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Items: 1 to 50 of 265

1.

Stem cell enriched lipotransfer reverses the effects of fibrosis in systemic sclerosis.

Almadori A, Griffin M, Ryan CM, Hunt DF, Hansen E, Kumar R, Abraham DJ, Denton CP, Butler PEM.

PLoS One. 2019 Jul 17;14(7):e0218068. doi: 10.1371/journal.pone.0218068. eCollection 2019.

2.

Endothelial C-Type Natriuretic Peptide Is a Critical Regulator of Angiogenesis and Vascular Remodeling.

Bubb KJ, Aubdool AA, Moyes AJ, Lewis S, Drayton JP, Tang O, Mehta V, Zachary IC, Abraham DJ, Tsui J, Hobbs AJ.

Circulation. 2019 Mar 26;139(13):1612-1628. doi: 10.1161/CIRCULATIONAHA.118.036344.

PMID:
30586761
3.

Hydrogel and membrane scaffold formulations of Frutalin (breadfruit lectin) within a polysaccharide galactomannan matrix have potential for wound healing.

de Sousa FD, Vasconselos PD, da Silva AFB, Mota EF, da Rocha Tomé A, Mendes FRDS, Gomes AMM, Abraham DJ, Shiwen X, Owen JS, Lourenzoni MR, Campos AR, Moreira RA, Monteiro-Moreira ACO.

Int J Biol Macromol. 2019 Jan;121:429-442. doi: 10.1016/j.ijbiomac.2018.10.050. Epub 2018 Oct 13.

PMID:
30326222
4.

Functional and phenotypic heterogeneity of Th17 cells in health and disease.

Bystrom J, Clanchy FIL, Taher TE, Al-Bogami M, Ong VH, Abraham DJ, Williams RO, Mageed RA.

Eur J Clin Invest. 2019 Jan;49(1):e13032. doi: 10.1111/eci.13032. Epub 2018 Nov 1. Review.

PMID:
30289986
5.

Insights into myofibroblasts and their activation in scleroderma: opportunities for therapy?

Gyftaki-Venieri DA, Abraham DJ, Ponticos M.

Curr Opin Rheumatol. 2018 Nov;30(6):581-587. doi: 10.1097/BOR.0000000000000543.

PMID:
30074511
6.

Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk.

Moreno-Moral A, Bagnati M, Koturan S, Ko JH, Fonseca C, Harmston N, Game L, Martin J, Ong V, Abraham DJ, Denton CP, Behmoaras J, Petretto E.

Ann Rheum Dis. 2018 Apr;77(4):596-601. doi: 10.1136/annrheumdis-2017-212454. Epub 2018 Jan 17.

7.

Molecular Basis for Dysregulated Activation of NKX2-5 in the Vascular Remodeling of Systemic Sclerosis.

Dritsoula A, Papaioannou I, Guerra SG, Fonseca C, Martin J, Herrick AL, Abraham DJ, Denton CP, Ponticos M.

Arthritis Rheumatol. 2018 Jun;70(6):920-931. doi: 10.1002/art.40419. Epub 2018 Apr 24.

8.

Association of Defective Regulation of Autoreactive Interleukin-6-Producing Transitional B Lymphocytes With Disease in Patients With Systemic Sclerosis.

Taher TE, Ong VH, Bystrom J, Hillion S, Simon Q, Denton CP, Pers JO, Abraham DJ, Mageed RA.

Arthritis Rheumatol. 2018 Mar;70(3):450-461. doi: 10.1002/art.40390. Epub 2018 Feb 6.

9.

STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis posttranscriptionally, and is essential for lung myofibroblast differentiation.

Papaioannou I, Xu S, Denton CP, Abraham DJ, Ponticos M.

Mol Biol Cell. 2018 Jan 15;29(2):84-95. doi: 10.1091/mbc.E17-06-0342. Epub 2017 Nov 15.

10.

Searching Novel Therapeutic Targets for Scleroderma: P2X7-Receptor Is Up-regulated and Promotes a Fibrogenic Phenotype in Systemic Sclerosis Fibroblasts.

Gentile D, Lazzerini PE, Gamberucci A, Natale M, Selvi E, Vanni F, Alì A, Taddeucci P, Del-Ry S, Cabiati M, Della-Latta V, Abraham DJ, Morales MA, Fulceri R, Laghi-Pasini F, Capecchi PL.

Front Pharmacol. 2017 Sep 13;8:638. doi: 10.3389/fphar.2017.00638. eCollection 2017.

11.

Frutapin, a lectin from Artocarpus incisa (breadfruit): cloning, expression and molecular insights.

de Sousa FD, da Silva BB, Furtado GP, Carneiro IS, Lobo MDP, Guan Y, Guo J, Coker AR, Lourenzoni MR, Guedes MIF, Owen JS, Abraham DJ, Monteiro-Moreira ACO, Moreira RA.

