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Mycobacterium tuberculosis Reporter Strains as Tools for Drug Discovery and Development.

Abramovitch RB.

IUBMB Life. 2018 Sep;70(9):818-825. doi: 10.1002/iub.1862. Epub 2018 Apr 29. Review.


HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter.

Zheng H, Williams JT, Coulson GB, Haiderer ER, Abramovitch RB.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e02459-17. doi: 10.1128/AAC.02459-17. Print 2018 Jul.


Genetic and metabolic regulation of Mycobacterium tuberculosis acid growth arrest.

Baker JJ, Abramovitch RB.

Sci Rep. 2018 Mar 8;8(1):4168. doi: 10.1038/s41598-018-22343-4.


CXCR4 Promotes Neuroblastoma Growth and Therapeutic Resistance through miR-15a/16-1-Mediated ERK and BCL2/Cyclin D1 Pathways.

Klein S, Abraham M, Bulvik B, Dery E, Weiss ID, Barashi N, Abramovitch R, Wald H, Harel Y, Olam D, Weiss L, Beider K, Eizenberg O, Wald O, Galun E, Pereg Y, Peled A.

Cancer Res. 2018 Mar 15;78(6):1471-1483. doi: 10.1158/0008-5472.CAN-17-0454. Epub 2017 Dec 19.


WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum.

Bosserman RE, Nguyen TT, Sanchez KG, Chirakos AE, Ferrell MJ, Thompson CR, Champion MM, Abramovitch RB, Champion PA.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10772-E10781. doi: 10.1073/pnas.1710167114. Epub 2017 Nov 27.


BOLD-MRI demonstrates acute placental and fetal organ hypoperfusion with fetal brain sparing during hypercapnia.

Ginosar Y, Gielchinsky Y, Nachmansson N, Hagai L, Shapiro J, Elchalal U, Abramovitch R.

Placenta. 2018 Mar;63:53-60. doi: 10.1016/j.placenta.2017.09.005. Epub 2017 Sep 11.


Impaired liver regeneration after hepatectomy and bleeding is associated with a shift from hepatocyte proliferation to hypertrophy.

Matot I, Nachmansson N, Duev O, Schulz S, Schroeder-Stein K, Frede S, Abramovitch R.

FASEB J. 2017 Dec;31(12):5283-5295. doi: 10.1096/fj.201700153R. Epub 2017 Aug 8.


Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics.

Coulson GB, Johnson BK, Zheng H, Colvin CJ, Fillinger RJ, Haiderer ER, Hammer ND, Abramovitch RB.

Cell Chem Biol. 2017 Aug 17;24(8):993-1004.e4. doi: 10.1016/j.chembiol.2017.06.018. Epub 2017 Aug 3.


2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

Jeon AB, Obregón-Henao A, Ackart DF, Podell BK, Belardinelli JM, Jackson M, Nguyen TV, Blackledge MS, Melander RJ, Melander C, Johnson BK, Abramovitch RB, Basaraba RJ.

PLoS One. 2017 Jul 27;12(7):e0180925. doi: 10.1371/journal.pone.0180925. eCollection 2017.


A bioluminescent Pseudomonas aeruginosa wound model reveals increased mortality of type 1 diabetic mice to biofilm infection.

Agostinho Hunt AM, Gibson JA, Larrivee CL, O'Reilly S, Navitskaya S, Needle DB, Abramovitch RB, Busik JV, Waters CM.

J Wound Care. 2017 Jul 1;26(Sup7):S24-S33. doi: 10.12968/jowc.2017.26.Sup7.S24.


Small Molecules That Sabotage Bacterial Virulence.

Johnson BK, Abramovitch RB.

Trends Pharmacol Sci. 2017 Apr;38(4):339-362. doi: 10.1016/ Epub 2017 Feb 14. Review.


Interleukin 6-dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis.

Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, Rosenberg N, Paldor M, Goldenberg D, Sonnenblick A, Peled A, Rose-John S, Galun E, Axelrod JH.

Hepatology. 2017 May;65(5):1600-1611. doi: 10.1002/hep.29004. Epub 2017 Mar 23.


Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence.

Zheng H, Colvin CJ, Johnson BK, Kirchhoff PD, Wilson M, Jorgensen-Muga K, Larsen SD, Abramovitch RB.

Nat Chem Biol. 2017 Feb;13(2):218-225. doi: 10.1038/nchembio.2259. Epub 2016 Dec 19.


