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Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2).

Gregory JM, Smith TJ, Slaughter JC, Mason HR, Hughey CC, Smith MS, Kandasamy B, Greeley SAW, Philipson LH, Naylor RN, Letourneau LR, Abumrad NN, Cherrington AD, Moore DJ.

Diabetes. 2019 Aug;68(8):1565-1576. doi: 10.2337/db19-0324. Epub 2019 May 15.


Metabolic Effects of Bile Acids: Potential Role in Bariatric Surgery.

Flynn CR, Albaugh VL, Abumrad NN.

Cell Mol Gastroenterol Hepatol. 2019;8(2):235-246. doi: 10.1016/j.jcmgh.2019.04.014. Epub 2019 May 7. Review.


Brief communication: β-cell function influences dopamine receptor availability.

Dunn JP, Abumrad NN, Patterson BW, Kessler RM, Tamboli RA.

PLoS One. 2019 Mar 8;14(3):e0212738. doi: 10.1371/journal.pone.0212738. eCollection 2019.


New-Onset Post-Transplant Diabetes Mellitus after Allogeneic Hematopoietic Cell Transplant Is Initiated by Insulin Resistance, Not Immunosuppressive Medications.

Engelhardt BG, Savani U, Jung DK, Powers AC, Jagasia M, Chen H, Winnick JJ, Tamboli RA, Crowe JE Jr, Abumrad NN.

Biol Blood Marrow Transplant. 2019 Jun;25(6):1225-1231. doi: 10.1016/j.bbmt.2019.02.001. Epub 2019 Feb 7.


First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers.

Pitchford LM, Rathmacher JA, Fuller JC Jr, Daniels JS, Morrison RD, Akers WS, Abumrad NN, Amarnath V, Currey PM, Roberts LJ, Oates JA, Boutaud O.

BMC Pharmacol Toxicol. 2019 Jan 5;20(1):1. doi: 10.1186/s40360-018-0281-7.


Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery.

Albaugh VL, Banan B, Antoun J, Xiong Y, Guo Y, Ping J, Alikhan M, Clements BA, Abumrad NN, Flynn CR.

Gastroenterology. 2019 Mar;156(4):1041-1051.e4. doi: 10.1053/j.gastro.2018.11.017. Epub 2018 Nov 13.


Subchronic (90-day) repeated dose oral toxicity study of 2-hydroxybenzylamine acetate in rabbit.

Fuller JC Jr, Pitchford LM, Abumrad NN, Rathmacher JA.

Regul Toxicol Pharmacol. 2018 Dec;100:52-58. doi: 10.1016/j.yrtph.2018.10.017. Epub 2018 Oct 22.


Attenuation of diet-induced hypothalamic inflammation following bariatric surgery in female mice.

Herrick MK, Favela KM, Simerly RB, Abumrad NN, Bingham NC.

Mol Med. 2018 Oct 24;24(1):56. doi: 10.1186/s10020-018-0057-y.


Subchronic (90-day) repeated dose toxicity study of 2-hydroxybenzylamine acetate in rats.

Fuller JC Jr, Pitchford LM, Abumrad NN, Rathmacher JA.

Regul Toxicol Pharmacol. 2018 Nov;99:225-232. doi: 10.1016/j.yrtph.2018.09.025. Epub 2018 Sep 25.


In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate.

Fuller JC Jr, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, Oates JA, Boutaud O, Rathmacher JA.

Food Chem Toxicol. 2018 Nov;121:541-548. doi: 10.1016/j.fct.2018.09.047. Epub 2018 Sep 22.


Acute and 28-day repeated dose toxicity evaluations of 2-hydroxybenzylamine acetate in mice and rats.

Pitchford LM, Smith JD, Abumrad NN, Rathmacher JA, Fuller JC Jr.

Regul Toxicol Pharmacol. 2018 Oct;98:190-198. doi: 10.1016/j.yrtph.2018.07.026. Epub 2018 Jul 31.


Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine reward.

Reddy IA, Smith NK, Erreger K, Ghose D, Saunders C, Foster DJ, Turner B, Poe A, Albaugh VL, McGuinness O, Hackett TA, Grueter BA, Abumrad NN, Flynn CR, Galli A.

PLoS Biol. 2018 Jul 26;16(7):e2006682. doi: 10.1371/journal.pbio.2006682. eCollection 2018 Jul.


Surgical treatment of obesity.

Albaugh VL, Abumrad NN.

