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Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice.

Capitano M, Zhao L, Cooper S, Thorsheim C, Suzuki A, Huang X, Dent AL, Marks MS, Abrams CS, Broxmeyer HE.

Blood. 2018 Sep 6;132(10):1027-1038. doi: 10.1182/blood-2017-09-806257. Epub 2018 Jul 24.


Selectins and chemokines use shared and distinct signals to activate β2 integrins in neutrophils.

Yago T, Zhang N, Zhao L, Abrams CS, McEver RP.

Blood Adv. 2018 Apr 10;2(7):731-744. doi: 10.1182/bloodadvances.2017015602.


A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis.

Xie Z, Hur SK, Zhao L, Abrams CS, Bankaitis VA.

Dev Cell. 2018 Mar 26;44(6):725-740.e4. doi: 10.1016/j.devcel.2018.02.025.


Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.

Zhao B, Mei Y, Cao L, Zhang J, Sumagin R, Yang J, Gao J, Schipma MJ, Wang Y, Thorsheim C, Zhao L, Stalker T, Stein B, Wen QJ, Crispino JD, Abrams CS, Ji P.

J Clin Invest. 2018 Jan 2;128(1):125-140. doi: 10.1172/JCI94518. Epub 2017 Nov 20.


Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis.

Zhao L, Thorsheim CL, Suzuki A, Stalker TJ, Min SH, Lian L, Fairn GD, Cockcroft S, Durham A, Krishnaswamy S, Abrams CS.

Nat Commun. 2017 Oct 31;8(1):1216. doi: 10.1038/s41467-017-01181-4.


Rapid Evaluation of Platelet Function With T2 Magnetic Resonance.

Cuker A, Husseinzadeh H, Lebedeva T, Marturano JE, Massefski W, Lowery TJ, Lambert MP, Abrams CS, Weisel JW, Cines DB.

Am J Clin Pathol. 2016 Dec;146(6):681-693. doi: 10.1093/ajcp/aqw189. Epub 2016 Dec 27.


PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.

Mironova YA, Lenk GM, Lin JP, Lee SJ, Twiss JL, Vaccari I, Bolino A, Havton LA, Min SH, Abrams CS, Shrager P, Meisler MH, Giger RJ.

Elife. 2016 Mar 23;5. pii: e13023. doi: 10.7554/eLife.13023.


Membrane grease eases platelet maturation.

Min SH, Abrams CS.

Blood. 2015 Aug 27;126(9):1055-6. doi: 10.1182/blood-2015-07-655241.


How I treat refractory thrombotic thrombocytopenic purpura.

Sayani FA, Abrams CS.

Blood. 2015 Jun 18;125(25):3860-7. doi: 10.1182/blood-2014-11-551580. Epub 2015 Mar 17. Review. Erratum in: Blood. 2017 Oct 5;130(14 ):1684.


Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models.

Meng R, Wu J, Harper DC, Wang Y, Kowalska MA, Abrams CS, Brass LF, Poncz M, Stalker TJ, Marks MS.

Blood. 2015 Mar 5;125(10):1623-32. doi: 10.1182/blood-2014-07-586727. Epub 2014 Dec 4.


Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.

Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS.

Nat Commun. 2014 Sep 2;5:4691. doi: 10.1038/ncomms5691.


Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation.

Lian L, Suzuki A, Hayes V, Saha S, Han X, Xu T, Yates JR 3rd, Poncz M, Kashina A, Abrams CS.

Haematologica. 2014 Mar;99(3):554-60. doi: 10.3324/haematol.2013.093047. Epub 2013 Nov 29.


Kindlin ignites a new flame.

Abrams CS.

Blood. 2013 Oct 3;122(14):2297-8. doi: 10.1182/blood-2013-08-519868. No abstract available.


RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation.

Suzuki A, Shin JW, Wang Y, Min SH, Poncz M, Choi JK, Discher DE, Carpenter CL, Lian L, Zhao L, Wang Y, Abrams CS.

PLoS One. 2013 Jul 23;8(7):e69315. doi: 10.1371/journal.pone.0069315. Print 2013.


Regulation of platelet plug formation by phosphoinositide metabolism.

Min SH, Abrams CS.

Blood. 2013 Aug 22;122(8):1358-65. doi: 10.1182/blood-2013-05-427716. Epub 2013 Jun 11. Review.


Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion.

Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS.

Blood. 2013 Apr 4;121(14):2743-52. doi: 10.1182/blood-2012-07-445205. Epub 2013 Jan 31.


The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients.

Hook KM, Abrams CS.

Clin Transl Sci. 2012 Feb;5(1):85-92. doi: 10.1111/j.1752-8062.2011.00351.x. Epub 2011 Dec 7. Review.


Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction.

Wang Y, Meng R, Hayes V, Fuentes R, Yu X, Abrams CS, Heijnen HF, Blobel GA, Marks MS, Poncz M.

Blood. 2011 Dec 1;118(23):6183-91. doi: 10.1182/blood-2011-06-363580. Epub 2011 Oct 11.


What is vinculin needed for in platelets?

Mitsios JV, Prevost N, Kasirer-Friede A, Gutierrez E, Groisman A, Abrams CS, Wang Y, Litvinov RI, Zemljic-Harpf A, Ross RS, Shattil SJ.

J Thromb Haemost. 2010 Oct;8(10):2294-304. doi: 10.1111/j.1538-7836.2010.03998.x.


Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain.

Volpicelli-Daley LA, Lucast L, Gong LW, Liu L, Sasaki J, Sasaki T, Abrams CS, Kanaho Y, De Camilli P.

J Biol Chem. 2010 Sep 10;285(37):28708-14. doi: 10.1074/jbc.M110.132191. Epub 2010 Jul 9.


Treatment options in heparin-induced thrombocytopenia.

Hook KM, Abrams CS.

Curr Opin Hematol. 2010 Sep;17(5):424-31. doi: 10.1097/MOH.0b013e32833c07a7. Review.


Six-month follow-up of patients with in-hospital thrombocytopenia during heparin-based anticoagulation (from the Complications After Thrombocytopenia Caused by Heparin [CATCH] registry).

Lopes RD, Ohman EM, Granger CB, Honeycutt EF, Anstrom KJ, Berger PB, Crespo EM, Oliveira GB, Moll S, Moliterno DJ, Abrams CS, Becker RC.

Am J Cardiol. 2009 Nov 1;104(9):1285-91. doi: 10.1016/j.amjcard.2009.06.045.


Why do phosphatidylinositol kinases have so many isoforms?

Min SH, Abrams CS.

Biochem J. 2009 Sep 14;423(1):e5-8. doi: 10.1042/BJ20091274.


Evaluation and management of thrombocytopenia and suspected heparin-induced thrombocytopenia in hospitalized patients: The Complications After Thrombocytopenia Caused by Heparin (CATCH) registry.

Crespo EM, Oliveira GB, Honeycutt EF, Becker RC, Berger PB, Moliterno DJ, Anstrom KJ, Abrams CS, Kleiman NS, Moll S, Rice L, Rodgers JE, Steinhubl SR, Tapson VF, Granger CB, Ohman EM; CATCH Registry Investigators.

Am Heart J. 2009 Apr;157(4):651-7. doi: 10.1016/j.ahj.2009.01.005. Epub 2009 Mar 17.


Romiplostim: chronic therapy for a chronic disease?

Cuker A, Abrams CS.

Blood. 2009 Mar 5;113(10):2122-3. doi: 10.1182/blood-2008-12-191486. No abstract available.


Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis.

Lian L, Wang Y, Flick M, Choi J, Scott EW, Degen J, Lemmon MA, Abrams CS.

Blood. 2009 Apr 9;113(15):3577-84. doi: 10.1182/blood-2008-09-178913. Epub 2009 Feb 3.


Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis.

Mao YS, Yamaga M, Zhu X, Wei Y, Sun HQ, Wang J, Yun M, Wang Y, Di Paolo G, Bennett M, Mellman I, Abrams CS, De Camilli P, Lu CY, Yin HL.

J Cell Biol. 2009 Jan 26;184(2):281-96. doi: 10.1083/jcb.200806121. Epub 2009 Jan 19.


Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.

Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D.

Science. 2008 Sep 5;321(5894):1350-3. doi: 10.1126/science.1160741.


Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.

Wang Y, Chen X, Lian L, Tang T, Stalker TJ, Sasaki T, Kanaho Y, Brass LF, Choi JK, Hartwig JH, Abrams CS.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14064-9. doi: 10.1073/pnas.0804139105. Epub 2008 Sep 4. Erratum in: Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1291. Kanaho, Yasunori [added].


Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.

Bezman NA, Lian L, Abrams CS, Brass LF, Kahn ML, Jordan MS, Koretzky GA.

J Exp Med. 2008 Aug 4;205(8):1775-88. doi: 10.1084/jem.20080240. Epub 2008 Jul 28.


Incidence and prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy.

Oliveira GB, Crespo EM, Becker RC, Honeycutt EF, Abrams CS, Anstrom KJ, Berger PB, Davidson-Ray LD, Eisenstein EL, Kleiman NS, Moliterno DJ, Moll S, Rice L, Rodgers JE, Steinhubl SR, Tapson VF, Ohman EM, Granger CB; Complications After Thrombocytopenia Caused by Heparin (CATCH) Registry Investigators.

