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High resolution crystal structure of substrate-free human neprilysin.

Moss S, Subramanian V, Acharya KR.

J Struct Biol. 2018 Jun 12. pii: S1047-8477(18)30142-4. doi: 10.1016/j.jsb.2018.06.004. [Epub ahead of print]


High resolution crystal structures of the receptor-binding domain of Clostridium botulinum neurotoxin serotypes A and FA.

Davies JR, Hackett GS, Liu SM, Acharya KR.

PeerJ. 2018 Mar 21;6:e4552. doi: 10.7717/peerj.4552. eCollection 2018.


A comparative bioinformatic analysis of C9orf72.

Iyer S, Acharya KR, Subramanian V.

PeerJ. 2018 Feb 19;6:e4391. doi: 10.7717/peerj.4391. eCollection 2018.


Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity.

Cozier GE, Schwager SL, Sharma RK, Chibale K, Sturrock ED, Acharya KR.

FEBS J. 2018 Apr;285(8):1477-1490. doi: 10.1111/febs.14421. Epub 2018 Mar 8.


Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme.

Abrie JA, Moolman WJA, Cozier GE, Schwager SL, Acharya KR, Sturrock ED.

Mol Pharmacol. 2018 Apr;93(4):344-354. doi: 10.1124/mol.117.110866. Epub 2018 Jan 25. Erratum in: Mol Pharmacol. 2018 May;93(5):416.


Prediction of structural consequences for disease causing variants in C21orf2 protein using computational approaches.

Iyer S, Acharya KR, Subramanian V.

J Biomol Struct Dyn. 2018 Feb 7:1-16. doi: 10.1080/07391102.2018.1429313. [Epub ahead of print]


Culture-Independent Identification of Mycobacterium avium Subspecies paratuberculosis in Ovine Tissues: Comparison with Bacterial Culture and Histopathological Lesions.

Acharya KR, Dhand NK, Whittington RJ, Plain KM.

Front Vet Sci. 2017 Dec 22;4:232. doi: 10.3389/fvets.2017.00232. eCollection 2017.


High resolution crystal structures of Clostridium botulinum neurotoxin A3 and A4 binding domains.

Davies JR, Rees J, Liu SM, Acharya KR.

J Struct Biol. 2018 May;202(2):113-117. doi: 10.1016/j.jsb.2017.12.010. Epub 2017 Dec 26.


The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme.

Fienberg S, Cozier GE, Acharya KR, Chibale K, Sturrock ED.

J Med Chem. 2018 Jan 11;61(1):344-359. doi: 10.1021/acs.jmedchem.7b01478. Epub 2017 Dec 21.


The structure of the S-layer of Clostridium difficile.

Bradshaw WJ, Roberts AK, Shone CC, Acharya KR.

J Cell Commun Signal. 2018 Mar;12(1):319-331. doi: 10.1007/s12079-017-0429-z. Epub 2017 Nov 23. Review.


The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile.

Bradshaw WJ, Kirby JM, Roberts AK, Shone CC, Acharya KR.

FEBS J. 2017 Dec;284(24):4343-4357. doi: 10.1111/febs.14310. Epub 2017 Nov 17.


Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin.

Davies AH, McGlashan J, Posner MG, Roberts AK, Shone CC, Acharya KR.

Biochem Biophys Rep. 2016 Aug 11;8:55-61. doi: 10.1016/j.bbrep.2016.08.011. eCollection 2016 Dec.


High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection.

Monaghan TM, Negm OH, MacKenzie B, Hamed MR, Shone CC, Humphreys DP, Acharya KR, Wilcox MH.

Clin Exp Gastroenterol. 2017 Jul 19;10:169-175. doi: 10.2147/CEG.S133939. eCollection 2017.


Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro.

Bradshaw WJ, Kirby JM, Roberts AK, Shone CC, Acharya KR.

FEBS J. 2017 Sep;284(17):2886-2898. doi: 10.1111/febs.14157. Epub 2017 Jul 23.


Detection of Mycobacterium avium subspecies paratuberculosis in powdered infant formula using IS900 quantitative PCR and liquid culture media.

Acharya KR, Dhand NK, Whittington RJ, Plain KM.

Int J Food Microbiol. 2017 Sep 18;257:1-9. doi: 10.1016/j.ijfoodmicro.2017.06.005. Epub 2017 Jun 8.


The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae.

Abu Hasan Z', Williams H, Ismail NM, Othman H, Cozier GE, Acharya KR, Isaac RE.

Sci Rep. 2017 Mar 27;7:45409. doi: 10.1038/srep45409.


