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Items: 1 to 50 of 133

1.

A Distinct Pool of Nav1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes.

Rougier JS, Essers MC, Gillet L, Guichard S, Sonntag S, Shmerling D, Abriel H.

Front Physiol. 2019 Jul 3;10:834. doi: 10.3389/fphys.2019.00834. eCollection 2019.

2.

A fundamental evaluation of the electrical properties and function of cardiac transverse tubules.

Vermij SH, Abriel H, Kucera JP.

Biochim Biophys Acta Mol Cell Res. 2019 Jun 30. pii: S0167-4889(18)30518-4. doi: 10.1016/j.bbamcr.2019.06.016. [Epub ahead of print] Review.

PMID:
31269418
3.

Cardiac Sodium Current Under Sympathetic ControlProtein Phosphatase 2A Regulates Cardiac Na+ Channels.

Marionneau C, Abriel H.

Circ Res. 2019 Mar;124(5):674-676. doi: 10.1161/CIRCRESAHA.119.314680. No abstract available.

PMID:
30817259
4.

Optimizing TRPM4 inhibitors in the MHFP6 chemical space.

Delalande C, Awale M, Rubin M, Probst D, Ozhathil LC, Gertsch J, Abriel H, Reymond JL.

Eur J Med Chem. 2019 Mar 15;166:167-177. doi: 10.1016/j.ejmech.2019.01.048. Epub 2019 Jan 24.

PMID:
30708257
5.

Editorial: Ion Channel Trafficking and Cardiac Arrhythmias.

van der Heyden MAG, Delisle BP, Abriel H.

Front Physiol. 2018 Sep 25;9:1254. doi: 10.3389/fphys.2018.01254. eCollection 2018. No abstract available.

6.

Corrigendum: Transcriptomic analyses of murine ventricular cardiomyocytes.

Chevalier M, Vermij SH, Wyler K, Gillet L, Keller I, Abriel H.

Sci Data. 2018 Oct 9;5:180216. doi: 10.1038/sdata.2018.216.

7.

Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells.

Tamò L, Hibaoui Y, Kallol S, Alves MP, Albrecht C, Hostettler KE, Feki A, Rougier JS, Abriel H, Knudsen L, Gazdhar A, Geiser T.

Am J Physiol Lung Cell Mol Physiol. 2018 Dec 1;315(6):L921-L932. doi: 10.1152/ajplung.00357.2017. Epub 2018 Sep 13.

PMID:
30211653
8.

Transcriptomic analyses of murine ventricular cardiomyocytes.

Chevalier M, Vermij SH, Wyler K, Gillet L, Keller I, Abriel H.

Sci Data. 2018 Aug 21;5:180170. doi: 10.1038/sdata.2018.170. Erratum in: Sci Data. 2018 Oct 09;5:180216.

9.

The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration.

Bianchi B, Smith PA, Abriel H.

Mol Brain. 2018 Jul 11;11(1):41. doi: 10.1186/s13041-018-0385-4.

10.

Functional implications of a rare variant in the sodium channel β1B subunit (SCN1B) in a 5-month-old male sudden infant death syndrome case.

Neubauer J, Rougier JS, Abriel H, Haas C.

HeartRhythm Case Rep. 2018 Mar 12;4(5):187-190. doi: 10.1016/j.hrcr.2018.01.010. eCollection 2018 May. No abstract available.

11.

Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.

Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, Ross-Kaschitza D, Simonin C, Rubin M, Gertsch J, Lochner M, Peinelt C, Reymond JL, Abriel H.

Br J Pharmacol. 2018 Jun;175(12):2504-2519. doi: 10.1111/bph.14220. Epub 2018 Apr 29.

12.

Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability.

Bianchi B, Ozhathil LC, Medeiros-Domingo A, Gollob MH, Abriel H.

Front Physiol. 2018 Mar 8;9:177. doi: 10.3389/fphys.2018.00177. eCollection 2018.

13.

Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in the intercalated disc.

Hichri E, Abriel H, Kucera JP.

