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Items: 43

1.

Mouse Models and Online Resources for Functional Analysis of Osteoporosis Genome-Wide Association Studies.

Maynard RD, Ackert-Bicknell CL.

Front Endocrinol (Lausanne). 2019 May 7;10:277. doi: 10.3389/fendo.2019.00277. eCollection 2019. Review.

2.

Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass.

Mesner LD, Calabrese GM, Al-Barghouthi B, Gatti DM, Sundberg JP, Churchill GA, Godfrey DA, Ackert-Bicknell CL, Farber CR.

PLoS Genet. 2019 May 1;15(5):e1008123. doi: 10.1371/journal.pgen.1008123. eCollection 2019 May.

3.

Author Correction: An atlas of genetic influences on osteoporosis in humans and mice.

Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG; 23andMe Research Team, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB.

Nat Genet. 2019 May;51(5):920. doi: 10.1038/s41588-019-0415-x.

PMID:
30988516
4.

An atlas of genetic influences on osteoporosis in humans and mice.

Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG; 23andMe Research Team, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB.

Nat Genet. 2019 Feb;51(2):258-266. doi: 10.1038/s41588-018-0302-x. Epub 2018 Dec 31. Erratum in: Nat Genet. 2019 May;51(5):920.

5.

Characterization of expression and alternative splicing of the gene cadherin-like and PC esterase domain containing 1 (Cped1).

Maynard RD, Godfrey DA, Medina-Gomez C, Ackert-Bicknell CL.

Gene. 2018 Oct 20;674:127-133. doi: 10.1016/j.gene.2018.06.060. Epub 2018 Jun 20.

PMID:
29935354
6.

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A, Hartwig FP, Evans DS, Joro R, Nedeljkovic I, Zheng HF, Zhu K, Atalay M, Liu CT, Nethander M, Broer L, Porleifsson G, Mullin BH, Handelman SK, Nalls MA, Jessen LE, Heppe DHM, Richards JB, Wang C, Chawes B, Schraut KE, Amin N, Wareham N, Karasik D, Van der Velde N, Ikram MA, Zemel BS, Zhou Y, Carlsson CJ, Liu Y, McGuigan FE, Boer CG, Bønnelykke K, Ralston SH, Robbins JA, Walsh JP, Zillikens MC, Langenberg C, Li-Gao R, Williams FMK, Harris TB, Akesson K, Jackson RD, Sigurdsson G, den Heijer M, van der Eerden BCJ, van de Peppel J, Spector TD, Pennell C, Horta BL, Felix JF, Zhao JH, Wilson SG, de Mutsert R, Bisgaard H, Styrkársdóttir U, Jaddoe VW, Orwoll E, Lakka TA, Scott R, Grant SFA, Lorentzon M, van Duijn CM, Wilson JF, Stefansson K, Psaty BM, Kiel DP, Ohlsson C, Ntzani E, van Wijnen AJ, Forgetta V, Ghanbari M, Logan JG, Williams GR, Bassett JHD, Croucher PI, Evangelou E, Uitterlinden AG, Ackert-Bicknell CL, Tobias JH, Evans DM, Rivadeneira F.

Am J Hum Genet. 2018 Jan 4;102(1):88-102. doi: 10.1016/j.ajhg.2017.12.005.

7.

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.

Kemp JP, Morris JA, Medina-Gomez C, Forgetta V, Warrington NM, Youlten SE, Zheng J, Gregson CL, Grundberg E, Trajanoska K, Logan JG, Pollard AS, Sparkes PC, Ghirardello EJ, Allen R, Leitch VD, Butterfield NC, Komla-Ebri D, Adoum AT, Curry KF, White JK, Kussy F, Greenlaw KM, Xu C, Harvey NC, Cooper C, Adams DJ, Greenwood CMT, Maurano MT, Kaptoge S, Rivadeneira F, Tobias JH, Croucher PI, Ackert-Bicknell CL, Bassett JHD, Williams GR, Richards JB, Evans DM.

