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Items: 1 to 50 of 61

1.

Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.

Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H.

J Comput Chem. 2019 Nov 21. doi: 10.1002/jcc.26105. [Epub ahead of print]

PMID:
31750558
2.

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16.

Khelashvili G, Falzone ME, Cheng X, Lee BC, Accardi A, Weinstein H.

Nat Commun. 2019 Oct 31;10(1):4972. doi: 10.1038/s41467-019-12865-4.

3.

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP.

Nat Commun. 2019 Sep 2;10(1):3956. doi: 10.1038/s41467-019-11753-1.

4.

Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase.

Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A.

Elife. 2019 Jan 16;8. pii: e43229. doi: 10.7554/eLife.43229.

5.

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.

Lee BC, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A.

Nat Commun. 2018 Aug 14;9(1):3251. doi: 10.1038/s41467-018-05724-1.

6.

Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.

Malvezzi M, Andra KK, Pandey K, Lee BC, Falzone ME, Brown A, Iqbal R, Menon AK, Accardi A.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7033-E7042. doi: 10.1073/pnas.1806721115. Epub 2018 Jun 20.

7.

Known structures and unknown mechanisms of TMEM16 scramblases and channels.

Falzone ME, Malvezzi M, Lee BC, Accardi A.

J Gen Physiol. 2018 Jul 2;150(7):933-947. doi: 10.1085/jgp.201711957. Epub 2018 Jun 18. Review.

8.

Probing the conformation of a conserved glutamic acid within the Cl- pathway of a CLC H+/Cl- exchanger.

Vien M, Basilio D, Leisle L, Accardi A.

J Gen Physiol. 2017 Apr 3;149(4):523-529. doi: 10.1085/jgp.201611682. Epub 2017 Feb 28.

9.

The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel.

Lee BC, Menon AK, Accardi A.

Biophys J. 2016 Nov 1;111(9):1919-1924. doi: 10.1016/j.bpj.2016.09.032.

10.

Robotic Surgery in Patients With Locally Advanced Cervical Cancer After Neoadjuvant Chemotherapy: Survival Outcomes.

Siesto G, Romano F, Accardi A, Bulletti C, Iedà NP, Vitobello D.

Int J Gynecol Cancer. 2016 Mar;26(3):521-7. doi: 10.1097/IGC.0000000000000632.

PMID:
26825842
11.

CELL SIGNALING. Lipids link ion channels and cancer.

Accardi A.

Science. 2015 Aug 21;349(6250):789-90. doi: 10.1126/science.aad0874. No abstract available.

PMID:
26293939
12.

Structure and gating of CLC channels and exchangers.

Accardi A.

J Physiol. 2015 Sep 15;593(18):4129-38. doi: 10.1113/JP270575. Epub 2015 Jul 28. Review.

13.
14.

Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes.

Accardi A.

Neuron. 2014 Dec 17;84(6):1110-2. doi: 10.1016/j.neuron.2014.12.008.

15.

TMEM16 proteins: unknown structure and confusing functions.

Picollo A, Malvezzi M, Accardi A.

J Mol Biol. 2015 Jan 16;427(1):94-105. doi: 10.1016/j.jmb.2014.09.028. Epub 2014 Oct 17. Review.

16.

Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.

Corral-Rodríguez MÁ, Stuiver M, Abascal-Palacios G, Diercks T, Oyenarte I, Ereño-Orbea J, de Opakua AI, Blanco FJ, Encinar JA, Spiwok V, Terashima H, Accardi A, Müller D, Martínez-Cruz LA.

Biochem J. 2014 Nov 15;464(1):23-34. doi: 10.1042/BJ20140409.

PMID:
25184538
17.

Rotationally adiabatic pair interactions of para- and ortho-hydrogen with the halogen molecules F2, Cl2, and Br2.

Berg M, Accardi A, Paulus B, Schmidt B.

J Chem Phys. 2014 Aug 21;141(7):074303. doi: 10.1063/1.4892599.

