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Items: 1 to 50 of 56

1.

Sex-specific metabolic functions of adipose Lipocalin-2.

Chella Krishnan K, Sabir S, Shum M, Meng Y, Acín-Pérez R, Lang JM, Floyd RR, Vergnes L, Seldin MM, Fuqua BK, Jayasekera DW, Nand SK, Anum DC, Pan C, Stiles L, Péterfy M, Reue K, Liesa M, Lusis AJ.

Mol Metab. 2019 Dec;30:30-47. doi: 10.1016/j.molmet.2019.09.009. Epub 2019 Sep 27.

2.

PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production.

Gómez-Escudero J, Clemente C, García-Weber D, Acín-Pérez R, Millán J, Enríquez JA, Bentley K, Carmeliet P, Arroyo AG.

Sci Rep. 2019 Oct 21;9(1):15022. doi: 10.1038/s41598-019-50866-x.

3.

A Thermogenic-Like Brown Adipose Tissue Phenotype Is Dispensable for Enhanced Glucose Tolerance in Female Mice.

Winn NC, Acin-Perez R, Woodford ML, Hansen SA, Haney MM, Ayedun LA, Rector RS, Vieira-Potter VJ, Shirihai OS, Sacks HS, Kanaley JA, Padilla J.

Diabetes. 2019 Sep;68(9):1717-1729. doi: 10.2337/db18-1070. Epub 2019 Mar 12.

PMID:
30862679
4.

How Mitochondrial Metabolism Contributes to Macrophage Phenotype and Functions.

Benmoussa K, Garaude J, Acín-Pérez R.

J Mol Biol. 2018 Oct 19;430(21):3906-3921. doi: 10.1016/j.jmb.2018.07.003. Epub 2018 Jul 10. Review.

PMID:
30006265
5.

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.

Torralba D, Baixauli F, Villarroya-Beltri C, Fernández-Delgado I, Latorre-Pellicer A, Acín-Pérez R, Martín-Cófreces NB, Jaso-Tamame ÁL, Iborra S, Jorge I, González-Aseguinolaza G, Garaude J, Vicente-Manzanares M, Enríquez JA, Mittelbrunn M, Sánchez-Madrid F.

Nat Commun. 2018 Jul 9;9(1):2658. doi: 10.1038/s41467-018-05077-9.

6.

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.

Matesanz N, Nikolic I, Leiva M, Pulgarín-Alfaro M, Santamans AM, Bernardo E, Mora A, Herrera-Melle L, Rodríguez E, Beiroa D, Caballero A, Martín-García E, Acín-Pérez R, Hernández-Cosido L, Leiva-Vega L, Torres JL, Centeno F, Nebreda AR, Enríquez JA, Nogueiras R, Marcos M, Sabio G.

PLoS Biol. 2018 Jul 6;16(7):e2004455. doi: 10.1371/journal.pbio.2004455. eCollection 2018 Jul.

7.

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion.

Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS.

Cell Metab. 2018 Apr 3;27(4):869-885.e6. doi: 10.1016/j.cmet.2018.03.003.

8.

Ablation of the stress protease OMA1 protects against heart failure in mice.

Acin-Perez R, Lechuga-Vieco AV, Del Mar Muñoz M, Nieto-Arellano R, Torroja C, Sánchez-Cabo F, Jiménez C, González-Guerra A, Carrascoso I, Benincá C, Quiros PM, López-Otín C, Castellano JM, Ruíz-Cabello J, Jiménez-Borreguero LJ, Enríquez JA.

Sci Transl Med. 2018 Mar 28;10(434). pii: eaan4935. doi: 10.1126/scitranslmed.aan4935.

PMID:
29593106
9.

Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function.

Padrón-Barthe L, Villalba-Orero M, Gómez-Salinero JM, Acín-Pérez R, Cogliati S, López-Olañeta M, Ortiz-Sánchez P, Bonzón-Kulichenko E, Vázquez J, García-Pavía P, Rosenthal N, Enríquez JA, Lara-Pezzi E.

J Am Coll Cardiol. 2018 Feb 13;71(6):654-667. doi: 10.1016/j.jacc.2017.11.067.

