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OTX2 restricts entry to the mouse germline.

Zhang J, Zhang M, Acampora D, Vojtek M, Yuan D, Simeone A, Chambers I.

Nature. 2018 Oct;562(7728):595-599. doi: 10.1038/s41586-018-0581-5. Epub 2018 Oct 3.


Feasibility of Implementing Patient Priorities Care for Older Adults with Multiple Chronic Conditions.

Blaum CS, Rosen J, Naik AD, Smith CD, Dindo L, Vo L, Hernandez-Bigos K, Esterson J, Geda M, Ferris R, Costello D, Acampora D, Meehan T, Tinetti ME.

J Am Geriatr Soc. 2018 Oct;66(10):2009-2016. doi: 10.1111/jgs.15465. Epub 2018 Oct 3.


Full Functional Knockout of Placental Growth Factor by Knockin with an Inactive Variant Able to Heterodimerize with VEGF-A.

Apicella I, Cicatiello V, Acampora D, Tarallo V, De Falco S.

Cell Rep. 2018 Jun 19;23(12):3635-3646. doi: 10.1016/j.celrep.2018.05.067.


Functional Antagonism between OTX2 and NANOG Specifies a Spectrum of Heterogeneous Identities in Embryonic Stem Cells.

Acampora D, Di Giovannantonio LG, Garofalo A, Nigro V, Omodei D, Lombardi A, Zhang J, Chambers I, Simeone A.

Stem Cell Reports. 2017 Nov 14;9(5):1642-1659. doi: 10.1016/j.stemcr.2017.09.019. Epub 2017 Oct 19.


Genetic Otx2 mis-localization delays critical period plasticity across brain regions.

Lee HHC, Bernard C, Ye Z, Acampora D, Simeone A, Prochiantz A, Di Nardo AA, Hensch TK.

Mol Psychiatry. 2017 May;22(5):785. doi: 10.1038/mp.2017.83. Epub 2017 Apr 4. No abstract available.


Genetic Otx2 mis-localization delays critical period plasticity across brain regions.

Lee HHC, Bernard C, Ye Z, Acampora D, Simeone A, Prochiantz A, Di Nardo AA, Hensch TK.

Mol Psychiatry. 2017 May;22(5):680-688. doi: 10.1038/mp.2017.1. Epub 2017 Feb 14. Erratum in: Mol Psychiatry. 2017 May;22(5):785.


Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial.

Juthani-Mehta M, Van Ness PH, Bianco L, Rink A, Rubeck S, Ginter S, Argraves S, Charpentier P, Acampora D, Trentalange M, Quagliarello V, Peduzzi P.

JAMA. 2016 Nov 8;316(18):1879-1887. doi: 10.1001/jama.2016.16141.


Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency.

Fiorenzano A, Pascale E, D'Aniello C, Acampora D, Bassalert C, Russo F, Andolfi G, Biffoni M, Francescangeli F, Zeuner A, Angelini C, Chazaud C, Patriarca EJ, Fico A, Minchiotti G.

Nat Commun. 2016 Sep 2;7:12589. doi: 10.1038/ncomms12589.


Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.

Acampora D, Omodei D, Petrosino G, Garofalo A, Savarese M, Nigro V, Di Giovannantonio LG, Mercadante V, Simeone A.

Cell Rep. 2016 Jun 21;15(12):2651-64. doi: 10.1016/j.celrep.2016.05.041. Epub 2016 Jun 9.


Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study.

Dodson JA, Geda M, Krumholz HM, Lorenze N, Murphy TE, Allore HG, Charpentier P, Tsang SW, Acampora D, Tinetti ME, Gill TM, Chaudhry SI.

BMC Health Serv Res. 2014 Nov 5;14:506. doi: 10.1186/s12913-014-0506-4.


Immunoprecipitation and mass spectrometry identify non-cell autonomous Otx2 homeoprotein in the granular and supragranular layers of mouse visual cortex.

Kim N, Acampora D, Dingli F, Loew D, Simeone A, Prochiantz A, Di Nardo AA.

F1000Res. 2014 Jul 30;3:178. doi: 10.12688/f1000research.4869.1. eCollection 2014.


Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons.

Panman L, Papathanou M, Laguna A, Oosterveen T, Volakakis N, Acampora D, Kurtsdotter I, Yoshitake T, Kehr J, Joodmardi E, Muhr J, Simeone A, Ericson J, Perlmann T.

Cell Rep. 2014 Aug 21;8(4):1018-25. doi: 10.1016/j.celrep.2014.07.016. Epub 2014 Aug 7.


Reorganization of enhancer patterns in transition from naive to primed pluripotency.

Buecker C, Srinivasan R, Wu Z, Calo E, Acampora D, Faial T, Simeone A, Tan M, Swigut T, Wysocka J.

Cell Stem Cell. 2014 Jun 5;14(6):838-53. doi: 10.1016/j.stem.2014.04.003.


Increased dopaminergic innervation in the brain of conditional mutant mice overexpressing Otx2: effects on locomotor behavior and seizure susceptibility.