J Physiol. 2018 Feb 15;596(4):563-589. doi: 10.1113/JP275351. Epub 2018 Jan 9.

14.

Annotation of functional impact of voltage-gated sodium channel mutations.

Hinard V, Britan A, Schaeffer M, Zahn-Zabal M, Thomet U, Rougier JS, Bairoch A, Abriel H, Gaudet P.

Hum Mutat. 2017 May;38(5):485-493. doi: 10.1002/humu.23191. Epub 2017 Feb 28.

15.

Refining the molecular organization of the cardiac intercalated disc.

Vermij SH, Abriel H, van Veen TA.

Cardiovasc Res. 2017 Mar 1;113(3):259-275. doi: 10.1093/cvr/cvw259. Review.

PMID:
28069669
16.

Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes.

Eichel CA, Beuriot A, Chevalier MY, Rougier JS, Louault F, Dilanian G, Amour J, Coulombe A, Abriel H, Hatem SN, Balse E.

Circ Res. 2016 Aug 5;119(4):544-56. doi: 10.1161/CIRCRESAHA.116.309254. Epub 2016 Jun 30.

PMID:
27364017
17.

Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block.

Syam N, Chatel S, Ozhathil LC, Sottas V, Rougier JS, Baruteau A, Baron E, Amarouch MY, Daumy X, Probst V, Schott JJ, Abriel H.

J Am Heart Assoc. 2016 May 20;5(5). pii: e001625. doi: 10.1161/JAHA.114.001625.

18.

8th Ascona International Workshop on Cardiomyocyte Biology, 3-7 May, 2015 Integration of Developmental and Environmental Cues in the Heart Congressi Stefano Franscini, Monte Verità, Ascona, Switzerland.

Schaub MC, Abriel H.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1691-5. doi: 10.1016/j.bbamcr.2016.04.008. Epub 2016 Apr 14. No abstract available.

19.

ICEPO: the ion channel electrophysiology ontology.

Hinard V, Britan A, Rougier JS, Bairoch A, Abriel H, Gaudet P.

Database (Oxford). 2016 Apr 7;2016. pii: baw017. doi: 10.1093/database/baw017. Print 2016.

20.

Complexity of cardiac ion channel macromolecular complexes.

Mohler PJ, Abriel H.

Cardiovasc Res. 2016 May 15;110(2):163-4. doi: 10.1093/cvr/cvw055. Epub 2016 Mar 16. No abstract available.

21.

Antiarrhythmic Action of Flecainide in Polymorphic Ventricular Arrhythmias Caused by a Gain-of-Function Mutation in the Nav 1.5 Sodium Channel.

Amarouch MY, Swan H, Leinonen J, Marjamaa A, Lahtinen AM, Kontula K, Toivonen L, Widen E, Abriel H.

Ann Noninvasive Electrocardiol. 2016 Jul;21(4):343-51. doi: 10.1111/anec.12312. Epub 2015 Oct 7.

PMID:
26965448
22.

Negative-dominance phenomenon with genetic variants of the cardiac sodium channel Nav1.5.

Sottas V, Abriel H.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1791-8. doi: 10.1016/j.bbamcr.2016.02.013. Epub 2016 Feb 22. Review.

23.

Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I.

Daumy X, Amarouch MY, Lindenbaum P, Bonnaud S, Charpentier E, Bianchi B, Nafzger S, Baron E, Fouchard S, Thollet A, Kyndt F, Barc J, Le Scouarnec S, Makita N, Le Marec H, Dina C, Gourraud JB, Probst V, Abriel H, Redon R, Schott JJ.

Int J Cardiol. 2016 Mar 15;207:349-58. doi: 10.1016/j.ijcard.2016.01.052. Epub 2016 Jan 11.

PMID:
26820365
24.

Cardiac voltage-gated calcium channel macromolecular complexes.

Rougier JS, Abriel H.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1806-12. doi: 10.1016/j.bbamcr.2015.12.014. Epub 2015 Dec 18. Review.