Biosci Rep. 2017 Jul 21;37(4). pii: BSR20170969. doi: 10.1042/BSR20170969. Print 2017 Aug 31.

12.

Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature.

Derrett-Smith EC, Martyanov V, Chighizola CB, Moinzadeh P, Campochiaro C, Khan K, Wood TA, Meroni PL, Abraham DJ, Ong VH, Lafyatis R, Whitfield ML, Denton CP.

Arthritis Res Ther. 2017 Jul 4;19(1):156. doi: 10.1186/s13075-017-1360-7.

13.

Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.

Taher TE, Bystrom J, Ong VH, Isenberg DA, Renaudineau Y, Abraham DJ, Mageed RA.

Clin Rev Allergy Immunol. 2017 Oct;53(2):237-264. doi: 10.1007/s12016-017-8609-4. Review.

14.

Brief Report: Anti-Eukaryotic Initiation Factor 2B Autoantibodies Are Associated With Interstitial Lung Disease in Patients With Systemic Sclerosis.

Betteridge ZE, Woodhead F, Lu H, Shaddick G, Bunn CC, Denton CP, Abraham DJ, du Bois RM, Lewis M, Wells AU, McHugh NJ.

Arthritis Rheumatol. 2016 Nov;68(11):2778-2783. doi: 10.1002/art.39755.

15.

Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring.

Ahadome SD, Abraham DJ, Rayapureddi S, Saw VP, Saban DR, Calder VL, Norman JT, Ponticos M, Daniels JT, Dart JK.

JCI Insight. 2016 Aug 4;1(12):e87001. doi: 10.1172/jci.insight.87001.

16.

Review: Frontiers of Antifibrotic Therapy in Systemic Sclerosis.

Distler JH, Feghali-Bostwick C, Soare A, Asano Y, Distler O, Abraham DJ.

Arthritis Rheumatol. 2017 Feb;69(2):257-267. doi: 10.1002/art.39865. Review. No abstract available.

17.

Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.

Evans IC, Barnes JL, Garner IM, Pearce DR, Maher TM, Shiwen X, Renzoni EA, Wells AU, Denton CP, Laurent GJ, Abraham DJ, McAnulty RJ.

Clin Sci (Lond). 2016 Apr;130(8):575-86. doi: 10.1042/CS20150697. Epub 2016 Jan 7.

18.

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.

Good RB, Gilbane AJ, Trinder SL, Denton CP, Coghlan G, Abraham DJ, Holmes AM.

Am J Pathol. 2015 Jul;185(7):1850-8. doi: 10.1016/j.ajpath.2015.03.019. Epub 2015 May 5.

PMID:
25956031
19.

Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis.

Clark KE, Lopez H, Abdi BA, Guerra SG, Shiwen X, Khan K, Etomi O, Martin GR, Abraham DJ, Denton CP, Stratton RJ.

Arthritis Res Ther. 2015 Mar 23;17:73. doi: 10.1186/s13075-015-0575-8.

20.

Macrophage epoxygenase determines a profibrotic transcriptome signature.

Behmoaras J, Diaz AG, Venda L, Ko JH, Srivastava P, Montoya A, Faull P, Webster Z, Moyon B, Pusey CD, Abraham DJ, Petretto E, Cook TH, Aitman TJ.

J Immunol. 2015 May 15;194(10):4705-4716. doi: 10.4049/jimmunol.1402979. Epub 2015 Apr 3.

21.

Erratum to: Thrombospondin 1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism.

Chen Y, Leask A, Abraham DJ, Kennedy L, Shi-Wen X, Denton CP, Black CM, Verjee LS, Eastwood M.

Fibrogenesis Tissue Repair. 2015 Mar 14;8:4. doi: 10.1186/s13069-015-0021-1. eCollection 2015.

22.

Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis.

Ponticos M, Papaioannou I, Xu S, Holmes AM, Khan K, Denton CP, Bou-Gharios G, Abraham DJ.

Arthritis Rheumatol. 2015 Jan;67(1):243-53. doi: 10.1002/art.38897.

23.

Stem cells of the lower limb: their role and potential in management of critical limb ischemia.

Hart CA, Tsui J, Khanna A, Abraham DJ, Baker DM.

Exp Biol Med (Maywood). 2013 Oct;238(10):1118-26. doi: 10.1177/1535370213503275. Epub 2013 Aug 30. Review.

PMID:
23996960
24.

Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease.

Lindahl GE, Stock CJ, Shi-Wen X, Leoni P, Sestini P, Howat SL, Bou-Gharios G, Nicholson AG, Denton CP, Grutters JC, Maher TM, Wells AU, Abraham DJ, Renzoni EA.