F1000Res. 2018 May 21;7. pii: F1000 Faculty Rev-617. doi: 10.12688/f1000research.13515.1. eCollection 2018. Review.


Insulin resistance is a significant determinant of sarcopenia in advanced kidney disease.

Deger SM, Hewlett JR, Gamboa J, Ellis CD, Hung AM, Siew ED, Mamnungu C, Sha F, Bian A, Stewart TG, Abumrad NN, Ikizler TA.

Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1108-E1120. doi: 10.1152/ajpendo.00070.2018. Epub 2018 Jun 12.


CD36 Modulates Fasting and Preabsorptive Hormone and Bile Acid Levels.

Shibao CA, Celedonio JE, Tamboli R, Sidani R, Love-Gregory L, Pietka T, Xiong Y, Wei Y, Abumrad NN, Abumrad NA, Flynn CR.

J Clin Endocrinol Metab. 2018 May 1;103(5):1856-1866. doi: 10.1210/jc.2017-01982.


Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients.

Deger SM, Hung AM, Gamboa JL, Siew ED, Ellis CD, Booker C, Sha F, Li H, Bian A, Stewart TG, Zent R, Mitch WE, Abumrad NN, Ikizler TA.

JCI Insight. 2017 Nov 16;2(22). pii: 95185. doi: 10.1172/jci.insight.95185. eCollection 2017 Nov 16.


Caloric Restriction-Induced Decreases in Dopamine Receptor Availability are Associated with Leptin Concentration.

Dunn JP, Abumrad NN, Kessler RM, Patterson BW, Li R, Marks-Shulman P, Tamboli RA.

Obesity (Silver Spring). 2017 Nov;25(11):1910-1915. doi: 10.1002/oby.22023. Epub 2017 Sep 25.


Bile acids and bariatric surgery.

Albaugh VL, Banan B, Ajouz H, Abumrad NN, Flynn CR.

Mol Aspects Med. 2017 Aug;56:75-89. doi: 10.1016/j.mam.2017.04.001. Epub 2017 Apr 17. Review.


Metabolic responses to exogenous ghrelin in obesity and early after Roux-en-Y gastric bypass in humans.

Tamboli RA, Antoun J, Sidani RM, Clements A, Harmata EE, Marks-Shulman P, Gaylinn BD, Williams B, Clements RH, Albaugh VL, Abumrad NN.

Diabetes Obes Metab. 2017 Sep;19(9):1267-1275. doi: 10.1111/dom.12952. Epub 2017 May 31.


Hyperinsulinemia and Insulin Resistance in Dopamine β-Hydroxylase Deficiency.

Arnold AC, Garland EM, Celedonio JE, Raj SR, Abumrad NN, Biaggioni I, Robertson D, Luther JM, Shibao CA.

J Clin Endocrinol Metab. 2017 Jan 1;102(1):10-14. doi: 10.1210/jc.2016-3274.


Erratum: Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin.

Knuth ND, Johannsen DL, Tamboli RA, Marks-Shulman PA, Huizenga R, Chen KY, Abumrad NN, Ravussin E, Hall KD.

Obesity (Silver Spring). 2016 Oct;24(10):2248. doi: 10.1002/oby.21634. Epub 2016 Aug 10. No abstract available.


High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients.

Deger SM, Hung AM, Ellis CD, Booker C, Bian A, Chen G, Abumrad NN, Ikizler TA.

Clin J Am Soc Nephrol. 2016 Jul 7;11(7):1227-35. doi: 10.2215/CJN.04150415. Epub 2016 Jun 8.


Jejunal administration of glucose enhances acyl ghrelin suppression in obese humans.

Tamboli RA, Sidani RM, Garcia AE, Antoun J, Isbell JM, Albaugh VL, Abumrad NN.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E252-9. doi: 10.1152/ajpendo.00082.2016. Epub 2016 Jun 7.


Recent advances in metabolic and bariatric surgery.

Albaugh VL, Flynn CR, Tamboli RA, Abumrad NN.

F1000Res. 2016 May 24;5. pii: F1000 Faculty Rev-978. doi: 10.12688/f1000research.7240.1. eCollection 2016. Review.


A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition.

Shibao CA, Celedonio JE, Ramirez CE, Love-Gregory L, Arnold AC, Choi L, Okamoto LE, Gamboa A, Biaggioni I, Abumrad NN, Abumrad NA.

J Clin Endocrinol Metab. 2016 Jul;101(7):2751-8. doi: 10.1210/jc.2016-1294. Epub 2016 May 4.


