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Items: 1 to 50 of 70

1.

Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment.

Ngo Nyekel F, Pacreau E, Benadda S, Msallam R, Åbrink M, Pejler G, Davoust J, Benhamou M, Charles N, Launay P, Blank U, Gautier G.

Front Immunol. 2018 Nov 20;9:2690. doi: 10.3389/fimmu.2018.02690. eCollection 2018.

2.

Mast cell chymase decreases the severity of group B Streptococcus infections.

Gendrin C, Shubin NJ, Boldenow E, Merillat S, Clauson M, Power D, Doran KS, Abrink M, Pejler G, Rajagopal L, Piliponsky AM.

J Allergy Clin Immunol. 2018 Jul;142(1):120-129.e6. doi: 10.1016/j.jaci.2017.07.042. Epub 2017 Sep 12.

3.

Mast cells are critical for the limitation of thrombin-induced skin inflammation.

Suender CA, Leist M, Åbrink M, Valentin P, Geldmacher A, Steinhoff M, Metz M, Maurer M.

Exp Dermatol. 2018 Jan;27(1):50-57. doi: 10.1111/exd.13407. Epub 2017 Oct 19.

PMID:
28787094
4.

Mast Cells and MCPT4 Chymase Promote Renal Impairment after Partial Ureteral Obstruction.

Pons M, Ali L, Beghdadi W, Danelli L, Alison M, Madjène LC, Calvo J, Claver J, Vibhushan S, Åbrink M, Pejler G, Poli-Mérol ML, Peuchmaur M, El Ghoneimi A, Blank U.

Front Immunol. 2017 May 4;8:450. doi: 10.3389/fimmu.2017.00450. eCollection 2017.

5.

Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis.

Digre A, Singh K, Åbrink M, Reijmers RM, Sandler S, Vlodavsky I, Li JP.

Sci Rep. 2017 Apr 12;7:46229. doi: 10.1038/srep46229.

6.

Highly Selective Cleavage of Cytokines and Chemokines by the Human Mast Cell Chymase and Neutrophil Cathepsin G.

Fu Z, Thorpe M, Alemayehu R, Roy A, Kervinen J, de Garavilla L, Åbrink M, Hellman L.

J Immunol. 2017 Feb 15;198(4):1474-1483. doi: 10.4049/jimmunol.1601223. Epub 2017 Jan 4.

7.

Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules.

Choi HW, Bowen SE, Miao Y, Chan CY, Miao EA, Abrink M, Moeser AJ, Abraham SN.

Immunity. 2016 Dec 20;45(6):1258-1269. doi: 10.1016/j.immuni.2016.11.003. Epub 2016 Dec 6.

8.

Increased Bone Mass in Female Mice Lacking Mast Cell Chymase.

Lind T, Gustafson AM, Calounova G, Hu L, Rasmusson A, Jonsson KB, Wernersson S, Åbrink M, Andersson G, Larsson S, Melhus H, Pejler G.

PLoS One. 2016 Dec 9;11(12):e0167964. doi: 10.1371/journal.pone.0167964. eCollection 2016.

9.

Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.

Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AM.

J Allergy Clin Immunol. 2017 Jan;139(1):323-334. doi: 10.1016/j.jaci.2016.03.051. Epub 2016 May 13.

10.

IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction.

Tejada T, Tan L, Torres RA, Calvert JW, Lambert JP, Zaidi M, Husain M, Berce MD, Naib H, Pejler G, Abrink M, Graham RM, Lefer DJ, Naqvi N, Husain A.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6949-54. doi: 10.1073/pnas.1603127113. Epub 2016 Jun 6.

11.

Serglycin proteoglycans limit enteropathy in Trichinella spiralis-infected mice.

Roy A, Sawesi O, Pettersson U, Dagälv A, Kjellén L, Lundén A, Åbrink M.

BMC Immunol. 2016 Jun 8;17(1):15. doi: 10.1186/s12865-016-0155-y.

12.

