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Items: 1 to 50 of 58

1.

New Guidelines for Publication of Manuscripts Describing Development and Application of Targeted Mass Spectrometry Measurements of Peptides and Proteins.

Abbatiello S, Ackermann BL, Borchers C, Bradshaw RA, Carr SA, Chalkley R, Choi M, Deutsch E, Domon B, Hoofnagle AN, Keshishian H, Kuhn E, Liebler DC, MacCoss M, MacLean B, Mani DR, Neubert H, Smith D, Vitek O, Zimmerman L.

Mol Cell Proteomics. 2017 Mar;16(3):327-328. doi: 10.1074/mcp.E117.067801. Epub 2017 Feb 9. No abstract available.

2.

Immunoaffinity MS: adding increased value through hybrid methods.

Ackermann BL.

Bioanalysis. 2016 Aug;8(15):1535-1537. No abstract available.

3.

Characterization and quantification of oxyntomodulin in human and rat plasma using high-resolution accurate mass LC-MS.

Cox JM, Berna MJ, Jin Z, Cox AL, Sloop KW, Gutierrez JA, Ackermann BL.

Bioanalysis. 2016 Aug;8(15):1579-1595. Epub 2016 Jun 17.

PMID:
27314304
4.

AAPS and US FDA Crystal City VI workshop on bioanalytical method validation for biomarkers.

Lowes S, Ackermann BL.

Bioanalysis. 2016 Feb;8(3):163-7. doi: 10.4155/bio.15.251. Epub 2016 Jan 22.

5.

Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry-Based Assays.

Hoofnagle AN, Whiteaker JR, Carr SA, Kuhn E, Liu T, Massoni SA, Thomas SN, Townsend RR, Zimmerman LJ, Boja E, Chen J, Crimmins DL, Davies SR, Gao Y, Hiltke TR, Ketchum KA, Kinsinger CR, Mesri M, Meyer MR, Qian WJ, Schoenherr RM, Scott MG, Shi T, Whiteley GR, Wrobel JA, Wu C, Ackermann BL, Aebersold R, Barnidge DR, Bunk DM, Clarke N, Fishman JB, Grant RP, Kusebauch U, Kushnir MM, Lowenthal MS, Moritz RL, Neubert H, Patterson SD, Rockwood AL, Rogers J, Singh RJ, Van Eyk JE, Wong SH, Zhang S, Chan DW, Chen X, Ellis MJ, Liebler DC, Rodland KD, Rodriguez H, Smith RD, Zhang Z, Zhang H, Paulovich AG.

Clin Chem. 2016 Jan;62(1):48-69. doi: 10.1373/clinchem.2015.250563.

6.

Circulating FGF21 proteolytic processing mediated by fibroblast activation protein.

Zhen EY, Jin Z, Ackermann BL, Thomas MK, Gutierrez JA.

Biochem J. 2016 Mar 1;473(5):605-14. doi: 10.1042/BJ20151085. Epub 2015 Dec 3.

7.

A validated LC-MS/MS method for neurotransmitter metabolite analysis in human cerebrospinal fluid using benzoyl chloride derivatization.

Cox JM, Butler JP, Lutzke BS, Jones BA, Buckholz JE, Biondolillo R, Talbot JA, Chernet E, Svensson KA, Ackermann BL.

Bioanalysis. 2015 Oct;7(19):2461-75. doi: 10.4155/bio.15.170. Epub 2015 Oct 16.

PMID:
26470737
8.

Pharmacodynamic comparison of LY3023703, a novel microsomal prostaglandin e synthase 1 inhibitor, with celecoxib.

Jin Y, Smith CL, Hu L, Campanale KM, Stoltz R, Huffman LG Jr, McNearney TA, Yang XY, Ackermann BL, Dean R, Regev A, Landschulz W.

Clin Pharmacol Ther. 2016 Mar;99(3):274-84. doi: 10.1002/cpt.260. Epub 2015 Nov 25.

PMID:
26351780
9.

Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach.

Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S.

Mol Cell Proteomics. 2014 Mar;13(3):907-17. doi: 10.1074/mcp.M113.036095. Epub 2014 Jan 17.

10.

Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung.

