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Items: 42

1.

Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin.

Apgar JM, Wilkening RR, Greenlee ML, Balkovec JM, Flattery AM, Abruzzo GK, Galgoci AM, Giacobbe RA, Gill CJ, Hsu MJ, Liberator P, Misura AS, Motyl M, Nielsen Kahn J, Powles M, Racine F, Dragovic J, Habulihaz B, Fan W, Kirwan R, Lee S, Liu H, Mamai A, Nelson K, Peel M.

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5813-8. doi: 10.1016/j.bmcl.2015.10.011. Epub 2015 Oct 9.

PMID:
26542966
2.

Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis.

Flattery AM, Hickey E, Gill CJ, Powles MA, Misura AS, Galgoci AM, Ellis JD, Zhang R, Sandhu P, Ronan J, Abruzzo GK.

Antimicrob Agents Chemother. 2011 Jul;55(7):3491-7. doi: 10.1128/AAC.01328-10. Epub 2011 Apr 25.

3.

In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection.

Gill CJ, Abruzzo GK, Flattery AM, Misura AS, Bartizal K, Hickey EJ.

Antimicrob Agents Chemother. 2007 Sep;51(9):3434-6. Epub 2007 Jul 2.

4.

Efficacy of caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans.

Bowman JC, Abruzzo GK, Flattery AM, Gill CJ, Hickey EJ, Hsu MJ, Kahn JN, Liberator PA, Misura AS, Pelak BA, Wang TC, Douglas CM.

Antimicrob Agents Chemother. 2006 Dec;50(12):4202-5. Epub 2006 Oct 2.

5.

Inactivation of Kex2p diminishes the virulence of Candida albicans.

Newport G, Kuo A, Flattery A, Gill C, Blake JJ, Kurtz MB, Abruzzo GK, Agabian N.

J Biol Chem. 2003 Jan 17;278(3):1713-20. Epub 2002 Nov 4.

6.

Arundifungin, a novel antifungal compound produced by fungi: biological activity and taxonomy of the producing organisms.

Cabello MA, Platas G, Collado J, Díez MT, Martín I, Vicente F, Meinz M, Onishi JC, Douglas C, Thompson J, Kurtz MB, Schwartz RE, Bills GF, Giacobbe RA, Abruzzo GK, Flattery AM, Kong L, Peláez F.

Int Microbiol. 2001 Jun;4(2):93-102.

PMID:
11770831
7.

Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate.

Bowman JC, Abruzzo GK, Anderson JW, Flattery AM, Gill CJ, Pikounis VB, Schmatz DM, Liberator PA, Douglas CM.

Antimicrob Agents Chemother. 2001 Dec;45(12):3474-81.

8.

The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms.

Peláez F, Cabello A, Platas G, Díez MT, González del Val A, Basilio A, Martán I, Vicente F, Bills GE, Giacobbe RA, Schwartz RE, Onish JC, Meinz MS, Abruzzo GK, Flattery AM, Kong L, Kurtz MB.

Syst Appl Microbiol. 2000 Oct;23(3):333-43.

PMID:
11108011
9.

Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice.

Abruzzo GK, Gill CJ, Flattery AM, Kong L, Leighton C, Smith JG, Pikounis VB, Bartizal K, Rosen H.

Antimicrob Agents Chemother. 2000 Sep;44(9):2310-8.

10.

Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase.

Mandala SM, Thornton RA, Milligan J, Rosenbach M, Garcia-Calvo M, Bull HG, Harris G, Abruzzo GK, Flattery AM, Gill CJ, Bartizal K, Dreikorn S, Kurtz MB.

J Biol Chem. 1998 Jun 12;273(24):14942-9.

11.

Antibacterial activity of lonchocarpol A.

Salvatore MJ, King AB, Graham AC, Onishi HR, Bartizal KF, Abruzzo GK, Gill CJ, Ramjit HG, Pitzenberger SM, Witherup KM.

J Nat Prod. 1998 May;61(5):640-2.

PMID:
9599265
12.

Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors.

Douglas CM, D'Ippolito JA, Shei GJ, Meinz M, Onishi J, Marrinan JA, Li W, Abruzzo GK, Flattery A, Bartizal K, Mitchell A, Kurtz MB.

