Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 141

1.

Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy.

Shekh-Ahmad T, Lieb A, Kovac S, Gola L, Christian Wigley W, Abramov AY, Walker MC.

Redox Biol. 2019 Jul 19;26:101278. doi: 10.1016/j.redox.2019.101278. [Epub ahead of print]

2.

Reactive oxygen species in status epilepticus.

Shekh-Ahmad T, Kovac S, Abramov AY, Walker MC.

Epilepsy Behav. 2019 Aug 1:106410. doi: 10.1016/j.yebeh.2019.07.011. [Epub ahead of print] Review.

PMID:
31378559
3.

Inorganic Polyphosphate Regulates AMPA and NMDA Receptors and Protects Against Glutamate Excitotoxicity via Activation of P2Y Receptors.

Maiolino M, O'Neill N, Lariccia V, Amoroso S, Sylantyev S, Angelova PR, Abramov AY.

J Neurosci. 2019 Jul 31;39(31):6038-6048. doi: 10.1523/JNEUROSCI.0314-19.2019. Epub 2019 May 30.

PMID:
31147524
4.

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.

Pauletti A, Terrone G, Shekh-Ahmad T, Salamone A, Ravizza T, Rizzi M, Pastore A, Pascente R, Liang LP, Villa BR, Balosso S, Abramov AY, van Vliet EA, Del Giudice E, Aronica E, Patel M, Walker MC, Vezzani A.

Brain. 2019 May 30. pii: awz130. doi: 10.1093/brain/awz130. [Epub ahead of print]

PMID:
31145451
5.

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.

Dolgacheva LP, Berezhnov AV, Fedotova EI, Zinchenko VP, Abramov AY.

J Bioenerg Biomembr. 2019 Jun;51(3):175-188. doi: 10.1007/s10863-019-09798-4. Epub 2019 May 3. Review.

6.

LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation.

Ludtmann MHR, Kostic M, Horne A, Gandhi S, Sekler I, Abramov AY.

Cell Death Dis. 2019 Mar 19;10(4):265. doi: 10.1038/s41419-019-1469-5.

7.

Synthetic Fragments of Receptor for Advanced Glycation End Products Bind Beta-Amyloid 1-40 and Protect Primary Brain Cells From Beta-Amyloid Toxicity.

Kamynina AV, Esteras N, Koroev DO, Bobkova NV, Balasanyants SM, Simonyan RA, Avetisyan AV, Abramov AY, Volpina OM.

Front Neurosci. 2018 Sep 27;12:681. doi: 10.3389/fnins.2018.00681. eCollection 2018.

8.

Different faces of neurodegeneration.

Abramov AY.

FEBS J. 2018 Oct;285(19):3544-3546. doi: 10.1111/febs.14646.

PMID:
30295008
9.

Signal transduction in astrocytes: Localization and release of inorganic polyphosphate.

Angelova PR, Iversen KZ, Teschemacher AG, Kasparov S, Gourine AV, Abramov AY.

Glia. 2018 Oct;66(10):2126-2136. doi: 10.1002/glia.23466. Epub 2018 Sep 7.

10.

Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice.

Liu Z, Solesio ME, Schaffler MB, Frikha-Benayed D, Rosen CJ, Werner H, Kopchick JJ, Pavlov EV, Abramov AY, Yakar S.

J Bone Miner Res. 2019 Jan;34(1):106-122. doi: 10.1002/jbmr.3573. Epub 2018 Sep 14.

PMID:
30216544
11.

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity.

Angelova PR, Vinogradova D, Neganova ME, Serkova TP, Sokolov VV, Bachurin SO, Shevtsova EF, Abramov AY.

Mol Neurobiol. 2019 Mar;56(3):2244-2255. doi: 10.1007/s12035-018-1204-8. Epub 2018 Jul 14.

12.

A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA.

Little D, Luft C, Mosaku O, Lorvellec M, Yao Z, Paillusson S, Kriston-Vizi J, Gandhi S, Abramov AY, Ketteler R, Devine MJ, Gissen P.

Sci Rep. 2018 Jun 13;8(1):9033. doi: 10.1038/s41598-018-27058-0.

13.

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.

Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, Devine MJ, Gissen P, Kunath T, Jaganjac M, Pavlov EV, Klenerman D, Abramov AY, Gandhi S.

Nat Commun. 2018 Jun 12;9(1):2293. doi: 10.1038/s41467-018-04422-2.

14.

Correction to: Impaired Bioenergetics in Mutant Mitochondrial DNA Determines Cell Fate during Seizure-Like Activity.

