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Whole body periodic acceleration in normal and reduced mucociliary clearance of conscious sheep.

Sabater JR, Sackner MA, Adams JA, Abraham WM.

PLoS One. 2019 Nov 7;14(11):e0224764. doi: 10.1371/journal.pone.0224764. eCollection 2019.


Losartan Rescues Inflammation-related Mucociliary Dysfunction in Relevant Models of Cystic Fibrosis.

Kim MD, Baumlin N, Yoshida M, Polineni D, Salathe SF, David JK, Peloquin CA, Wanner A, Dennis JS, Sailland J, Whitney P, Horrigan FT, Sabater JR, Abraham WM, Salathe M.

Am J Respir Crit Care Med. 2020 Feb 1;201(3):313-324. doi: 10.1164/rccm.201905-0990OC.


Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors.

Chung S, Baumlin N, Dennis JS, Moore R, Salathe SF, Whitney PL, Sabater J, Abraham WM, Kim MD, Salathe M.

Am J Respir Crit Care Med. 2019 Nov 1;200(9):1134-1145. doi: 10.1164/rccm.201811-2087OC.


Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease.

Terryah ST, Fellner RC, Ahmad S, Moore PJ, Reidel B, Sesma JI, Kim CS, Garland AL, Scott DW, Sabater JR, Carpenter J, Randell SH, Kesimer M, Abraham WM, Arendshorst WJ, Tarran R.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L192-L205. doi: 10.1152/ajplung.00546.2016. Epub 2017 Oct 5.


SPX-101 Is a Novel Epithelial Sodium Channel-targeted Therapeutic for Cystic Fibrosis That Restores Mucus Transport.

Scott DW, Walker MP, Sesma J, Wu B, Stuhlmiller TJ, Sabater JR, Abraham WM, Crowder TM, Christensen DJ, Tarran R.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):734-744. doi: 10.1164/rccm.201612-2445OC.


Kinin B1 receptor antagonist BI113823 reduces allergen-induced airway inflammation and mucus secretion in mice.

Gurusamy M, Nasseri S, Lee H, Jung B, Lee D, Khang G, Abraham WM, Doods H, Wu D.

Pharmacol Res. 2016 Feb;104:132-9. doi: 10.1016/j.phrs.2015.12.017. Epub 2015 Dec 30.


Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma.

Takahashi G, Asanuma F, Suzuki N, Hattori M, Sakamoto S, Kugimiya A, Tomita Y, Kuwajima G, Abraham WM, Deguchi M, Arimura A, Shichijo M.

Eur J Pharmacol. 2015 Oct 15;765:15-23. doi: 10.1016/j.ejphar.2015.08.003. Epub 2015 Aug 12.


NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia.

Coote KJ, Paisley D, Czarnecki S, Tweed M, Watson H, Young A, Sugar R, Vyas M, Smith NJ, Baettig U, Groot-Kormelink PJ, Gosling M, Lock R, Ethell B, Williams G, Schumacher A, Harris J, Abraham WM, Sabater J, Poll CT, Faller T, Collingwood SP, Danahay H.

Br J Pharmacol. 2015 Jun;172(11):2814-26. doi: 10.1111/bph.13075. Epub 2015 Apr 23.


Structure activity relationship of brevenal hydrazide derivatives.

Goodman A, McCall JR, Jacocks HM, Thompson A, Baden D, Abraham WM, Bourdelais A.

Mar Drugs. 2014 Mar 28;12(4):1839-58. doi: 10.3390/md12041839.


Heparin-derived supersulfated disaccharide inhibits allergic airway responses in sheep.

Ahmed T, Smith G, Abraham WM.

Pulm Pharmacol Ther. 2014 Jun;28(1):77-86. doi: 10.1016/j.pupt.2013.12.001. Epub 2013 Dec 17.


Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction.

Moy LY, Jia Y, Caniga M, Lieber G, Gil M, Fernandez X, Sirkowski E, Miller R, Alexander JP, Lee HH, Shin JD, Ellis JM, Chen H, Wilhelm A, Yu H, Vincent S, Chapman RW, Kelly N, Hickey E, Abraham WM, Northrup A, Miller T, Houshyar H, Crackower MA.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):1085-92. doi: 10.1165/rcmb.2013-0200OC.


Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion.

Tarran R, Sabater JR, Clarke TC, Tan CD, Davies CM, Liu J, Yeung A, Garland AL, Stutts MJ, Abraham WM, Phillips G, Baker WR, Wright CD, Wilbert S.

Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L746-56. doi: 10.1152/ajplung.00292.2012. Epub 2013 Mar 29.


