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Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.

Dubrot J, Duraes FV, Harlé G, Schlaeppi A, Brighouse D, Madelon N, Göpfert C, Stokar-Regenscheit N, Acha-Orbea H, Reith W, Gannagé M, Hugues S.

Life Sci Alliance. 2018 Dec 17;1(6):e201800164. doi: 10.26508/lsa.201800164. eCollection 2018 Dec.


Importance of EMT Factor ZEB1 in cDC1 "MutuDC Line" Mediated Induction of Th1 Immune Response.

Smita S, Ahad A, Ghosh A, Biswas VK, Koga MM, Gupta B, Acha-Orbea H, Raghav SK.

Front Immunol. 2018 Nov 13;9:2604. doi: 10.3389/fimmu.2018.02604. eCollection 2018.


Establishment and Characterization of a Functionally Competent Type 2 Conventional Dendritic Cell Line.

Pigni M, Ashok D, Stevanin M, Acha-Orbea H.

Front Immunol. 2018 Aug 24;9:1912. doi: 10.3389/fimmu.2018.01912. eCollection 2018.


Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.

Ciarlo E, Heinonen T, Théroude C, Herderschee J, Mombelli M, Lugrin J, Pfefferlé M, Tyrrell B, Lensch S, Acha-Orbea H, Le Roy D, Auwerx J, Roger T.

Front Immunol. 2017 Aug 28;8:1037. doi: 10.3389/fimmu.2017.01037. eCollection 2017.


Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.

Ciarlo E, Heinonen T, Lugrin J, Acha-Orbea H, Le Roy D, Auwerx J, Roger T.

Sci Rep. 2017 Jun 20;7(1):3853. doi: 10.1038/s41598-017-04263-x.


Distinct pathophysiological cytokine profiles for discrimination between autoimmune pancreatitis, chronic pancreatitis, and pancreatic ductal adenocarcinoma.

Ghassem-Zadeh S, Gaida MM, Szanyi S, Acha-Orbea H, Frossard JL, Hinz U, Hackert T, Strobel O, Felix K.

J Transl Med. 2017 Jun 2;15(1):126. doi: 10.1186/s12967-017-1227-3.


Interleukin-35-Producing CD8α+ Dendritic Cells Acquire a Tolerogenic State and Regulate T Cell Function.

Haller S, Duval A, Migliorini R, Stevanin M, Mack V, Acha-Orbea H.

Front Immunol. 2017 Feb 8;8:98. doi: 10.3389/fimmu.2017.00098. eCollection 2017.


CD11b regulates the Treg/Th17 balance in murine arthritis via IL-6.

Stevanin M, Busso N, Chobaz V, Pigni M, Ghassem-Zadeh S, Zhang L, Acha-Orbea H, Ehirchiou D.

Eur J Immunol. 2017 Apr;47(4):637-645. doi: 10.1002/eji.201646565. Epub 2017 Mar 13.


Derivation and Utilization of Functional CD8(+) Dendritic Cell Lines.

Pigni M, Ashok D, Acha-Orbea H.

Methods Mol Biol. 2016;1423:39-49. doi: 10.1007/978-1-4939-3606-9_3.


Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection.

Margaroli C, Oberle S, Lavanchy C, Scherer S, Rosa M, Strasser A, Pellegrini M, Zehn D, Acha-Orbea H, Ehirchiou D.

Eur J Immunol. 2016 Jun;46(6):1427-37. doi: 10.1002/eji.201545857.


Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis.

Thelemann C, Haller S, Blyszczuk P, Kania G, Rosa M, Eriksson U, Rotman S, Reith W, Acha-Orbea H.

Eur J Immunol. 2016 Mar;46(3):656-64. doi: 10.1002/eji.201545945. Epub 2015 Dec 22.


Dendritic Cells Cause Bone Lesions in a New Mouse Model of Histiocytosis.

Grosjean F, Nasi S, Schneider P, Chobaz V, Liu A, Mordasini V, Moullec K, Vezzoni P, Lavanchy C, Busso N, Acha-Orbea H, Ehirchiou D.