Nat Genet. 2017 Oct;49(10):1468-1475. doi: 10.1038/ng.3949. Epub 2017 Sep 4.

8.

A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density.

Charette JR, Earp SE, Bell BA, Ackert-Bicknell CL, Godfrey DA, Rao S, Anand-Apte B, Nishina PM, Peachey NS.

Mol Vis. 2017 Mar 18;23:140-148. eCollection 2017.

9.

Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2.

Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Jakobsdottir J, Wassel C, Register TC, Oei L, Alonso N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P, Lorentzen E, Vandenput L, Langefeld C, Raffield L, Terry G, Cox AJ, Allison MA, Criqui MH, Bowden D, Ikram MA, Mellström D, Karlsson MK, Carr J, Budoff M, Phillips C, Cupples LA, Chou WC, Myers RH, Ralston SH, Gautvik KM, Cawthon PM, Cummings S, Karasik D, Rivadeneira F, Gudnason V, Orwoll ES, Harris TB, Ohlsson C, Kiel DP, Hsu YH.

J Bone Miner Res. 2016 Dec;31(12):2085-2097. doi: 10.1002/jbmr.2913. Epub 2016 Sep 6.

10.

Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice.

Parker CC, Gopalakrishnan S, Carbonetto P, Gonzales NM, Leung E, Park YJ, Aryee E, Davis J, Blizard DA, Ackert-Bicknell CL, Lionikas A, Pritchard JK, Palmer AA.

Nat Genet. 2016 Aug;48(8):919-26. doi: 10.1038/ng.3609. Epub 2016 Jul 4.

11.

Genetics of aging bone.

Adams DJ, Rowe DW, Ackert-Bicknell CL.

Mamm Genome. 2016 Aug;27(7-8):367-80. doi: 10.1007/s00335-016-9650-y. Epub 2016 Jun 6. Review.

12.

How do bisphosphonates affect fracture healing?

Kates SL, Ackert-Bicknell CL.

Injury. 2016 Jan;47 Suppl 1:S65-8. doi: 10.1016/S0020-1383(16)30015-8. Review.

13.

Passenger Gene Mutations: Unwanted Guests in Genetically Modified Mice.

Ackert-Bicknell CL, Rosen CJ.

J Bone Miner Res. 2016 Feb;31(2):270-3. doi: 10.1002/jbmr.2772. Epub 2016 Jan 19. No abstract available.

14.

Mapping of Craniofacial Traits in Outbred Mice Identifies Major Developmental Genes Involved in Shape Determination.

Pallares LF, Carbonetto P, Gopalakrishnan S, Parker CC, Ackert-Bicknell CL, Palmer AA, Tautz D.

PLoS Genet. 2015 Nov 2;11(11):e1005607. doi: 10.1371/journal.pgen.1005607. eCollection 2015 Nov.

15.

