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Metabolomics-Based Biosignatures of Prostate Cancer in Patients Following Radiotherapy.

Nalbantoglu S, Abu-Asab M, Suy S, Collins S, Amri H.

OMICS. 2019 Apr;23(4):214-223. doi: 10.1089/omi.2019.0006.


Localization of human recombinant adenoviral vectors to the mitochondria following transduction of human cell lines.

Morrison BJ, Abu-Asab M, Morris JC, Steel JC.

Acta Virol. 2019;63(1):111-116. doi: 10.4149/av_2019_114.


Homozygous frameshift mutations in FAT1 cause a syndrome characterized by colobomatous-microphthalmia, ptosis, nephropathy and syndactyly.

Lahrouchi N, George A, Ratbi I, Schneider R, Elalaoui SC, Moosa S, Bharti S, Sharma R, Abu-Asab M, Onojafe F, Adadi N, Lodder EM, Laarabi FZ, Lamsyah Y, Elorch H, Chebbar I, Postma AV, Lougaris V, Plebani A, Altmueller J, Kyrieleis H, Meiner V, McNeill H, Bharti K, Lyonnet S, Wollnik B, Henrion-Caude A, Berraho A, Hildebrandt F, Bezzina CR, Brooks BP, Sefiani A.

Nat Commun. 2019 Mar 12;10(1):1180. doi: 10.1038/s41467-019-08547-w.


FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia.

Manoli I, Sysol JR, Epping MW, Li L, Wang C, Sloan JL, Pass A, Gagné J, Ktena YP, Li L, Trivedi NS, Ouattara B, Zerfas PM, Hoffmann V, Abu-Asab M, Tsokos MG, Kleiner DE, Garone C, Cusmano-Ozog K, Enns GM, Vernon HJ, Andersson HC, Grunewald S, Elkahloun AG, Girard CL, Schnermann J, DiMauro S, Andres-Mateos E, Vandenberghe LH, Chandler RJ, Venditti CP.

JCI Insight. 2018 Dec 6;3(23). pii: 124351. doi: 10.1172/jci.insight.124351.


Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3.

Onojafe IF, Megan LH, Melch MG, Aderemi JO, Alur RP, Abu-Asab MS, Chan CC, Bernardini IM, Albert JS, Cogliati T, Adams DR, Brooks BP.

Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):4945-4952. doi: 10.1167/iovs.16-20293.


CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.

Maeda K, Otomo K, Yoshida N, Abu-Asab MS, Ichinose K, Nishino T, Kono M, Ferretti A, Bhargava R, Maruyama S, Bickerton S, Fahmy TM, Tsokos MG, Tsokos GC.

J Clin Invest. 2018 Aug 1;128(8):3445-3459. doi: 10.1172/JCI99507. Epub 2018 Jul 9.


A Mouse Model of Schnyder Corneal Dystrophy with the N100S Point Mutation.

Dong F, Jin X, Boettler MA, Sciulli H, Abu-Asab M, Del Greco C, Wang S, Hu YC, Campos MM, Jackson SN, Muller L, Woods AS, Combs CA, Zhang J, Nickerson ML, Kruth HS, Weiss JS, Kao WW.

Sci Rep. 2018 Jul 5;8(1):10219. doi: 10.1038/s41598-018-28545-0.


Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation.

Zhang Y, Zhao L, Wang X, Ma W, Lazere A, Qian HH, Zhang J, Abu-Asab M, Fariss RN, Roger JE, Wong WT.

Sci Adv. 2018 Mar 21;4(3):eaap8492. doi: 10.1126/sciadv.aap8492. eCollection 2018 Mar.


Nevirapine-induced liver lipid-SER inclusions and other ultrastructural aberrations.

Sastry J, Mohammed H, Campos MM, Uetrecht J, Abu-Asab M.

Ultrastruct Pathol. 2018 Mar-Apr;42(2):108-115. doi: 10.1080/01913123.2017.1422831. Epub 2018 Feb 9.


Mitochondrial autophagosomes as a mechanism of drug resistance in breast carcinoma.

Abunimer AN, Mohammed H, Cook KL, Soto-Pantoja DR, Campos MM, Abu-Asab MS.

Ultrastruct Pathol. 2018 Mar-Apr;42(2):170-180. doi: 10.1080/01913123.2017.1419328. Epub 2018 Feb 8.


Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors.

