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Items: 44


Neuropathological correlates of amyloid PET imaging in Down syndrome.

Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD.

Dev Neurobiol. 2019 Jul;79(7):750-766. doi: 10.1002/dneu.22713. Epub 2019 Aug 17. Review.


Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease.

Harper MM, Hedberg-Buenz A, Herlein J, Abrahamson EE, Anderson MG, Kuehn MH, Kardon RH, Poolman P, Ikonomovic MD.

Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2716-2725. doi: 10.1167/iovs.18-26353.


Acute and chronic effects of single dose memantine after controlled cortical impact injury in adult rats.

Abrahamson EE, Poloyac SM, Dixon CE, Dekosky ST, Ikonomovic MD.

Restor Neurol Neurosci. 2019;37(3):245-263. doi: 10.3233/RNN-190909.


Modeling Herpes Simplex Virus 1 Infections in Human Central Nervous System Neuronal Cells Using Two- and Three-Dimensional Cultures Derived from Induced Pluripotent Stem Cells.

D'Aiuto L, Bloom DC, Naciri JN, Smith A, Edwards TG, McClain L, Callio JA, Jessup M, Wood J, Chowdari K, Demers M, Abrahamson EE, Ikonomovic MD, Viggiano L, De Zio R, Watkins S, Kinchington PR, Nimgaonkar VL.

J Virol. 2019 Apr 17;93(9). pii: e00111-19. doi: 10.1128/JVI.00111-19. Print 2019 May 1.


Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia.

Perez SE, Miguel JC, He B, Malek-Ahmadi M, Abrahamson EE, Ikonomovic MD, Lott I, Doran E, Alldred MJ, Ginsberg SD, Mufson EJ.

Acta Neuropathol. 2019 Mar;137(3):413-436. doi: 10.1007/s00401-019-01965-6. Epub 2019 Feb 7.


Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load.

Minhas DS, Price JC, Laymon CM, Becker CR, Klunk WE, Tudorascu DL, Abrahamson EE, Hamilton RL, Kofler JK, Mathis CA, Lopez OL, Ikonomovic MD.

Neuroimage Clin. 2018 Apr 4;19:182-189. doi: 10.1016/j.nicl.2018.04.007. eCollection 2018.


Novel therapies for combating chronic neuropathological sequelae of TBI.

Ikonomovic MD, Abrahamson EE, Carlson SW, Graham SH, Dixon CE.

Neuropharmacology. 2019 Feb;145(Pt B):160-176. doi: 10.1016/j.neuropharm.2018.06.021. Epub 2018 Jun 20. Review.


Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.

Krivinko JM, Erickson SL, Abrahamson EE, Wills ZP, Ikonomovic MD, Penzes P, Sweet RA.

Neurobiol Aging. 2017 Jun;54:59-70. doi: 10.1016/j.neurobiolaging.2017.02.006. Epub 2017 Feb 16.


Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer's disease.

Mi Z, Abrahamson EE, Ryu AY, Fish KN, Sweet RA, Mufson EJ, Ikonomovic MD.

Neurobiol Aging. 2017 Jul;55:159-166. doi: 10.1016/j.neurobiolaging.2017.01.022. Epub 2017 Feb 4.


Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study.

Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford F, Alvarez V, Stein T, McKee AC.

Brain Inj. 2016;30(12):1399-1413.


Disordered APP metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders.

Ikonomovic MD, Mi Z, Abrahamson EE.

Ageing Res Rev. 2017 Mar;34:51-63. doi: 10.1016/j.arr.2016.11.003. Epub 2016 Nov 6. Review.


Tenascin-C Is Associated with Cored Amyloid-β Plaques in Alzheimer Disease and Pathology Burdened Cognitively Normal Elderly.

Mi Z, Halfter W, Abrahamson EE, Klunk WE, Mathis CA, Mufson EJ, Ikonomovic MD.

J Neuropathol Exp Neurol. 2016 Sep;75(9):868-76. doi: 10.1093/jnen/nlw062. Epub 2016 Jul 21. Erratum in: J Neuropathol Exp Neurol. 2016 Dec;75(12):1190.


[F-18]AV-1451 positron emission tomography retention in choroid plexus: More than "off-target" binding.

Ikonomovic MD, Abrahamson EE, Price JC, Mathis CA, Klunk WE.

Ann Neurol. 2016 Aug;80(2):307-8. doi: 10.1002/ana.24706. Epub 2016 Jul 7. No abstract available.


Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease.