Antimicrob Agents Chemother. 1997 Nov;41(11):2471-9.

13.

Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis.

Abruzzo GK, Flattery AM, Gill CJ, Kong L, Smith JG, Pikounis VB, Balkovec JM, Bouffard AF, Dropinski JF, Rosen H, Kropp H, Bartizal K.

Antimicrob Agents Chemother. 1997 Nov;41(11):2333-8.

14.

In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).

Bartizal K, Gill CJ, Abruzzo GK, Flattery AM, Kong L, Scott PM, Smith JG, Leighton CE, Bouffard A, Dropinski JF, Balkovec J.

Antimicrob Agents Chemother. 1997 Nov;41(11):2326-32.

15.

Evaluation of experimental therapeutics in a new mouse model of Helicobacter felis utilizing 16S rRNA polymerase chain reaction for detection.

Smith JG, Kong L, Abruzzo GK, Gill CJ, Flattery AM, Scott PM, Silver L, Kropp H, Bartizal K.

Scand J Gastroenterol. 1997 Apr;32(4):297-302.

PMID:
9140149
16.

New model of oropharyngeal and gastrointestinal colonization by Candida albicans in CD4+ T-cell-deficient mice for evaluation of antifungal agents.

Flattery AM, Abruzzo GK, Gill CJ, Smith JG, Bartizal K.

Antimicrob Agents Chemother. 1996 Jul;40(7):1604-9.

17.

A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.

Kong L, Smith JG, Bramhill D, Abruzzo GK, Bonfiglio C, Cioffe C, Flattery AM, Gill CJ, Lynch L, Scott PM, Silver L, Thompson C, Kropp H, Bartizal K.

Clin Diagn Lab Immunol. 1996 Jan;3(1):73-8.

18.

PCR detection of colonization by Helicobacter pylori in conventional, euthymic mice based on the 16S ribosomal gene sequence.

Smith JG, Kong L, Abruzzo GK, Gill CJ, Flattery AM, Scott PM, Bramhill D, Cioffe C, Thompson CM, Bartizal K.

Clin Diagn Lab Immunol. 1996 Jan;3(1):66-72.

19.

In vivo evaluation of three acid-stable azalide compounds, L-701,677, L-708,299 and L-708,365 compared to erythromycin, azithromycin and clarithromycin.

Gill CJ, Abruzzo GK, Flattery AM, Smith JG, Jackson J, Kong L, Wilkening R, Shankaran K, Kropp H, Bartizal K.

J Antibiot (Tokyo). 1995 Oct;48(10):1141-7.

20.

Evaluation of water-soluble pneumocandin analogs L-733560, L-705589, and L-731373 with mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis.

Abruzzo GK, Flattery AM, Gill CJ, Kong L, Smith JG, Krupa D, Pikounis VB, Kropp H, Bartizal K.

Antimicrob Agents Chemother. 1995 May;39(5):1077-81.

21.

In vitro evaluation of the pneumocandin antifungal agent L-733560, a new water-soluble hybrid of L-705589 and L-731373.

Bartizal K, Scott T, Abruzzo GK, Gill CJ, Pacholok C, Lynch L, Kropp H.

Antimicrob Agents Chemother. 1995 May;39(5):1070-6.

22.

Synthesis and antifungal activity of novel cationic pneumocandin B(o) derivatives.

Bouffard FA, Zambias RA, Dropinski JF, Balkovec JM, Hammond ML, Abruzzo GK, Bartizal KF, Marrinan JA, Kurtz MB, McFadden DC, et al.

J Med Chem. 1994 Jan 21;37(2):222-5. No abstract available.

PMID:
8295208
23.

Restricticin, a novel glycine-containing antifungal agent.

Schwartz RE, Dufresne C, Flor JE, Kempf AJ, Wilson KE, Lam T, Onishi J, Milligan J, Fromtling RA, Abruzzo GK, et al.

J Antibiot (Tokyo). 1991 May;44(5):463-71.

24.

Lack of cross-resistance between efrotomycin and antibacterial agents used in the therapy of human and animal infections.

Jacks TM, Frazier EG, Abruzzo GK, Graham AC, Fromtling RA.