Giannelou A, Wang H, Zhou Q, Park YH, Abu-Asab MS, Ylaya K, Stone DL, Sediva A, Sleiman R, Sramkova L, Bhatla D, Serti E, Tsai WL, Yang D, Bishop K, Carrington B, Pei W, Deuitch N, Brooks S, Edwan JH, Joshi S, Prader S, Kaiser D, Owen WC, Sonbul AA, Zhang Y, Niemela JE, Burgess SM, Boehm M, Rehermann B, Chae J, Quezado MM, Ombrello AK, Buckley RH, Grom AA, Remmers EF, Pachlopnik JM, Su HC, Gutierrez-Cruz G, Hewitt SM, Sood R, Risma K, Calvo KR, Rosenzweig SD, Gadina M, Hafner M, Sun HW, Kastner DL, Aksentijevich I.

Ann Rheum Dis. 2018 Apr;77(4):612-619. doi: 10.1136/annrheumdis-2017-212401. Epub 2018 Jan 22.


Protein phosphatase 2A inhibition enhances radiation sensitivity and reduces tumor growth in chordoma.

Hao S, Song H, Zhang W, Seldomridge A, Jung J, Giles AJ, Hutchinson MK, Cao X, Colwell N, Lita A, Larion M, Maric D, Abu-Asab M, Quezado M, Kramp T, Camphausen K, Zhuang Z, Gilbert MR, Park DM.

Neuro Oncol. 2018 May 18;20(6):799-809. doi: 10.1093/neuonc/nox241.


Novel Targeting of Transcription and Metabolism in Glioblastoma.

Su YT, Chen R, Wang H, Song H, Zhang Q, Chen LY, Lappin H, Vasconcelos G, Lita A, Maric D, Li A, Celiku O, Zhang W, Meetze K, Estok T, Larion M, Abu-Asab M, Zhuang Z, Yang C, Gilbert MR, Wu J.

Clin Cancer Res. 2018 Mar 1;24(5):1124-1137. doi: 10.1158/1078-0432.CCR-17-2032. Epub 2017 Dec 18.


Loss of endothelial planar cell polarity and cellular clearance mechanisms in age-related macular degeneration.

Campos MM, Abu-Asab MS.

Ultrastruct Pathol. 2017 Sep-Oct;41(5):312-319. doi: 10.1080/01913123.2017.1348418. Epub 2017 Aug 10.


Adverse effects of antiretroviral therapy on liver hepatocytes and endothelium in HIV patients: An ultrastructural perspective.

Chwiki S, Campos MM, McLaughlin ME, Kleiner DE, Kovacs JA, Morse CG, Abu-Asab MS.

Ultrastruct Pathol. 2017 Mar-Apr;41(2):186-195. doi: 10.1080/01913123.2017.1282066. Epub 2017 Feb 28.


PhyloOncology: Understanding cancer through phylogenetic analysis.

Somarelli JA, Ware KE, Kostadinov R, Robinson JM, Amri H, Abu-Asab M, Fourie N, Diogo R, Swofford D, Townsend JP.

Biochim Biophys Acta Rev Cancer. 2017 Apr;1867(2):101-108. doi: 10.1016/j.bbcan.2016.10.006. Epub 2016 Oct 31. Review.


Study of Clinical Survival and Gene Expression in a Sample of Pancreatic Ductal Adenocarcinoma by Parsimony Phylogenetic Analysis.

Nalbantoglu S, Abu-Asab M, Tan M, Zhang X, Cai L, Amri H.

OMICS. 2016 Jul;20(7):442-7. doi: 10.1089/omi.2016.0059.


A Systems Biology Interpretation of Array Comparative Genomic Hybridization (aCGH) Data through Phylogenetics.

Abunimer AN, Salazar J, Noursi DP, Abu-Asab MS.

OMICS. 2016 Mar;20(3):169-79. doi: 10.1089/omi.2015.0184.


NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration.

Wang Y, Hanus JW, Abu-Asab MS, Shen D, Ogilvy A, Ou J, Chu XK, Shi G, Li W, Wang S, Chan CC.

Int J Mol Sci. 2016 Jan 8;17(1). pii: E73. doi: 10.3390/ijms17010073.


Responses of Multipotent Retinal Stem Cells to IL-1β, IL-18, or IL-17.

Chen S, Shen D, Popp NA, Ogilvy AJ, Tuo J, Abu-Asab M, Xie T, Chan CC.

J Ophthalmol. 2015;2015:369312. doi: 10.1155/2015/369312. Epub 2015 Oct 4.


Computational Tools for Parsimony Phylogenetic Analysis of Omics Data.

Salazar J, Amri H, Noursi D, Abu-Asab M.

OMICS. 2015 Aug;19(8):471-7. doi: 10.1089/omi.2015.0018. Epub 2015 Jun 3.


Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells.

Fliedner SM, Yang C, Thompson E, Abu-Asab M, Hsu CM, Lampert G, Eiden L, Tischler AS, Wesley R, Zhuang Z, Lehnert H, Pacak K.

Am J Cancer Res. 2015 Mar 15;5(4):1558-70. eCollection 2015.