Mizukami K, Akatsu H, Abrahamson EE, Mi Z, Ikonomovic MD.

Neuropathology. 2016 Apr;36(2):135-45. doi: 10.1111/neup.12241. Epub 2015 Aug 21.


Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer's disease.

Pivtoraiko VN, Abrahamson EE, Leurgans SE, DeKosky ST, Mufson EJ, Ikonomovic MD.

Neurobiol Aging. 2015 Jan;36(1):12-9. doi: 10.1016/j.neurobiolaging.2014.06.021. Epub 2014 Jun 24.


Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease.

Perez SE, He B, Nadeem M, Wuu J, Scheff SW, Abrahamson EE, Ikonomovic MD, Mufson EJ.

Biol Psychiatry. 2015 Apr 15;77(8):693-703. doi: 10.1016/j.biopsych.2013.12.016. Epub 2014 Jan 11.


Immunohistochemical analysis of ubiquilin-1 in the human hippocampus: association with neurofibrillary tangle pathology.

Mizukami K, Abrahamson EE, Mi Z, Ishikawa M, Watanabe K, Kinoshita S, Asada T, Ikonomovic MD.

Neuropathology. 2014 Feb;34(1):11-8. doi: 10.1111/neup.12055. Epub 2013 Jul 21.


Dendritic spine density, morphology, and fibrillar actin content surrounding amyloid-β plaques in a mouse model of amyloid-β deposition.

Kirkwood CM, Ciuchta J, Ikonomovic MD, Fish KN, Abrahamson EE, Murray PS, Klunk WE, Sweet RA.

J Neuropathol Exp Neurol. 2013 Aug;72(8):791-800. doi: 10.1097/NEN.0b013e31829ecc89.


Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice.

Abrahamson EE, Foley LM, Dekosky ST, Hitchens TK, Ho C, Kochanek PM, Ikonomovic MD.

J Cereb Blood Flow Metab. 2013 Jun;33(6):826-33. doi: 10.1038/jcbfm.2013.24. Epub 2013 Feb 27.


β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis.

Murray PS, Kirkwood CM, Gray MC, Ikonomovic MD, Paljug WR, Abrahamson EE, Henteleff RA, Hamilton RL, Kofler JK, Klunk WE, Lopez OL, Penzes P, Sweet RA.

Neurobiol Aging. 2012 Dec;33(12):2807-16. doi: 10.1016/j.neurobiolaging.2012.02.015. Epub 2012 Mar 17.


Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study.

Ikonomovic MD, Abrahamson EE, Price JC, Hamilton RL, Mathis CA, Paljug WR, Debnath ML, Cohen AD, Mizukami K, DeKosky ST, Lopez OL, Klunk WE.

Acta Neuropathol. 2012 Mar;123(3):433-47. doi: 10.1007/s00401-012-0943-2. Epub 2012 Jan 24.


Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease.

Ikonomovic MD, Klunk WE, Abrahamson EE, Wuu J, Mathis CA, Scheff SW, Mufson EJ, DeKosky ST.

Neurology. 2011 Jul 5;77(1):39-47. doi: 10.1212/WNL.0b013e3182231419. Epub 2011 Jun 22.


An immunohistochemical study of the serotonin 1A receptor in the hippocampus of subjects with Alzheimer's disease.

Mizukami K, Ishikawa M, Akatsu H, Abrahamson EE, Ikonomovic MD, Asada T.

Neuropathology. 2011 Oct;31(5):503-9. doi: 10.1111/j.1440-1789.2010.01193.x. Epub 2011 Jan 27.


Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice.

Cohen AD, Ikonomovic MD, Abrahamson EE, Paljug WR, Dekosky ST, Lefterov IM, Koldamova RP, Shao L, Debnath ML, Mason NS, Mathis CA, Klunk WE.

Lett Drug Des Discov. 2009 Sep;6(6):437.


Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels.

Abrahamson EE, Ikonomovic MD, Dixon CE, DeKosky ST.

Ann Neurol. 2009 Sep;66(3):407-14. doi: 10.1002/ana.21731.


Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease.

Ikonomovic MD, Wecker L, Abrahamson EE, Wuu J, Counts SE, Ginsberg SD, Mufson EJ, Dekosky ST.

Arch Neurol. 2009 May;66(5):646-51. doi: 10.1001/archneurol.2009.46.


An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression.

Iwakiri M, Mizukami K, Ikonomovic MD, Ishikawa M, Abrahamson EE, DeKosky ST, Asada T.