PMID:
25149782
18.

Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter.

Basilio D, Noack K, Picollo A, Accardi A.

Nat Struct Mol Biol. 2014 May;21(5):456-63. doi: 10.1038/nsmb.2814. Epub 2014 Apr 20.

19.

Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels.

Terashima H, Picollo A, Accardi A.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19354-9. doi: 10.1073/pnas.1312014110. Epub 2013 Oct 28.

20.

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel.

Malvezzi M, Chalat M, Janjusevic R, Picollo A, Terashima H, Menon AK, Accardi A.

Nat Commun. 2013;4:2367. doi: 10.1038/ncomms3367.

21.

Moments of the longitudinal proton structure function FL from global data in the Q(2) range 0.75-45.0  (GeV/c)(2).

Monaghan P, Accardi A, Christy ME, Keppel CE, Melnitchouk W, Zhu L.

Phys Rev Lett. 2013 Apr 12;110(15):152002. Epub 2013 Apr 9.

PMID:
25167253
22.

Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger.

Picollo A, Xu Y, Johner N, Bernèche S, Accardi A.

Nat Struct Mol Biol. 2012 Apr 8;19(5):525-31, S1. doi: 10.1038/nsmb.2277.

23.

Robotic radical parametrectomy with pelvic lymphadenectomy: our experience and review of the literature.

Vitobello D, Siesto G, Bulletti C, Accardi A, Iedà N.

Eur J Surg Oncol. 2012 Jun;38(6):548-54. doi: 10.1016/j.ejso.2012.02.188. Epub 2012 Mar 17. Review.

PMID:
22425283
24.

[Risk assessment: use of the SOBANE model at the Health Authority of Lodi province].

Giametta P, Ciocca M, Accardi A, Berri A, Ariano E.

Ann Ig. 2011 Mar-Apr;23(2):147-59. Italian.

PMID:
21770231
25.

Gynecological fertility-sparing surgery.

Vitobello D, Siesto G, Bulletti C, Accardi A, Levi Setti PE.

Placenta. 2011 Sep;32 Suppl 3:S224-31. doi: 10.1016/j.placenta.2011.06.017. Epub 2011 Jul 18. Review.

PMID:
21764446
26.

PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.

Ying SW, Tibbs GR, Picollo A, Abbas SY, Sanford RL, Accardi A, Hofmann F, Ludwig A, Goldstein PA.

J Neurosci. 2011 Jul 13;31(28):10412-23. doi: 10.1523/JNEUROSCI.0021-11.2011.

27.

A dystroglycan mutation associated with limb-girdle muscular dystrophy.

Hara Y, Balci-Hayta B, Yoshida-Moriguchi T, Kanagawa M, Beltrán-Valero de Bernabé D, Gündeşli H, Willer T, Satz JS, Crawford RW, Burden SJ, Kunz S, Oldstone MB, Accardi A, Talim B, Muntoni F, Topaloğlu H, Dinçer P, Campbell KP.

N Engl J Med. 2011 Mar 10;364(10):939-46. doi: 10.1056/NEJMoa1006939.

28.

From synchronous to sequential double proton transfer: quantum dynamics simulations for the model porphine.

Accardi A, Barth I, Kühn O, Manz J.

J Phys Chem A. 2010 Oct 28;114(42):11252-62. doi: 10.1021/jp103435d.

PMID:
20961160
29.

Proton block of the CLC-5 Cl-/H+ exchanger.

Picollo A, Malvezzi M, Accardi A.

J Gen Physiol. 2010 Jun;135(6):653-9. doi: 10.1085/jgp.201010428.

30.

CLC channels and transporters: proteins with borderline personalities.

Accardi A, Picollo A.

Biochim Biophys Acta. 2010 Aug;1798(8):1457-64. doi: 10.1016/j.bbamem.2010.02.022. Epub 2010 Feb 24. Review.

31.

Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters.

Picollo A, Malvezzi M, Houtman JC, Accardi A.