Holzer TR, Fulford AD, Nedderman DM, Umberger TS, Hozak RR, Joshi A, Melemed SA, Benjamin LE, Plowman GD, Schade AE, Ackermann BL, Konrad RJ, Nasir A.

PLoS One. 2013 Nov 14;8(11):e80292. doi: 10.1371/journal.pone.0080292. eCollection 2013.

11.

Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous biomolecules.

Jones BR, Schultz GA, Eckstein JA, Ackermann BL.

Bioanalysis. 2012 Oct;4(19):2343-56. doi: 10.4155/bio.12.200.

PMID:
23088461
12.

Understanding the role of immunoaffinity-based mass spectrometry methods for clinical applications.

Ackermann BL.

Clin Chem. 2012 Dec;58(12):1620-2. doi: 10.1373/clinchem.2012.193714. Epub 2012 Oct 18. No abstract available.

13.

Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation.

Cox JM, Troutt JS, Knierman MD, Siegel RW, Qian YW, Ackermann BL, Konrad RJ.

Anal Biochem. 2012 Nov 15;430(2):130-7. doi: 10.1016/j.ab.2012.08.011. Epub 2012 Aug 23.

PMID:
22922382
14.

A novel, high-sensitivity and drug-tolerant sandwich immunoassay for the quantitative measurement of circulating proteins.

Sloan JH, Ackermann BL, Carpenter JW, Nguyen HT, Stopa K, Siegel RW, Konrad RJ.

Bioanalysis. 2012 Feb;4(3):241-8. doi: 10.4155/bio.11.312.

PMID:
22303828
15.

A comparison of mortality and cardiac biomarker response between three outbred stocks of Sprague Dawley rats treated with isoproterenol.

Schultze AE, Main BW, Hall DG, Hoffman WP, Lee HY, Ackermann BL, Pritt ML, Smith HW.

Toxicol Pathol. 2011 Jun;39(4):576-88. doi: 10.1177/0192623311402219. Epub 2011 Apr 5.

PMID:
21467541
16.

Comparison of assay formats for drug-tolerant immunogenicity testing.

Butterfield AM, Chain JS, Ackermann BL, Konrad RJ.

Bioanalysis. 2010 Dec;2(12):1961-9. doi: 10.4155/bio.10.136.

PMID:
21110740
17.

Conference report: Applied Pharmaceutical Analysis 2009 Conference.

Ackermann BL.

Bioanalysis. 2010 Feb;2(2):185-8. doi: 10.4155/bio.09.169. No abstract available.

18.

N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes.

Fell MJ, Witkin JM, Falcone JF, Katner JS, Perry KW, Hart J, Rorick-Kehn L, Overshiner CD, Rasmussen K, Chaney SF, Benvenga MJ, Li X, Marlow DL, Thompson LK, Luecke SK, Wafford KA, Seidel WF, Edgar DM, Quets AT, Felder CC, Wang X, Heinz BA, Nikolayev A, Kuo MS, Mayhugh D, Khilevich A, Zhang D, Ebert PJ, Eckstein JA, Ackermann BL, Swanson SP, Catlow JT, Dean RA, Jackson K, Tauscher-Wisniewski S, Marek GJ, Schkeryantz JM, Svensson KA.

J Pharmacol Exp Ther. 2011 Jan;336(1):165-77. doi: 10.1124/jpet.110.172957. Epub 2010 Oct 14.

PMID:
20947638
19.

Quantification of gemcitabine incorporation into human DNA by LC/MS/MS as a surrogate measure for target engagement.

Wickremsinhe ER, Lutzke BS, Jones BR, Schultz GA, Freeman AB, Pratt SE, Bones AM, Ackermann BL.

Anal Chem. 2010 Aug 1;82(15):6576-83. doi: 10.1021/ac100984h.

PMID:
20698580
20.

Hybrid immunoaffinity--mass spectrometric methods for efficient protein biomarker verification in pharmaceutical development.

Ackermann BL.

Bioanalysis. 2009 May;1(2):265-8. doi: 10.4155/bio.09.49. No abstract available.

21.

The development of methodology for clinical measurement of 5-lipoxygenase pathway intermediates from human peripheral blood mononuclear cells.