Kovac S, Preza E, Houlden H, Walker MC, Abramov AY.

Mol Neurobiol. 2019 Jan;56(1):335. doi: 10.1007/s12035-018-1110-0.

PMID:
29779174
15.

Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro.

Wilson ER, Kugathasan U, Abramov AY, Clark AJ, Bennett DLH, Reilly MM, Greensmith L, Kalmar B.

Neurobiol Dis. 2018 Sep;117:1-14. doi: 10.1016/j.nbd.2018.05.008. Epub 2018 May 18.

16.

Impaired Bioenergetics in Mutant Mitochondrial DNA Determines Cell Fate During Seizure-Like Activity.

Kovac S, Preza E, Houlden H, Walker MC, Abramov AY.

Mol Neurobiol. 2019 Jan;56(1):321-334. doi: 10.1007/s12035-018-1078-9. Epub 2018 Apr 27. Erratum in: Mol Neurobiol. 2018 May 19;:.

PMID:
29704197
17.

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

Kundel F, Hong L, Falcon B, McEwan WA, Michaels TCT, Meisl G, Esteras N, Abramov AY, Knowles TJP, Goedert M, Klenerman D.

ACS Chem Neurosci. 2018 Jun 20;9(6):1276-1282. doi: 10.1021/acschemneuro.8b00094. Epub 2018 Apr 8.

18.

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.

Shekh-Ahmad T, Eckel R, Dayalan Naidu S, Higgins M, Yamamoto M, Dinkova-Kostova AT, Kovac S, Abramov AY, Walker MC.

Brain. 2018 May 1;141(5):1390-1403. doi: 10.1093/brain/awy071.

PMID:
29538645
19.

Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.

Bartolome F, Esteras N, Martin-Requero A, Boutoleau-Bretonniere C, Vercelletto M, Gabelle A, Ber IL, Honda T, Dinkova-Kostova AT, Hardy J, Carro E, Abramov AY.

Sci Rep. 2018 Mar 1;8(1):4064. doi: 10.1038/s41598-018-22152-9.

20.

CORM-401 induces calcium signalling, NO increase and activation of pentose phosphate pathway in endothelial cells.

Kaczara P, Proniewski B, Lovejoy C, Kus K, Motterlini R, Abramov AY, Chlopicki S.

FEBS J. 2018 Apr;285(7):1346-1358. doi: 10.1111/febs.14411. Epub 2018 Mar 8.

21.

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration.

Angelova PR, Abramov AY.

FEBS Lett. 2018 Mar;592(5):692-702. doi: 10.1002/1873-3468.12964. Epub 2018 Jan 18. Review.

22.

Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation.

Angelova PR, Barilani M, Lovejoy C, Dossena M, Viganò M, Seresini A, Piga D, Gandhi S, Pezzoli G, Abramov AY, Lazzari L.

Redox Biol. 2018 Apr;14:474-484. doi: 10.1016/j.redox.2017.10.016. Epub 2017 Oct 20.

23.

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy.

Manole A, Jaunmuktane Z, Hargreaves I, Ludtmann MHR, Salpietro V, Bello OD, Pope S, Pandraud A, Horga A, Scalco RS, Li A, Ashokkumar B, Lourenço CM, Heales S, Horvath R, Chinnery PF, Toro C, Singleton AB, Jacques TS, Abramov AY, Muntoni F, Hanna MG, Reilly MM, Revesz T, Kullmann DM, Jepson JEC, Houlden H.

Brain. 2017 Nov 1;140(11):2820-2837. doi: 10.1093/brain/awx231.

24.

Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation.

Delgado-Camprubi M, Esteras N, Soutar MP, Plun-Favreau H, Abramov AY.

Cell Death Differ. 2017 Dec;24(12):2210. doi: 10.1038/cdd.2017.175. Epub 2017 Oct 13.

25.

iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.

Arber C, Angelova PR, Wiethoff S, Tsuchiya Y, Mazzacuva F, Preza E, Bhatia KP, Mills K, Gout I, Abramov AY, Hardy J, Duce JA, Houlden H, Wray S.

PLoS One. 2017 Sep 1;12(9):e0184104. doi: 10.1371/journal.pone.0184104. eCollection 2017.

26.

Reactive Oxygen Species Produced by a Photodynamic Effect Induced Calcium Signal in Neurons and Astrocytes.

Neginskaya M, Berezhnaya E, Uzdensky AB, Abramov AY.

Mol Neurobiol. 2018 Jan;55(1):96-102. doi: 10.1007/s12035-017-0721-1.

