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Inflammatory Responses Reprogram TREGS Through Impairment of Neuropilin-1.

Chen TH, Arra M, Mbalaviele G, Swarnkar G, Abu-Amer Y.

Sci Rep. 2019 Jul 18;9(1):10429. doi: 10.1038/s41598-019-46934-x.


Stem cell-derived extracellular vesicles attenuate the early inflammatory response after tendon injury and repair.

Shen H, Yoneda S, Abu-Amer Y, Guilak F, Gelberman RH.

J Orthop Res. 2019 Jul 9. doi: 10.1002/jor.24406. [Epub ahead of print]


Attenuation of NF-κB in Intestinal Epithelial Cells Is Sufficient to Mitigate the Bone Loss Comorbidity of Experimental Mouse Colitis.

Ke K, Chen TH, Arra M, Mbalaviele G, Swarnkar G, Abu-Amer Y.

J Bone Miner Res. 2019 May 20. doi: 10.1002/jbmr.3759. [Epub ahead of print]


Targeting vascular endothelial growth factor ameliorates PMMA-particles induced inflammatory osteolysis in murine calvaria.

Abu-Amer W, Arra M, Clohisy JCF, Abu-Amer Y, Swarnkar G.

Bone. 2019 Jun;123:86-91. doi: 10.1016/j.bone.2019.03.025. Epub 2019 Mar 21.


Targeting the NF-κB signaling pathway in chronic tendon disease.

Abraham AC, Shah SA, Golman M, Song L, Li X, Kurtaliaj I, Akbar M, Millar NL, Abu-Amer Y, Galatz LM, Thomopoulos S.

Sci Transl Med. 2019 Feb 27;11(481). pii: eaav4319. doi: 10.1126/scitranslmed.aav4319.


Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.

Xiao J, Wang C, Yao JC, Alippe Y, Xu C, Kress D, Civitelli R, Abu-Amer Y, Kanneganti TD, Link DC, Mbalaviele G.

PLoS Biol. 2018 Nov 2;16(11):e3000047. doi: 10.1371/journal.pbio.3000047. eCollection 2018 Nov.


ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1.

Rohatgi N, Zou W, Collins PL, Brestoff JR, Chen TH, Abu-Amer Y, Teitelbaum SL.

Blood Adv. 2018 Oct 9;2(19):2467-2477. doi: 10.1182/bloodadvances.2018018309.


Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.

Wang C, Hockerman S, Jacobsen EJ, Alippe Y, Selness SR, Hope HR, Hirsch JL, Mnich SJ, Saabye MJ, Hood WF, Bonar SL, Abu-Amer Y, Haimovich A, Hoffman HM, Monahan JB, Mbalaviele G.

J Exp Med. 2018 May 7;215(5):1315-1325. doi: 10.1084/jem.20172063. Epub 2018 Mar 16.


From the Cover: Lung-Specific Overexpression of Constitutively Active IKK2 Induces Pulmonary and Systemic Inflammations but Not Hypothalamic Inflammation and Glucose Intolerance.

Chen M, Zhou H, Xu Y, Qiu L, Hu Z, Qin X, Chen S, Zhang Y, Cao Q, Abu-Amer Y, Ying Z.

Toxicol Sci. 2017 Nov 1;160(1):4-14. doi: 10.1093/toxsci/kfx154.


Loss of Dnmt3b in Chondrocytes Leads to Delayed Endochondral Ossification and Fracture Repair.

Wang C, Abu-Amer Y, O'Keefe RJ, Shen J.

J Bone Miner Res. 2018 Feb;33(2):283-297. doi: 10.1002/jbmr.3305. Epub 2017 Nov 2.


NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis.

Swarnkar G, Chen TH, Arra M, Nasir AM, Mbalaviele G, Abu-Amer Y.

Sci Rep. 2017 Oct 3;7(1):12600. doi: 10.1038/s41598-017-12707-7.


Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation.

Alippe Y, Wang C, Ricci B, Xiao J, Qu C, Zou W, Novack DV, Abu-Amer Y, Civitelli R, Mbalaviele G.

Sci Rep. 2017 Jul 26;7(1):6630. doi: 10.1038/s41598-017-07014-0.


Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells.

Wang C, Xu CX, Alippe Y, Qu C, Xiao J, Schipani E, Civitelli R, Abu-Amer Y, Mbalaviele G.

Sci Rep. 2017 Jul 7;7(1):4880. doi: 10.1038/s41598-017-05033-5.


PPAR-γ regulates pharmacological but not physiological or pathological osteoclast formation.