Bacillus anthracis edema but not lethal toxin challenge in rats is associated with depressed myocardial function in hearts isolated and tested in a Langendorff system.

Li Y, Abu-Asab M, Su J, Qiu P, Feng J, Ohanjanian L, Kumar HS, Fitz Y, Eichacker PQ, Cui X.

Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1592-602. doi: 10.1152/ajpheart.00851.2014. Epub 2015 Apr 10.


Carney triad, SDH-deficient tumors, and Sdhb+/- mice share abnormal mitochondria.

Szarek E, Ball ER, Imperiale A, Tsokos M, Faucz FR, Giubellino A, Moussallieh FM, Namer IJ, Abu-Asab MS, Pacak K, Taïeb D, Carney JA, Stratakis CA.

Endocr Relat Cancer. 2015 Jun;22(3):345-52. doi: 10.1530/ERC-15-0069. Epub 2015 Mar 25.


Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma.

Joe MK, Nakaya N, Abu-Asab M, Tomarev SI.

Hum Mol Genet. 2015 Jun 15;24(12):3322-34. doi: 10.1093/hmg/ddv082. Epub 2015 Mar 3.


When is a vesicle not just a vesicle: mitochondrial spheroids and mitochondrial autophagosomes.

Cook KL, Soto-Pantoja DR, Jin L, Abu-Asab M, Clarke R.

Cell Biosci. 2014 Nov 14;4:66. doi: 10.1186/2045-3701-4-66. eCollection 2014. No abstract available.


Nonalcoholic Steatohepatitis and Hepatic Fibrosis in HIV-1-Monoinfected Adults With Elevated Aminotransferase Levels on Antiretroviral Therapy.

Morse CG, McLaughlin M, Matthews L, Proschan M, Thomas F, Gharib AM, Abu-Asab M, Orenstein A, Engle RE, Hu X, Lempicki R, Hadigan C, Kleiner DE, Heller T, Kovacs JA.

Clin Infect Dis. 2015 May 15;60(10):1569-78. doi: 10.1093/cid/civ101. Epub 2015 Feb 13.


Inflammation and Cell Death in Age-Related Macular Degeneration: An Immunopathological and Ultrastructural Model.

Ardeljan CP, Ardeljan D, Abu-Asab M, Chan CC.

J Clin Med. 2014;3(4):1542-60. doi: 10.3390/jcm3041542.


Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice.

Sultana A, Nakaya N, Dong L, Abu-Asab M, Qian H, Tomarev SI.

Exp Neurol. 2014 Nov;261:802-11. doi: 10.1016/j.expneurol.2014.09.002. Epub 2014 Sep 10.


Menin immunoreactivity in secretory granules of human pancreatic islet cells.

Debelenko LV, Agarwal S, Du Q, Yan W, Erickson HS, Abu-Asab M, Raffeld MA, Libutti SK, Marx SJ, Emmert-Buck MR.

Appl Immunohistochem Mol Morphol. 2014 Nov-Dec;22(10):748-55. doi: 10.1097/PAI.0000000000000046.


SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome.

Shi CS, Qi HY, Boularan C, Huang NN, Abu-Asab M, Shelhamer JH, Kehrl JH.

J Immunol. 2014 Sep 15;193(6):3080-9. doi: 10.4049/jimmunol.1303196. Epub 2014 Aug 18.


aldh7a1 regulates eye and limb development in zebrafish.

Babcock HE, Dutta S, Alur RP, Brocker C, Vasiliou V, Vitale S, Abu-Asab M, Brooks BP.

PLoS One. 2014 Jul 8;9(7):e101782. doi: 10.1371/journal.pone.0101782. eCollection 2014.


Implications of DNA leakage in eyes of mutant mice.

Ogilvy AJ, Shen D, Wang Y, Chan CC, Abu-Asab MS.

Ultrastruct Pathol. 2014 Oct;38(5):335-43. doi: 10.3109/01913123.2014.927406. Epub 2014 Jun 25.


CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells.

Kaur S, Singh SP, Elkahloun AG, Wu W, Abu-Asab MS, Roberts DD.

Matrix Biol. 2014 Jul;37:49-59. doi: 10.1016/j.matbio.2014.05.007. Epub 2014 Jun 2.


Upregulation of hypoxia-inducible factors and autophagy in von Hippel-Lindau-associated retinal hemangioblastoma.

Wang Y, Abu-Asab MS, Shen D, Zhuang Z, Chew EY, Chan CC.

Graefes Arch Clin Exp Ophthalmol. 2014 Aug;252(8):1319-27. doi: 10.1007/s00417-014-2660-0. Epub 2014 May 24.


Knockdown of estrogen receptor-α induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death.