10.

ISG15 governs mitochondrial function in macrophages following vaccinia virus infection.

Baldanta S, Fernández-Escobar M, Acín-Perez R, Albert M, Camafeita E, Jorge I, Vázquez J, Enríquez JA, Guerra S.

PLoS Pathog. 2017 Oct 27;13(10):e1006651. doi: 10.1371/journal.ppat.1006651. eCollection 2017 Oct.

11.

MKK6 controls T3-mediated browning of white adipose tissue.

Matesanz N, Bernardo E, Acín-Pérez R, Manieri E, Pérez-Sieira S, Hernández-Cosido L, Montalvo-Romeral V, Mora A, Rodríguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Álvarez CV, Marcos M, Enríquez JA, Nogueiras R, Sabio G.

Nat Commun. 2017 Oct 11;8(1):856. doi: 10.1038/s41467-017-00948-z.

12.

Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.

Pera M, Larrea D, Guardia-Laguarta C, Montesinos J, Velasco KR, Agrawal RR, Xu Y, Chan RB, Di Paolo G, Mehler MF, Perumal GS, Macaluso FP, Freyberg ZZ, Acin-Perez R, Enriquez JA, Schon EA, Area-Gomez E.

EMBO J. 2017 Nov 15;36(22):3356-3371. doi: 10.15252/embj.201796797. Epub 2017 Oct 10.

13.

MicroRNA-661 modulates redox and metabolic homeostasis in colon cancer.

Gómez de Cedrón M, Acín Pérez R, Sánchez-Martínez R, Molina S, Herranz J, Feliu J, Reglero G, Enríquez JA, Ramírez de Molina A.

Mol Oncol. 2017 Dec;11(12):1768-1787. doi: 10.1002/1878-0261.12142. Epub 2017 Nov 6.

14.

Corrigendum: Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.

Latorre-Pellicer A, Moreno-Loshuertos R, Lechuga-Vieco AV, Sánchez-Cabo F, Torroja C, Acín-Pérez R, Calvo E, Aix E, González-Guerra A, Logan A, Bernad-Miana ML, Romanos E, Cruz R, Cogliati S, Sobrino B, Carracedo Á, Pérez-Martos A, Fernández-Silva P, Ruíz-Cabello J, Murphy MP, Flores I, Vázquez J, Enríquez JA.

Nature. 2017 Feb 2;542(7639):124. doi: 10.1038/nature20773. Epub 2016 Dec 7. No abstract available.

PMID:
27926738
15.

Mitochondrial Health in Aging and Age-Related Metabolic Disease.

Sebastián D, Acín-Pérez R, Morino K.

Oxid Med Cell Longev. 2016;2016:5831538. doi: 10.1155/2016/5831538. Epub 2016 Jul 13. No abstract available.

16.

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.

Latorre-Pellicer A, Moreno-Loshuertos R, Lechuga-Vieco AV, Sánchez-Cabo F, Torroja C, Acín-Pérez R, Calvo E, Aix E, González-Guerra A, Logan A, Bernad-Miana ML, Romanos E, Cruz R, Cogliati S, Sobrino B, Carracedo Á, Pérez-Martos A, Fernández-Silva P, Ruíz-Cabello J, Murphy MP, Flores I, Vázquez J, Enríquez JA.

Nature. 2016 Jul 28;535(7613):561-5. Epub 2016 Jul 6.

PMID:
27383793
17.

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.

Garaude J, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, Pelegrín P, Sander LE, Enríquez JA, Sancho D.

Nat Immunol. 2016 Sep;17(9):1037-1045. doi: 10.1038/ni.3509. Epub 2016 Jun 27.

18.

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.

Gómez-Del Arco P, Perdiguero E, Yunes-Leites PS, Acín-Pérez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jiménez-Alcázar M, Segalés J, López-Maderuelo D, Ornés B, Jiménez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Muñoz-Cánoves P, Redondo JM.

Cell Metab. 2016 May 10;23(5):881-92. doi: 10.1016/j.cmet.2016.04.008.

19.