25.

Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes.

Laedermann CJ, Abriel H, Decosterd I.

Front Pharmacol. 2015 Nov 5;6:263. doi: 10.3389/fphar.2015.00263. eCollection 2015. Review.

26.

Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death.

Abriel H, Rougier JS, Jalife J.

Circ Res. 2015 Jun 5;116(12):1971-88. doi: 10.1161/CIRCRESAHA.116.305017. Review.

27.

Genetic background of Brugada syndrome is more complex than what we would like it to be!

Abriel H.

Cardiovasc Res. 2015 Jun 1;106(3):351-2. doi: 10.1093/cvr/cvv135. Epub 2015 Apr 29. No abstract available.

PMID:
25926434
28.

Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.

29.

Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications.

Marionneau C, Abriel H.

J Mol Cell Cardiol. 2015 May;82:36-47. doi: 10.1016/j.yjmcc.2015.02.013. Epub 2015 Mar 4. Review.

PMID:
25748040
30.

Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels.

Amarouch MY, Abriel H.

Front Physiol. 2015 Feb 17;6:45. doi: 10.3389/fphys.2015.00045. eCollection 2015. Review.

31.

Force-controlled patch clamp of beating cardiac cells.

Ossola D, Amarouch MY, Behr P, Vörös J, Abriel H, Zambelli T.

Nano Lett. 2015 Mar 11;15(3):1743-50. doi: 10.1021/nl504438z. Epub 2015 Feb 6.

PMID:
25639960
32.

Complex genetic background in a large family with Brugada syndrome.

Saber S, Amarouch MY, Fazelifar AF, Haghjoo M, Emkanjoo Z, Alizadeh A, Houshmand M, Gavrilenko AV, Abriel H, Zaklyazminskaya EV.

Physiol Rep. 2015 Jan 27;3(1). pii: e12256. doi: 10.14814/phy2.12256. Print 2015 Jan 1.

33.

Functional interaction between S1 and S4 segments in voltage-gated sodium channels revealed by human channelopathies.

Amarouch MY, Kasimova MA, Tarek M, Abriel H.

Channels (Austin). 2014;8(5):414-20. doi: 10.4161/19336950.2014.958922.

34.

Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current.

Gillet L, Rougier JS, Shy D, Sonntag S, Mougenot N, Essers M, Shmerling D, Balse E, Hatem SN, Abriel H.

Heart Rhythm. 2015 Jan;12(1):181-92. doi: 10.1016/j.hrthm.2014.09.057. Epub 2014 Nov 18.

PMID:
25447080
35.

Inherited progressive cardiac conduction disorders.

Baruteau AE, Probst V, Abriel H.

Curr Opin Cardiol. 2015 Jan;30(1):33-9. doi: 10.1097/HCO.0000000000000134. Review.

36.

Late cardiac sodium current can be assessed using automated patch-clamp.

Chevalier M, Amuzescu B, Gawali V, Todt H, Knott T, Scheel O, Abriel H.

F1000Res. 2014 Oct 16;3:245. doi: 10.12688/f1000research.5544.1. eCollection 2014.

37.

Targeting the sodium channel NaV1.5 to specific membrane compartments of cardiac cells: not a simple task!

Shy D, Gillet L, Abriel H.

Circ Res. 2014 Nov 7;115(11):901-3. doi: 10.1161/CIRCRESAHA.114.305305. No abstract available.

PMID:
25378529
38.

Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels.

Rougier JS, Albesa M, Syam N, Halet G, Abriel H, Viard P.

Pflugers Arch. 2015 Sep;467(9):1919-29. doi: 10.1007/s00424-014-1636-6. Epub 2014 Nov 5.

39.

Elucidating sodium channel NaV1.5 clustering in cardiac myocytes using super-resolution techniques.

Gillet L, Shy D, Abriel H.

Cardiovasc Res. 2014 Nov 1;104(2):231-3. doi: 10.1093/cvr/cvu221. Epub 2014 Oct 23. No abstract available.