Targeting Serglycin Prevents Metastasis in Murine Mammary Carcinoma.

Roy A, Femel J, Huijbers EJ, Spillmann D, Larsson E, Ringvall M, Olsson AK, Åbrink M.

PLoS One. 2016 May 25;11(5):e0156151. doi: 10.1371/journal.pone.0156151. eCollection 2016.

13.

Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets.

Klein O, Ngo-Nyekel F, Stefanache T, Torres R, Salomonsson M, Hallgren J, Rådinger M, Bambouskova M, Campbell M, Cohen-Mor S, Dema B, Rose CG, Abrink M, Charles N, Ainooson G, Paivandy A, Pavlova VG, Serrano-Candelas E, Yu Y, Hellman L, Jensen BM, Van Anrooij B, Grootens J, Gura HK, Stylianou M, Tobio A, Blank U, Öhrvik H, Maurer M.

Scand J Immunol. 2016 Jun;83(6):465-72. doi: 10.1111/sji.12436. No abstract available.

14.

Serglycin protects against high fat diet-induced increase in serum LDL in mice.

Meen AJ, Drevon CA, Pejler G, Jenssen TG, Olstad OK, Åbrink M, Kolset SO.

Glycoconj J. 2015 Dec;32(9):703-14. doi: 10.1007/s10719-015-9621-7. Epub 2015 Sep 21.

PMID:
26391682
15.

Loss of Serglycin Promotes Primary Tumor Growth and Vessel Functionality in the RIP1-Tag2 Mouse Model for Spontaneous Insulinoma Formation.

Hamilton A, Basic V, Andersson S, Abrink M, Ringvall M.

PLoS One. 2015 May 15;10(5):e0126688. doi: 10.1371/journal.pone.0126688. eCollection 2015.

16.

Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism.

Reber LL, Daubeuf F, Pejler G, Abrink M, Frossard N.

J Immunol. 2014 Feb 15;192(4):1847-54. doi: 10.4049/jimmunol.1300875. Epub 2014 Jan 22.

17.

Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation.

Roy A, Ganesh G, Sippola H, Bolin S, Sawesi O, Dagälv A, Schlenner SM, Feyerabend T, Rodewald HR, Kjellén L, Hellman L, Åbrink M.

J Biol Chem. 2014 Jan 3;289(1):237-50. doi: 10.1074/jbc.M112.435156. Epub 2013 Nov 20.

18.

Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis.

Waern I, Karlsson I, Thorpe M, Schlenner SM, Feyerabend TB, Rodewald HR, Åbrink M, Hellman L, Pejler G, Wernersson S.

Biol Chem. 2012 Dec;393(12):1555-67.

PMID:
23667909
19.

The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.

Piliponsky AM, Chen CC, Rios EJ, Treuting PM, Lahiri A, Abrink M, Pejler G, Tsai M, Galli SJ.

Am J Pathol. 2012 Sep;181(3):875-86. doi: 10.1016/j.ajpath.2012.05.013.

20.

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D.

J Clin Invest. 2012 Feb;122(2):748-58. doi: 10.1172/JCI58815. Epub 2012 Jan 9.

21.

Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.

Dagälv A, Holmborn K, Kjellén L, Abrink M.

J Biol Chem. 2011 Dec 30;286(52):44433-40. doi: 10.1074/jbc.M111.303891. Epub 2011 Nov 2.

22.

Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.

Akahoshi M, Song CH, Piliponsky AM, Metz M, Guzzetta A, Abrink M, Schlenner SM, Feyerabend TB, Rodewald HR, Pejler G, Tsai M, Galli SJ.

J Clin Invest. 2011 Oct;121(10):4180-91. doi: 10.1172/JCI46139. Epub 2011 Sep 19.

23.

Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid.

Lin L, Bankaitis E, Heimbach L, Li N, Abrink M, Pejler G, An L, Diaz LA, Werb Z, Liu Z.