Sabiporide improves cardiovascular function, decreases the inflammatory response and reduces mortality in acute metabolic acidosis in pigs.

Wu D, Kraut JA, Abraham WM.

PLoS One. 2013;8(1):e53932. doi: 10.1371/journal.pone.0053932. Epub 2013 Jan 10.


Effect of oral and intravenous heparin tetrasaccharide on allergic airway responses: critical role of N-sulfation.

Ahmed T, Smith G, Abraham WM.

Pulm Pharmacol Ther. 2013 Apr;26(2):180-8. doi: 10.1016/j.pupt.2012.10.004. Epub 2012 Oct 22.


NHE1 inhibition improves tissue perfusion and resuscitation outcome after severe hemorrhage.

Wu D, Russano K, Kouz I, Abraham WM.

J Surg Res. 2013 May;181(2):e75-81. doi: 10.1016/j.jss.2012.07.026. Epub 2012 Jul 31.


Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence.

Ahmed T, Smith G, Vlahov I, Abraham WM.

Respir Res. 2012 Jan 23;13:6. doi: 10.1186/1465-9921-13-6.


Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma.

Hewson CA, Patel S, Calzetta L, Campwala H, Havard S, Luscombe E, Clarke PA, Peachell PT, Matera MG, Cazzola M, Page C, Abraham WM, Williams CM, Clark JD, Liu WL, Clarke NP, Yeadon M.

J Pharmacol Exp Ther. 2012 Mar;340(3):656-65. doi: 10.1124/jpet.111.186379. Epub 2011 Dec 7.


Florida Red Tide Toxins (Brevetoxins) and Longitudinal Respiratory Effects in Asthmatics.

Bean JA, Fleming LE, Kirkpatrick B, Backer LC, Nierenberg K, Reich A, Cheng YS, Wanner A, Benson J, Naar J, Pierce R, Abraham WM, Kirkpatrick G, Hollenbeck J, Zaias J, Mendes E, Baden DG.

Harmful Algae. 2011 Sep 1;10(6):744-748.


Aerosolized Red Tide Toxins (Brevetoxins) and Asthma: Continued health effects after 1 hour beach exposure.

Kirkpatrick B, Fleming LE, Bean JA, Nierenberg K, Backer LC, Cheng YS, Pierce R, Reich A, Naar J, Wanner A, Abraham WM, Zhou Y, Hollenbeck J, Baden DG.

Harmful Algae. 2011 Jan 1;10(2):138-143.


Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep.

Zaias J, Fleming LE, Baden DG, Abraham WM.

Inhal Toxicol. 2011 Mar;23(4):205-11. doi: 10.3109/08958378.2011.558936.


Review of Florida Red Tide and Human Health Effects.

Fleming LE, Kirkpatrick B, Backer LC, Walsh CJ, Nierenberg K, Clark J, Reich A, Hollenbeck J, Benson J, Cheng YS, Naar J, Pierce R, Bourdelais AJ, Abraham WM, Kirkpatrick G, Zaias J, Wanner A, Mendes E, Shalat S, Hoagland P, Stephan W, Bean J, Watkins S, Clarke T, Byrne M, Baden DG.

Harmful Algae. 2011 Jan 1;10(2):224-233.


Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo.

Dillon PF, Root-Bernstein R, Robinson NE, Abraham WM, Berney C.

PLoS One. 2010 Dec 13;5(12):e15130. doi: 10.1371/journal.pone.0015130.


Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist.

Gervais FG, Sawyer N, Stocco R, Hamel M, Krawczyk C, Sillaots S, Denis D, Wong E, Wang Z, Gallant M, Abraham WM, Slipetz D, Crackower MA, O'Neill GP.

Mol Pharmacol. 2011 Jan;79(1):69-76. doi: 10.1124/mol.110.068585. Epub 2010 Oct 13.


Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS).

Carron CP, Trujillo JI, Olson KL, Huang W, Hamper BC, Dice T, Neal BE, Pelc MJ, Day JE, Rohrer DC, Kiefer JR, Moon JB, Schweitzer BA, Blake TD, Turner SR, Woerndle R, Case BL, Bono CP, Dilworth VM, Funckes-Shippy CL, Hood BL, Jerome GM, Kornmeier CM, Radabaugh MR, Williams ML, Davies MS, Wegner CD, Welsch DJ, Abraham WM, Warren CJ, Dowty ME, Hua F, Zutshi A, Yang JZ, Thorarensen A.

ACS Med Chem Lett. 2010 Feb 2;1(2):59-63. doi: 10.1021/ml900025z. eCollection 2010 May 13.


