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Items: 42

1.

Binding and structural asymmetry governs ligand sensitivity in a cyclic nucleotide-gated ion channel.

Ng LCT, Zhuang M, Van Petegem F, Li YX, Accili EA.

J Gen Physiol. 2019 Sep 3. pii: jgp.201812162. doi: 10.1085/jgp.201812162. [Epub ahead of print]

PMID:
31481514
2.

Cation and voltage dependence of lidocaine inhibition of the hyperpolarization-activated cyclic nucleotide-gated HCN1 channel.

Putrenko I, Yip R, Schwarz SKW, Accili EA.

Sci Rep. 2017 Apr 28;7(1):1281. doi: 10.1038/s41598-017-01253-x.

3.

The Ih Channel Gene Promotes Synaptic Transmission and Coordinated Movement in Drosophila melanogaster.

Hegle AP, Frank CA, Berndt A, Klose M, Allan DW, Accili EA.

Front Mol Neurosci. 2017 Feb 24;10:41. doi: 10.3389/fnmol.2017.00041. eCollection 2017.

4.

Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.

Ng LCT, Putrenko I, Baronas V, Van Petegem F, Accili EA.

Structure. 2016 Oct 4;24(10):1629-1642. doi: 10.1016/j.str.2016.06.024. Epub 2016 Aug 25.

5.

A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.

Akimoto M, Zhang Z, Boulton S, Selvaratnam R, VanSchouwen B, Gloyd M, Accili EA, Lange OF, Melacini G.

J Biol Chem. 2014 Aug 8;289(32):22205-20. doi: 10.1074/jbc.M114.572164. Epub 2014 May 30.

6.

Allosteric coupling of the inner activation gate to the outer pore of a potassium channel.

Peters CJ, Fedida D, Accili EA.

Sci Rep. 2013 Oct 23;3:3025. doi: 10.1038/srep03025.

7.

Architecture of the HCN selectivity filter and control of cation permeation.

Macri V, Angoli D, Accili EA.

Sci Rep. 2012;2:894. doi: 10.1038/srep00894. Epub 2012 Nov 27.

8.

Asymmetric divergence in structure and function of HCN channel duplicates in Ciona intestinalis.

Jackson HA, Hegle A, Nazzari H, Jegla T, Accili EA.

PLoS One. 2012;7(11):e47590. doi: 10.1371/journal.pone.0047590. Epub 2012 Nov 2.

9.

Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization.

Whitaker GM, Lynn FC, McIntosh CH, Accili EA.

PLoS One. 2012;7(3):e32675. doi: 10.1371/journal.pone.0032675. Epub 2012 Mar 7.

10.

Mechanism of accelerated current decay caused by an episodic ataxia type-1-associated mutant in a potassium channel pore.

Peters CJ, Werry D, Gill HS, Accili EA, Fedida D.

J Neurosci. 2011 Nov 30;31(48):17449-59. doi: 10.1523/JNEUROSCI.2940-11.2011.

11.

Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity.

Chow SS, Van Petegem F, Accili EA.

J Biol Chem. 2012 Jan 2;287(1):600-6. doi: 10.1074/jbc.M111.269563. Epub 2011 Nov 14.

12.

Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression.

Hegle AP, Nazzari H, Roth A, Angoli D, Accili EA.

Am J Physiol Cell Physiol. 2010 May;298(5):C1066-76. doi: 10.1152/ajpcell.00389.2009. Epub 2010 Feb 3.

13.

The molecular basis for the actions of KVbeta1.2 on the opening and closing of the KV1.2 delayed rectifier channel.

Peters CJ, Vaid M, Horne AJ, Fedida D, Accili EA.

Channels (Austin). 2009 Sep-Oct;3(5):314-22. Epub 2009 Sep 16.

PMID:
19713757
14.

In situ co-distribution and functional interactions of SAP97 with sinoatrial isoforms of HCN channels.

Peters CJ, Chow SS, Angoli D, Nazzari H, Cayabyab FS, Morshedian A, Accili EA.

J Mol Cell Cardiol. 2009 May;46(5):636-43. doi: 10.1016/j.yjmcc.2009.01.010. Epub 2009 Jan 27.

PMID:
19336273
15.

Alanine scanning of the S6 segment reveals a unique and cAMP-sensitive association between the pore and voltage-dependent opening in HCN channels.

Macri V, Nazzari H, McDonald E, Accili EA.

J Biol Chem. 2009 Jun 5;284(23):15659-67. doi: 10.1074/jbc.M809164200. Epub 2009 Mar 6.

16.

Using Bioluminescence Resonance Energy Transfer to measure ion channel assembly.

Whitaker GM, Accili EA.

Methods Mol Biol. 2008;491:189-97. doi: 10.1007/978-1-59745-526-8_15.

PMID:
18998094
17.