PLoS One. 2015 Aug 6;10(8):e0133917. doi: 10.1371/journal.pone.0133917. eCollection 2015.


TLR3-Mediated CD8+ Dendritic Cell Activation Is Coupled with Establishment of a Cell-Intrinsic Antiviral State.

Széles L, Meissner F, Dunand-Sauthier I, Thelemann C, Hersch M, Singovski S, Haller S, Gobet F, Fuertes Marraco SA, Mann M, Garcin D, Acha-Orbea H, Reith W.

J Immunol. 2015 Aug 1;195(3):1025-33. doi: 10.4049/jimmunol.1402033. Epub 2015 Jun 22.


Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells.

Cohen SB, Smith NL, McDougal C, Pepper M, Shah S, Yap GS, Acha-Orbea H, Jiang A, Clausen BE, Rudd BD, Denkers EY.

J Immunol. 2015 Jan 1;194(1):210-22.


Timing is everything: dendritic cell subsets in murine Leishmania infection.

Ashok D, Acha-Orbea H.

Trends Parasitol. 2014 Oct;30(10):499-507. doi: 10.1016/ Epub 2014 Sep 2. Review.


Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses.

von Burg N, Chappaz S, Baerenwaldt A, Horvath E, Bose Dasgupta S, Ashok D, Pieters J, Tacchini-Cottier F, Rolink A, Acha-Orbea H, Finke D.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12835-40. doi: 10.1073/pnas.1406908111. Epub 2014 Aug 18.


Extensive remodeling of DC function by rapid maturation-induced transcriptional silencing.

Seguín-Estévez Q, Dunand-Sauthier I, Lemeille S, Iseli C, Ibberson M, Ioannidis V, Schmid CD, Rousseau P, Barras E, Geinoz A, Xenarios I, Acha-Orbea H, Reith W.

Nucleic Acids Res. 2014 Sep;42(15):9641-55. doi: 10.1093/nar/gku674. Epub 2014 Aug 7.


Large T Antigen-Specific Cytotoxic T Cells Protect Against Dendritic Cell Tumors through Perforin-Mediated Mechanisms Independent of CD4 T Cell Help.

Duval A, Fuertes Marraco SA, Schwitter D, Leuenberger L, Acha-Orbea H.

Front Immunol. 2014 Jul 17;5:338. doi: 10.3389/fimmu.2014.00338. eCollection 2014.


Maintaining dendritic cell viability in culture.

Vremec D, Hansen J, Strasser A, Acha-Orbea H, Zhan Y, O'Keeffe M, Shortman K.

Mol Immunol. 2015 Feb;63(2):264-7. doi: 10.1016/j.molimm.2014.07.011. Epub 2014 Jul 28.


Cross-presenting dendritic cells are required for control of Leishmania major infection.

Ashok D, Schuster S, Ronet C, Rosa M, Mack V, Lavanchy C, Marraco SF, Fasel N, Murphy KM, Tacchini-Cottier F, Acha-Orbea H.

Eur J Immunol. 2014 May;44(5):1422-32. doi: 10.1002/eji.201344242. Epub 2014 Mar 25.


Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis.

Thelemann C, Eren RO, Coutaz M, Brasseit J, Bouzourene H, Rosa M, Duval A, Lavanchy C, Mack V, Mueller C, Reith W, Acha-Orbea H.

PLoS One. 2014 Jan 28;9(1):e86844. doi: 10.1371/journal.pone.0086844. eCollection 2014.


MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity.

Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari NL, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W, Cenci S.

J Bone Miner Res. 2014 Feb;29(2):290-303. doi: 10.1002/jbmr.2090.


Activin a inhibits antigen-induced allergy in murine epicutaneous sensitization.

Kypriotou M, Rivero D, Haller S, Mariotto A, Huber M, Acha-Orbea H, Werner S, Hohl D.

Front Immunol. 2013 Aug 22;4:246. doi: 10.3389/fimmu.2013.00246. eCollection 2013.