Characterization of tamulamides A and B, polyethers isolated from the marine dinoflagellate Karenia brevis.

Truxal LT, Bourdelais AJ, Jacocks H, Abraham WM, Baden DG.

J Nat Prod. 2010 Apr 23;73(4):536-40. doi: 10.1021/np900541w.


Dual inhibition of cathepsin G and chymase is effective in animal models of pulmonary inflammation.

Maryanoff BE, de Garavilla L, Greco MN, Haertlein BJ, Wells GI, Andrade-Gordon P, Abraham WM.

Am J Respir Crit Care Med. 2010 Feb 1;181(3):247-53. doi: 10.1164/rccm.200904-0627OC. Epub 2009 Oct 29.


Resuscitation with Na+/H+ exchanger inhibitor in traumatic haemorrhagic shock: cardiopulmonary performance, oxygen transport and tissue inflammation.

Wu D, Qi J, Dai H, Doods H, Abraham WM.

Clin Exp Pharmacol Physiol. 2010 Mar;37(3):337-42. doi: 10.1111/j.1440-1681.2009.05296.x. Epub 2009 Sep 21.


Exposure and effect assessment of aerosolized red tide toxins (brevetoxins) and asthma.

Fleming LE, Bean JA, Kirkpatrick B, Cheng YS, Pierce R, Naar J, Nierenberg K, Backer LC, Wanner A, Reich A, Zhou Y, Watkins S, Henry M, Zaias J, Abraham WM, Benson J, Cassedy A, Hollenbeck J, Kirkpatrick G, Clarke T, Baden DG.

Environ Health Perspect. 2009 Jul;117(7):1095-100. doi: 10.1289/ehp.0900673. Epub 2009 Apr 13.


Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases.

Sexton DJ, Chen T, Martik D, Kuzmic P, Kuang G, Chen J, Nixon AE, Zuraw BL, Forteza RM, Abraham WM, Wood CR.

Biochem J. 2009 Aug 13;422(2):383-92. doi: 10.1042/BJ20090010.


A prostaglandin D2 receptor antagonist modifies experimental asthma in sheep.

Shichijo M, Arimura A, Hirano Y, Yasui K, Suzuki N, Deguchi M, Abraham WM.

Clin Exp Allergy. 2009 Sep;39(9):1404-14. doi: 10.1111/j.1365-2222.2009.03275.x. Epub 2009 May 26.


Low-volume resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor.

Wu D, Dai H, Arias J, Latta L, Abraham WM.

Crit Care Med. 2009 Jun;37(6):1994-9. doi: 10.1097/CCM.0b013e3181a0052e.


Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease.

Coote K, Atherton-Watson HC, Sugar R, Young A, MacKenzie-Beevor A, Gosling M, Bhalay G, Bloomfield G, Dunstan A, Bridges RJ, Sabater JR, Abraham WM, Tully D, Pacoma R, Schumacher A, Harris J, Danahay H.

J Pharmacol Exp Ther. 2009 May;329(2):764-74. doi: 10.1124/jpet.108.148155. Epub 2009 Feb 3.


Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.

McKew JC, Lee KL, Shen MW, Thakker P, Foley MA, Behnke ML, Hu B, Sum FW, Tam S, Hu Y, Chen L, Kirincich SJ, Michalak R, Thomason J, Ipek M, Wu K, Wooder L, Ramarao MK, Murphy EA, Goodwin DG, Albert L, Xu X, Donahue F, Ku MS, Keith J, Nickerson-Nutter CL, Abraham WM, Williams C, Hegen M, Clark JD.

J Med Chem. 2008 Jun 26;51(12):3388-413. doi: 10.1021/jm701467e. Epub 2008 May 23.


The porcine lung as a potential model for cystic fibrosis.

Rogers CS, Abraham WM, Brogden KA, Engelhardt JF, Fisher JT, McCray PB Jr, McLennan G, Meyerholz DK, Namati E, Ostedgaard LS, Prather RS, Sabater JR, Stoltz DA, Zabner J, Welsh MJ.

Am J Physiol Lung Cell Mol Physiol. 2008 Aug;295(2):L240-63. doi: 10.1152/ajplung.90203.2008. Epub 2008 May 16. Review.


Modeling of asthma, COPD and cystic fibrosis in sheep.

Abraham WM.

Pulm Pharmacol Ther. 2008 Oct;21(5):743-54. doi: 10.1016/j.pupt.2008.01.010. Epub 2008 Feb 6. Review.


Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.

