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Items: 23

1.

Adverse vacuolation in multiple tissues in cynomolgus monkeys following repeat-dose administration of a PEGylated protein.

Fletcher AM, Tellier P, Douville J, Mansell P, Graziano MJ, Mangipudy RS, Brodie TA, Achanzar WE.

Toxicol Lett. 2019 Dec 15;317:120-129. doi: 10.1016/j.toxlet.2019.09.023. Epub 2019 Sep 30.

PMID:
31580884
2.

Evaluation of microRNAs-208 and 133a/b as differential biomarkers of acute cardiac and skeletal muscle toxicity in rats.

Calvano J, Achanzar W, Murphy B, DiPiero J, Hixson C, Parrula C, Burr H, Mangipudy R, Tirmenstein M.

Toxicol Appl Pharmacol. 2016 Dec 1;312:53-60. doi: 10.1016/j.taap.2015.11.015. Epub 2015 Nov 25.

PMID:
26627004
3.

PEGylated Biopharmaceuticals: Current Experience and Considerations for Nonclinical Development.

Ivens IA, Achanzar W, Baumann A, Brändli-Baiocco A, Cavagnaro J, Dempster M, Depelchin BO, Rovira AR, Dill-Morton L, Lane JH, Reipert BM, Salcedo T, Schweighardt B, Tsuruda LS, Turecek PL, Sims J.

Toxicol Pathol. 2015 Oct;43(7):959-83. doi: 10.1177/0192623315591171. Epub 2015 Aug 3. Review.

PMID:
26239651
4.

Quantitative analysis of polyethylene glycol (PEG) and PEGylated proteins in animal tissues by LC-MS/MS coupled with in-source CID.

Gong J, Gu X, Achanzar WE, Chadwick KD, Gan J, Brock BJ, Kishnani NS, Humphreys WG, Iyer RA.

Anal Chem. 2014 Aug 5;86(15):7642-9. doi: 10.1021/ac501507g. Epub 2014 Jul 8.

PMID:
25003239
5.

DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues.

Harstad EB, Rosenblum JS, Gorrell MD, Achanzar WE, Minimo L, Wu J, Rosini-Marthaler L, Gullo R, Ordway ND, Kirby MS, Chadwick KD, Cosma GN, Moyer CF.

Regul Pept. 2013 Sep 10;186:26-35. doi: 10.1016/j.regpep.2013.07.003. Epub 2013 Jul 12.

PMID:
23850796
6.

Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs.

Tomlinson L, Tirmenstein MA, Janovitz EB, Aranibar N, Ott KH, Kozlosky JC, Patrone LM, Achanzar WE, Augustine KA, Brannen KC, Carlson KE, Charlap JH, Dubrow KM, Kang L, Rosini LT, Panzica-Kelly JM, Flint OP, Moulin FJ, Megill JR, Zhang H, Bennett MJ, Horvath JJ.

Toxicol Sci. 2012 Oct;129(2):268-79. doi: 10.1093/toxsci/kfs217. Epub 2012 Jul 21.

PMID:
22821849
7.

Production of metallothionein polyclonal antibodies using chickens as model.

Ortiz-Bueno AM, León-Chávez BA, Ruiz-Tagle A, Lozano-Zarain P, Castro-Caballero L, Achanzar WE, Brambila E.

Appl Biochem Biotechnol. 2009 Sep;158(3):502-11. doi: 10.1007/s12010-008-8349-2. Epub 2008 Oct 25.

PMID:
18953512
8.

Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists.

Geese WJ, Achanzar W, Rubin C, Hariharan N, Cheng P, Tomlinson L, Ordway N, Dracopoli NC, Delmonte T, Hui L, Krishnan B, Cosma G, Ranade K.

Pharmacogenet Genomics. 2008 Oct;18(10):903-10. doi: 10.1097/FPC.0b013e32830a6ea0.

PMID:
18794727
9.

Urine acidification has no effect on peroxisome proliferator-activated receptor (PPAR) signaling or epidermal growth factor (EGF) expression in rat urinary bladder urothelium.

Achanzar WE, Moyer CF, Marthaler LT, Gullo R, Chen SJ, French MH, Watson LM, Rhodes JW, Kozlosky JC, White MR, Foster WR, Burgun JJ, Car BD, Cosma GN, Dominick MA.

Toxicol Appl Pharmacol. 2007 Sep 15;223(3):246-56. Epub 2007 Jul 3.

PMID:
17663016
10.

Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation.

Benbrahim-Tallaa L, Waterland RA, Styblo M, Achanzar WE, Webber MM, Waalkes MP.

Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98. Epub 2005 Jan 18.

PMID:
16039940
11.

Interferon alpha induction of metallothionein in rat liver is not linked to interleukin-1, interleukin-6, or tumor necrosis factor alpha.

Guevara-Ortiz JM, Omar-Castellanos V, León-Chávez BA, Achanzar WE, Brambila E.

Exp Mol Pathol. 2005 Aug;79(1):33-8. Epub 2005 Apr 12.

PMID:
16005709
12.

Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero.

Waalkes MP, Liu J, Chen H, Xie Y, Achanzar WE, Zhou YS, Cheng ML, Diwan BA.

J Natl Cancer Inst. 2004 Mar 17;96(6):466-74.

PMID:
15026472
13.

Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation.

Takiguchi M, Achanzar WE, Qu W, Li G, Waalkes MP.

Exp Cell Res. 2003 Jun 10;286(2):355-65.

PMID:
12749863
14.

Metallothionein is a potential negative regulator of apoptosis.

Shimoda R, Achanzar WE, Qu W, Nagamine T, Takagi H, Mori M, Waalkes MP.

Toxicol Sci. 2003 Jun;73(2):294-300. Epub 2003 Apr 15.

PMID:
12700406
15.

Inorganic arsenite-induced malignant transformation of human prostate epithelial cells.

Achanzar WE, Brambila EM, Diwan BA, Webber MM, Waalkes MP.

J Natl Cancer Inst. 2002 Dec 18;94(24):1888-91.

PMID:
12488483
16.
17.
18.

Cadmium-induced malignant transformation of human prostate epithelial cells.

Achanzar WE, Diwan BA, Liu J, Quader ST, Webber MM, Waalkes MP.

Cancer Res. 2001 Jan 15;61(2):455-8.

20.
21.

Possible role of caspase-3 inhibition in cadmium-induced blockage of apoptosis.

Yuan C, Kadiiska M, Achanzar WE, Mason RP, Waalkes MP.

Toxicol Appl Pharmacol. 2000 May 1;164(3):321-9.

PMID:
10799343
22.

Cadmium induces c-myc, p53, and c-jun expression in normal human prostate epithelial cells as a prelude to apoptosis.

Achanzar WE, Achanzar KB, Lewis JG, Webber MM, Waalkes MP.

Toxicol Appl Pharmacol. 2000 May 1;164(3):291-300.

PMID:
10799339
23.

A nematode gene required for sperm vesicle fusion.

Achanzar WE, Ward S.

J Cell Sci. 1997 May;110 ( Pt 9):1073-81.

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