Lipoprotein Profiles in Class III Obese Caucasian and African American Women with Nonalcoholic Fatty Liver Disease.

Garcia AE, Kasim N, Tamboli RA, Gonzalez RS, Antoun J, Eckert EA, Marks-Shulman PA, Dunn J, Wattacheril J, Wallen T, Abumrad NN, Flynn CR.

PLoS One. 2015 Nov 23;10(11):e0142676. doi: 10.1371/journal.pone.0142676. eCollection 2015.


Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery.

Flynn CR, Albaugh VL, Cai S, Cheung-Flynn J, Williams PE, Brucker RM, Bordenstein SR, Guo Y, Wasserman DH, Abumrad NN.

Nat Commun. 2015 Jul 21;6:7715. doi: 10.1038/ncomms8715.


Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids.

Albaugh VL, Flynn CR, Cai S, Xiao Y, Tamboli RA, Abumrad NN.

J Clin Endocrinol Metab. 2015 Sep;100(9):E1225-33. doi: 10.1210/jc.2015-2467. Epub 2015 Jul 21.


Hepatic TLR4 signaling in obese NAFLD.

Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM Jr, Abumrad NN, Flynn CR.

Am J Physiol Gastrointest Liver Physiol. 2015 Aug 15;309(4):G270-8. doi: 10.1152/ajpgi.00304.2014. Epub 2015 Jun 25.


A post-developmental genetic screen for zebrafish models of inherited liver disease.

Kim SH, Wu SY, Baek JI, Choi SY, Su Y, Flynn CR, Gamse JT, Ess KC, Hardiman G, Lipschutz JH, Abumrad NN, Rockey DC.

PLoS One. 2015 May 7;10(5):e0125980. doi: 10.1371/journal.pone.0125980. eCollection 2015.


The battle of the bulge: defense versus offense.

Magkos F, Tamboli RA, Abumrad NN, Klein S.

Am J Clin Nutr. 2014 Oct;100(4):991-2. doi: 10.3945/ajcn.114.096529. Epub 2014 Aug 27. No abstract available.


Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin.

Knuth ND, Johannsen DL, Tamboli RA, Marks-Shulman PA, Huizenga R, Chen KY, Abumrad NN, Ravussin E, Hall KD.

Obesity (Silver Spring). 2014 Dec;22(12):2563-9. doi: 10.1002/oby.20900. Epub 2014 Sep 19. Erratum in: Obesity (Silver Spring). 2016 Oct;24(10):2248.


Omega-3 fatty acids inhibit the up-regulation of endothelial chemokines in maintenance hemodialysis patients.

Hung AM, Booker C, Ellis CD, Siew ED, Graves AJ, Shintani A, Abumrad NN, Himmelfarb J, Ikizler TA.

Nephrol Dial Transplant. 2015 Feb;30(2):266-74. doi: 10.1093/ndt/gfu283. Epub 2014 Sep 9.


Striatal dopamine homeostasis is altered in mice following Roux-en-Y gastric bypass surgery.

Reddy IA, Wasserman DH, Ayala JE, Hasty AH, Abumrad NN, Galli A.

ACS Chem Neurosci. 2014 Oct 15;5(10):943-51. doi: 10.1021/cn500137d. Epub 2014 Aug 5.


Early weight regain after gastric bypass does not affect insulin sensitivity but is associated with elevated ghrelin.

Tamboli RA, Breitman I, Marks-Shulman PA, Jabbour K, Melvin W, Williams B, Clements RH, Feurer ID, Abumrad NN.

Obesity (Silver Spring). 2014 Jul;22(7):1617-22. doi: 10.1002/oby.20776. Epub 2014 Apr 29.


Regulation of novelty seeking by midbrain dopamine D2/D3 signaling and ghrelin is altered in obesity.

Savage SW, Zald DH, Cowan RL, Volkow ND, Marks-Shulman PA, Kessler RM, Abumrad NN, Dunn JP.

Obesity (Silver Spring). 2014 Jun;22(6):1452-7. doi: 10.1002/oby.20690. Epub 2014 Feb 11.


Effects of proximal gut bypass on glucose tolerance and insulin sensitivity in humans.

Breitman I, Isbell JM, Saliba J, Jabbour K, Flynn CR, Marks-Shulman PA, Laferrère B, Abumrad NN, Tamboli RA.

Diabetes Care. 2013 Apr;36(4):e57. doi: 10.2337/dc12-1722. No abstract available.


Mouse Models of Bariatric Surgery.

Yin DP, Boyd KL, Williams PE, Abumrad NN, Wasserman DH.