Neuropathology. 2009 Jun;29(3):263-9. doi: 10.1111/j.1440-1789.2008.00978.x. Epub 2008 Nov 19.


Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease.

Ikonomovic MD, Abrahamson EE, Uz T, Manev H, Dekosky ST.

J Histochem Cytochem. 2008 Dec;56(12):1065-73. doi: 10.1369/jhc.2008.951855. Epub 2008 Aug 4.


Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease.

Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND, Lopresti BJ, Ziolko S, Bi W, Paljug WR, Debnath ML, Hope CE, Isanski BA, Hamilton RL, DeKosky ST.

Brain. 2008 Jun;131(Pt 6):1630-45. doi: 10.1093/brain/awn016. Epub 2008 Mar 12.


Superior frontal cortex cholinergic axon density in mild cognitive impairment and early Alzheimer disease.

Ikonomovic MD, Abrahamson EE, Isanski BA, Wuu J, Mufson EJ, DeKosky ST.

Arch Neurol. 2007 Sep;64(9):1312-7.


Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans.

DeKosky ST, Abrahamson EE, Ciallella JR, Paljug WR, Wisniewski SR, Clark RS, Ikonomovic MD.

Arch Neurol. 2007 Apr;64(4):541-4.


X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease.

Ikonomovic MD, Abrahamson EE, Isanski BA, Debnath ML, Mathis CA, Dekosky ST, Klunk WE.

Methods Enzymol. 2006;412:123-44. Review.


Lesions of suprachiasmatic nucleus efferents selectively affect rest-activity rhythm.

Abrahamson EE, Moore RY.

Mol Cell Endocrinol. 2006 Jun 27;252(1-2):46-56.


Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome.

Abrahamson EE, Ikonomovic MD, Ciallella JR, Hope CE, Paljug WR, Isanski BA, Flood DG, Clark RS, DeKosky ST.

Exp Neurol. 2006 Feb;197(2):437-50. Epub 2005 Nov 21.


Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.

Klunk WE, Lopresti BJ, Ikonomovic MD, Lefterov IM, Koldamova RP, Abrahamson EE, Debnath ML, Holt DP, Huang GF, Shao L, DeKosky ST, Price JC, Mathis CA.

J Neurosci. 2005 Nov 16;25(46):10598-606.


Apolipoprotein D is a component of compact but not diffuse amyloid-beta plaques in Alzheimer's disease temporal cortex.

Desai PP, Ikonomovic MD, Abrahamson EE, Hamilton RL, Isanski BA, Hope CE, Klunk WE, DeKosky ST, Kamboh MI.

Neurobiol Dis. 2005 Nov;20(2):574-82.


Changes in hippocampal GABABR1 subunit expression in Alzheimer's patients: association with Braak staging.

Iwakiri M, Mizukami K, Ikonomovic MD, Ishikawa M, Hidaka S, Abrahamson EE, DeKosky ST, Asada T.

Acta Neuropathol. 2005 May;109(5):467-74. Epub 2005 Mar 10.


Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury.

Ikonomovic MD, Uryu K, Abrahamson EE, Ciallella JR, Trojanowski JQ, Lee VM, Clark RS, Marion DW, Wisniewski SR, DeKosky ST.

Exp Neurol. 2004 Nov;190(1):192-203.


Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies.

DeKosky ST, Abrahamson EE, Taffe KM, Dixon CE, Kochanek PM, Ikonomovic MD.

J Neurochem. 2004 Aug;90(4):998-1004.


Time course analysis of hippocampal nerve growth factor and antioxidant enzyme activity following lateral controlled cortical impact brain injury in the rat.

DeKosky ST, Taffe KM, Abrahamson EE, Dixon CE, Kochanek PM, Ikonomovic MD.

J Neurotrauma. 2004 May;21(5):491-500.


Alterations in hippocampal voltage-gated calcium channel alpha 1 subunit expression patterns after kainate-induced status epilepticus in aging rats.

Kelly KM, Ikonomovic MD, Abrahamson EE, Kharlamov EA, Hentosz TM, Armstrong DM.

Epilepsy Res. 2003 Nov;57(1):15-32.


The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems.

Abrahamson EE, Leak RK, Moore RY.

Neuroreport. 2001 Feb 12;12(2):435-40.


The posterior hypothalamic area: chemoarchitecture and afferent connections.

Abrahamson EE, Moore RY.

Brain Res. 2001 Jan 19;889(1-2):1-22.


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