The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency.

Guarás A, Perales-Clemente E, Calvo E, Acín-Pérez R, Loureiro-Lopez M, Pujol C, Martínez-Carrascoso I, Nuñez E, García-Marqués F, Rodríguez-Hernández MA, Cortés A, Diaz F, Pérez-Martos A, Moraes CT, Fernández-Silva P, Trifunovic A, Navas P, Vazquez J, Enríquez JA.

Cell Rep. 2016 Apr 5;15(1):197-209. doi: 10.1016/j.celrep.2016.03.009. Epub 2016 Mar 24.

20.

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses.

Baixauli F, Acín-Pérez R, Villarroya-Beltrí C, Mazzeo C, Nuñez-Andrade N, Gabandé-Rodriguez E, Ledesma MD, Blázquez A, Martin MA, Falcón-Pérez JM, Redondo JM, Enríquez JA, Mittelbrunn M.

Cell Metab. 2015 Sep 1;22(3):485-98. doi: 10.1016/j.cmet.2015.07.020. Epub 2015 Aug 20.

21.

Laminar shear stress regulates mitochondrial dynamics, bioenergetics responses and PRX3 activation in endothelial cells.

Bretón-Romero R, Acín-Perez R, Rodríguez-Pascual F, Martínez-Molledo M, Brandes RP, Rial E, Enríquez JA, Lamas S.

Biochim Biophys Acta. 2014 Nov;1843(11):2403-13. doi: 10.1016/j.bbamcr.2014.07.003. Epub 2014 Jul 17.

22.

ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity.

Quirós PM, Español Y, Acín-Pérez R, Rodríguez F, Bárcena C, Watanabe K, Calvo E, Loureiro M, Fernández-García MS, Fueyo A, Vázquez J, Enríquez JA, López-Otín C.

Cell Rep. 2014 Jul 24;8(2):542-56. doi: 10.1016/j.celrep.2014.06.018. Epub 2014 Jul 10.

23.

An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions.

Moreno V, Gonzalo P, Gómez-Escudero J, Pollán Á, Acín-Pérez R, Breckenridge M, Yáñez-Mó M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enríquez JA, Dejana E, Sánchez-Madrid F, Arroyo AG.

J Cell Sci. 2014 Sep 1;127(Pt 17):3768-81. doi: 10.1242/jcs.149518. Epub 2014 Jul 2.

24.

ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.

Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sanchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G, Enríquez JA.

Cell Metab. 2014 Jun 3;19(6):1020-33. doi: 10.1016/j.cmet.2014.04.015. Epub 2014 May 22.

25.

A new non-canonical pathway of Gα(q) protein regulating mitochondrial dynamics and bioenergetics.

Benincá C, Planagumà J, de Freitas Shuck A, Acín-Perez R, Muñoz JP, de Almeida MM, Brown JH, Murphy AN, Zorzano A, Enríquez JA, Aragay AM.

Cell Signal. 2014 May;26(5):1135-46. doi: 10.1016/j.cellsig.2014.01.009. Epub 2014 Jan 18.

26.

The function of the respiratory supercomplexes: the plasticity model.

Acin-Perez R, Enriquez JA.

Biochim Biophys Acta. 2014 Apr;1837(4):444-50. doi: 10.1016/j.bbabio.2013.12.009. Epub 2013 Dec 22. Review.

27.

Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.

Rivera-Torres J, Acín-Perez R, Cabezas-Sánchez P, Osorio FG, Gonzalez-Gómez C, Megias D, Cámara C, López-Otín C, Enríquez JA, Luque-García JL, Andrés V.

J Proteomics. 2013 Oct 8;91:466-77. doi: 10.1016/j.jprot.2013.08.008. Epub 2013 Aug 20.

PMID:
23969228
28.

Supercomplex assembly determines electron flux in the mitochondrial electron transport chain.

Lapuente-Brun E, Moreno-Loshuertos R, Acín-Pérez R, Latorre-Pellicer A, Colás C, Balsa E, Perales-Clemente E, Quirós PM, Calvo E, Rodríguez-Hernández MA, Navas P, Cruz R, Carracedo Á, López-Otín C, Pérez-Martos A, Fernández-Silva P, Fernández-Vizarra E, Enríquez JA.