PMID:
28844112
27.

Photo-Induced Oxidative Stress Impairs Mitochondrial Metabolism in Neurons and Astrocytes.

Berezhnaya E, Neginskaya M, Uzdensky AB, Abramov AY.

Mol Neurobiol. 2018 Jan;55(1):90-95. doi: 10.1007/s12035-017-0720-2.

28.

Mitochondrial calcium imbalance in Parkinson's disease.

Ludtmann MHR, Abramov AY.

Neurosci Lett. 2018 Jan 10;663:86-90. doi: 10.1016/j.neulet.2017.08.044. Epub 2017 Aug 26. Review.

PMID:
28838811
29.

Interaction of misfolded proteins and mitochondria in neurodegenerative disorders.

Abramov AY, Berezhnov AV, Fedotova EI, Zinchenko VP, Dolgacheva LP.

Biochem Soc Trans. 2017 Jul 21. pii: BST20170024. doi: 10.1042/BST20170024. [Epub ahead of print] Review.

PMID:
28733489
30.

Mitochondrial deficits and abnormal mitochondrial retrograde axonal transport play a role in the pathogenesis of mutant Hsp27-induced Charcot Marie Tooth Disease.

Kalmar B, Innes A, Wanisch K, Kolaszynska AK, Pandraud A, Kelly G, Abramov AY, Reilly MM, Schiavo G, Greensmith L.

Hum Mol Genet. 2017 Sep 1;26(17):3313-3326. doi: 10.1093/hmg/ddx216.

31.

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.

Pauletti A, Terrone G, Shekh-Ahmad T, Salamone A, Ravizza T, Rizzi M, Pastore A, Pascente R, Liang LP, Villa BR, Balosso S, Abramov AY, van Vliet EA, Del Giudice E, Aronica E, Antoine DJ, Patel M, Walker MC, Vezzani A.

Brain. 2017 Jul 1;140(7):1885-1899. doi: 10.1093/brain/awx117. Retraction in: Brain. 2019 May 30;:.

32.

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS.

Hall CE, Yao Z, Choi M, Tyzack GE, Serio A, Luisier R, Harley J, Preza E, Arber C, Crisp SJ, Watson PMD, Kullmann DM, Abramov AY, Wray S, Burley R, Loh SHY, Martins LM, Stevens MM, Luscombe NM, Sibley CR, Lakatos A, Ule J, Gandhi S, Patani R.

Cell Rep. 2017 May 30;19(9):1739-1749. doi: 10.1016/j.celrep.2017.05.024.

33.

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.

Bartolome F, Esteras N, Martin-Requero A, Boutoleau-Bretonniere C, Vercelletto M, Gabelle A, Le Ber I, Honda T, Dinkova-Kostova AT, Hardy J, Carro E, Abramov AY.

Sci Rep. 2017 May 10;7(1):1666. doi: 10.1038/s41598-017-01678-4. Erratum in: Sci Rep. 2018 Mar 1;8(1):4064.

34.

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons.

Ludtmann MHR, Arber C, Bartolome F, de Vicente M, Preza E, Carro E, Houlden H, Gandhi S, Wray S, Abramov AY.

J Biol Chem. 2017 May 26;292(21):8907-8917. doi: 10.1074/jbc.M116.762898. Epub 2017 Mar 30.

35.

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration.

Esteras N, Rohrer JD, Hardy J, Wray S, Abramov AY.

Redox Biol. 2017 Aug;12:410-422. doi: 10.1016/j.redox.2017.03.008. Epub 2017 Mar 10.

36.

Carbon monoxide shifts energetic metabolism from glycolysis to oxidative phosphorylation in endothelial cells.

Kaczara P, Motterlini R, Kus K, Zakrzewska A, Abramov AY, Chlopicki S.

FEBS Lett. 2016 Oct;590(20):3469-3480. doi: 10.1002/1873-3468.12434. Epub 2016 Oct 11.

37.

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.

Ludtmann MH, Angelova PR, Ninkina NN, Gandhi S, Buchman VL, Abramov AY.

J Neurosci. 2016 Oct 12;36(41):10510-10521.

38.

Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation.

Delgado-Camprubi M, Esteras N, Soutar MP, Plun-Favreau H, Abramov AY.

Cell Death Differ. 2017 Jan;24(1):120-131. doi: 10.1038/cdd.2016.104. Epub 2016 Sep 30. Erratum in: Cell Death Differ. 2017 Oct 13;:.

39.

Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications.