Role of major histocompatibility complex class II expression by non-hematopoietic cells in autoimmune and inflammatory disorders: facts and fiction.

Duraes FV, Thelemann C, Sarter K, Acha-Orbea H, Hugues S, Reith W.

Tissue Antigens. 2013 Jul;82(1):1-15. doi: 10.1111/tan.12136. Review.


Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research.

Fuertes Marraco SA, Grosjean F, Duval A, Rosa M, Lavanchy C, Ashok D, Haller S, Otten LA, Steiner QG, Descombes P, Luber CA, Meissner F, Mann M, Szeles L, Reith W, Acha-Orbea H.

Front Immunol. 2012 Nov 7;3:331. doi: 10.3389/fimmu.2012.00331. eCollection 2012.


Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells.

Chevrier S, Genton C, Malissen B, Malissen M, Acha-Orbea H.

Front Immunol. 2012 Feb 24;3:27. doi: 10.3389/fimmu.2012.00027. eCollection 2012.


A novel Th cell epitope of Candida albicans mediates protection from fungal infection.

Bär E, Gladiator A, Bastidas S, Roschitzki B, Acha-Orbea H, Oxenius A, LeibundGut-Landmann S.

J Immunol. 2012 Jun 1;188(11):5636-43. doi: 10.4049/jimmunol.1200594. Epub 2012 Apr 23.


Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.

Siegert S, Huang HY, Yang CY, Scarpellino L, Carrie L, Essex S, Nelson PJ, Heikenwalder M, Acha-Orbea H, Buckley CD, Marsland BJ, Zehn D, Luther SA.

PLoS One. 2011;6(11):e27618. doi: 10.1371/journal.pone.0027618. Epub 2011 Nov 14.


Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo.

Fuertes Marraco SA, Scott CL, Bouillet P, Ives A, Masina S, Vremec D, Jansen ES, O'Reilly LA, Schneider P, Fasel N, Shortman K, Strasser A, Acha-Orbea H.

PLoS One. 2011;6(6):e20189. doi: 10.1371/journal.pone.0020189. Epub 2011 Jun 2.


An improved synthesis of dansylated α-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells.

Cheng JM, Chee SH, Knight DA, Acha-Orbea H, Hermans IF, Timmer MS, Stocker BL.

Carbohydr Res. 2011 May 15;346(7):914-26. doi: 10.1016/j.carres.2011.02.014. Epub 2011 Feb 19.


Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function.

Dunand-Sauthier I, Santiago-Raber ML, Capponi L, Vejnar CE, Schaad O, Irla M, Seguín-Estévez Q, Descombes P, Zdobnov EM, Acha-Orbea H, Reith W.

Blood. 2011 Apr 28;117(17):4490-500. doi: 10.1182/blood-2010-09-308064. Epub 2011 Mar 8.


Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis.

Ives A, Ronet C, Prevel F, Ruzzante G, Fuertes-Marraco S, Schutz F, Zangger H, Revaz-Breton M, Lye LF, Hickerson SM, Beverley SM, Acha-Orbea H, Launois P, Fasel N, Masina S.

Science. 2011 Feb 11;331(6018):775-8. doi: 10.1126/science.1199326.


IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression.

Xu Y, Schnorrer P, Proietto A, Kowalski G, Febbraio MA, Acha-Orbea H, Dickins RA, Villadangos JA.

J Immunol. 2011 Mar 15;186(6):3666-73. doi: 10.4049/jimmunol.1001934. Epub 2011 Feb 7.


Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo.

Ramelli G, Fuertes S, Narayan S, Busso N, Acha-Orbea H, So A.

Immunology. 2010 Jan;129(1):20-7. doi: 10.1111/j.1365-2567.2009.03144.x. Epub 2009 Jun 22.


Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.

Schmutz S, Bosco N, Chappaz S, Boyman O, Acha-Orbea H, Ceredig R, Rolink AG, Finke D.

