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Items: 7


GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration.

Ackeifi C, Wang P, Karakose E, Manning Fox JE, González BJ, Liu H, Wilson J, Swartz E, Berrouet C, Li Y, Kumar K, MacDonald PE, Sanchez R, Thorens B, DeVita R, Homann D, Egli D, Scott DK, Garcia-Ocaña A, Stewart AF.

Sci Transl Med. 2020 Feb 12;12(530). pii: eaaw9996. doi: 10.1126/scitranslmed.aaw9996.


Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors.

Ackeifi C, Swartz E, Kumar K, Liu H, Chalada S, Karakose E, Scott DK, Garcia-Ocaña A, Sanchez R, DeVita RJ, Stewart AF, Wang P.

JCI Insight. 2020 Jan 16;5(1). pii: 132594. doi: 10.1172/jci.insight.132594.


Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells.

Wang P, Karakose E, Liu H, Swartz E, Ackeifi C, Zlatanic V, Wilson J, González BJ, Bender A, Takane KK, Ye L, Harb G, Pagliuca F, Homann D, Egli D, Argmann C, Scott DK, Garcia-Ocaña A, Stewart AF.

Cell Metab. 2019 Mar 5;29(3):638-652.e5. doi: 10.1016/j.cmet.2018.12.005. Epub 2018 Dec 20.


Advances in drug discovery for human beta cell regeneration.

Karakose E, Ackeifi C, Wang P, Stewart AF.

Diabetologia. 2018 Aug;61(8):1693-1699. doi: 10.1007/s00125-018-4639-6. Epub 2018 May 16. Review.


Cell-Based Methods to Identify Inducers of Human Pancreatic Beta-Cell Proliferation.

Ackeifi CA, Swartz EA, Wang P.

Methods Mol Biol. 2018;1787:87-100. doi: 10.1007/978-1-4939-7847-2_7.


A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.

Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA, Arvanites AC, Davidow LS, Woolf CJ, Rubin LL.

Cell Stem Cell. 2013 Jun 6;12(6):713-26. doi: 10.1016/j.stem.2013.04.003. Epub 2013 Apr 18.


Nuclear receptor coactivators are coexpressed with steroid receptors and regulated by estradiol in mouse brain.

Tognoni CM, Chadwick JG Jr, Ackeifi CA, Tetel MJ.

Neuroendocrinology. 2011;94(1):49-57. doi: 10.1159/000323780. Epub 2011 Feb 9.

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