Arch Intern Med. 2008 Jan 14;168(1):94-102. doi: 10.1001/archinternmed.2007.65.


Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.

Wang Y, Litvinov RI, Chen X, Bach TL, Lian L, Petrich BG, Monkley SJ, Kanaho Y, Critchley DR, Sasaki T, Birnbaum MJ, Weisel JW, Hartwig J, Abrams CS.

J Clin Invest. 2008 Feb;118(2):812-9. doi: 10.1172/JCI34239. Erratum in: J Clin Invest. 2009 Feb;119(2):421. Kanaho, Yasunori [added].


New insights and therapeutics for immune-mediated thrombocytopenia.

Metjian A, Abrams CS.

Expert Rev Cardiovasc Ther. 2008 Jan;6(1):71-84. Review.


Phospholipase cbeta is critical for T cell chemotaxis.

Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS.

J Immunol. 2007 Aug 15;179(4):2223-7.


A novel testis ubiquitin-binding protein gene arose by exon shuffling in hominoids.

Babushok DV, Ohshima K, Ostertag EM, Chen X, Wang Y, Mandal PK, Okada N, Abrams CS, Kazazian HH Jr.

Genome Res. 2007 Aug;17(8):1129-38. Epub 2007 Jul 10.


PIP5KI gamma is required for cardiovascular and neuronal development.

Wang Y, Lian L, Golden JA, Morrisey EE, Abrams CS.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11748-53. Epub 2007 Jul 3.


Bexarotene blunts malignant T-cell chemotaxis in Sezary syndrome: reduction of chemokine receptor 4-positive lymphocytes and decreased chemotaxis to thymus and activation-regulated chemokine.

Richardson SK, Newton SB, Bach TL, Budgin JB, Benoit BM, Lin JH, Yoon JS, Wysocka M, Abrams CS, Rook AH.

Am J Hematol. 2007 Sep;82(9):792-7.


Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.

Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA.

Nat Med. 2007 Mar;13(3):324-31. Epub 2007 Feb 18.


PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.

Bach TL, Kerr WT, Wang Y, Bauman EM, Kine P, Whiteman EL, Morgan RS, Williamson EK, Ostap EM, Burkhardt JK, Koretzky GA, Birnbaum MJ, Abrams CS.

Blood. 2007 Feb 1;109(3):1147-55. Epub 2006 Sep 28.


A new horizon for the treatment of heparin-induced thrombocytopenia?

Abrams CS.

Curr Hematol Rep. 2006 Mar;5(1):1-4. Review. No abstract available.


Clinical presentation and laboratory diagnosis of heparin-induced thrombocytopenia.

Pollak ES, Abrams CS.

Semin Thorac Cardiovasc Surg. 2005 Spring;17(1):80-4. Review.


Intracellular signaling in platelets.

Abrams CS.

Curr Opin Hematol. 2005 Sep;12(5):401-5. Review.


Identification, diagnosis and treatment of heparin-induced thrombocytopenia and thrombosis: a registry of prolonged heparin use and thrombocytopenia among hospitalized patients with and without cardiovascular disease. The Complication After Thrombocytopenia Caused by Heparin (CATCH) Registry steering committee.

Ohman EM, Granger CB, Rice L, Abrams CS, Becker RC, Berger PB, Kleiman NS, Moliterno D, Moll S, Rodgers JE, Steinhubl SS, Tapson VF, Sinnaeve P, Anstrom KJ; Complication After Thrombocytopenia Caused by Heparin (CATCH) Registry.

J Thromb Thrombolysis. 2005 Feb;19(1):11-9.


The relative role of PLCbeta and PI3Kgamma in platelet activation.

Lian L, Wang Y, Draznin J, Eslin D, Bennett JS, Poncz M, Wu D, Abrams CS.

Blood. 2005 Jul 1;106(1):110-7. Epub 2005 Feb 10.


Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets.

Yang SA, Carpenter CL, Abrams CS.

J Biol Chem. 2004 Oct 1;279(40):42331-6. Epub 2004 Jul 23.


Atrial fibrillation and strokes: new drugs and a new attitude.

Abrams CS, Merli GJ.

Am J Manag Care. 2004 Apr;10(3 Suppl):S48-9. Review. No abstract available.


Signaling, drugs and apoptosis of myeloma cells.

Carroll M, Abrams CS.

Cancer Biol Ther. 2004 Feb;3(2):195-6. Epub 2004 Feb 1. No abstract available.


Thrombocytopenia after treatment with platelet glycoprotein IIb/IIIa inhibitors.

Abrams CS, Cines DB.

Curr Hematol Rep. 2004 Mar;3(2):143-7. Review.


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