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A, Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C, Kleinman A, Styrkarsdottir U, Liu CT, Uggla C, Evans DS, Nielson CM, Walter K, Pettersson-Kymmer U, McCarthy S, Eriksson J, Kwan T, Jhamai M, Trajanoska K, Memari Y, Min J, Huang J, Danecek P, Wilmot B, Li R, Chou WC, Mokry LE, Moayyeri A, Claussnitzer M, Cheng CH, Cheung W, Medina-Gómez C, Ge B, Chen SH, Choi K, Oei L, Fraser J, Kraaij R, Hibbs MA, Gregson CL, Paquette D, Hofman A, Wibom C, Tranah GJ, Marshall M, Gardiner BB, Cremin K, Auer P, Hsu L, Ring S, Tung JY, Thorleifsson G, Enneman AW, van Schoor NM, de Groot LC, van der Velde N, Melin B, Kemp JP, Christiansen C, Sayers A, Zhou Y, Calderari S, van Rooij J, Carlson C, Peters U, Berlivet S, Dostie J, Uitterlinden AG, Williams SR, Farber C, Grinberg D, LaCroix AZ, Haessler J, Chasman DI, Giulianini F, Rose LM, Ridker PM, Eisman JA, Nguyen TV, Center JR, Nogues X, Garcia-Giralt N, Launer LL, Gudnason V, Mellström D, Vandenput L, Amin N, van Duijn CM, Karlsson MK, Ljunggren Ö, Svensson O, Hallmans G, Rousseau F, Giroux S, Bussière J, Arp PP, Koromani F, Prince RL, Lewis JR, Langdahl BL, Hermann AP, Jensen JE, Kaptoge S, Khaw KT, Reeve J, Formosa MM, Xuereb-Anastasi A, Åkesson K, McGuigan FE, Garg G, Olmos JM, Zarrabeitia MT, Riancho JA, Ralston SH, Alonso N, Jiang X, Goltzman D, Pastinen T, Grundberg E, Gauguier D, Orwoll ES, Karasik D, Davey-Smith G; AOGC Consortium, Smith AV, Siggeirsdottir K, Harris TB, Zillikens MC, van Meurs JB, Thorsteinsdottir U, Maurano MT, Timpson NJ, Soranzo N, Durbin R, Wilson SG, Ntzani EE, Brown MA, Stefansson K, Hinds DA, Spector T, Cupples LA, Ohlsson C, Greenwood CM; UK10K Consortium, Jackson RD, Rowe DW, Loomis CA, Evans DM, Ackert-Bicknell CL, Joyner AL, Duncan EL, Kiel DP, Rivadeneira F, Richards JB.

Nature. 2015 Oct 1;526(7571):112-7. doi: 10.1038/nature14878. Epub 2015 Sep 14.

16.

Genetic regulation of bone strength: a review of animal model studies.

Adams DJ, Ackert-Bicknell CL.

Bonekey Rep. 2015 Jul 8;4:714. doi: 10.1038/bonekey.2015.83. eCollection 2015. Review.

17.

Aging Research Using Mouse Models.

Ackert-Bicknell CL, Anderson LC, Sheehan S, Hill WG, Chang B, Churchill GA, Chesler EJ, Korstanje R, Peters LL.

Curr Protoc Mouse Biol. 2015 Jun 1;5(2):95-133. doi: 10.1002/9780470942390.mo140195.

18.

Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.

Kemp JP, Medina-Gomez C, Estrada K, St Pourcain B, Heppe DH, Warrington NM, Oei L, Ring SM, Kruithof CJ, Timpson NJ, Wolber LE, Reppe S, Gautvik K, Grundberg E, Ge B, van der Eerden B, van de Peppel J, Hibbs MA, Ackert-Bicknell CL, Choi K, Koller DL, Econs MJ, Williams FM, Foroud T, Zillikens MC, Ohlsson C, Hofman A, Uitterlinden AG, Davey Smith G, Jaddoe VW, Tobias JH, Rivadeneira F, Evans DM.

PLoS Genet. 2014 Jun 19;10(6):e1004423. doi: 10.1371/journal.pgen.1004423. eCollection 2014 Jun.

19.

Impact of the environment on the skeleton: is it modulated by genetic factors?

Ackert-Bicknell CL, Karasik D.

Curr Osteoporos Rep. 2013 Sep;11(3):219-28. doi: 10.1007/s11914-013-0151-6. Review.

20.

Modeling hepatic osteodystrophy in Abcb4 deficient mice.

Hochrath K, Ehnert S, Ackert-Bicknell CL, Lau Y, Schmid A, Krawczyk M, Hengstler JG, Dunn J, Hiththetiya K, Rathkolb B, Micklich K, Hans W, Fuchs H, Gailus-Durner V, Wolf E, de Angelis MH, Dooley S, Paigen B, Wildemann B, Lammert F, Nüssler AK.