J Biol Chem. 2011 Oct 28;286(43):37358-67. doi: 10.1074/jbc.M111.272401. Epub 2011 Aug 31.

24.

A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway.

Melo FR, Waern I, Rönnberg E, Åbrink M, Lee DM, Schlenner SM, Feyerabend TB, Rodewald HR, Turk B, Wernersson S, Pejler G.

J Biol Chem. 2011 Feb 18;286(7):5423-33. doi: 10.1074/jbc.M110.176461. Epub 2010 Dec 1.

25.

The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5.

Younan G, Suber F, Xing W, Shi T, Kunori Y, Abrink M, Pejler G, Schlenner SM, Rodewald HR, Moore FD Jr, Stevens RL, Adachi R, Austen KF, Gurish MF.

J Immunol. 2010 Dec 15;185(12):7681-90. doi: 10.4049/jimmunol.1002803. Epub 2010 Nov 12.

26.

Serglycin-independent release of active mast cell proteases in response to Toxoplasma gondii infection.

Sawesi O, Spillmann D, Lundén A, Wernersson S, Åbrink M.

J Biol Chem. 2010 Dec 3;285(49):38005-13. doi: 10.1074/jbc.M110.118471. Epub 2010 Sep 23.

27.

Vaccination against the extra domain-B of fibronectin as a novel tumor therapy.

Huijbers EJ, Ringvall M, Femel J, Kalamajski S, Lukinius A, Abrink M, Hellman L, Olsson AK.

FASEB J. 2010 Nov;24(11):4535-44. doi: 10.1096/fj.10-163022. Epub 2010 Jul 15.

PMID:
20634349
28.

Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis.

Scandiuzzi L, Beghdadi W, Daugas E, Abrink M, Tiwari N, Brochetta C, Claver J, Arouche N, Zang X, Pretolani M, Monteiro RC, Pejler G, Blank U.

J Immunol. 2010 Jul 1;185(1):624-33. doi: 10.4049/jimmunol.0902129. Epub 2010 Jun 7.

29.

Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism.

Groschwitz KR, Ahrens R, Osterfeld H, Gurish MF, Han X, Abrink M, Finkelman FD, Pejler G, Hogan SP.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22381-6. doi: 10.1073/pnas.0906372106. Epub 2009 Dec 16.

30.

Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation.

Waern I, Jonasson S, Hjoberg J, Bucht A, Abrink M, Pejler G, Wernersson S.

J Immunol. 2009 Nov 15;183(10):6369-76. doi: 10.4049/jimmunol.0900180. Epub 2009 Oct 19.

31.

Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation.

Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP.

Circulation. 2009 Sep 15;120(11):973-82. doi: 10.1161/CIRCULATIONAHA.109.849679. Epub 2009 Aug 31.

32.

Serglycin proteoglycan is not implicated in localizing exocrine pancreas enzymes to zymogen granules.

Niemann CU, Cowland JB, Ralfkiaer E, Abrink M, Pejler G, Borregaard N.

Eur J Cell Biol. 2009 Aug;88(8):473-9. doi: 10.1016/j.ejcb.2009.03.002. Epub 2009 May 14.

PMID:
19446360
33.

Serglycin proteoglycan: regulating the storage and activities of hematopoietic proteases.

Pejler G, Abrink M, Wernersson S.

Biofactors. 2009 Jan-Feb;35(1):61-8. doi: 10.1002/biof.11. Review.

PMID:
19319847
34.

Age-related enlargement of lymphoid tissue and altered leukocyte composition in serglycin-deficient mice.

Wernersson S, Braga T, Sawesi O, Waern I, Nilsson KE, Pejler G, Abrink M.

J Leukoc Biol. 2009 Mar;85(3):401-8. doi: 10.1189/jlb.1008670. Epub 2008 Dec 16.

PMID:
19088175
35.

Reduction with dithiothreitol causes serglycin-specific defects in secretory granule integrity of bone marrow derived mast cells.

Braga T, Ringvall M, Tveit H, Abrink M, Pejler G.

