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Items: 1 to 50 of 108

1.

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis.

Vogrin AJ, Bower NI, Gunzburg MJ, Roufail S, Okuda KS, Paterson S, Headey SJ, Stacker SA, Hogan BM, Achen MG.

Cell Rep. 2019 Aug 20;28(8):2023-2036.e4. doi: 10.1016/j.celrep.2019.07.055.

2.

Modulation of Immunity by Lymphatic Dysfunction in Lymphedema.

Yuan Y, Arcucci V, Levy SM, Achen MG.

Front Immunol. 2019 Jan 29;10:76. doi: 10.3389/fimmu.2019.00076. eCollection 2019. Review.

3.

CCL27/CCL28-CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells.

Karnezis T, Farnsworth RH, Harris NC, Williams SP, Caesar C, Byrne DJ, Herle P, Macheda ML, Shayan R, Zhang YF, Yazar S, Takouridis SJ, Gerard C, Fox SB, Achen MG, Stacker SA.

Cancer Res. 2019 Apr 1;79(7):1558-1572. doi: 10.1158/0008-5472.CAN-18-1858. Epub 2019 Feb 1.

PMID:
30709930
4.

Exit Stage Left: A Tumor Cell's Journey from Lymph Node to Beyond.

Achen MG, Stacker SA.

Trends Cancer. 2018 Aug;4(8):519-522. doi: 10.1016/j.trecan.2018.05.007. Epub 2018 Jun 6.

PMID:
30064660
5.

The evolving role of lymphatics in cancer metastasis.

Farnsworth RH, Achen MG, Stacker SA.

Curr Opin Immunol. 2018 Aug;53:64-73. doi: 10.1016/j.coi.2018.04.008. Epub 2018 Apr 23. Review.

PMID:
29698919
6.

Emerging Roles for VEGF-D in Human Disease.

Stacker SA, Achen MG.

Biomolecules. 2018 Jan 4;8(1). pii: E1. doi: 10.3390/biom8010001. Review.

7.

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling.

Williams SP, Odell AF, Karnezis T, Farnsworth RH, Gould CM, Li J, Paquet-Fifield S, Harris NC, Walter A, Gregory JL, Lamont SF, Liu R, Takano EA, Nowell CJ, Bower NI, Resnick D, Smyth GK, Coultas L, Hogan BM, Fox SB, Mueller SN, Simpson KJ, Achen MG, Stacker SA.

Sci Signal. 2017 Oct 3;10(499). pii: eaal2987. doi: 10.1126/scisignal.aal2987.

PMID:
28974649
8.

The fibrinolysis inhibitor α2-antiplasmin restricts lymphatic remodelling and metastasis in a mouse model of cancer.

Paquet-Fifield S, Roufail S, Zhang YF, Sofian T, Byrne DJ, Coughlin PB, Fox SB, Stacker SA, Achen MG.

Growth Factors. 2017 Jun;35(2-3):61-75. doi: 10.1080/08977194.2017.1349765. Epub 2017 Jul 11.

PMID:
28697634
9.

Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology.

Williams SP, Gould CM, Nowell CJ, Karnezis T, Achen MG, Simpson KJ, Stacker SA.

Sci Data. 2017 Mar 1;4:170009. doi: 10.1038/sdata.2017.9.

10.

A Three-Dimensional Lymphatic Endothelial Cell Tube Formation Assay to Identify Novel Kinases Involved in Lymphatic Vessel Remodeling.

Gambino TJ, Williams SP, Caesar C, Resnick D, Nowell CJ, Farnsworth RH, Achen MG, Stacker SA, Karnezis T.

Assay Drug Dev Technol. 2017 Jan;15(1):30-43. doi: 10.1089/adt.2016.764.

PMID:
28092460
11.

Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development.

Bower NI, Vogrin AJ, Le Guen L, Chen H, Stacker SA, Achen MG, Hogan BM.

Development. 2017 Feb 1;144(3):507-518. doi: 10.1242/dev.146969. Epub 2017 Jan 13.

12.

The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment.

Hendry SA, Farnsworth RH, Solomon B, Achen MG, Stacker SA, Fox SB.

Front Immunol. 2016 Dec 20;7:621. doi: 10.3389/fimmu.2016.00621. eCollection 2016. Review.

13.

Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D.