PMID:
25341893
40.

p.L1612P, a novel voltage-gated sodium channel Nav1.7 mutation inducing a cold sensitive paroxysmal extreme pain disorder.

Suter MR, Bhuiyan ZA, Laedermann CJ, Kuntzer T, Schaller M, Stauffacher MW, Roulet E, Abriel H, Decosterd I, Wider C.

Anesthesiology. 2015 Feb;122(2):414-23. doi: 10.1097/ALN.0000000000000476.

41.

Gain-of-function mutation of the SCN5A gene causes exercise-induced polymorphic ventricular arrhythmias.

Swan H, Amarouch MY, Leinonen J, Marjamaa A, Kucera JP, Laitinen-Forsblom PJ, Lahtinen AM, Palotie A, Kontula K, Toivonen L, Abriel H, Widen E.

Circ Cardiovasc Genet. 2014 Dec;7(6):771-81. doi: 10.1161/CIRCGENETICS.114.000703. Epub 2014 Sep 10.

42.

PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.

Shy D, Gillet L, Ogrodnik J, Albesa M, Verkerk AO, Wolswinkel R, Rougier JS, Barc J, Essers MC, Syam N, Marsman RF, van Mil AM, Rotman S, Redon R, Bezzina CR, Remme CA, Abriel H.

Circulation. 2014 Jul 8;130(2):147-60. doi: 10.1161/CIRCULATIONAHA.113.007852. Epub 2014 Jun 3.

PMID:
24895455
43.

Ubiquitylation of voltage-gated sodium channels.

Laedermann CJ, Decosterd I, Abriel H.

Handb Exp Pharmacol. 2014;221:231-50. doi: 10.1007/978-3-642-41588-3_11. Review.

PMID:
24737239
44.

Unexpected α-α interactions with NaV1.5 genetic variants in Brugada syndrome.

Abriel H, Sottas V.

Circ Cardiovasc Genet. 2014 Apr;7(2):97-9. doi: 10.1161/CIRCGENETICS.114.000590. No abstract available.

PMID:
24736849
45.

Glycosylation of TRPM4 and TRPM5 channels: molecular determinants and functional aspects.

Syam N, Rougier JS, Abriel H.

Front Cell Neurosci. 2014 Feb 24;8:52. doi: 10.3389/fncel.2014.00052. eCollection 2014.

46.

Electrophysiological properties of mouse and epitope-tagged human cardiac sodium channel Na v1.5 expressed in HEK293 cells.

Reinhard K, Rougier JS, Ogrodnik J, Abriel H.

Version 2. F1000Res. 2013 Feb 13 [revised 2013 Jan 1];2:48. doi: 10.12688/f1000research.2-48.v2. eCollection 2013.

47.

Computational tools to investigate genetic cardiac channelopathies.

Abriel H, de Lange E, Kucera JP, Loussouarn G, Tarek M.

Front Physiol. 2013 Dec 26;4:390. doi: 10.3389/fphys.2013.00390. eCollection 2013.

48.

Expression, purification, and projection structure by single particle electron microscopy of functional human TRPM4 heterologously expressed in Xenopus laevis oocytes.

Clémençon B, Fine M, Lüscher B, Baumann MU, Surbek DV, Abriel H, Hediger MA.

Protein Expr Purif. 2014 Mar;95:169-76. doi: 10.1016/j.pep.2013.11.017. Epub 2013 Dec 10.

PMID:
24333049
49.

A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.

Andersen MN, Krzystanek K, Petersen F, Bomholtz SH, Olesen SP, Abriel H, Jespersen T, Rasmussen HB.

J Biol Chem. 2013 Dec 27;288(52):36841-54. doi: 10.1074/jbc.M113.525931. Epub 2013 Nov 8.

50.

β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells.

Laedermann CJ, Syam N, Pertin M, Decosterd I, Abriel H.

Front Cell Neurosci. 2013 Aug 30;7:137. doi: 10.3389/fncel.2013.00137. eCollection 2013.

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