Mol Immunol. 2009 Jan;46(3):422-8. doi: 10.1016/j.molimm.2008.10.019. Epub 2008 Dec 6.

PMID:
19059647
36.

Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis.

Magnusson SE, Pejler G, Kleinau S, Abrink M.

FASEB J. 2009 Mar;23(3):875-82. doi: 10.1096/fj.08-120394. Epub 2008 Nov 14.

PMID:
19010978
37.

Generation and characterization of a Gdf1 conditional null allele.

Bengtsson H, Epifantseva I, Abrink M, Kylberg A, Kullander K, Ebendal T, Usoskin D.

Genesis. 2008 Jul;46(7):368-72. doi: 10.1002/dvg.20408.

PMID:
18615710
38.

Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin.

Grujic M, Christensen JP, Sørensen MR, Abrink M, Pejler G, Thomsen AR.

J Immunol. 2008 Jul 15;181(2):1043-51.

39.

Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.

Piliponsky AM, Chen CC, Nishimura T, Metz M, Rios EJ, Dobner PR, Wada E, Wada K, Zacharias S, Mohanasundaram UM, Faix JD, Abrink M, Pejler G, Pearl RG, Tsai M, Galli SJ.

Nat Med. 2008 Apr;14(4):392-8. doi: 10.1038/nm1738. Epub 2008 Mar 30.

40.

Serotonin and histamine storage in mast cell secretory granules is dependent on serglycin proteoglycan.

Ringvall M, Rönnberg E, Wernersson S, Duelli A, Henningsson F, Abrink M, García-Faroldi G, Fajardo I, Pejler G.

J Allergy Clin Immunol. 2008 Apr;121(4):1020-6. doi: 10.1016/j.jaci.2007.11.031. Epub 2008 Jan 30.

PMID:
18234316
41.

Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice.

Woulfe DS, Lilliendahl JK, August S, Rauova L, Kowalska MA, Abrink M, Pejler G, White JG, Schick BP.

Blood. 2008 Apr 1;111(7):3458-67. Epub 2007 Dec 19.

42.

Mast cell proteases.

Pejler G, Abrink M, Ringvall M, Wernersson S.

Adv Immunol. 2007;95:167-255. Review.

PMID:
17869614
43.

Rab27b regulates mast cell granule dynamics and secretion.

Mizuno K, Tolmachova T, Ushakov DS, Romao M, Abrink M, Ferenczi MA, Raposo G, Seabra MC.

Traffic. 2007 Jul;8(7):883-92.

44.

Rab27b regulates number and secretion of platelet dense granules.

Tolmachova T, Abrink M, Futter CE, Authi KS, Seabra MC.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5872-7. Epub 2007 Mar 23.

45.

Bcl-2 and Bcl-XL are indispensable for the late phase of mast cell development from mouse embryonic stem cells.

Möller C, Karlberg M, Abrink M, Nakayama KI, Motoyama N, Nilsson G.

Exp Hematol. 2007 Mar;35(3):385-93.

PMID:
17309819
46.

Neutrophil elastase depends on serglycin proteoglycan for localization in granules.

Niemann CU, Abrink M, Pejler G, Fischer RL, Christensen EI, Knight SD, Borregaard N.

Blood. 2007 May 15;109(10):4478-86. Epub 2007 Feb 1.

47.

Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells.

Braga T, Grujic M, Lukinius A, Hellman L, Abrink M, Pejler G.

Biochem J. 2007 Apr 1;403(1):49-57.

48.
49.

A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components.

Henningsson F, Hergeth S, Cortelius R, Abrink M, Pejler G.

FEBS J. 2006 Nov;273(21):4901-12. Epub 2006 Sep 28.

50.

Mast cells can enhance resistance to snake and honeybee venoms.

Metz M, Piliponsky AM, Chen CC, Lammel V, Abrink M, Pejler G, Tsai M, Galli SJ.

Science. 2006 Jul 28;313(5786):526-30.

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