Regulation of cell surface expression of functional pacemaker channels by a motif in the B-helix of the cyclic nucleotide-binding domain.

Nazzari H, Angoli D, Chow SS, Whitaker G, Leclair L, McDonald E, Macri V, Zahynacz K, Walker V, Accili EA.

Am J Physiol Cell Physiol. 2008 Sep;295(3):C642-52. doi: 10.1152/ajpcell.00062.2008. Epub 2008 Jul 9.

19.

Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells.

Qu Y, Whitaker GM, Hove-Madsen L, Tibbits GF, Accili EA.

J Physiol. 2008 Feb 1;586(3):701-16. Epub 2007 Nov 22.

20.

HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels.

Whitaker GM, Angoli D, Nazzari H, Shigemoto R, Accili EA.

J Biol Chem. 2007 Aug 3;282(31):22900-9. Epub 2007 Jun 6.

21.

Evolution and structural diversification of hyperpolarization-activated cyclic nucleotide-gated channel genes.

Jackson HA, Marshall CR, Accili EA.

Physiol Genomics. 2007 May 11;29(3):231-45. Epub 2007 Jan 16.

PMID:
17227887
22.
23.

A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels.

Tran N, Proenza C, Macri V, Petigara F, Sloan E, Samler S, Accili EA.

J Biol Chem. 2002 Nov 15;277(46):43588-92. Epub 2002 Aug 21.

24.

Separable gating mechanisms in a Mammalian pacemaker channel.

Macri V, Proenza C, Agranovich E, Angoli D, Accili EA.

J Biol Chem. 2002 Sep 27;277(39):35939-46. Epub 2002 Jul 16.

25.

Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels.

Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA.

J Biol Chem. 2002 Aug 16;277(33):29634-42. Epub 2002 May 28.

26.

From funny current to HCN channels: 20 years of excitation.

Accili EA, Proenza C, Baruscotti M, DiFrancesco D.

News Physiol Sci. 2002 Feb;17:32-7. Review.

PMID:
11821534
27.

Pacemaker channels produce an instantaneous current.

Proenza C, Angoli D, Agranovich E, Macri V, Accili EA.

J Biol Chem. 2002 Feb 15;277(7):5101-9. Epub 2001 Dec 7.

28.

Two distinct pathways of muscarinic current responses in rabbit sino-atrial node myocytes.

Accili EA, Redaelli G, DiFrancesco D.

Pflugers Arch. 1998 Dec;437(1):164-7.

PMID:
9817803
29.

Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4.

Accili EA, Kuryshev YA, Wible BA, Brown AM.

J Physiol. 1998 Oct 15;512 ( Pt 2):325-36.

30.

Functional consequences of ROMK mutants linked to antenatal Bartter's syndrome and implications for treatment.

Schwalbe RA, Bianchi L, Accili EA, Brown AM.

Hum Mol Genet. 1998 Jun;7(6):975-80.

PMID:
9580661
31.

Cloning and expression of a novel K+ channel regulatory protein, KChAP.

Wible BA, Yang Q, Kuryshev YA, Accili EA, Brown AM.

J Biol Chem. 1998 May 8;273(19):11745-51.

32.
33.

Separable Kvbeta subunit domains alter expression and gating of potassium channels.

Accili EA, Kiehn J, Yang Q, Wang Z, Brown AM, Wible BA.

J Biol Chem. 1997 Oct 10;272(41):25824-31.

35.

Properties and modulation of If in newborn versus adult cardiac SA node.

Accili EA, Robinson RB, DiFrancesco D.

Am J Physiol. 1997 Mar;272(3 Pt 2):H1549-52.

PMID:
9087633
36.
37.
38.

Primary cell culture of human enteric neurons : submucosal plexus.

Accili EA, Buchan AM.

Methods Mol Med. 1996;2:357-67. doi: 10.1385/0-89603-335-X:357.

PMID:
21359754
39.

Neural somatostatin, vasoactive intestinal polypeptide and substance P in canine and human jejunum.

Accili EA, Dhatt N, Buchan AM.

Neurosci Lett. 1995 Feb 6;185(1):37-40.

PMID:
7537358
40.

Presence and actions of vasoactive intestinal peptide in the isolated rabbit heart.

Accili EA, Buchan AM, Kwok YN, Ledsome JR, Brown JC.

Can J Physiol Pharmacol. 1995 Jan;73(1):134-9.

PMID:
7541311
41.

The release of somatostatin-14 from human submucosal ganglia in tissue culture.

Accili EA, McIntosh CH, Buchan AM.

Can J Physiol Pharmacol. 1993 Aug;71(8):619-24.

PMID:
7905778
42.

Effects of carbon dioxide on hindlimb vascular resistance in the acute spinal cat.

Accili EA, Puttaswamaiah S, Lioy F.

J Auton Nerv Syst. 1988 Aug;23(2):87-94.

PMID:
3139737

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