Methods Find Exp Clin Pharmacol. 1989 Nov;11(11):697-701.

PMID:
2695724
25.
26.

L-658,310, a new injectable cephalosporin. III. Experimental chemotherapeutics and pharmacokinetics in laboratory animals.

Gilfillan EC, Pelak BA, Weissberger BA, Abruzzo GK, Fromtling RA, Bland JA, Hadley SK, Gadebusch HH.

J Antibiot (Tokyo). 1989 May;42(5):815-22.

27.

L-658,310, a new injectable cephalosporin. I. In vitro antibacterial properties.

Weissberger BA, Abruzzo GK, Fromtling RA, Gill C, Ponticas S, Valiant ME, Shungu DL, Gadebusch HH.

J Antibiot (Tokyo). 1989 May;42(5):795-806.

28.
29.

L-656,575 (OCP-9-176): a novel oxacephem. In vitro activity against aerobic and anaerobic clinical bacterial isolates.

Weissberger B, Abruzzo GK, Fromtling RA, Valiant ME, Shungu DL, Gadebusch HH.

J Antibiot (Tokyo). 1988 Aug;41(8):1130-6.

30.

Renal pathology and spleen cell chemiluminescence of mice infected with a wild-type and a low-virulence mutant of Candida albicans.

Fromtling RA, Abruzzo GK, Edison A, Manning-Zweerink M.

Zentralbl Bakteriol Mikrobiol Hyg A. 1988 May;268(3):405-15.

PMID:
3043983
31.
32.

Use of chemiluminescence to evaluate the influence of antifungal agents on immune cell function.

Fromtling RA, Abruzzo GK, Turnbull TA, Giltinan DM, Capizzi TP.

Ann N Y Acad Sci. 1988;544:270-83. No abstract available.

PMID:
3214070
33.

Candida tropicalis infection in normal, diabetic, and neutropenic mice.

Fromtling RA, Abruzzo GK, Giltinan DM.

J Clin Microbiol. 1987 Aug;25(8):1416-20.

34.

Effects of bifonazole, fluconazole, itraconazole, and terbinafine on the chemiluminescence response of immune cells.

Abruzzo GK, Fromtling RA, Turnbull TA, Giltinan DM.

J Antimicrob Chemother. 1987 Jul;20(1):61-8.

PMID:
3040658
35.

Influence of six antifungal agents on the chemiluminescence response of mouse spleen cells.

Abruzzo GK, Giltinan DM, Capizzi TP, Fromtling RA.

Antimicrob Agents Chemother. 1986 Apr;29(4):602-7.

36.

Cryptococcus neoformans: comparisons of in vitro antifungal susceptibilities of serotypes AD and BC.

Fromtling RA, Abruzzo GK, Bulmer GS.

Mycopathologia. 1986 Apr;94(1):27-30.

PMID:
3014339
37.

Design and analysis considerations in evaluating the chemiluminescence response of mouse spleen cells.

Giltinan DM, Capizzi TP, Abruzzo GK, Fromtling RA.

J Clin Microbiol. 1986 Mar;23(3):531-5.

38.

Norfloxacin versus trimethoprim-sulphamethoxazole: efficacy in a model of ascending urinary tract infection in normal and streptozotocin-induced diabetic mice.

Fromtling RA, Abruzzo GK, Gilfillan EC, Pelak BA, Gadebusch HH.

J Antimicrob Chemother. 1985 Dec;16(6):735-41.

PMID:
3912365
39.

Chemiluminescence as a tool for the evaluation of antimicrobial agents: a review.

Fromtling RA, Abruzzo GK.

Methods Find Exp Clin Pharmacol. 1985 Sep;7(9):493-500. Review.

PMID:
3908855
40.

In vitro effect of pH and glucose concentration on the antibacterial activity of norfloxacin in urine.

Fromtling RA, Abruzzo GK, Gadebusch HH.

Methods Find Exp Clin Pharmacol. 1984 Dec;6(12):737-41.

PMID:
6241649
41.
42.

Occurrence and characterization of plasmids in field isolates of Bordetella bronchiseptica.

Graham AC, Abruzzo GK.

Am J Vet Res. 1982 Oct;43(10):1852-5.

PMID:
7149391

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