Willey MB, Alborn WE, Lutzke BS, Lelacheur RM, White RJ, Stavrakis G, Konrad RJ, Ackermann BL.

J Pharm Biomed Anal. 2008 Dec 15;48(5):1397-403. doi: 10.1016/j.jpba.2008.09.034. Epub 2008 Sep 30.

PMID:
18996667
22.

Current applications of liquid chromatography/mass spectrometry in pharmaceutical discovery after a decade of innovation.

Ackermann BL, Berna MJ, Eckstein JA, Ott LW, Chaudhary AK.

Annu Rev Anal Chem (Palo Alto Calif). 2008;1:357-96. doi: 10.1146/annurev.anchem.1.031207.112855. Review.

PMID:
20636083
23.

Analysis of glutamine, glutamate, pyroglutamate, and GABA in cerebrospinal fluid using ion pairing HPLC with positive electrospray LC/MS/MS.

Eckstein JA, Ammerman GM, Reveles JM, Ackermann BL.

J Neurosci Methods. 2008 Jun 30;171(2):190-6. doi: 10.1016/j.jneumeth.2008.02.019. Epub 2008 Mar 18.

PMID:
18433876
24.

Simultaneous profiling of multiple neurochemical pathways from a single cerebrospinal fluid sample using GC/MS/MS with electron capture detection.

Eckstein JA, Ammerman GM, Reveles JM, Ackermann BL.

J Mass Spectrom. 2008 Jun;43(6):782-90. doi: 10.1002/jms.1376.

PMID:
18286669
25.

Quantification of heart fatty acid binding protein as a biomarker for drug-induced cardiac and musculoskeletal necroses.

Zhen EY, Berna MJ, Jin Z, Pritt ML, Watson DE, Ackermann BL, Hale JE.

Proteomics Clin Appl. 2007 Jul;1(7):661-71. doi: 10.1002/prca.200700006. Epub 2007 Jun 8.

PMID:
21136721
26.

Strategic use of immunoprecipitation and LC/MS/MS for trace-level protein quantification: myosin light chain 1, a biomarker of cardiac necrosis.

Berna MJ, Zhen Y, Watson DE, Hale JE, Ackermann BL.

Anal Chem. 2007 Jun 1;79(11):4199-205. Epub 2007 Apr 21.

PMID:
17447729
27.

Coupling immunoaffinity techniques with MS for quantitative analysis of low-abundance protein biomarkers.

Ackermann BL, Berna MJ.

Expert Rev Proteomics. 2007 Apr;4(2):175-86. Review.

PMID:
17425454
28.

A review of nanoelectrospray ionization applications for drug metabolism and pharmacokinetics.

Wickremsinhe ER, Singh G, Ackermann BL, Gillespie TA, Chaudhary AK.

Curr Drug Metab. 2006 Dec;7(8):913-28. Review.

PMID:
17168691
29.

Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry.

Oe T, Ackermann BL, Inoue K, Berna MJ, Garner CO, Gelfanova V, Dean RA, Siemers ER, Holtzman DM, Farlow MR, Blair IA.

Rapid Commun Mass Spectrom. 2006;20(24):3723-35.

PMID:
17117458
30.

Quantification of serine enantiomers in rat brain microdialysate using Marfey's reagent and LC/MS/MS.

Berna MJ, Ackermann BL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Feb 1;846(1-2):359-63. Epub 2006 Sep 7.

PMID:
16962391
31.

The role of mass spectrometry in biomarker discovery and measurement.

Ackermann BL, Hale JE, Duffin KL.

Curr Drug Metab. 2006 Jun;7(5):525-39. Review.

PMID:
16787160
32.

Liquid chromatography/tandem mass spectrometry characterization of oxidized amyloid beta peptides as potential biomarkers of Alzheimer's disease.

Inoue K, Garner C, Ackermann BL, Oe T, Blair IA.

Rapid Commun Mass Spectrom. 2006;20(5):911-8.

PMID:
16470704
33.

Data-driven analysis approach for biomarker discovery using molecular-profiling technologies.

