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Items: 37


Molecular characterization of Mycobacterium bovis infection in cattle and buffalo in Amazon Region, Brazil.

Carneiro PAM, Pasquatti TN, Takatani H, Zumárraga MJ, Marfil MJ, Barnard C, Fitzgerald SD, Abramovitch RB, Araujo FR, Kaneene JB.

Vet Med Sci. 2019 Sep 30. doi: 10.1002/vms3.203. [Epub ahead of print]


Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme.

Zheng H, Williams JT, Aleiwi B, Ellsworth E, Abramovitch RB.

ACS Chem Biol. 2019 Oct 14. doi: 10.1021/acschembio.8b00849. [Epub ahead of print]


Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance.

Williams JT, Haiderer ER, Coulson GB, Conner KN, Ellsworth E, Chen C, Alvarez-Cabrera N, Li W, Jackson M, Dick T, Abramovitch RB.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00547-19. doi: 10.1128/AAC.00547-19. Print 2019 Oct.


Acid Fasting: Modulation of Mycobacterium tuberculosis Metabolism at Acidic pH.

Baker JJ, Dechow SJ, Abramovitch RB.

Trends Microbiol. 2019 Jul 16. pii: S0966-842X(19)30160-X. doi: 10.1016/j.tim.2019.06.005. [Epub ahead of print] Review.


2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain.

Jeon AB, Ackart DF, Li W, Jackson M, Melander RJ, Melander C, Abramovitch RB, Chicco AJ, Basaraba RJ, Obregón-Henao A.

Sci Rep. 2019 Feb 6;9(1):1513. doi: 10.1038/s41598-018-38064-7.


Mycobacterium tuberculosis Reporter Strains as Tools for Drug Discovery and Development.

Abramovitch RB.

IUBMB Life. 2018 Sep;70(9):818-825. doi: 10.1002/iub.1862. Epub 2018 Apr 29. Review.


HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter.

Zheng H, Williams JT, Coulson GB, Haiderer ER, Abramovitch RB.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e02459-17. doi: 10.1128/AAC.02459-17. Print 2018 Jul.


Genetic and metabolic regulation of Mycobacterium tuberculosis acid growth arrest.

Baker JJ, Abramovitch RB.

Sci Rep. 2018 Mar 8;8(1):4168. doi: 10.1038/s41598-018-22343-4.


WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum.

Bosserman RE, Nguyen TT, Sanchez KG, Chirakos AE, Ferrell MJ, Thompson CR, Champion MM, Abramovitch RB, Champion PA.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10772-E10781. doi: 10.1073/pnas.1710167114. Epub 2017 Nov 27.


Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics.

Coulson GB, Johnson BK, Zheng H, Colvin CJ, Fillinger RJ, Haiderer ER, Hammer ND, Abramovitch RB.

Cell Chem Biol. 2017 Aug 17;24(8):993-1004.e4. doi: 10.1016/j.chembiol.2017.06.018. Epub 2017 Aug 3.


2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

Jeon AB, Obregón-Henao A, Ackart DF, Podell BK, Belardinelli JM, Jackson M, Nguyen TV, Blackledge MS, Melander RJ, Melander C, Johnson BK, Abramovitch RB, Basaraba RJ.

PLoS One. 2017 Jul 27;12(7):e0180925. doi: 10.1371/journal.pone.0180925. eCollection 2017.


A bioluminescent Pseudomonas aeruginosa wound model reveals increased mortality of type 1 diabetic mice to biofilm infection.

Agostinho Hunt AM, Gibson JA, Larrivee CL, O'Reilly S, Navitskaya S, Needle DB, Abramovitch RB, Busik JV, Waters CM.

J Wound Care. 2017 Jul 1;26(Sup7):S24-S33. doi: 10.12968/jowc.2017.26.Sup7.S24.


Small Molecules That Sabotage Bacterial Virulence.

Johnson BK, Abramovitch RB.

Trends Pharmacol Sci. 2017 Apr;38(4):339-362. doi: 10.1016/ Epub 2017 Feb 14. Review.


Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence.

Zheng H, Colvin CJ, Johnson BK, Kirchhoff PD, Wilson M, Jorgensen-Muga K, Larsen SD, Abramovitch RB.

Nat Chem Biol. 2017 Feb;13(2):218-225. doi: 10.1038/nchembio.2259. Epub 2016 Dec 19.


A Nonsense Mutation in Mycobacterium marinum That Is Suppressible by a Novel Mechanism.

Williams EA, Mba Medie F, Bosserman RE, Johnson BK, Reyna C, Ferrell MJ, Champion MM, Abramovitch RB, Champion PA.

Infect Immun. 2017 Jan 26;85(2). pii: e00653-16. doi: 10.1128/IAI.00653-16. Print 2017 Feb.


Polysorbates prevent biofilm formation and pathogenesis of Escherichia coli O104:H4.

Sloup RE, Cieza RJ, Needle DB, Abramovitch RB, Torres AG, Waters CM.