Science. 2013 Jun 28;340(6140):1567-70. doi: 10.1126/science.1230381.

PMID:
23812712
29.

Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment.

Villa-Bellosta R, Rivera-Torres J, Osorio FG, Acín-Pérez R, Enriquez JA, López-Otín C, Andrés V.

Circulation. 2013 Jun 18;127(24):2442-51. doi: 10.1161/CIRCULATIONAHA.112.000571. Epub 2013 May 20.

PMID:
23690466
30.

Increased learning and brain long-term potentiation in aged mice lacking DNA polymerase μ.

Lucas D, Delgado-García JM, Escudero B, Albo C, Aza A, Acín-Pérez R, Torres Y, Moreno P, Enríquez JA, Samper E, Blanco L, Fairén A, Bernad A, Gruart A.

PLoS One. 2013;8(1):e53243. doi: 10.1371/journal.pone.0053243. Epub 2013 Jan 3.

31.

Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency.

García-Corzo L, Luna-Sánchez M, Doerrier C, García JA, Guarás A, Acín-Pérez R, Bullejos-Peregrín J, López A, Escames G, Enríquez JA, Acuña-Castroviejo D, López LC.

Hum Mol Genet. 2013 Mar 15;22(6):1233-48. doi: 10.1093/hmg/dds530. Epub 2012 Dec 18.

PMID:
23255162
32.

Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.

Gong J, Hoyos B, Acin-Perez R, Vinogradov V, Shabrova E, Zhao F, Leitges M, Fischman D, Manfredi G, Hammerling U.

FASEB J. 2012 Aug;26(8):3537-49. doi: 10.1096/fj.11-197376. Epub 2012 May 9.

33.

Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.

Liu W, Acín-Peréz R, Geghman KD, Manfredi G, Lu B, Li C.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12920-4. doi: 10.1073/pnas.1107332108. Epub 2011 Jul 18.

34.

Hiding in plain sight: uncovering a new function of vitamin A in redox signaling.

Hoyos B, Acin-Perez R, Fischman DA, Manfredi G, Hammerling U.

Biochim Biophys Acta. 2012 Jan;1821(1):241-7. doi: 10.1016/j.bbalip.2011.06.014. Epub 2011 Jun 25. Review.

PMID:
21763457
35.

A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.

Acin-Perez R, Russwurm M, Günnewig K, Gertz M, Zoidl G, Ramos L, Buck J, Levin LR, Rassow J, Manfredi G, Steegborn C.

J Biol Chem. 2011 Sep 2;286(35):30423-32. doi: 10.1074/jbc.M111.266379. Epub 2011 Jul 1.

36.

Protein phosphorylation and prevention of cytochrome oxidase inhibition by ATP: coupled mechanisms of energy metabolism regulation.

Acin-Perez R, Gatti DL, Bai Y, Manfredi G.

Cell Metab. 2011 Jun 8;13(6):712-9. doi: 10.1016/j.cmet.2011.03.024.

37.

Evolution meets disease: penetrance and functional epistasis of mitochondrial tRNA mutations.

Moreno-Loshuertos R, Ferrín G, Acín-Pérez R, Gallardo ME, Viscomi C, Pérez-Martos A, Zeviani M, Fernández-Silva P, Enríquez JA.

PLoS Genet. 2011 Apr;7(4):e1001379. doi: 10.1371/journal.pgen.1001379. Epub 2011 Apr 21.

38.

Are zinc-finger domains of protein kinase C dynamic structures that unfold by lipid or redox activation?

Zhao F, Ilbert M, Varadan R, Cremers CM, Hoyos B, Acin-Perez R, Vinogradov V, Cowburn D, Jakob U, Hammerling U.

Antioxid Redox Signal. 2011 Mar 1;14(5):757-66. doi: 10.1089/ars.2010.3773. Epub 2011 Jan 4.

39.

Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?

Perales-Clemente E, Fernández-Silva P, Acín-Pérez R, Pérez-Martos A, Enríquez JA.