A Nonsense Mutation in Mycobacterium marinum That Is Suppressible by a Novel Mechanism.

Williams EA, Mba Medie F, Bosserman RE, Johnson BK, Reyna C, Ferrell MJ, Champion MM, Abramovitch RB, Champion PA.

Infect Immun. 2017 Jan 26;85(2). pii: e00653-16. doi: 10.1128/IAI.00653-16. Print 2017 Feb.


Cyclosporin a induces renal episodic hypoxia.

Fähling M, Mathia S, Scheidl J, Abramovitch R, Milman Z, Paliege A, Peters H, Persson PB, Heyman SN, Rosenberger C.

Acta Physiol (Oxf). 2017 Mar;219(3):625-639. doi: 10.1111/apha.12811. Epub 2016 Oct 18.


Polysorbates prevent biofilm formation and pathogenesis of Escherichia coli O104:H4.

Sloup RE, Cieza RJ, Needle DB, Abramovitch RB, Torres AG, Waters CM.

Biofouling. 2016 Oct;32(9):1131-1140.


Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo.

Liu Y, Tan S, Huang L, Abramovitch RB, Rohde KH, Zimmerman MD, Chen C, Dartois V, VanderVen BC, Russell DG.

J Exp Med. 2016 May 2;213(5):809-25. doi: 10.1084/jem.20151248. Epub 2016 Apr 25.


SPARTA: Simple Program for Automated reference-based bacterial RNA-seq Transcriptome Analysis.

Johnson BK, Scholz MB, Teal TK, Abramovitch RB.

BMC Bioinformatics. 2016 Feb 4;17:66. doi: 10.1186/s12859-016-0923-y.


The knockdown of H19lncRNA reveals its regulatory role in pluripotency and tumorigenesis of human embryonic carcinoma cells.

Zeira E, Abramovitch R, Meir K, Even Ram S, Gil Y, Bulvik B, Bromberg Z, Levkovitch O, Nahmansson N, Adar R, Reubinoff B, Galun E, Gropp M.

Oncotarget. 2015 Oct 27;6(33):34691-703. doi: 10.18632/oncotarget.5787.


Inhaled carbon dioxide causes dose-dependent paradoxical bradypnea in animals anesthetized with pentobarbital, but not with isoflurane or ketamine.

Ginosar Y, Nachmanson NC, Shapiro J, Weissman C, Abramovitch R.

Respir Physiol Neurobiol. 2015 Oct;217:1-7. doi: 10.1016/j.resp.2015.06.003. Epub 2015 Jun 19.


The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence.

Johnson BK, Colvin CJ, Needle DB, Mba Medie F, Champion PA, Abramovitch RB.

Antimicrob Agents Chemother. 2015 Aug;59(8):4436-45. doi: 10.1128/AAC.00719-15. Epub 2015 May 18.


Macrophage infection models for Mycobacterium tuberculosis.

Johnson BK, Abramovitch RB.

Methods Mol Biol. 2015;1285:329-41. doi: 10.1007/978-1-4939-2450-9_20.


Practical Applications of in Vivo and ex Vivo MRI in Toxicologic Pathology Using a Novel High-performance Compact MRI System.

Tempel-Brami C, Schiffenbauer YS, Nyska A, Ezov N, Spector I, Abramovitch R, Maronpot RR.

Toxicol Pathol. 2015 Jul;43(5):633-50. doi: 10.1177/0192623314568390. Epub 2015 Feb 18. Review.


Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment.

VanderVen BC, Fahey RJ, Lee W, Liu Y, Abramovitch RB, Memmott C, Crowe AM, Eltis LD, Perola E, Deininger DD, Wang T, Locher CP, Russell DG.

PLoS Pathog. 2015 Feb 12;11(2):e1004679. doi: 10.1371/journal.ppat.1004679. eCollection 2015 Feb.


Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.

Hijazi N, Abu Fanne R, Abramovitch R, Yarovoi S, Higazi M, Abdeen S, Basheer M, Maraga E, Cines DB, Higazi AA.

Blood. 2015 Apr 16;125(16):2558-67. doi: 10.1182/blood-2014-08-588442. Epub 2015 Feb 11.


Monitoring brain tumor vascular heamodynamic following anti-angiogenic therapy with advanced magnetic resonance imaging in mice.

Laufer S, Mazuz A, Nachmansson N, Fellig Y, Corn BW, Bokstein F, Bashat DB, Abramovitch R.