PCR Inhibition of a Quantitative PCR for Detection of Mycobacterium avium Subspecies Paratuberculosis DNA in Feces: Diagnostic Implications and Potential Solutions.

Acharya KR, Dhand NK, Whittington RJ, Plain KM.

Front Microbiol. 2017 Feb 2;8:115. doi: 10.3389/fmicb.2017.00115. eCollection 2017.


Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.

Bradshaw WJ, Rehman S, Pham TT, Thiyagarajan N, Lee RL, Subramanian V, Acharya KR.

Sci Rep. 2017 Feb 8;7:41996. doi: 10.1038/srep41996.


Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor.

Masuyer G, Cozier GE, Kramer GJ, Bachmann BO, Acharya KR.

FEBS J. 2016 Dec;283(23):4357-4369. doi: 10.1111/febs.13928. Epub 2016 Nov 6.


Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme.

Larmuth KM, Masuyer G, Douglas RG, Schwager SL, Acharya KR, Sturrock ED.

FEBS J. 2016 Mar;283(6):1060-76. doi: 10.1111/febs.13647. Epub 2016 Feb 9.


Structural basis of substrate specificity in porcine RNase 4.

Liang S, Acharya KR.

FEBS J. 2016 Mar;283(5):912-28. doi: 10.1111/febs.13646. Epub 2016 Feb 5.


Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa.

Schmidt A, Hammerbacher AS, Bastian M, Nieken KJ, Klockgether J, Merighi M, Lapouge K, Poschgan C, Kölle J, Acharya KR, Ulrich M, Tümmler B, Unden G, Kaever V, Lory S, Haas D, Schwarz S, Döring G.

Environ Microbiol. 2016 Oct;18(10):3390-3402. doi: 10.1111/1462-2920.13208. Epub 2016 Feb 4.


Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme.

Masuyer G, Douglas RG, Sturrock ED, Acharya KR.

Sci Rep. 2015 Sep 25;5:13742. doi: 10.1038/srep13742.


A new high-resolution crystal structure of the Drosophila melanogaster angiotensin converting enzyme homologue, AnCE.

Harrison C, Acharya KR.

FEBS Open Bio. 2015 Aug 11;5:661-7. doi: 10.1016/j.fob.2015.08.004. eCollection 2015.


Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site.

Iyer S, La-Borde PJ, Payne KA, Parsons MR, Turner AJ, Isaac RE, Acharya KR.

FEBS Open Bio. 2015 Apr 2;5:292-302. doi: 10.1016/j.fob.2015.03.013. eCollection 2015.


Molecular features of the sortase enzyme family.

Bradshaw WJ, Davies AH, Chambers CJ, Roberts AK, Shone CC, Acharya KR.

FEBS J. 2015 Jun;282(11):2097-114. doi: 10.1111/febs.13288. Epub 2015 Apr 24. Review.


Structure and function of a Clostridium difficile sortase enzyme.

Chambers CJ, Roberts AK, Shone CC, Acharya KR.

Sci Rep. 2015 Mar 24;5:9449. doi: 10.1038/srep09449.


Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide.

Bradshaw WJ, Roberts AK, Shone CC, Acharya KR.

Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):295-303. doi: 10.1107/S2053230X15001065. Epub 2015 Feb 19.


Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7.

Ramaswamy S, Sleiman MH, Masuyer G, Arbez-Gindre C, Micha-Screttas M, Calogeropoulou T, Steele BR, Acharya KR.

FEBS J. 2015 Jan;282(2):372-87. doi: 10.1111/febs.13140. Epub 2014 Nov 24.


Angiotensin-I converting enzyme (ACE): structure, biological roles, and molecular basis for chloride ion dependence.

Masuyer G, Yates CJ, Sturrock ED, Acharya KR.

Biol Chem. 2014 Oct;395(10):1135-49. doi: 10.1515/hsz-2014-0157. Review.


ACE for all - a molecular perspective.

Harrison C, Acharya KR.

J Cell Commun Signal. 2014 Sep;8(3):195-210. doi: 10.1007/s12079-014-0236-8. Epub 2014 Jul 16.


The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile.

Bradshaw WJ, Kirby JM, Thiyagarajan N, Chambers CJ, Davies AH, Roberts AK, Shone CC, Acharya KR.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1983-93. doi: 10.1107/S1399004714009997. Epub 2014 Jun 29.


Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes.

Kramer GJ, Mohd A, Schwager SL, Masuyer G, Acharya KR, Sturrock ED, Bachmann BO.

ACS Med Chem Lett. 2014 Feb 4;5(4):346-51. doi: 10.1021/ml4004588. eCollection 2014 Apr 10.