Tripathi PP, Di Giovannantonio LG, Sanguinetti E, Acampora D, Allegra M, Caleo M, Wurst W, Simeone A, Bozzi Y.

Neuroscience. 2014 Mar 7;261:173-83. doi: 10.1016/j.neuroscience.2013.12.045. Epub 2013 Dec 30.


Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity.

Di Giovannantonio LG, Di Salvio M, Omodei D, Prakash N, Wurst W, Pierani A, Acampora D, Simeone A.

Development. 2014 Jan;141(2):377-88. doi: 10.1242/dev.102954. Epub 2013 Dec 11.


Graded Otx2 activities demonstrate dose-sensitive eye and retina phenotypes.

Bernard C, Kim HT, Torero Ibad R, Lee EJ, Simonutti M, Picaud S, Acampora D, Simeone A, Di Nardo AA, Prochiantz A, Moya KL, Kim JW.

Hum Mol Genet. 2014 Apr 1;23(7):1742-53. doi: 10.1093/hmg/ddt562. Epub 2013 Nov 13.


The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord.

Meziane H, Fraulob V, Riet F, Krezel W, Selloum M, Geffarth M, Acampora D, Hérault Y, Simeone A, Brand M, Dollé P, Rhinn M.

PeerJ. 2013 Aug 29;1:e142. doi: 10.7717/peerj.142. eCollection 2013.


The transcription factor Otx2 regulates choroid plexus development and function.

Johansson PA, Irmler M, Acampora D, Beckers J, Simeone A, Götz M.

Development. 2013 Mar;140(5):1055-66. doi: 10.1242/dev.090860. Epub 2013 Jan 30.


Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition.

Acampora D, Di Giovannantonio LG, Simeone A.

Development. 2013 Jan 1;140(1):43-55. doi: 10.1242/dev.085290. Epub 2012 Nov 15.


Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability.

Di Giovannantonio LG, Di Salvio M, Acampora D, Prakash N, Wurst W, Simeone A.

Dev Biol. 2013 Jan 1;373(1):176-83. doi: 10.1016/j.ydbio.2012.10.022. Epub 2012 Oct 29.


Integration of fall prevention into state policy in Connecticut.

Murphy TE, Baker DI, Leo-Summers LS, Bianco L, Gottschalk M, Acampora D, King MB.

Gerontologist. 2013 Jun;53(3):508-15. doi: 10.1093/geront/gns122. Epub 2012 Oct 4.


Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome.

Ferone G, Thomason HA, Antonini D, De Rosa L, Hu B, Gemei M, Zhou H, Ambrosio R, Rice DP, Acampora D, van Bokhoven H, Del Vecchio L, Koster MI, Tadini G, Spencer-Dene B, Dixon M, Dixon J, Missero C.

EMBO Mol Med. 2012 Mar;4(3):192-205. doi: 10.1002/emmm.201100199. Epub 2012 Jan 13.


Combined deficiency of alpha and epsilon sarcoglycan disrupts the cardiac dystrophin complex.

Lancioni A, Rotundo IL, Kobayashi YM, D'Orsi L, Aurino S, Nigro G, Piluso G, Acampora D, Cacciottolo M, Campbell KP, Nigro V.

Hum Mol Genet. 2011 Dec 1;20(23):4644-54. doi: 10.1093/hmg/ddr398. Epub 2011 Sep 2.


Otx genes in neurogenesis of mesencephalic dopaminergic neurons.

Simeone A, Puelles E, Omodei D, Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Tomasetti C.

Dev Neurobiol. 2011 Aug;71(8):665-79. doi: 10.1002/dneu.20877. Review.


The role of otx2 in adult mesencephalic-diencephalic dopaminergic neurons.

Simeone A, Di Salvio M, Di Giovannantonio LG, Acampora D, Omodei D, Tomasetti C.

Mol Neurobiol. 2011 Apr;43(2):107-13. doi: 10.1007/s12035-010-8148-y. Epub 2010 Nov 18. Review.


Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP.

Di Salvio M, Di Giovannantonio LG, Acampora D, Prosperi R, Omodei D, Prakash N, Wurst W, Simeone A.

Nat Neurosci. 2010 Dec;13(12):1481-8. doi: 10.1038/nn.2661. Epub 2010 Nov 7.


Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain.

Di Salvio M, Di Giovannantonio LG, Omodei D, Acampora D, Simeone A.

Int J Dev Biol. 2010;54(5):939-45. doi: 10.1387/ijdb.092974ms.


Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma.

Omodei D, Acampora D, Russo F, De Filippi R, Severino V, Di Francia R, Frigeri F, Mancuso P, De Chiara A, Pinto A, Casola S, Simeone A.

Am J Pathol. 2009 Dec;175(6):2609-17. doi: 10.2353/ajpath.2009.090542. Epub 2009 Nov 5.


The role of Otx genes in progenitor domains of ventral midbrain.

Simeone A, Puelles E, Acampora D, Omodei D, Mancuso P, Giovanni Di Giovannantonio L.

Adv Exp Med Biol. 2009;651:36-46. Review.


Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm.

Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Simeone A.

