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Identification of C2CD4A as a human diabetes susceptibility gene with a role in β cell insulin secretion.

Kuo T, Kraakman MJ, Damle M, Gill R, Lazar MA, Accili D.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20033-20042. doi: 10.1073/pnas.1904311116. Epub 2019 Sep 16.


Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-Expressing Neurons.

Ren H, Vieira-de-Abreu A, Yan S, Reilly AM, Chan O, Accili D.

Endocrinology. 2019 Sep 1;160(9):2038-2048. doi: 10.1210/en.2019-00341.


Reprogramming Cells to Make Insulin.

McKimpson WM, Accili D.

J Endocr Soc. 2019 Apr 24;3(6):1214-1226. doi: 10.1210/js.2019-00040. eCollection 2019 Jun 1. Review.


Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β-cell dysfunction.

Kuo T, Damle M, González BJ, Egli D, Lazar MA, Accili D.

JCI Insight. 2019 May 23;5. pii: 128351. doi: 10.1172/jci.insight.128351.


A fluorescent reporter assay of differential gene expression response to insulin in hepatocytes.

McKimpson WM, Accili D.

Am J Physiol Cell Physiol. 2019 Jul 1;317(1):C143-C151. doi: 10.1152/ajpcell.00504.2018. Epub 2019 May 15.


Identification of Insulin-Responsive Transcription Factors That Regulate Glucose Production by Hepatocytes.

Wang L, Liu Q, Kitamoto T, Hou J, Qin J, Accili D.

Diabetes. 2019 Jun;68(6):1156-1167. doi: 10.2337/db18-1236. Epub 2019 Apr 1.


microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function.

Langlet F, Tarbier M, Haeusler RA, Camastra S, Ferrannini E, Friedländer MR, Accili D.

Mol Metab. 2018 Nov;17:49-60. doi: 10.1016/j.molmet.2018.08.003. Epub 2018 Aug 11.


Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences.

Molusky MM, Hsieh J, Lee SX, Ramakrishnan R, Tascau L, Haeusler RA, Accili D, Tall AR.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1493-1503. doi: 10.1161/ATVBAHA.118.311212. Epub 2018 May 31.


Distinct roles of systemic and local actions of insulin on pancreatic β-cells.

Kitamoto T, Sakurai K, Lee EY, Yokote K, Accili D, Miki T.

Metabolism. 2018 May;82:100-110. doi: 10.1016/j.metabol.2017.12.017. Epub 2018 Jan 7.


Expression of Concern. The IR1152 Mutant Insulin Receptor Selectively Impairs Insulin Action in Skeletal Muscle but Not in Liver. Diabetes 2000;49:1194-1202. DOI: PMID: 10909978.

Caruso M, Miele C, Oliva A, Condorelli G, Oriente F, Riccardi G, Capaldo B, Fiory F, Accili D, Formisano P, Beguinot F.

Diabetes. 2017 Nov 6. pii: db17ec2017a. doi: 10.2337/db17-ec2017a. [Epub ahead of print] No abstract available.


Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling.

Langlet F, Haeusler RA, Lindén D, Ericson E, Norris T, Johansson A, Cook JR, Aizawa K, Wang L, Buettner C, Accili D.

Cell. 2017 Nov 2;171(4):824-835.e18. doi: 10.1016/j.cell.2017.09.045. Epub 2017 Oct 19.


Biochemical and cellular properties of insulin receptor signalling.

Haeusler RA, McGraw TE, Accili D.

Nat Rev Mol Cell Biol. 2018 Jan;19(1):31-44. doi: 10.1038/nrm.2017.89. Epub 2017 Oct 4. Review.


Alain Ktorza, PhD.

Thorens B, Accili D, Ahrén B, Boitard C, Seino S, Cerasi E.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:3. doi: 10.1111/dom.13036. No abstract available.


Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice.

Ishida E, Kim-Muller JY, Accili D.

Diabetes. 2017 Aug;66(8):2092-2101. doi: 10.2337/db16-1213. Epub 2017 May 15.


When β-cells fail: lessons from dedifferentiation.

Accili D, Talchai SC, Kim-Muller JY, Cinti F, Ishida E, Ordelheide AM, Kuo T, Fan J, Son J.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:117-22. doi: 10.1111/dom.12723. Review.


Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.

Kim-Muller JY, Fan J, Kim YJ, Lee SA, Ishida E, Blaner WS, Accili D.

Nat Commun. 2016 Aug 30;7:12631. doi: 10.1038/ncomms12631.


Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.

O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR.

J Clin Invest. 2016 Sep 1;126(9):3433-46. doi: 10.1172/JCI86522. Epub 2016 Aug 15.


Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE.

Diabetes. 2016 Jun;65(6):1577-89. doi: 10.2337/db15-1128. Epub 2016 Mar 25.


Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice.

Westerterp M, Tsuchiya K, Tattersall IW, Fotakis P, Bochem AE, Molusky MM, Ntonga V, Abramowicz S, Parks JS, Welch CL, Kitajewski J, Accili D, Tall AR.

Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1328-37. doi: 10.1161/ATVBAHA.115.306670. Epub 2016 May 19.


FoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes.

Kim-Muller JY, Kim YJ, Fan J, Zhao S, Banks AS, Prentki M, Accili D.

J Biol Chem. 2016 May 6;291(19):10162-72. doi: 10.1074/jbc.M115.705608. Epub 2016 Mar 16.


Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction.

Kuo T, Kim-Muller JY, McGraw TE, Accili D.

J Biol Chem. 2016 Apr 29;291(18):9648-56. doi: 10.1074/jbc.M115.702183. Epub 2016 Feb 25.


Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes.

Cinti F, Bouchi R, Kim-Muller JY, Ohmura Y, Sandoval PR, Masini M, Marselli L, Suleiman M, Ratner LE, Marchetti P, Accili D.

J Clin Endocrinol Metab. 2016 Mar;101(3):1044-54. doi: 10.1210/jc.2015-2860. Epub 2015 Dec 29.


Hypoglycemia Secondary to Sulfonylurea Ingestion in a Patient with End Stage Renal Disease: Results from a 72-Hour Fast.

Abraham A, Rubin M, Accili D, Bilezikian JP, Pajvani UB.

Case Rep Endocrinol. 2015;2015:742781. doi: 10.1155/2015/742781. Epub 2015 Nov 17.


Erratum to: The new biology of diabetes.

Pajvani UB, Accili D.

Diabetologia. 2015 Nov;58(11):2683. doi: 10.1007/s00125-015-3758-6. No abstract available.


The Islet and Metabolism Keep Time.

Thorens B, Accili D, Ahrén B, Cerasi E, Seino S, Boitard C.

Diabetes Obes Metab. 2015 Sep;17 Suppl 1:3-5. doi: 10.1111/dom.12547. No abstract available.


The new biology of diabetes.

Pajvani UB, Accili D.

Diabetologia. 2015 Nov;58(11):2459-68. doi: 10.1007/s00125-015-3722-5. Epub 2015 Aug 7. Review. Erratum in: Diabetologia. 2015 Nov;58(11):2683.


Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin.

Ren H, Cook JR, Kon N, Accili D.

Diabetes. 2015 Nov;64(11):3670-9. doi: 10.2337/db15-0390. Epub 2015 Jul 15.


Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions.

Qiang L, Kon N, Zhao W, Jiang L, Knight CM, Welch C, Pajvani U, Gu W, Accili D.

Cell Rep. 2015 Jun 23;11(11):1797-808. doi: 10.1016/j.celrep.2015.05.025. Epub 2015 Jun 11.


Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity.

Mayoral R, Osborn O, McNelis J, Johnson AM, Oh DY, Izquierdo CL, Chung H, Li P, Traves PG, Bandyopadhyay G, Pessentheiner AR, Ofrecio JM, Cook JR, Qiang L, Accili D, Olefsky JM.

Mol Metab. 2015 Mar 5;4(5):378-91. doi: 10.1016/j.molmet.2015.02.007. eCollection 2015 May.


Pathogenesis of selective insulin resistance in isolated hepatocytes.

Cook JR, Langlet F, Kido Y, Accili D.

J Biol Chem. 2015 May 29;290(22):13972-80. doi: 10.1074/jbc.M115.638197. Epub 2015 Apr 14.


Ceci n'est pas science.

Accili D.

Cell Metab. 2015 Apr 7;21(4):503-4. doi: 10.1016/j.cmet.2015.03.011.


Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function.

Talchai SC, Accili D.

Diabetes. 2015 Aug;64(8):2868-79. doi: 10.2337/db14-1696. Epub 2015 Mar 17.


A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism.

Cook JR, Matsumoto M, Banks AS, Kitamura T, Tsuchiya K, Accili D.

Diabetes. 2015 Jun;64(6):1951-65. doi: 10.2337/db14-1506. Epub 2015 Jan 9.


Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors.

Haeusler RA, Hartil K, Vaitheesvaran B, Arrieta-Cruz I, Knight CM, Cook JR, Kammoun HL, Febbraio MA, Gutierrez-Juarez R, Kurland IJ, Accili D.

Nat Commun. 2014 Oct 13;5:5190. doi: 10.1038/ncomms6190.


Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice.

Kim-Muller JY, Zhao S, Srivastava S, Mugabo Y, Noh HL, Kim YR, Madiraju SR, Ferrante AW, Skolnik EY, Prentki M, Accili D.

Cell Metab. 2014 Oct 7;20(4):593-602. doi: 10.1016/j.cmet.2014.08.012. Epub 2014 Sep 25.