Bone. 2013 Aug;55(2):501-11. doi: 10.1016/j.bone.2013.03.012. Epub 2013 Mar 29.

21.

Canonical A-to-I and C-to-U RNA editing is enriched at 3'UTRs and microRNA target sites in multiple mouse tissues.

Gu T, Buaas FW, Simons AK, Ackert-Bicknell CL, Braun RE, Hibbs MA.

PLoS One. 2012;7(3):e33720. doi: 10.1371/journal.pone.0033720. Epub 2012 Mar 20.

22.

Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density.

Ackert-Bicknell CL, Demissie S, Tsaih SW, Beamer WG, Cupples LA, Paigen BJ, Hsu YH, Kiel DP, Karasik D.

Bone. 2012 May;50(5):1188-95. doi: 10.1016/j.bone.2012.01.011. Epub 2012 Jan 28.

23.

The need for mouse models in osteoporosis genetics research.

Ackert-Bicknell CL, Hibbs MA.

Bonekey Rep. 2012 Jun 13;1:98. doi: 10.1038/bonekey.2012.98. eCollection 2012.

24.

HDL cholesterol and bone mineral density: is there a genetic link?

Ackert-Bicknell CL.

Bone. 2012 Feb;50(2):525-33. doi: 10.1016/j.bone.2011.07.002. Review.

25.

Genetic analysis in the Collaborative Cross breeding population.

Philip VM, Sokoloff G, Ackert-Bicknell CL, Striz M, Branstetter L, Beckmann MA, Spence JS, Jackson BL, Galloway LD, Barker P, Wymore AM, Hunsicker PR, Durtschi DC, Shaw GS, Shinpock S, Manly KF, Miller DR, Donohue KD, Culiat CT, Churchill GA, Lariviere WR, Palmer AA, O'Hara BF, Voy BH, Chesler EJ.

Genome Res. 2011 Aug;21(8):1223-38. doi: 10.1101/gr.113886.110. Epub 2011 Jul 6.

26.

Functional genomics complements quantitative genetics in identifying disease-gene associations.

Guan Y, Ackert-Bicknell CL, Kell B, Troyanskaya OG, Hibbs MA.

PLoS Comput Biol. 2010 Nov 11;6(11):e1000991. doi: 10.1371/journal.pcbi.1000991.

27.

BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat.

Beamer WG, Shultz KL, Coombs HF 3rd, DeMambro VE, Reinholdt LG, Ackert-Bicknell CL, Canalis E, Rosen CJ, Donahue LR.

J Bone Miner Res. 2011 Jan;26(1):88-99. doi: 10.1002/jbmr.200.

28.

Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map.

Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW.

J Bone Miner Res. 2010 Aug;25(8):1808-20. doi: 10.1002/jbmr.72.

29.

A new standard genetic map for the laboratory mouse.

Cox A, Ackert-Bicknell CL, Dumont BL, Ding Y, Bell JT, Brockmann GA, Wergedal JE, Bult C, Paigen B, Flint J, Tsaih SW, Churchill GA, Broman KW.

Genetics. 2009 Aug;182(4):1335-44. doi: 10.1534/genetics.109.105486. Epub 2009 Jun 17.

30.

Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I.

Ackert-Bicknell CL, Shockley KR, Horton LG, Lecka-Czernik B, Churchill GA, Rosen CJ.

Endocrinology. 2009 Mar;150(3):1330-40. doi: 10.1210/en.2008-0936. Epub 2008 Oct 23.

31.

PPARG by dietary fat interaction influences bone mass in mice and humans.

Ackert-Bicknell CL, Demissie S, Marín de Evsikova C, Hsu YH, DeMambro VE, Karasik D, Cupples LA, Ordovas JM, Tucker KL, Cho K, Canalis E, Paigen B, Churchill GA, Forejt J, Beamer WG, Ferrari S, Bouxsein ML, Kiel DP, Rosen CJ.