Zou W, Rohatgi N, Chen TH, Schilling J, Abu-Amer Y, Teitelbaum SL.

Nat Med. 2016 Nov 8;22(11):1203-1205. doi: 10.1038/nm.4208. No abstract available.


Myeloid Deletion of Nemo Causes Osteopetrosis in Mice Owing to Upregulation of Transcriptional Repressors.

Swarnkar G, Shim K, Nasir AM, Seehra K, Chen HP, Mbalaviele G, Abu-Amer Y.

Sci Rep. 2016 Jul 20;6:29896. doi: 10.1038/srep29896.


Inflammation and epigenetic regulation in osteoarthritis.

Shen J, Abu-Amer Y, O'Keefe RJ, McAlinden A.

Connect Tissue Res. 2017 Jan;58(1):49-63. doi: 10.1080/03008207.2016.1208655. Epub 2016 Jul 7. Review.


Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.

Wang C, Qu C, Alippe Y, Bonar SL, Civitelli R, Abu-Amer Y, Hottiger MO, Mbalaviele G.

Cell Death Dis. 2016 Mar 24;7:e2153. doi: 10.1038/cddis.2016.58.


Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice.

Chen TH, Swarnkar G, Mbalaviele G, Abu-Amer Y.

Cell Death Dis. 2015 Apr 16;6:e1723. doi: 10.1038/cddis.2015.87.


Regulation of NF-κB signaling in osteoclasts and myeloid progenitors.

Swarnkar G, Abu-Amer Y.

Methods Mol Biol. 2015;1280:527-42. doi: 10.1007/978-1-4939-2422-6_31.


Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling.

Swarnkar G, Karuppaiah K, Mbalaviele G, Chen TH, Abu-Amer Y.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):154-9. doi: 10.1073/pnas.1415213112. Epub 2014 Dec 22.


NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.

Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G.

FASEB J. 2015 Apr;29(4):1269-79. doi: 10.1096/fj.14-264804. Epub 2014 Dec 4.


Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.

Swarnkar G, Zhang K, Mbalaviele G, Long F, Abu-Amer Y.

PLoS One. 2014 Mar 11;9(3):e91421. doi: 10.1371/journal.pone.0091421. eCollection 2014.


Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.

Cassel SL, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, Iwakura Y, Shayakhmetov DM, Bassuk AG, Abu-Amer Y, Brogden KA, Burns TL, Sutterwala FS, Ferguson PJ.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1072-7. doi: 10.1073/pnas.1318685111. Epub 2014 Jan 6.


Ubiquitin-like domain of IKKβ regulates osteoclastogenesis and osteolysis.

Zhang Y, Otero JE, Abu-Amer Y.

Calcif Tissue Int. 2013 Jul;93(1):78-85. doi: 10.1007/s00223-013-9735-5. Epub 2013 May 18.


NF-κB signaling and bone resorption.

Abu-Amer Y.

Osteoporos Int. 2013 Sep;24(9):2377-86. doi: 10.1007/s00198-013-2313-x. Epub 2013 Mar 7. Review.


Blockade of JNK and NFAT pathways attenuates orthopedic particle-stimulated osteoclastogenesis of human osteoclast precursors and murine calvarial osteolysis.

Yamanaka Y, Clohisy JC, Ito H, Matsuno T, Abu-Amer Y.

J Orthop Res. 2013 Jan;31(1):67-72. doi: 10.1002/jor.22200. Epub 2012 Jul 27.


Constitutively active canonical NF-κB pathway induces severe bone loss in mice.

Otero JE, Chen T, Zhang K, Abu-Amer Y.

PLoS One. 2012;7(6):e38694. doi: 10.1371/journal.pone.0038694. Epub 2012 Jun 7.


Lysine392, a K63-linked ubiquitination site in NEMO, mediates inflammatory osteoclastogenesis and osteolysis.

Alhawagri M, Yamanaka Y, Ballard D, Oltz E, Abu-Amer Y.

J Orthop Res. 2012 Apr;30(4):554-60. doi: 10.1002/jor.21555. Epub 2011 Sep 12.


Polyubiquitination events mediate polymethylmethacrylate (PMMA) particle activation of NF-kappaB pathway.

Yamanaka Y, Karuppaiah K, Abu-Amer Y.

J Biol Chem. 2011 Jul 8;286(27):23735-41. doi: 10.1074/jbc.M111.223669. Epub 2011 May 12.


Evidence that the kinase-truncated c-Src regulates NF-κB signaling by targeting NEMO.

Dai S, Abu-Amer W, Karuppaiah K, Abu-Amer Y.