Cook KL, Clarke PA, Parmar J, Hu R, Schwartz-Roberts JL, Abu-Asab M, Wärri A, Baumann WT, Clarke R.

FASEB J. 2014 Sep;28(9):3891-905. doi: 10.1096/fj.13-247353. Epub 2014 May 23.


Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.

Ardeljan D, Wang Y, Park S, Shen D, Chu XK, Yu CR, Abu-Asab M, Tuo J, Eberhart CG, Olsen TW, Mullins RF, White G, Wadsworth S, Scaria A, Chan CC.

PLoS One. 2014 Apr 29;9(4):e95900. doi: 10.1371/journal.pone.0095900. eCollection 2014.


Myocilin is involved in NgR1/Lingo-1-mediated oligodendrocyte differentiation and myelination of the optic nerve.

Kwon HS, Nakaya N, Abu-Asab M, Kim HS, Tomarev SI.

J Neurosci. 2014 Apr 16;34(16):5539-51. doi: 10.1523/JNEUROSCI.4731-13.2014.


Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration.

Wang Y, Abu-Asab MS, Yu CR, Tang Z, Shen D, Tuo J, Li X, Chan CC.

Lab Invest. 2014 Jun;94(6):674-82. doi: 10.1038/labinvest.2014.60. Epub 2014 Apr 7.


Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy.

Cook KL, Soto-Pantoja DR, Abu-Asab M, Clarke PA, Roberts DD, Clarke R.

Cell Biosci. 2014 Mar 27;4(1):16. doi: 10.1186/2045-3701-4-16.


An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors.

Brim H, Abu-Asab MS, Nouraie M, Salazar J, Deleo J, Razjouyan H, Mokarram P, Schaffer AA, Naghibhossaini F, Ashktorab H.

PLoS One. 2014 Jan 27;9(1):e82185. doi: 10.1371/journal.pone.0082185. eCollection 2014.


Systems Biology Profiling of AMD on the Basis of Gene Expression.

Abu-Asab MS, Salazar J, Tuo J, Chan CC.

J Ophthalmol. 2013;2013:453934. doi: 10.1155/2013/453934. Epub 2013 Nov 14.


Klotho regulates retinal pigment epithelial functions and protects against oxidative stress.

Kokkinaki M, Abu-Asab M, Gunawardena N, Ahern G, Javidnia M, Young J, Golestaneh N.

J Neurosci. 2013 Oct 9;33(41):16346-59. doi: 10.1523/JNEUROSCI.0402-13.2013.


Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia.

Manoli I, Sysol JR, Li L, Houillier P, Garone C, Wang C, Zerfas PM, Cusmano-Ozog K, Young S, Trivedi NS, Cheng J, Sloan JL, Chandler RJ, Abu-Asab M, Tsokos M, Elkahloun AG, Rosen S, Enns GM, Berry GT, Hoffmann V, DiMauro S, Schnermann J, Venditti CP.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13552-7. doi: 10.1073/pnas.1302764110. Epub 2013 Jul 29.


Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.

Kwon HS, Johnson TV, Joe MK, Abu-Asab M, Zhang J, Chan CC, Tomarev SI.

J Biol Chem. 2013 Sep 13;288(37):26357-71. doi: 10.1074/jbc.M112.446138. Epub 2013 Jul 29.


Identifying early events of gene expression in breast cancer with systems biology phylogenetics.

Abu-Asab MS, Abu-Asab N, Loffredo CA, Clarke R, Amri H.

Cytogenet Genome Res. 2013;139(3):206-14. doi: 10.1159/000348433. Epub 2013 Apr 3.


GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells.

Schwartz-Roberts JL, Shajahan AN, Cook KL, Wärri A, Abu-Asab M, Clarke R.

Mol Cancer Ther. 2013 Apr;12(4):448-59. doi: 10.1158/1535-7163.MCT-12-0617. Epub 2013 Feb 8.


Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy.

Wang Y, Abu-Asab MS, Li W, Aronow ME, Singh AD, Chan CC.

BMC Ophthalmol. 2012 Nov 13;12:56. doi: 10.1186/1471-2415-12-56.


Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients.

Brim H, Lee E, Abu-Asab MS, Chaouchi M, Razjouyan H, Namin H, Goel A, Schäffer AA, Ashktorab H.

PLoS One. 2012;7(8):e40392. doi: 10.1371/journal.pone.0040392. Epub 2012 Aug 6.


CD47 deficiency confers cell and tissue radioprotection by activation of autophagy.

Soto-Pantoja DR, Miller TW, Pendrak ML, DeGraff WG, Sullivan C, Ridnour LA, Abu-Asab M, Wink DA, Tsokos M, Roberts DD.

Autophagy. 2012 Nov;8(11):1628-42. doi: 10.4161/auto.21562. Epub 2012 Aug 9.

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