PLoS One. 2014 Dec 15;9(12):e115093. doi: 10.1371/journal.pone.0115093. eCollection 2014.


Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver.

Ella E, Heim D, Stoyanov E, Harari-Steinfeld R, Steinfeld I, Pappo O, Perlman TS, Nachmansson N, Rivkin L, Olam D, Abramovitch R, Wege H, Galun E, Goldenberg D.

Oncotarget. 2014 Nov 15;5(21):10318-31.


Slow growth of Mycobacterium tuberculosis at acidic pH is regulated by phoPR and host-associated carbon sources.

Baker JJ, Johnson BK, Abramovitch RB.

Mol Microbiol. 2014 Oct;94(1):56-69. doi: 10.1111/mmi.12688. Epub 2014 Jul 13.


Assessment with unenhanced MRI techniques of renal morphology and hemodynamic changes during acute kidney injury and chronic kidney disease in mice.

Milman Z, Axelrod JH, Heyman SN, Nachmansson N, Abramovitch R.

Am J Nephrol. 2014;39(3):268-78. doi: 10.1159/000360093. Epub 2014 Mar 21.


TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI.

Komar-Stossel C, Gross E, Dery E, Corchia N, Meir K, Fried I, Abramovitch R.

PLoS One. 2014 Mar 6;9(3):e90224. doi: 10.1371/journal.pone.0090224. eCollection 2014.


Mutant KRAS is a druggable target for pancreatic cancer.

Zorde Khvalevsky E, Gabai R, Rachmut IH, Horwitz E, Brunschwig Z, Orbach A, Shemi A, Golan T, Domb AJ, Yavin E, Giladi H, Rivkin L, Simerzin A, Eliakim R, Khalaileh A, Hubert A, Lahav M, Kopelman Y, Goldin E, Dancour A, Hants Y, Arbel-Alon S, Abramovitch R, Shemi A, Galun E.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20723-8. doi: 10.1073/pnas.1314307110. Epub 2013 Dec 2.


Quantitative functional MRI biomarkers improved early detection of colorectal liver metastases.

Edrei Y, Freiman M, Sklair-Levy M, Tsarfaty G, Gross E, Joskowicz L, Abramovitch R.

J Magn Reson Imaging. 2014 May;39(5):1246-53. doi: 10.1002/jmri.24270. Epub 2013 Sep 4.


Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell.

Tan S, Sukumar N, Abramovitch RB, Parish T, Russell DG.

PLoS Pathog. 2013;9(4):e1003282. doi: 10.1371/journal.ppat.1003282. Epub 2013 Apr 4.


Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice.

Barashi N, Weiss ID, Wald O, Wald H, Beider K, Abraham M, Klein S, Goldenberg D, Axelrod J, Pikarsky E, Abramovitch R, Zeira E, Galun E, Peled A.

Hepatology. 2013 Sep;58(3):1021-30. doi: 10.1002/hep.26403. Epub 2013 Jul 12.


MRI multiparametric hemodynamic characterization of the normal brain.

Artzi M, Aizenstein O, Abramovitch R, Bashat DB.

Neuroscience. 2013 Jun 14;240:269-76. doi: 10.1016/j.neuroscience.2013.03.004. Epub 2013 Mar 13.


Resuscitation with aged blood exacerbates liver injury in a hemorrhagic rat model.

Matot I, Katz M, Pappo O, Zelig O, Corchia N, Yedgar S, Barshtein G, Bennett-Guerrero E, Abramovitch R.

Crit Care Med. 2013 Mar;41(3):842-9. doi: 10.1097/CCM.0b013e3182711b38. Erratum in: Crit Care Med. 2013 Apr;41(4):e41. Guerrero, Elliot Bennett [corrected to Bennett-Guerrero, Elliot].


Hemodynamic response magnetic resonance imaging: application for renal hemodynamic characterization.

Milman Z, Heyman SN, Corchia N, Edrei Y, Axelrod JH, Rosenberger C, Tsarfati G, Abramovitch R.

Nephrol Dial Transplant. 2013 May;28(5):1150-6. doi: 10.1093/ndt/gfs541. Epub 2013 Jan 4.


Hemodynamic response imaging: a potential tool for the assessment of angiogenesis in brain tumors.