Eosinophil granule proteins: form and function.

Acharya KR, Ackerman SJ.

J Biol Chem. 2014 Jun 20;289(25):17406-15. doi: 10.1074/jbc.R113.546218. Epub 2014 May 6. Review.


Structures of complexes of a metal-independent glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-acetylgalactosamine (UDP-GalNAc) and its hydrolysis products.

Pham TT, Stinson B, Thiyagarajan N, Lizotte-Waniewski M, Brew K, Acharya KR.

J Biol Chem. 2014 Mar 21;289(12):8041-50. doi: 10.1074/jbc.M113.545384. Epub 2014 Jan 23.


Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE).

Yates CJ, Masuyer G, Schwager SL, Akif M, Sturrock ED, Acharya KR.

J Biol Chem. 2014 Jan 17;289(3):1798-814. doi: 10.1074/jbc.M113.512335. Epub 2013 Dec 2.


Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme.

Masuyer G, Akif M, Czarny B, Beau F, Schwager SL, Sturrock ED, Isaac RE, Dive V, Acharya KR.

FEBS J. 2014 Feb;281(3):943-56. doi: 10.1111/febs.12660. Epub 2013 Dec 24.


Absence of cell surface expression of human ACE leads to perinatal death.

Michaud A, Acharya KR, Masuyer G, Quenech'du N, Gribouval O, Morinière V, Gubler MC, Corvol P.

Hum Mol Genet. 2014 Mar 15;23(6):1479-91. doi: 10.1093/hmg/ddt535. Epub 2013 Oct 24.


Engineered botulinum neurotoxins as new therapeutics.

Masuyer G, Chaddock JA, Foster KA, Acharya KR.

Annu Rev Pharmacol Toxicol. 2014;54:27-51. doi: 10.1146/annurev-pharmtox-011613-135935. Epub 2013 Aug 30. Review.


Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors.

Douglas RG, Sharma RK, Masuyer G, Lubbe L, Zamora I, Acharya KR, Chibale K, Sturrock ED.

Clin Sci (Lond). 2014 Feb;126(4):305-13. doi: 10.1042/CS20130403.


Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule.

Thiyagarajan N, Acharya KR.

FEBS Open Bio. 2012 Dec 26;3:65-70. doi: 10.1016/j.fob.2012.12.003. Print 2013.


Structure and function of cytidine monophosphate kinase from Yersinia pseudotuberculosis, essential for virulence but not for survival.

Walker NJ, Clark EA, Ford DC, Bullifent HL, McAlister EV, Duffield ML, Acharya KR, Oyston PC.

Open Biol. 2012 Dec 5;2(12):120142. doi: 10.1098/rsob.120142.


Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen.

Thiyagarajan N, Pham TT, Stinson B, Sundriyal A, Tumbale P, Lizotte-Waniewski M, Brew K, Acharya KR.

Sci Rep. 2012;2:940. doi: 10.1038/srep00940. Epub 2012 Dec 7.


Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues.

Iyer S, Holloway DE, Acharya KR.

FEBS J. 2013 Jan;280(1):302-18. doi: 10.1111/febs.12071. Epub 2012 Dec 11.


Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster.

Akif M, Masuyer G, Bingham RJ, Sturrock ED, Isaac RE, Acharya KR.

FEBS J. 2012 Dec;279(24):4525-34. doi: 10.1111/febs.12038. Epub 2012 Nov 22.


Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides.

Masuyer G, Schwager SL, Sturrock ED, Isaac RE, Acharya KR.

Sci Rep. 2012;2:717. doi: 10.1038/srep00717. Epub 2012 Oct 9.


Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.

Thiyagarajan N, Ferguson R, Subramanian V, Acharya KR.

Nat Commun. 2012;3:1121. doi: 10.1038/ncomms2126.


Structure based drug design of angiotensin-I converting enzyme inhibitors.

Anthony CS, Masuyer G, Sturrock ED, Acharya KR.

Curr Med Chem. 2012;19(6):845-55. Review.


Engineering botulinum neurotoxin domains for activation by toxin light chain.

Stancombe PR, Masuyer G, Birch-Machin I, Beard M, Foster KA, Chaddock JA, Acharya KR.

FEBS J. 2012 Feb;279(3):515-23. doi: 10.1111/j.1742-4658.2011.08444.x. Epub 2011 Dec 23.


Structures of engineered Clostridium botulinum neurotoxin derivatives.

Masuyer G, Stancombe P, Chaddock JA, Acharya KR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1466-72. doi: 10.1107/S1744309111034671. Epub 2011 Nov 25.

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