Biofouling. 2016 Oct;32(9):1131-1140.


Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo.

Liu Y, Tan S, Huang L, Abramovitch RB, Rohde KH, Zimmerman MD, Chen C, Dartois V, VanderVen BC, Russell DG.

J Exp Med. 2016 May 2;213(5):809-25. doi: 10.1084/jem.20151248. Epub 2016 Apr 25.


SPARTA: Simple Program for Automated reference-based bacterial RNA-seq Transcriptome Analysis.

Johnson BK, Scholz MB, Teal TK, Abramovitch RB.

BMC Bioinformatics. 2016 Feb 4;17:66. doi: 10.1186/s12859-016-0923-y.


The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence.

Johnson BK, Colvin CJ, Needle DB, Mba Medie F, Champion PA, Abramovitch RB.

Antimicrob Agents Chemother. 2015 Aug;59(8):4436-45. doi: 10.1128/AAC.00719-15. Epub 2015 May 18.


Macrophage infection models for Mycobacterium tuberculosis.

Johnson BK, Abramovitch RB.

Methods Mol Biol. 2015;1285:329-41. doi: 10.1007/978-1-4939-2450-9_20.


Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment.

VanderVen BC, Fahey RJ, Lee W, Liu Y, Abramovitch RB, Memmott C, Crowe AM, Eltis LD, Perola E, Deininger DD, Wang T, Locher CP, Russell DG.

PLoS Pathog. 2015 Feb 12;11(2):e1004679. doi: 10.1371/journal.ppat.1004679. eCollection 2015 Feb.


Slow growth of Mycobacterium tuberculosis at acidic pH is regulated by phoPR and host-associated carbon sources.

Baker JJ, Johnson BK, Abramovitch RB.

Mol Microbiol. 2014 Oct;94(1):56-69. doi: 10.1111/mmi.12688. Epub 2014 Jul 13.


Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell.

Tan S, Sukumar N, Abramovitch RB, Parish T, Russell DG.

PLoS Pathog. 2013;9(4):e1003282. doi: 10.1371/journal.ppat.1003282. Epub 2013 Apr 4.


aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome.

Abramovitch RB, Rohde KH, Hsu FF, Russell DG.

Mol Microbiol. 2011 May;80(3):678-94. doi: 10.1111/j.1365-2958.2011.07601.x. Epub 2011 Mar 14.


Mycobacterium tuberculosis wears what it eats.

Russell DG, VanderVen BC, Lee W, Abramovitch RB, Kim MJ, Homolka S, Niemann S, Rohde KH.

Cell Host Microbe. 2010 Jul 22;8(1):68-76. doi: 10.1016/j.chom.2010.06.002. Review.


Mycobacterium tuberculosis invasion of macrophages: linking bacterial gene expression to environmental cues.

Rohde KH, Abramovitch RB, Russell DG.

Cell Host Microbe. 2007 Nov 15;2(5):352-64.


The N-terminal region of Pseudomonas type III effector AvrPtoB elicits Pto-dependent immunity and has two distinct virulence determinants.

Xiao F, He P, Abramovitch RB, Dawson JE, Nicholson LK, Sheen J, Martin GB.

Plant J. 2007 Nov;52(4):595-614. Epub 2007 Aug 31.


A bacterial E3 ubiquitin ligase targets a host protein kinase to disrupt plant immunity.

Rosebrock TR, Zeng L, Brady JJ, Abramovitch RB, Xiao F, Martin GB.

Nature. 2007 Jul 19;448(7151):370-4.


Bacterial elicitation and evasion of plant innate immunity.

Abramovitch RB, Anderson JC, Martin GB.

Nat Rev Mol Cell Biol. 2006 Aug;7(8):601-11. Review.


Type III effector AvrPtoB requires intrinsic E3 ubiquitin ligase activity to suppress plant cell death and immunity.

Abramovitch RB, Janjusevic R, Stebbins CE, Martin GB.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2851-6. Epub 2006 Feb 13.


A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase.

Janjusevic R, Abramovitch RB, Martin GB, Stebbins CE.

Science. 2006 Jan 13;311(5758):222-6. Epub 2005 Dec 22.


Strategies used by bacterial pathogens to suppress plant defenses.

Abramovitch RB, Martin GB.

Curr Opin Plant Biol. 2004 Aug;7(4):356-64. Review.


The ukb1 gene encodes a putative protein kinase required for bud site selection and pathogenicity in Ustilago maydis.

Abramovitch RB, Yang G, Kronstad JW.

Fungal Genet Biol. 2002 Oct;37(1):98-108.


Genomewide identification of Pseudomonas syringae pv. tomato DC3000 promoters controlled by the HrpL alternative sigma factor.

Fouts DE, Abramovitch RB, Alfano JR, Baldo AM, Buell CR, Cartinhour S, Chatterjee AK, D'Ascenzo M, Gwinn ML, Lazarowitz SG, Lin NC, Martin GB, Rehm AH, Schneider DJ, van Dijk K, Tang X, Collmer A.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2275-80.

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