The mind and the belly: a glance at how the nervous system directs metabolism.

Accili D, Ahrén B, Boitard C, Seino S, Thorens B, Cerasi E.

Diabetes Obes Metab. 2014 Sep;16 Suppl 1:1-3. doi: 10.1111/dom.12353. No abstract available.


Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons.

Ren H, Lu TY, McGraw TE, Accili D.

Diabetes. 2015 Feb;64(2):405-17. doi: 10.2337/db14-0752. Epub 2014 Sep 3.


FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures.

Bouchi R, Foo KS, Hua H, Tsuchiya K, Ohmura Y, Sandoval PR, Ratner LE, Egli D, Leibel RL, Accili D.

Nat Commun. 2014 Jun 30;5:4242. doi: 10.1038/ncomms5242.


Glut4 expression defines an insulin-sensitive hypothalamic neuronal population.

Ren H, Yan S, Zhang B, Lu TY, Arancio O, Accili D.

Mol Metab. 2014 Apr 19;3(4):452-9. doi: 10.1016/j.molmet.2014.04.006. eCollection 2014 Jul.


Preserved energy balance in mice lacking FoxO1 in neurons of Nkx2.1 lineage reveals functional heterogeneity of FoxO1 signaling within the hypothalamus.

Heinrich G, Meece K, Wardlaw SL, Accili D.

Diabetes. 2014 May;63(5):1572-82. doi: 10.2337/db13-0651. Epub 2014 Jan 31.


Increased density of inhibitory noradrenergic parenchymal nerve fibers in hypertrophic islets of Langerhans of obese mice.

Giannulis I, Mondini E, Cinti F, Frontini A, Murano I, Barazzoni R, Barbatelli G, Accili D, Cinti S.

Nutr Metab Cardiovasc Dis. 2014 Apr;24(4):384-92. doi: 10.1016/j.numecd.2013.09.006. Epub 2013 Oct 23.


A differential dielectric affinity glucose sensor.

Huang X, Leduc C, Ravussin Y, Li S, Davis E, Song B, Li D, Xu K, Accili D, Wang Q, Leibel R, Lin Q.

Lab Chip. 2014 Jan 21;14(2):294-301. doi: 10.1039/c3lc51026c. Epub 2013 Nov 13.


Shifting the paradigm of islet inflammation--good guy or bad guy?

Ahrén B, Accili D, Boitard C, Cerasi E, Thorens B, Seino S.

Diabetes Obes Metab. 2013 Sep;15 Suppl 3:4-9. doi: 10.1111/dom.12184. No abstract available.


A MEMS differential viscometric sensor for affinity glucose detection in continuous glucose monitoring.

Huang X, Li S, Davis E, Leduc C, Ravussin Y, Cai H, Song B, Li D, Accili D, Leibel R, Wang Q, Lin Q.

J Micromech Microeng. 2013 May;23(5):55020.


Human insulin resistance is associated with increased plasma levels of 12α-hydroxylated bile acids.

Haeusler RA, Astiarraga B, Camastra S, Accili D, Ferrannini E.

Diabetes. 2013 Dec;62(12):4184-91. doi: 10.2337/db13-0639. Epub 2013 Jul 24.


Blunted refeeding response and increased locomotor activity in mice lacking FoxO1 in synapsin-Cre-expressing neurons.

Ren H, Plum-Morschel L, Gutierrez-Juarez R, Lu TY, Kim-Muller JY, Heinrich G, Wardlaw SL, Silver R, Accili D.

Diabetes. 2013 Oct;62(10):3373-83. doi: 10.2337/db13-0597. Epub 2013 Jul 8.


Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.

Pajvani UB, Qiang L, Kangsamaksin T, Kitajewski J, Ginsberg HN, Accili D.

Nat Med. 2013 Aug;19(8):1054-60. doi: 10.1038/nm.3259. Epub 2013 Jul 7.


Application of combined omics platforms to accelerate biomedical discovery in diabesity.

Kurland IJ, Accili D, Burant C, Fischer SM, Kahn BB, Newgard CB, Ramagiri S, Ronnett GV, Ryals JA, Sanders M, Shambaugh J, Shockcor J, Gross SS.

Ann N Y Acad Sci. 2013 May;1287:1-16. doi: 10.1111/nyas.12116. Epub 2013 May 9.


Expanded granulocyte/monocyte compartment in myeloid-specific triple FoxO knockout increases oxidative stress and accelerates atherosclerosis in mice.

Tsuchiya K, Westerterp M, Murphy AJ, Subramanian V, Ferrante AW Jr, Tall AR, Accili D.

Circ Res. 2013 Mar 29;112(7):992-1003. doi: 10.1161/CIRCRESAHA.112.300749. Epub 2013 Feb 18.

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