J Cell Biochem. 2011 Sep;112(9):2463-70. doi: 10.1002/jcb.23170.


Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesis.

Darwech I, Otero JE, Alhawagri MA, Abu-Amer Y.

J Biol Chem. 2010 Aug 13;285(33):25522-30. doi: 10.1074/jbc.M110.121533. Epub 2010 Jun 9.


Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization.

Zhang Z, Xing X, Hensley G, Chang LW, Liao W, Abu-Amer Y, Sandell LJ.

Arthritis Rheum. 2010 Jul;62(7):1993-2003. doi: 10.1002/art.27473.


IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis.

Otero JE, Dai S, Alhawagri MA, Darwech I, Abu-Amer Y.

J Bone Miner Res. 2010 Jun;25(6):1282-94. doi: 10.1002/jbmr.4.


Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis.

Darwech I, Otero J, Alhawagri M, Dai S, Abu-Amer Y.

J Cell Biochem. 2009 Dec 15;108(6):1337-45. doi: 10.1002/jcb.22364.


Inflammation, cancer, and bone loss.

Abu-Amer Y.

Curr Opin Pharmacol. 2009 Aug;9(4):427-33. doi: 10.1016/j.coph.2009.06.007. Epub 2009 Jul 2. Review.


NFAT2 is an essential mediator of orthopedic particle-induced osteoclastogenesis.

Yamanaka Y, Abu-Amer W, Foglia D, Otero J, Clohisy JC, Abu-Amer Y.

J Orthop Res. 2008 Dec;26(12):1577-84. doi: 10.1002/jor.20714.


Defective osteoclastogenesis by IKKbeta-null precursors is a result of receptor activator of NF-kappaB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation.

Otero JE, Dai S, Foglia D, Alhawagri M, Vacher J, Pasparakis M, Abu-Amer Y.

J Biol Chem. 2008 Sep 5;283(36):24546-53. doi: 10.1074/jbc.M800434200. Epub 2008 Jun 19.


Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss.

Abu-Amer Y, Darwech I, Otero J.

Autoimmunity. 2008 Apr;41(3):204-11. doi: 10.1080/08916930701694543. Review.


Cutting edge: IL-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism.

Dufort FJ, Bleiman BF, Gumina MR, Blair D, Wagner DJ, Roberts MF, Abu-Amer Y, Chiles TC.

J Immunol. 2007 Oct 15;179(8):4953-7.


Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies.

Abu-Amer Y, Darwech I, Clohisy JC.

Arthritis Res Ther. 2007;9 Suppl 1:S6. Review.


Systems level analysis of osteoclastogenesis reveals intrinsic and extrinsic regulatory interactions.

Kiesel J, Miller C, Abu-Amer Y, Aurora R.

Dev Dyn. 2007 Aug;236(8):2181-97.


Map kinase c-JUN N-terminal kinase mediates PMMA induction of osteoclasts.

Yamanaka Y, Abu-Amer Y, Faccio R, Clohisy JC.

J Orthop Res. 2006 Jul;24(7):1349-57.


Inhibition of p38 mitogen-activated protein kinase prevents inflammatory bone destruction.

Mbalaviele G, Anderson G, Jones A, De Ciechi P, Settle S, Mnich S, Thiede M, Abu-Amer Y, Portanova J, Monahan J.

J Pharmacol Exp Ther. 2006 Jun;317(3):1044-53. Epub 2006 Feb 24.


Advances in osteoclast differentiation and function.

Abu-Amer Y.

Curr Drug Targets Immune Endocr Metabol Disord. 2005 Sep;5(3):347-55. Review.


Inhibition of inflammatory bone erosion by constitutively active STAT-6 through blockade of JNK and NF-kappaB activation.

Hirayama T, Dai S, Abbas S, Yamanaka Y, Abu-Amer Y.

Arthritis Rheum. 2005 Sep;52(9):2719-29.


Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo.

Kitaura H, Sands MS, Aya K, Zhou P, Hirayama T, Uthgenannt B, Wei S, Takeshita S, Novack DV, Silva MJ, Abu-Amer Y, Ross FP, Teitelbaum SL.

J Immunol. 2004 Oct 15;173(8):4838-46.


TNF receptor type 1 regulates RANK ligand expression by stromal cells and modulates osteoclastogenesis.

Abu-Amer Y, Abbas S, Hirayama T.

J Cell Biochem. 2004 Nov 15;93(5):980-9.


The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis.

Dai S, Hirayama T, Abbas S, Abu-Amer Y.

J Biol Chem. 2004 Sep 3;279(36):37219-22. Epub 2004 Jul 13.

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