Curr Protoc Mouse Biol. 2012 Dec 1;2012. pii: mo120087.


Adenosine-5'-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets.

Rathmacher JA, Fuller JC Jr, Baier SM, Abumrad NN, Angus HF, Sharp RL.

J Int Soc Sports Nutr. 2012 Oct 9;9(1):48. doi: 10.1186/1550-2783-9-48.


Relationship of dopamine type 2 receptor binding potential with fasting neuroendocrine hormones and insulin sensitivity in human obesity.

Dunn JP, Kessler RM, Feurer ID, Volkow ND, Patterson BW, Ansari MS, Li R, Marks-Shulman P, Abumrad NN.

Diabetes Care. 2012 May;35(5):1105-11. doi: 10.2337/dc11-2250. Epub 2012 Mar 19.


Increased COMT expression in PCOS biology.

Nair S, Al-Hendy A, Tamboli RA, Marks-Shulman PA, Abumrad NN.

Mol Cell Endocrinol. 2012 May 15;355(1):188-9. doi: 10.1016/j.mce.2012.02.002. Epub 2012 Feb 10. No abstract available.


Mouse Models of Bariatric Surgery.

Yin DP, Boyd KL, Williams PE, Abumrad NN, Wasserman DH.

Curr Protoc Mouse Biol. 2012 Dec 1;2(4):295-306. doi: 10.1002/9780470942390.mo120087.


Reduction in inflammatory gene expression in skeletal muscle from Roux-en-Y gastric bypass patients randomized to omentectomy.

Tamboli RA, Hajri T, Jiang A, Marks-Shulman PA, Williams DB, Clements RH, Melvin W, Bowen BP, Shyr Y, Abumrad NN, Flynn CR.

PLoS One. 2011;6(12):e28577. doi: 10.1371/journal.pone.0028577. Epub 2011 Dec 16.


Hepatic and peripheral insulin sensitivity and diabetes remission at 1 month after Roux-en-Y gastric bypass surgery in patients randomized to omentectomy.

Dunn JP, Abumrad NN, Breitman I, Marks-Shulman PA, Flynn CR, Jabbour K, Feurer ID, Tamboli RA.

Diabetes Care. 2012 Jan;35(1):137-42. doi: 10.2337/dc11-1383. Epub 2011 Oct 31.


Vitamin D status affects strength gains in older adults supplemented with a combination of β-hydroxy-β-methylbutyrate, arginine, and lysine: a cohort study.

Fuller JC Jr, Baier S, Flakoll P, Nissen SL, Abumrad NN, Rathmacher JA.

JPEN J Parenter Enteral Nutr. 2011 Nov;35(6):757-62. doi: 10.1177/0148607111413903. Epub 2011 Aug 1.


Exercise-Induced Muscle Damage is Not Attenuated by Maximuscle β-Hydroxy-β-Methylbutyrate-1000™ Supplementation.

Abumrad NN, Rathmacher JA.

J Strength Cond Res. 2011 Jul;25(7):1-2. doi: 10.1519/JSC.0b013e3181f7c3a8. Epub 2011 May 6. No abstract available.


Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice.

Yin DP, Gao Q, Ma LL, Yan W, Williams PE, McGuinness OP, Wasserman DH, Abumrad NN.

Ann Surg. 2011 Jul;254(1):73-82. doi: 10.1097/SLA.0b013e3182197035.


Reduction of 8-iso-prostaglandin F2α in the first week after Roux-en-Y gastric bypass surgery.

Ueda Y, Hajri T, Peng D, Marks-Shulman PA, Tamboli RA, Shukrallah B, Saliba J, Jabbour K, El-Rifai W, Abumrad NA, Abumrad NN.

Obesity (Silver Spring). 2011 Aug;19(8):1663-8. doi: 10.1038/oby.2011.58. Epub 2011 Apr 7.


Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery.

Hansen EN, Tamboli RA, Isbell JM, Saliba J, Dunn JP, Marks-Shulman PA, Abumrad NN.

Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G795-802. doi: 10.1152/ajpgi.00019.2011. Epub 2011 Mar 3.


Regulation of adiponectin production by insulin: interactions with tumor necrosis factor-α and interleukin-6.

Hajri T, Tao H, Wattacheril J, Marks-Shulman P, Abumrad NN.

Am J Physiol Endocrinol Metab. 2011 Feb;300(2):E350-60. doi: 10.1152/ajpendo.00307.2010. Epub 2010 Nov 9.

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