Costanzo MJ, Yabut SC, Zhang HC, White KB, de Garavilla L, Wang Y, Minor LK, Tounge BA, Barnakov AN, Lewandowski F, Milligan C, Spurlino JC, Abraham WM, Boswell-Smith V, Page CP, Maryanoff BE.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2114-21. doi: 10.1016/j.bmcl.2008.01.093. Epub 2008 Jan 30.


Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease.

Hirsh AJ, Zhang J, Zamurs A, Fleegle J, Thelin WR, Caldwell RA, Sabater JR, Abraham WM, Donowitz M, Cha B, Johnson KB, St George JA, Johnson MR, Boucher RC.

J Pharmacol Exp Ther. 2008 Apr;325(1):77-88. doi: 10.1124/jpet.107.130443. Epub 2008 Jan 24.


Synthesis, modeling, and biological evaluation of analogues of the semisynthetic brevetoxin antagonist beta-naphthoyl-brevetoxin.

Michelliza S, Abraham WM, Jacocks HM, Schuster T, Baden DG.

Chembiochem. 2007 Dec 17;8(18):2233-9.


Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.

Lee KL, Behnke ML, Foley MA, Chen L, Wang W, Vargas R, Nunez J, Tam S, Mollova N, Xu X, Shen MW, Ramarao MK, Goodwin DG, Nickerson-Nutter CL, Abraham WM, Williams C, Clark JD, McKew JC.

Bioorg Med Chem. 2008 Feb 1;16(3):1345-58. Epub 2007 Oct 22.


Na+/H+ exchange inhibition delays the onset of hypovolemic circulatory shock in pigs.

Wu D, Arias J, Bassuk J, Doods H, Seidler R, Adams JA, Abraham WM.

Shock. 2008 Apr;29(4):519-25.


L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.

Huang Z, Dias R, Jones T, Liu S, Styhler A, Claveau D, Otu F, Ng K, Laliberte F, Zhang L, Goetghebeur P, Abraham WM, Macdonald D, Dubé D, Gallant M, Lacombe P, Girard Y, Young RN, Turner MJ, Nicholson DW, Mancini JA.

Biochem Pharmacol. 2007 Jun 15;73(12):1971-81. Epub 2007 Mar 16.


Hyaluronan blocks porcine pancreatic elastase-induced mucociliary dysfunction in allergic sheep.

Scuri M, Sabater JR, Abraham WM.

J Appl Physiol (1985). 2007 Jun;102(6):2324-31. Epub 2007 Mar 29.


Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).

Sturino CF, O'Neill G, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Aubin Y, Bateman KP, Chauret N, Day SH, Lévesque JF, Seto C, Silva JH, Trimble LA, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, Abraham WM, Jones T, McAuliffe M, Piechuta H, Nicoll-Griffith DA, Wang Z, Zamboni R, Young RN, Metters KM.

J Med Chem. 2007 Feb 22;50(4):794-806.


Aerosolized red-tide toxins (brevetoxins) and asthma.

Fleming LE, Kirkpatrick B, Backer LC, Bean JA, Wanner A, Reich A, Zaias J, Cheng YS, Pierce R, Naar J, Abraham WM, Baden DG.

Chest. 2007 Jan;131(1):187-94.


Efficacy of IL-13 neutralization in a sheep model of experimental asthma.

Kasaian MT, Donaldson DD, Tchistiakova L, Marquette K, Tan XY, Ahmed A, Jacobson BA, Widom A, Cook TA, Xu X, Barry AB, Goldman SJ, Abraham WM.

Am J Respir Cell Mol Biol. 2007 Mar;36(3):368-76. Epub 2006 Oct 5.


Whole-body periodic acceleration modifies experimental asthma in sheep.

Abraham WM, Ahmed A, Serebriakov I, Lauredo IT, Bassuk J, Adams JA, Sackner MA.

Am J Respir Crit Care Med. 2006 Oct 1;174(7):743-52. Epub 2006 Jul 20.


Aerosolized Florida Red Tide Toxins and Human Health Effects.

Abraham WM, Baden DG.

Oceanography (Wash D C). 2006 Jun;19(2):107-109. No abstract available.


Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent.

Lawson EC, Santulli RJ, Dyatkin AB, Ballentine SA, Abraham WM, Rudman S, Page CP, de Garavilla L, Damiano BP, Kinney WA, Maryanoff BE.

Bioorg Med Chem. 2006 Jun 15;14(12):4208-16. Epub 2006 Feb 21.


Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease.

Abraham WM, Scuri M, Farmer SG.

Eur J Pharmacol. 2006 Mar 8;533(1-3):215-21. Epub 2006 Feb 7. Review.


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