Nucleic Acids Res. 2011 Jan;39(1):225-34. doi: 10.1093/nar/gkq769. Epub 2010 Sep 7.

40.

Regulation of intermediary metabolism by the PKCdelta signalosome in mitochondria.

Acin-Perez R, Hoyos B, Gong J, Vinogradov V, Fischman DA, Leitges M, Borhan B, Starkov A, Manfredi G, Hammerling U.

FASEB J. 2010 Dec;24(12):5033-42. doi: 10.1096/fj.10-166934. Epub 2010 Aug 26.

41.

Five entry points of the mitochondrially encoded subunits in mammalian complex I assembly.

Perales-Clemente E, Fernández-Vizarra E, Acín-Pérez R, Movilla N, Bayona-Bafaluy MP, Moreno-Loshuertos R, Pérez-Martos A, Fernández-Silva P, Enríquez JA.

Mol Cell Biol. 2010 Jun;30(12):3038-47. doi: 10.1128/MCB.00025-10. Epub 2010 Apr 12.

42.

Mitochondrial DNA mutations affect calcium handling in differentiated neurons.

Trevelyan AJ, Kirby DM, Smulders-Srinivasan TK, Nooteboom M, Acin-Perez R, Enriquez JA, Whittington MA, Lightowlers RN, Turnbull DM.

Brain. 2010 Mar;133(Pt 3):787-96. doi: 10.1093/brain/awq023. Epub 2010 Mar 5.

43.

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations.

Abramov AY, Smulders-Srinivasan TK, Kirby DM, Acin-Perez R, Enriquez JA, Lightowlers RN, Duchen MR, Turnbull DM.

Brain. 2010 Mar;133(Pt 3):797-807. doi: 10.1093/brain/awq015. Epub 2010 Feb 15.

44.

Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation.

Aguiló JI, Anel A, Catalán E, Sebastián A, Acín-Pérez R, Naval J, Wallich R, Simon MM, Pardo J.

Immunol Cell Biol. 2010 Jul;88(5):545-54. doi: 10.1038/icb.2010.5. Epub 2010 Feb 2.

PMID:
20125115
45.

Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects.

Acin-Perez R, Salazar E, Brosel S, Yang H, Schon EA, Manfredi G.

EMBO Mol Med. 2009 Nov;1(8-9):392-406. doi: 10.1002/emmm.200900046.

46.

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.

Yang H, Brosel S, Acin-Perez R, Slavkovich V, Nishino I, Khan R, Goldberg IJ, Graziano J, Manfredi G, Schon EA.

Hum Mol Genet. 2010 Jan 1;19(1):170-80. doi: 10.1093/hmg/ddp477.

47.

Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis.

Acin-Perez R, Hoyos B, Zhao F, Vinogradov V, Fischman DA, Harris RA, Leitges M, Wongsiriroj N, Blaner WS, Manfredi G, Hammerling U.

FASEB J. 2010 Feb;24(2):627-36. doi: 10.1096/fj.09-142281. Epub 2009 Oct 7.

48.

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation.

Kirby DM, Rennie KJ, Smulders-Srinivasan TK, Acin-Perez R, Whittington M, Enriquez JA, Trevelyan AJ, Turnbull DM, Lightowlers RN.

Cell Prolif. 2009 Aug;42(4):413-24. doi: 10.1111/j.1365-2184.2009.00612.x. Epub 2009 Jun 23.

49.

Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation.

Acin-Perez R, Salazar E, Kamenetsky M, Buck J, Levin LR, Manfredi G.

Cell Metab. 2009 Mar;9(3):265-76. doi: 10.1016/j.cmet.2009.01.012.

50.

PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.

Liu W, Vives-Bauza C, Acín-Peréz- R, Yamamoto A, Tan Y, Li Y, Magrané J, Stavarache MA, Shaffer S, Chang S, Kaplitt MG, Huang XY, Beal MF, Manfredi G, Li C.

PLoS One. 2009;4(2):e4597. doi: 10.1371/journal.pone.0004597. Epub 2009 Feb 26.

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