J Bone Miner Res. 2008 Sep;23(9):1398-408. doi: 10.1359/jbmr.080419.

32.

A chromosomal inversion within a quantitative trait locus has a major effect on adipogenesis and osteoblastogenesis.

Ackert-Bicknell CL, Salisbury JL, Horowitz M, DeMambro VE, Horton LG, Shultz KL, Lecka-Czernik B, Rosen CJ.

Ann N Y Acad Sci. 2007 Nov;1116:291-305. Epub 2007 Jun 21.

PMID:
17584978
33.

Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.

Wergedal JE, Ackert-Bicknell CL, Beamer WG, Mohan S, Baylink DJ, Srivastava AK.

J Lipid Res. 2007 Aug;48(8):1724-34. Epub 2007 May 13.

34.

Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes.

Beamer WG, Shultz KL, Ackert-Bicknell CL, Horton LG, Delahunty KM, Coombs HF 3rd, Donahue LR, Canalis E, Rosen CJ.

J Bone Miner Res. 2007 Aug;22(8):1187-96.

35.

Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry.

Wergedal JE, Ackert-Bicknell CL, Tsaih SW, Sheng MH, Li R, Mohan S, Beamer WG, Churchill GA, Baylink DJ.

J Bone Miner Res. 2006 Aug;21(8):1256-66.

36.

Genetic increase in serum insulin-like growth factor-I (IGF-I) in C3H/HeJ compared with C57BL/6J mice is associated with increased transcription from the IGF-I exon 2 promoter.

Adamo ML, Ma X, Ackert-Bicknell CL, Donahue LR, Beamer WG, Rosen CJ.

Endocrinology. 2006 Jun;147(6):2944-55. Epub 2006 Mar 9.

PMID:
16527837
37.

Expression of terminal differentiation proteins defines stages of mouse mammary gland development.

Mikaelian I, Hovick M, Silva KA, Burzenski LM, Shultz LD, Ackert-Bicknell CL, Cox GA, Sundberg JP.

Vet Pathol. 2006 Jan;43(1):36-49.

PMID:
16407485
38.

Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density.

Wergedal JE, Sheng MH, Ackert-Bicknell CL, Beamer WG, Baylink DJ.

Bone. 2005 Jan;36(1):111-22. Epub 2004 Nov 24.

PMID:
15664009
39.

Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program.

Rosen CJ, Ackert-Bicknell CL, Adamo ML, Shultz KL, Rubin J, Donahue LR, Horton LG, Delahunty KM, Beamer WG, Sipos J, Clemmons D, Nelson T, Bouxsein ML, Horowitz M.

Bone. 2004 Nov;35(5):1046-58.

PMID:
15542029
40.

High-resolution genetic map of X-linked juvenile-type granulosa cell tumor susceptibility genes in mouse.

Dorward AM, Shultz KL, Ackert-Bicknell CL, Eicher EM, Beamer WG.

Cancer Res. 2003 Dec 1;63(23):8197-202.

41.

Mouse genetic model for bone strength and size phenotypes: NZB/B1NJ and RF/J inbred strains.

Wergedal JE, Sheng MH, Ackert-Bicknell CL, Beamer WG, Baylink DJ.

Bone. 2002 Dec;31(6):670-4.

PMID:
12531560
42.

Circulating levels of IGF-1 directly regulate bone growth and density.

Yakar S, Rosen CJ, Beamer WG, Ackert-Bicknell CL, Wu Y, Liu JL, Ooi GT, Setser J, Frystyk J, Boisclair YR, LeRoith D.

J Clin Invest. 2002 Sep;110(6):771-81.

43.

IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo.

Rubin J, Ackert-Bicknell CL, Zhu L, Fan X, Murphy TC, Nanes MS, Marcus R, Holloway L, Beamer WG, Rosen CJ.

J Clin Endocrinol Metab. 2002 Sep;87(9):4273-9.

PMID:
12213884

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