Ben Bashat D, Artzi M, Ben Ami H, Aizenstein O, Blumenthal DT, Bokstein F, Corn BW, Ram Z, Kanner AA, Lifschitz-Mercer B, Solar I, Kolatt T, Palmon M, Edrei Y, Abramovitch R.

PLoS One. 2012;7(11):e49416. doi: 10.1371/journal.pone.0049416. Epub 2012 Nov 27.


Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice.

Edrei Y, Gross E, Corchia N, Abramovitch R.

Br J Cancer. 2012 Aug 7;107(4):658-66. doi: 10.1038/bjc.2012.322. Epub 2012 Jul 17.


fMRI-based hierarchical SVM model for the classification and grading of liver fibrosis.

Sela Y, Freiman M, Dery E, Edrei Y, Safadi R, Pappo O, Joskowicz L, Abramovitch R.

IEEE Trans Biomed Eng. 2011 Sep;58(9):2574-81. doi: 10.1109/TBME.2011.2159501. Epub 2011 Jun 13.


Synthesis of tetrahydronaphthalene lignan esters by intramolecular cyclization of ethyl p-azidophenyl-2-phenylalkanoates and evaluation of the growth inhibition of human tumor cell lines.

Pinto O, Sardinha J, Vaz PD, Piedade F, Calhorda MJ, Abramovitch R, Nazareth N, Pinto M, Nascimento MS, Rauter AP.

J Med Chem. 2011 May 12;54(9):3175-87. doi: 10.1021/jm101182s. Epub 2011 Apr 19.


aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome.

Abramovitch RB, Rohde KH, Hsu FF, Russell DG.

Mol Microbiol. 2011 May;80(3):678-94. doi: 10.1111/j.1365-2958.2011.07601.x. Epub 2011 Mar 14.


Vascular profile characterization of liver tumors by magnetic resonance imaging using hemodynamic response imaging in mice.

Edrei Y, Gross E, Corchia N, Tsarfaty G, Galun E, Pappo O, Abramovitch R.

Neoplasia. 2011 Mar;13(3):244-53.


Mycobacterium tuberculosis wears what it eats.

Russell DG, VanderVen BC, Lee W, Abramovitch RB, Kim MJ, Homolka S, Niemann S, Rohde KH.

Cell Host Microbe. 2010 Jul 22;8(1):68-76. doi: 10.1016/j.chom.2010.06.002. Review.


Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: signaling partners, hierarchy and physiological significance.

Cohen I, Maoz M, Turm H, Grisaru-Granovsky S, Maly B, Uziely B, Weiss E, Abramovitch R, Gross E, Barzilay O, Qiu Y, Bar-Shavit R.

PLoS One. 2010 Jun 15;5(6):e11135. doi: 10.1371/journal.pone.0011135. Erratum in: PLoS One. 2010;5(12) doi: 10.1371/annotation/7ed84180-ec3d-46c0-8c10-f7b830999f8d.


Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia/hypertrophy switch.

Gielchinsky Y, Laufer N, Weitman E, Abramovitch R, Granot Z, Bergman Y, Pikarsky E.

Genes Dev. 2010 Mar 15;24(6):543-8. doi: 10.1101/gad.563110.


Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks.

Barash H, R Gross E, Edrei Y, Ella E, Israel A, Cohen I, Corchia N, Ben-Moshe T, Pappo O, Pikarsky E, Goldenberg D, Shiloh Y, Galun E, Abramovitch R.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2207-12. doi: 10.1073/pnas.0908867107. Epub 2010 Jan 25.


Toll-like receptor 3 signaling attenuates liver regeneration.

Zorde-Khvalevsky E, Abramovitch R, Barash H, Spivak-Pohis I, Rivkin L, Rachmilewitz J, Galun E, Giladi H.

Hepatology. 2009 Jul;50(1):198-206. doi: 10.1002/hep.22973.


Interaction between CXCR4 and CCL20 pathways regulates tumor growth.

Beider K, Abraham M, Begin M, Wald H, Weiss ID, Wald O, Pikarsky E, Abramovitch R, Zeira E, Galun E, Nagler A, Peled A.

PLoS One. 2009;4(4):e5125. doi: 10.1371/journal.pone.0005125. Epub 2009 Apr 2.


Classification of suspected liver metastases using fMRI images: a machine learning approach.

Freiman M, Edrei Y, Sela Y, Shmidmayer Y, Gross E, Joskowicz L, Abramovitch R.

Med Image Comput Comput Assist Interv. 2008;11(Pt 1):93-100.


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