Nat Struct Mol Biol. 2009 Dec;16(12):1294-301. doi: 10.1038/nsmb.1704. Epub 2009 Nov 8.

32.

Quasi light fields: extending the light field to coherent radiation.

Accardi A, Wornell G.

J Opt Soc Am A Opt Image Sci Vis. 2009 Sep;26(9):2055-66.

PMID:
19721692
33.

Nonadiabatic quantum dynamics and laser control of Br2 in solid argon.

Accardi A, Borowski A, Kühn O.

J Phys Chem A. 2009 Jul 2;113(26):7491-8. doi: 10.1021/jp900551n.

PMID:
19438200
34.

Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger.

Jayaram H, Accardi A, Wu F, Williams C, Miller C.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11194-9. doi: 10.1073/pnas.0804503105. Epub 2008 Aug 4.

35.

To ATP or not to ATP: this is the question.

Accardi A.

J Gen Physiol. 2008 Feb;131(2):105-8. doi: 10.1085/jgp.200709953. No abstract available.

36.

Uncoupling and turnover in a Cl-/H+ exchange transporter.

Walden M, Accardi A, Wu F, Xu C, Williams C, Miller C.

J Gen Physiol. 2007 Apr;129(4):317-29.

37.

Synergism between halide binding and proton transport in a CLC-type exchanger.

Accardi A, Lobet S, Williams C, Miller C, Dutzler R.

J Mol Biol. 2006 Sep 29;362(4):691-9. Epub 2006 Aug 2.

PMID:
16949616
38.

Separate ion pathways in a Cl-/H+ exchanger.

Accardi A, Walden M, Nguitragool W, Jayaram H, Williams C, Miller C.

J Gen Physiol. 2005 Dec;126(6):563-70.

39.

Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels.

Accardi A, Miller C.

Nature. 2004 Feb 26;427(6977):803-7.

PMID:
14985752
40.

Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels.

Accardi A, Kolmakova-Partensky L, Williams C, Miller C.

J Gen Physiol. 2004 Feb;123(2):109-19. Epub 2004 Jan 12.

41.

Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.

Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12607-12. Epub 2003 Oct 20.

42.

Conformational changes in the pore of CLC-0.

Accardi A, Pusch M.

J Gen Physiol. 2003 Sep;122(3):277-93. Epub 2003 Aug 11.

43.

Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.

Estévez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M.

Neuron. 2003 Apr 10;38(1):47-59.

44.

Pneumonia: bugs, drugs, and laboratory duds.

Accardi A.

Cal J Emerg Med. 2003 Apr;4(2):31-5. No abstract available.

45.

Mechanisms of block of muscle type CLC chloride channels (Review).

Pusch M, Accardi A, Liantonio A, Guida P, Traverso S, Camerino DC, Conti F.

Mol Membr Biol. 2002 Oct-Dec;19(4):285-92. Review.

PMID:
12512775
46.

A biological role for prokaryotic ClC chloride channels.

Iyer R, Iverson TM, Accardi A, Miller C.

Nature. 2002 Oct 17;419(6908):715-8.

PMID:
12384697
47.

Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid.

Liantonio A, Accardi A, Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Traverso S, Guida P, Pierno S, De Luca A, Camerino DC, Pusch M.

Mol Pharmacol. 2002 Aug;62(2):265-71.

PMID:
12130677
48.

Enhanced diagnosis of narrow complex tachycardias with increased electrocardiograph speed.

Accardi AJ, Miller R, Holmes JF.

J Emerg Med. 2002 Feb;22(2):123-6.

PMID:
11858914
49.

Bioterrorism.

Accardi AJ.

Cal J Emerg Med. 2002 Jan;3(1):5-7. No abstract available.

50.

Drastic reduction of the slow gate of human muscle chloride channel (ClC-1) by mutation C277S.

Accardi A, Ferrera L, Pusch M.

J Physiol. 2001 Aug 1;534(Pt 3):745-52.

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