jan 1;234(1):75-80. doi: 10.2460/javma.234.1.75. Review.


Operating in the dark: a night-vision system for surgery in retinas susceptible to light damage.

Komáromy AM, Acland GM, Aguirre GD.

Arch Ophthalmol. 2008 May;126(5):714-7. doi: 10.1001/archopht.126.5.714.


Targeting gene expression to cones with human cone opsin promoters in recombinant AAV.

Komáromy AM, Alexander JJ, Cooper AE, Chiodo VA, Glushakova LG, Acland GM, Hauswirth WW, Aguirre GD.

Gene Ther. 2008 Jul;15(14):1049-55. doi: 10.1038/gt.2008.32. Epub 2008 Mar 13. Erratum in: Gene Ther. 2008 Jul;15(14):1073. Glushakova, L G [added]. Gene Ther. 2011 Dec;18(12):1179.


Effects of the topically applied calcium-channel blocker flunarizine on intraocular pressure in clinically normal dogs.

Greller AL, Hoffman AR, Liu C, Ying GS, Vudathala DK, Acland GM, Komáromy AM.

Am J Vet Res. 2008 Feb;69(2):273-8. doi: 10.2460/ajvr.69.2.273.


Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer.

Bennicelli J, Wright JF, Komaromy A, Jacobs JB, Hauck B, Zelenaia O, Mingozzi F, Hui D, Chung D, Rex TS, Wei Z, Qu G, Zhou S, Zeiss C, Arruda VR, Acland GM, Dell'Osso LF, High KA, Maguire AM, Bennett J.

Mol Ther. 2008 Mar;16(3):458-65. doi: 10.1038/ Epub 2008 Jan 22.


Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray.

Paez GL, Zangerl B, Sellers K, Acland GM, Aguirre GD.

Adv Exp Med Biol. 2008;613:179-84. doi: 10.1007/978-0-387-74904-4_20. No abstract available.


Measurement of segregating behaviors in experimental silver fox pedigrees.

Kukekova AV, Trut LN, Chase K, Shepeleva DV, Vladimirova AV, Kharlamova AV, Oskina IN, Stepika A, Klebanov S, Erb HN, Acland GM.

Behav Genet. 2008 Mar;38(2):185-94. Epub 2007 Nov 21.


Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds.

Parker HG, Kukekova AV, Akey DT, Goldstein O, Kirkness EF, Baysac KC, Mosher DS, Aguirre GD, Acland GM, Ostrander EA.

Genome Res. 2007 Nov;17(11):1562-71. Epub 2007 Oct 4.


Independent origin and restricted distribution of RPGR deletions causing XLPRA.

Zangerl B, Johnson JL, Acland GM, Aguirre GD.

J Hered. 2007;98(5):526-30. Epub 2007 Jul 23.


Canine and human visual cortex intact and responsive despite early retinal blindness from RPE65 mutation.

Aguirre GK, Komáromy AM, Cideciyan AV, Brainard DH, Aleman TS, Roman AJ, Avants BB, Gee JC, Korczykowski M, Hauswirth WW, Acland GM, Aguirre GD, Jacobson SG.

PLoS Med. 2007 Jun;4(6):e230.


A random model for mapping imprinted quantitative trait loci in a structured pedigree: an implication for mapping canine hip dysplasia.

Liu T, Todhunter RJ, Wu S, Hou W, Mateescu R, Zhang Z, Burton-Wurster NI, Acland GM, Lust G, Wu R.

Genomics. 2007 Aug;90(2):276-84. Epub 2007 May 24.


Bestrophin gene mutations cause canine multifocal retinopathy: a novel animal model for best disease.

Guziewicz KE, Zangerl B, Lindauer SJ, Mullins RF, Sandmeyer LS, Grahn BH, Stone EM, Acland GM, Aguirre GD.

Invest Ophthalmol Vis Sci. 2007 May;48(5):1959-67.


Cloning and characterization of canine PAX6 and evaluation as a candidate gene in a canine model of aniridia.

Hunter LS, Sidjanin DJ, Hijar MV, Johnson JL, Kirkness E, Acland GM, Aguirre GD.

Mol Vis. 2007 Mar 26;13:431-42.


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