J Immunol. 2009 Aug 15;183(4):2217-21. doi: 10.4049/jimmunol.0802911. Epub 2009 Jul 27.


CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche.

Chevrier S, Genton C, Kallies A, Karnowski A, Otten LA, Malissen B, Malissen M, Botto M, Corcoran LM, Nutt SL, Acha-Orbea H.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3895-900. doi: 10.1073/pnas.0809736106. Epub 2009 Feb 19.


Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells.

Wang Y, Kissenpfennig A, Mingueneau M, Richelme S, Perrin P, Chevrier S, Genton C, Lucas B, DiSanto JP, Acha-Orbea H, Malissen B, Malissen M.

J Immunol. 2008 Feb 1;180(3):1565-75.


In vivo transformation of mouse conventional CD8alpha+ dendritic cells leads to progressive multisystem histiocytosis.

Steiner QG, Otten LA, Hicks MJ, Kaya G, Grosjean F, Saeuberli E, Lavanchy C, Beermann F, McClain KL, Acha-Orbea H.

Blood. 2008 Feb 15;111(4):2073-82. Epub 2007 Nov 20.


TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts.

Bossen C, Cachero TG, Tardivel A, Ingold K, Willen L, Dobles M, Scott ML, Maquelin A, Belnoue E, Siegrist CA, Chevrier S, Acha-Orbea H, Leung H, Mackay F, Tschopp J, Schneider P.

Blood. 2008 Feb 1;111(3):1004-12. Epub 2007 Oct 17.


Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.

Link A, Vogt TK, Favre S, Britschgi MR, Acha-Orbea H, Hinz B, Cyster JG, Luther SA.

Nat Immunol. 2007 Nov;8(11):1255-65. Epub 2007 Sep 23.


Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.

Meier D, Bornmann C, Chappaz S, Schmutz S, Otten LA, Ceredig R, Acha-Orbea H, Finke D.

Immunity. 2007 May;26(5):643-54.


Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells.

Luther SA, Serre K, Cunningham AF, Khan M, Acha-Orbea H, MacLennan IC, Toellner KM.

Eur J Immunol. 2007 Jun;37(6):1476-84.


Immune response to MMTV infection.

Acha-Orbea H, Shakhov AN, Finke D.

Front Biosci. 2007 Jan 1;12:1594-609. Review.


The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity.

Genton C, Wang Y, Izui S, Malissen B, Delsol G, Fournié GJ, Malissen M, Acha-Orbea H.

J Immunol. 2006 Aug 15;177(4):2285-93.


Revisiting the specificity of the MHC class II transactivator CIITA in vivo.

Otten LA, Leibundgut-Landmann S, Huarte J, Kos-Braun IC, Lavanchy C, Barras E, Borisch B, Steimle V, Acha-Orbea H, Reith W.

Eur J Immunol. 2006 Jun;36(6):1548-58.


LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major.

Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J.

Eur J Immunol. 2006 Jun;36(6):1465-73.


Identification of proteoglycans as the APRIL-specific binding partners.

Ingold K, Zumsteg A, Tardivel A, Huard B, Steiner QG, Cachero TG, Qiang F, Gorelik L, Kalled SL, Acha-Orbea H, Rennert PD, Tschopp J, Schneider P.

J Exp Med. 2005 May 2;201(9):1375-83. Epub 2005 Apr 25.


MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells.

LeibundGut-Landmann S, Waldburger JM, Reis e Sousa C, Acha-Orbea H, Reith W.

Nat Immunol. 2004 Sep;5(9):899-908. Epub 2004 Aug 22.


Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes.

LeibundGut-Landmann S, Waldburger JM, Krawczyk M, Otten LA, Suter T, Fontana A, Acha-Orbea H, Reith W.

Eur J Immunol. 2004 Jun;34(6):1513-25. Review.


Passive immunization with neutralizing antibodies interrupts the mouse mammary tumor virus life cycle.

Mpandi M, Otten LA, Lavanchy C, Acha-Orbea H, Finke D.

J Virol. 2003 Sep;77(17):9369-77.

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