Davydova N, Harris NC, Roufail S, Paquet-Fifield S, Ishaq M, Streltsov VA, Williams SP, Karnezis T, Stacker SA, Achen MG.

J Biol Chem. 2016 Dec 30;291(53):27265-27278. doi: 10.1074/jbc.M116.736801. Epub 2016 Nov 16.

14.

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors.

Stacker SA, Halford MM, Roufail S, Caesar C, Achen MG.

J Vis Exp. 2016 Mar 15;(109). doi: 10.3791/53867.

15.

VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury.

Sato T, Paquet-Fifield S, Harris NC, Roufail S, Turner DJ, Yuan Y, Zhang YF, Fox SB, Hibbs ML, Wilkinson-Berka JL, Williams RA, Stacker SA, Sly PD, Achen MG.

J Pathol. 2016 Jun;239(2):152-61. doi: 10.1002/path.4708. Epub 2016 Mar 30.

16.

Intestinal-specific activatable Myb initiates colon tumorigenesis in mice.

Malaterre J, Pereira L, Putoczki T, Millen R, Paquet-Fifield S, Germann M, Liu J, Cheasley D, Sampurno S, Stacker SA, Achen MG, Ward RL, Waring P, Mantamadiotis T, Ernst M, Ramsay RG.

Oncogene. 2016 May 12;35(19):2475-84. doi: 10.1038/onc.2015.305. Epub 2015 Aug 24.

17.

Exploring the role of endothelium in the tumour response to anti-angiogenic therapy.

He YC, Halford MM, Achen MG, Stacker SA.

Biochem Soc Trans. 2014 Dec;42(6):1569-75. doi: 10.1042/BST20140173. Review.

PMID:
25399572
18.

A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma.

Lewin J, Khamly KK, Young RJ, Mitchell C, Hicks RJ, Toner GC, Ngan SY, Chander S, Powell GJ, Herschtal A, Te Marvelde L, Desai J, Choong PF, Stacker SA, Achen MG, Ferris N, Fox S, Slavin J, Thomas DM.

Br J Cancer. 2014 Dec 9;111(12):2254-61. doi: 10.1038/bjc.2014.537. Epub 2014 Oct 16.

19.

Lymphangiogenesis and lymphatic vessel remodelling in cancer.

Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG.

Nat Rev Cancer. 2014 Mar;14(3):159-72. doi: 10.1038/nrc3677. Review.

PMID:
24561443
20.

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.

Le Guen L, Karpanen T, Schulte D, Harris NC, Koltowska K, Roukens G, Bower NI, van Impel A, Stacker SA, Achen MG, Schulte-Merker S, Hogan BM.

Development. 2014 Mar;141(6):1239-49. doi: 10.1242/dev.100495. Epub 2014 Feb 12.

22.

VEGFD regulates blood vascular development by modulating SOX18 activity.

Duong T, Koltowska K, Pichol-Thievend C, Le Guen L, Fontaine F, Smith KA, Truong V, Skoczylas R, Stacker SA, Achen MG, Koopman P, Hogan BM, Francois M.

Blood. 2014 Feb 13;123(7):1102-12. doi: 10.1182/blood-2013-04-495432. Epub 2013 Nov 22.

23.

Lymphovascular and neural regulation of metastasis: shared tumour signalling pathways and novel therapeutic approaches.

Le CP, Karnezis T, Achen MG, Stacker SA, Sloan EK.

Best Pract Res Clin Anaesthesiol. 2013 Dec;27(4):409-25. doi: 10.1016/j.bpa.2013.10.008. Epub 2013 Oct 15. Review.

24.

Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development.

Kartopawiro J, Bower NI, Karnezis T, Kazenwadel J, Betterman KL, Lesieur E, Koltowska K, Astin J, Crosier P, Vermeren S, Achen MG, Stacker SA, Smith KA, Harvey NL, François M, Hogan BM.

Hum Mol Genet. 2014 Mar 1;23(5):1286-97. doi: 10.1093/hmg/ddt518. Epub 2013 Oct 24.

PMID:
24163130
25.

Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy.

Devaud C, Westwood JA, John LB, Flynn JK, Paquet-Fifield S, Duong CP, Yong CS, Pegram HJ, Stacker SA, Achen MG, Stewart TJ, Snyder LA, Teng MW, Smyth MJ, Darcy PK, Kershaw MH.