Kinghorn KJ, Castillo-Quan JI, Li L, Bhatia KP, Abramov AY, Hardy J, Partridge L.

Brain. 2016 Dec;139(Pt 12):e68. Epub 2016 Aug 6. No abstract available.

PMID:
27497489
40.

Alpha-synuclein and beta-amyloid - different targets, same players: calcium, free radicals and mitochondria in the mechanism of neurodegeneration.

Angelova PR, Abramov AY.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):1110-1115. doi: 10.1016/j.bbrc.2016.07.103. Epub 2016 Jul 26. Review.

PMID:
27470584
41.

Functional role of mitochondrial reactive oxygen species in physiology.

Angelova PR, Abramov AY.

Free Radic Biol Med. 2016 Nov;100:81-85. doi: 10.1016/j.freeradbiomed.2016.06.005. Epub 2016 Jun 11. Review.

PMID:
27296839
42.

'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia'.

Abeti R, Parkinson MH, Hargreaves IP, Angelova PR, Sandi C, Pook MA, Giunti P, Abramov AY.

Cell Death Dis. 2016 May 26;7:e2237. doi: 10.1038/cddis.2016.111.

43.

Melatonin prevents cytosolic calcium overload, mitochondrial damage and cell death due to toxically high doses of dexamethasone-induced oxidative stress in human neuroblastoma SH-SY5Y cells.

Suwanjang W, Abramov AY, Charngkaew K, Govitrapong P, Chetsawang B.

Neurochem Int. 2016 Jul;97:34-41. doi: 10.1016/j.neuint.2016.05.003. Epub 2016 May 4.

PMID:
27155536
44.

Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data.

Mok KY, Sheerin U, Simón-Sánchez J, Salaka A, Chester L, Escott-Price V, Mantripragada K, Doherty KM, Noyce AJ, Mencacci NE, Lubbe SJ; International Parkinson's Disease Genomics Consortium (IPDGC), Williams-Gray CH, Barker RA, van Dijk KD, Berendse HW, Heutink P, Corvol JC, Cormier F, Lesage S, Brice A, Brockmann K, Schulte C, Gasser T, Foltynie T, Limousin P, Morrison KE, Clarke CE, Sawcer S, Warner TT, Lees AJ, Morris HR, Nalls MA, Singleton AB, Hardy J, Abramov AY, Plagnol V, Williams NM, Wood NW.

Lancet Neurol. 2016 May;15(6):585-96. doi: 10.1016/S1474-4422(16)00071-5. Epub 2016 Mar 24.

45.

Ca2+ is a key factor in α-synuclein-induced neurotoxicity.

Angelova PR, Ludtmann MH, Horrocks MH, Negoda A, Cremades N, Klenerman D, Dobson CM, Wood NW, Pavlov EV, Gandhi S, Abramov AY.

J Cell Sci. 2016 May 1;129(9):1792-801. doi: 10.1242/jcs.180737. Epub 2016 Mar 17.

46.

Intracellular pH Modulates Autophagy and Mitophagy.

Berezhnov AV, Soutar MP, Fedotova EI, Frolova MS, Plun-Favreau H, Zinchenko VP, Abramov AY.

J Biol Chem. 2016 Apr 15;291(16):8701-8. doi: 10.1074/jbc.M115.691774. Epub 2016 Feb 18.

47.

Modulation of mitochondrial ion transport by inorganic polyphosphate - essential role in mitochondrial permeability transition pore.

Baev AY, Negoda A, Abramov AY.

J Bioenerg Biomembr. 2017 Feb;49(1):49-55. doi: 10.1007/s10863-016-9650-3. Epub 2016 Feb 18.

48.

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.

Iljina M, Garcia GA, Horrocks MH, Tosatto L, Choi ML, Ganzinger KA, Abramov AY, Gandhi S, Wood NW, Cremades N, Dobson CM, Knowles TP, Klenerman D.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1206-15. doi: 10.1073/pnas.1524128113. Epub 2016 Feb 16.

49.

Role of inorganic polyphosphate in mammalian cells: from signal transduction and mitochondrial metabolism to cell death.

Angelova PR, Baev AY, Berezhnov AV, Abramov AY.

Biochem Soc Trans. 2016 Feb;44(1):40-5. doi: 10.1042/BST20150223. Review.

PMID:
26862186
50.

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function.

Esteras N, Dinkova-Kostova AT, Abramov AY.

Biol Chem. 2016 May;397(5):383-400. doi: 10.1515/hsz-2015-0295. Review.

PMID:
26812787

Supplemental Content

Loading ...
Support Center