Wei T, Liao B, Ackermann BL, Jolly RA, Eckstein JA, Kulkarni NH, Helvering LM, Goldstein KM, Shou J, Estrem ST, Ryan TP, Colet JM, Thomas CE, Stevens JL, Onyia JE.

Biomarkers. 2005 Mar-Jun;10(2-3):153-72.

PMID:
16076730
34.

Development of an ion-pair reverse-phase liquid chromatographic/tandem mass spectrometry method for the determination of an 18-mer phosphorothioate oligonucleotide in mouse liver tissue.

Murphy AT, Brown-Augsburger P, Yu RZ, Geary RS, Thibodeaux S, Ackermann BL.

Eur J Mass Spectrom (Chichester). 2005;11(2):209-15.

PMID:
16046805
35.

Results from a bench marking survey on Supporting Chemical Synthesis and Structural Elucidation in the Pharmaceutical Industry.

Peake DA, Ackermann BL.

J Am Soc Mass Spectrom. 2005 Apr;16(4):599-605. No abstract available.

PMID:
15871168
36.

Validating regulatory-compliant wide dynamic range bioanalytical assays using chip-based nanoelectrospray tandem mass spectrometry.

Wickremsinhe ER, Ackermann BL, Chaudhary AK.

Rapid Commun Mass Spectrom. 2005;19(1):47-56.

PMID:
15570573
37.

Results from a bench marking survey on cassette dosing practices in the pharmaceutical industry.

Ackermann BL.

J Am Soc Mass Spectrom. 2004 Sep;15(9):1374-7. No abstract available.

38.

Characterization of dark liver pigment observed in rats after subchronic dosing of the beta3-adrenergic receptor agonist LY368842.

He MM, Barbuch RJ, Abraham TL, Lindsay TJ, Jackson DA, Ackermann BL, Wilke AV, Jensen CB.

Chem Res Toxicol. 2003 Jul;16(7):912-9.

PMID:
12870894
39.

Demonstration of direct bioanalysis of drugs in plasma using nanoelectrospray infusion from a silicon chip coupled with tandem mass spectrometry.

Dethy JM, Ackermann BL, Delatour C, Henion JD, Schultz GA.

Anal Chem. 2003 Feb 15;75(4):805-11.

PMID:
12622370
40.

Recent advances in use of LC/MS/MS for quantitative high-throughput bioanalytical support of drug discovery.

Ackermann BL, Berna MJ, Murphy AT.

Curr Top Med Chem. 2002 Jan;2(1):53-66. Review.

PMID:
11899065
41.

Effects of flow rate on high-throughput quantitative analysis of protein-precipitated plasma using liquid chromatography/tandem mass spectrometry.

Murphy AT, Berna MJ, Holsapple JL, Ackermann BL.

Rapid Commun Mass Spectrom. 2002;16(6):537-43.

PMID:
11870891
42.

In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin.

Fisher MB, Campanale K, Ackermann BL, VandenBranden M, Wrighton SA.

Drug Metab Dispos. 2000 May;28(5):560-6.

PMID:
10772635
44.

Evidence for a novel pentyl radical adduct of the cyclic nitrone spin trap MDL 101,002.

Dage JL, Ackermann BL, Barbuch RJ, Bernotas RC, Ohlweiler DF, Haegele KD, Thomas CE.

Free Radic Biol Med. 1997;22(5):807-12.

PMID:
9119249
45.
46.

AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1.

Akeson AL, Woods CW, Hsieh LC, Bohnke RA, Ackermann BL, Chan KY, Robinson JL, Yanofsky SD, Jacobs JW, Barrett RW, Bowlin TL.

J Biol Chem. 1996 Nov 29;271(48):30517-23.

47.
48.

Evidence for a lysine-specific fragmentation in fast-atom bombardment mass spectra of peptides.

Ackermann BL, Barbuch RJ, Coutant JE, Krstenansky JL, Owen TJ.

Rapid Commun Mass Spectrom. 1992 Apr;6(4):257-64.

PMID:
1373977
49.

Metabolism of the anticoagulant peptide, MDL 28,050, in rats.

Knadler MP, Ackermann BL, Coutant JE, Hurst GH.

Drug Metab Dispos. 1992 Jan-Feb;20(1):89-95.

PMID:
1347003
50.

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