Mol Ther. 2014 Jan;22(1):18-27. doi: 10.1038/mt.2013.219. Epub 2013 Sep 19.

26.

Vascular remodeling in cancer.

Farnsworth RH, Lackmann M, Achen MG, Stacker SA.

Oncogene. 2014 Jul 3;33(27):3496-505. doi: 10.1038/onc.2013.304. Epub 2013 Aug 5. Review.

PMID:
23912450
27.

Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis.

Matsumoto M, Roufail S, Inder R, Caesar C, Karnezis T, Shayan R, Farnsworth RH, Sato T, Achen MG, Mann GB, Stacker SA.

Clin Exp Metastasis. 2013 Aug;30(6):819-32. doi: 10.1007/s10585-013-9581-x. Epub 2013 Apr 17.

PMID:
23591595
28.

Vascular endothelial growth factor-d modulates caliber and function of initial lymphatics in the dermis.

Paquet-Fifield S, Levy SM, Sato T, Shayan R, Karnezis T, Davydova N, Nowell CJ, Roufail S, Ma GZ, Zhang YF, Stacker SA, Achen MG.

J Invest Dermatol. 2013 Aug;133(8):2074-84. doi: 10.1038/jid.2013.83. Epub 2013 Feb 25.

29.

The VEGF signaling pathway in cancer: the road ahead.

Stacker SA, Achen MG.

Chin J Cancer. 2013 Jun;32(6):297-302. doi: 10.5732/cjc.012.10319. Epub 2013 Feb 19.

30.

The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology.

Harris NC, Davydova N, Roufail S, Paquet-Fifield S, Paavonen K, Karnezis T, Zhang YF, Sato T, Rothacker J, Nice EC, Stacker SA, Achen MG.

J Biol Chem. 2013 Mar 22;288(12):8176-86. doi: 10.1074/jbc.M112.439299. Epub 2013 Feb 12.

31.

Tumor location and nature of lymphatic vessels are key determinants of cancer metastasis.

Shayan R, Inder R, Karnezis T, Caesar C, Paavonen K, Ashton MW, Mann GB, Taylor GI, Achen MG, Stacker SA.

Clin Exp Metastasis. 2013 Mar;30(3):345-56. doi: 10.1007/s10585-012-9541-x. Epub 2012 Nov 3.

PMID:
23124573
32.

The connection between lymphangiogenic signalling and prostaglandin biology: a missing link in the metastatic pathway.

Karnezis T, Shayan R, Fox S, Achen MG, Stacker SA.

Oncotarget. 2012 Aug;3(8):893-906. Epub 2012 Aug 19. Review.

33.

Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.

Betterman KL, Paquet-Fifield S, Asselin-Labat ML, Visvader JE, Butler LM, Stacker SA, Achen MG, Harvey NL.

Am J Pathol. 2012 Dec;181(6):2225-38. doi: 10.1016/j.ajpath.2012.08.035. Epub 2012 Oct 11.

PMID:
23063660
34.

Vascular endothelial growth factor-D: signaling mechanisms, biology, and clinical relevance.

Achen MG, Stacker SA.

Growth Factors. 2012 Oct;30(5):283-96. Epub 2012 Jul 20.

PMID:
22817635
35.

Lymphatic vessel density in primary melanomas predicts sentinel lymph node status and risk of metastasis.

Shayan R, Karnezis T, Murali R, Wilmott JS, Ashton MW, Taylor GI, Thompson JF, Hersey P, Achen MG, Scolyer RA, Stacker SA.

Histopathology. 2012 Oct;61(4):702-10. doi: 10.1111/j.1365-2559.2012.04310.x.

PMID:
22734806
36.

VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium.

Karnezis T, Shayan R, Caesar C, Roufail S, Harris NC, Ardipradja K, Zhang YF, Williams SP, Farnsworth RH, Chai MG, Rupasinghe TW, Tull DL, Baldwin ME, Sloan EK, Fox SB, Achen MG, Stacker SA.

Cancer Cell. 2012 Feb 14;21(2):181-95. doi: 10.1016/j.ccr.2011.12.026.

37.

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.

Davydova N, Streltsov VA, Roufail S, Lovrecz GO, Stacker SA, Adams TE, Achen MG.