Mech Dev. 2009 Oct;126(10):882-97. doi: 10.1016/j.mod.2009.07.003. Epub 2009 Jul 15.


Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon.

Omodei D, Acampora D, Mancuso P, Prakash N, Di Giovannantonio LG, Wurst W, Simeone A.

Development. 2008 Oct;135(20):3459-70. doi: 10.1242/dev.027003.


Effect of dissemination of evidence in reducing injuries from falls.

Tinetti ME, Baker DI, King M, Gottschalk M, Murphy TE, Acampora D, Carlin BP, Leo-Summers L, Allore HG.

N Engl J Med. 2008 Jul 17;359(3):252-61. doi: 10.1056/NEJMoa0801748.


A randomized trial of an education program to enhance older driver performance.

Marottoli RA, Ness PH, Araujo KL, Iannone LP, Acampora D, Charpentier P, Peduzzi P.

J Gerontol A Biol Sci Med Sci. 2007 Oct;62(10):1113-9.


Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development.

Ryu S, Mahler J, Acampora D, Holzschuh J, Erhardt S, Omodei D, Simeone A, Driever W.

Curr Biol. 2007 May 15;17(10):873-80. Epub 2007 May 3. Erratum in: Curr Biol. 2008 Feb 26;18(4):310.


A randomized trial of a physical conditioning program to enhance the driving performance of older persons.

Marottoli RA, Allore H, Araujo KL, Iannone LP, Acampora D, Gottschalk M, Charpentier P, Kasl S, Peduzzi P.

J Gen Intern Med. 2007 May;22(5):590-7.


Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation.

Puelles E, Acampora D, Gogoi R, Tuorto F, Papalia A, Guillemot F, Ang SL, Simeone A.

J Neurosci. 2006 May 31;26(22):5955-64.


Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants.

Foucher I, Mione M, Simeone A, Acampora D, Bally-Cuif L, Houart C.

Development. 2006 May;133(10):1891-900. Epub 2006 Apr 12.


Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice.

Borgkvist A, Puelles E, Carta M, Acampora D, Ang SL, Wurst W, Goiny M, Fisone G, Simeone A, Usiello A.

Mol Cell Neurosci. 2006 Feb;31(2):293-302. Epub 2005 Oct 26.


Otx genes in the evolution of the vertebrate brain.

Acampora D, Annino A, Tuorto F, Puelles E, Lucchesi W, Papalia A, Simeone A.

Brain Res Bull. 2005 Sep 15;66(4-6):410-20. Epub 2005 Feb 24. Review.


Dissemination of an evidence-based multicomponent fall risk-assessment and -management strategy throughout a geographic area.

Baker DI, King MB, Fortinsky RH, Graff LG 4th, Gottschalk M, Acampora D, Preston J, Brown CJ, Tinetti ME.

J Am Geriatr Soc. 2005 Apr;53(4):675-80.


Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain.

Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang SL, Wurst W, Simeone A.

Development. 2004 May;131(9):2037-48.


Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.

Levantini E, Giorgetti A, Cerisoli F, Traggiai E, Guidi A, Martin R, Acampora D, Aplan PD, Keller G, Simeone A, Iscove NN, Hoang T, Magli MC.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10299-303. Epub 2003 Aug 21.


OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.

Acampora D, Annino A, Puelles E, Alfano I, Tuorto F, Simeone A.

Gene Expr Patterns. 2003 Aug;3(4):497-501.


Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.

Brodski C, Weisenhorn DM, Signore M, Sillaber I, Oesterheld M, Broccoli V, Acampora D, Simeone A, Wurst W.

J Neurosci. 2003 May 15;23(10):4199-207.


The effects of a targeted multicomponent delirium intervention on postdischarge outcomes for hospitalized older adults.

Bogardus ST Jr, Desai MM, Williams CS, Leo-Summers L, Acampora D, Inouye SK.

Am J Med. 2003 Apr 1;114(5):383-90.


Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.

Puelles E, Acampora D, Lacroix E, Signore M, Annino A, Tuorto F, Filosa S, Corte G, Wurst W, Ang SL, Simeone A.

Nat Neurosci. 2003 May;6(5):453-60.


Morphological organization of somatosensory cortex in Otx1(-/-) mice.

Cipelletti B, Avanzini G, Vitellaro-Zuccarello L, Franceschetti S, Sancini G, Lavazza T, Acampora D, Simeone A, Spreafico R, Frassoni C.

Neuroscience. 2002;115(3):657-67.


The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum.

Gogoi RN, Schubert FR, Martinez-Barbera JP, Acampora D, Simeone A, Lumsden A.

Mech Dev. 2002 Jun;114(1-2):213-7.


The Otx family.

Simeone A, Puelles E, Acampora D.

Curr Opin Genet Dev. 2002 Aug;12(4):409-15. Review.


Differences between African Americans and whites in the outcome of heart failure: Evidence for a greater functional decline in African Americans.

Vaccarino V, Gahbauer E, Kasl SV, Charpentier PA, Acampora D, Krumholz HM.

Am Heart J. 2002 Jun;143(6):1058-67.


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