Protein Expr Purif. 2012 Mar;82(1):232-9. doi: 10.1016/j.pep.2012.01.001. Epub 2012 Jan 10.

PMID:
22261343
38.

A role for bone morphogenetic protein-4 in lymph node vascular remodeling and primary tumor growth.

Farnsworth RH, Karnezis T, Shayan R, Matsumoto M, Nowell CJ, Achen MG, Stacker SA.

Cancer Res. 2011 Oct 15;71(20):6547-57. doi: 10.1158/0008-5472.CAN-11-0200. Epub 2011 Aug 25.

39.

Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer.

Harris NC, Paavonen K, Davydova N, Roufail S, Sato T, Zhang YF, Karnezis T, Stacker SA, Achen MG.

FASEB J. 2011 Aug;25(8):2615-25. doi: 10.1096/fj.10-179788. Epub 2011 Apr 22.

PMID:
21515745
40.

The VD1 neutralizing antibody to vascular endothelial growth factor-D: binding epitope and relationship to receptor binding.

Davydova N, Roufail S, Streltsov VA, Stacker SA, Achen MG.

J Mol Biol. 2011 Apr 8;407(4):581-93. doi: 10.1016/j.jmb.2011.02.009. Epub 2011 Feb 18.

PMID:
21315726
41.

Targeting lymphatic vessel functions through tyrosine kinases.

Williams SP, Karnezis T, Achen MG, Stacker SA.

J Angiogenes Res. 2010 Aug 11;2:13. doi: 10.1186/2040-2384-2-13.

42.

Vascular endothelial growth factor-D over-expressing tumor cells induce differential effects on uterine vasculature in a mouse model of endometrial cancer.

Girling JE, Donoghue JF, Lederman FL, Cann LM, Achen MG, Stacker SA, Rogers PA.

Reprod Biol Endocrinol. 2010 Jul 8;8:84. doi: 10.1186/1477-7827-8-84.

43.

Elevated level of inhibin-alpha subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer.

Balanathan P, Williams ED, Wang H, Pedersen JS, Horvath LG, Achen MG, Stacker SA, Risbridger GP.

Br J Cancer. 2009 Jun 2;100(11):1784-93. doi: 10.1038/sj.bjc.6605089. Epub 2009 May 12.

44.

From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in cancer therapy.

Stacker SA, Achen MG.

Lymphat Res Biol. 2008;6(3-4):165-72. doi: 10.1089/lrb.2008.1015. Review.

PMID:
19093789
45.

Sox18 induces development of the lymphatic vasculature in mice.

François M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, Paavonen K, Karnezis T, Shayan R, Downes M, Davidson T, Tutt D, Cheah KS, Stacker SA, Muscat GE, Achen MG, Dejana E, Koopman P.

Nature. 2008 Dec 4;456(7222):643-7. doi: 10.1038/nature07391. Epub 2008 Oct 19.

PMID:
18931657
46.

Targeting tumor stroma.

Achen MG, Stacker SA.

Curr Cancer Drug Targets. 2008 Sep;8(6):446. No abstract available.

PMID:
18781890
47.

Molecular control of lymphatic metastasis.

Achen MG, Stacker SA.

Ann N Y Acad Sci. 2008;1131:225-34. doi: 10.1196/annals.1413.020. Review.

PMID:
18519975
48.

Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.

Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, Baldwin ME, Stacker SA, Achen MG, Alitalo K.

Mol Cell Biol. 2008 Aug;28(15):4843-50. doi: 10.1128/MCB.02214-07. Epub 2008 Jun 2.

49.

A system for quantifying the patterning of the lymphatic vasculature.

Shayan R, Karnezis T, Tsantikos E, Williams SP, Runting AS, Ashton MW, Achen MG, Hibbs ML, Stacker SA.

Growth Factors. 2007 Dec;25(6):417-25. doi: 10.1080/08977190801932550.

PMID:
18365872
50.

Molecular pathways for lymphangiogenesis and their role in human disease.

Stacker SA, Farnsworth RH, Karnezis T, Shayan R, Smith DP, Paavonen K, Davydova N, Caesar C, Inder R, Baldwin ME, McColl BK, Roufail S, Williams RA, Hughes RA, Alitalo K, Achen MG.

Novartis Found Symp. 2007;281:38-43; discussion 44-53, 208-9. Review.

PMID:
17534064

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