Respir Res. 2013 Aug 2;14:80. doi: 10.1186/1465-9921-14-80.

25.

Efficacy of the specific endothelin a receptor antagonist zibotentan (ZD4054) in colorectal cancer: a preclinical study.

Haque SU, Dashwood MR, Heetun M, Shiwen X, Farooqui N, Ramesh B, Welch H, Savage FJ, Ogunbiyi O, Abraham DJ, Loizidou M.

Mol Cancer Ther. 2013 Aug;12(8):1556-67. doi: 10.1158/1535-7163.MCT-12-0975. Epub 2013 May 30.

26.

Agonistic anti-ICAM-1 antibodies in scleroderma: activation of endothelial pro-inflammatory cascades.

Wolf SI, Howat S, Abraham DJ, Pearson JD, Lawson C.

Vascul Pharmacol. 2013 Jul-Aug;59(1-2):19-26. doi: 10.1016/j.vph.2013.05.002. Epub 2013 May 16.

27.

Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis.

De Lauretis A, Sestini P, Pantelidis P, Hoyles R, Hansell DM, Goh NS, Zappala CJ, Visca D, Maher TM, Denton CP, Ong VH, Abraham DJ, Kelleher P, Hector L, Wells AU, Renzoni EA.

J Rheumatol. 2013 Apr;40(4):435-46. doi: 10.3899/jrheum.120725. Epub 2013 Feb 1.

PMID:
23378460
28.

Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis.

Stock CJ, Sato H, Fonseca C, Banya WA, Molyneaux PL, Adamali H, Russell AM, Denton CP, Abraham DJ, Hansell DM, Nicholson AG, Maher TM, Wells AU, Lindahl GE, Renzoni EA.

Thorax. 2013 May;68(5):436-41. doi: 10.1136/thoraxjnl-2012-201786. Epub 2013 Jan 15.

PMID:
23321605
29.

Cell signalling pathways leading to novel therapeutic strategies in cardiovascular disease.

Shaw SG, Abraham DJ, Baker DM, Tsui J.

Cardiol Res Pract. 2012;2012:475094. doi: 10.1155/2012/475094. Epub 2012 Dec 24. No abstract available.

30.

Cyclic mechanical stress downregulates endothelin-1 and its responsive genes independently of TGFβ1 in dermal fibroblasts.

Peters AS, Brunner G, Blumbach K, Abraham DJ, Krieg T, Eckes B.

Exp Dermatol. 2012 Oct;21(10):765-70. doi: 10.1111/exd.12010.

PMID:
23078398
31.

Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts.

Shi-wen X, Thompson K, Khan K, Liu S, Murphy-Marshman H, Baron M, Denton CP, Leask A, Abraham DJ.

Rheumatology (Oxford). 2012 Dec;51(12):2146-54. doi: 10.1093/rheumatology/kes234. Epub 2012 Sep 12.

PMID:
22977060
32.

Potential of Novel EPO Derivatives in Limb Ischemia.

Joshi D, Tsui J, Yu R, Shiwen X, Selvakumar S, Abraham DJ, Baker DM.

Cardiol Res Pract. 2012;2012:213785. doi: 10.1155/2012/213785. Epub 2012 Feb 22.

33.

Morphometric analysis of intralobular, interlobular and pleural lymphatics in normal human lung.

Sozio F, Rossi A, Weber E, Abraham DJ, Nicholson AG, Wells AU, Renzoni EA, Sestini P.

J Anat. 2012 Apr;220(4):396-404. doi: 10.1111/j.1469-7580.2011.01473.x. Epub 2012 Jan 30.

34.

Modulation of fibrosis in systemic sclerosis by nitric oxide and antioxidants.

Dooley A, Bruckdorfer KR, Abraham DJ.

Cardiol Res Pract. 2012;2012:521958. doi: 10.1155/2012/521958. Epub 2011 Oct 31.

35.

Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin.

Abdulmalik O, Ghatge MS, Musayev FN, Parikh A, Chen Q, Yang J, Nnamani I, Danso-Danquah R, Eseonu DN, Asakura T, Abraham DJ, Venitz J, Safo MK.

Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):920-8. doi: 10.1107/S0907444911036353. Epub 2011 Oct 19. Erratum in: Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1076.

36.

Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin.

Holmes AM, Ponticos M, Shi-Wen X, Denton CP, Abraham DJ.

J Cell Commun Signal. 2011 Aug;5(3):173-7. doi: 10.1007/s12079-011-0140-4. Epub 2011 Jul 19.

37.

Loss of PTEN expression by dermal fibroblasts causes skin fibrosis.

Parapuram SK, Shi-wen X, Elliott C, Welch ID, Jones H, Baron M, Denton CP, Abraham DJ, Leask A.

J Invest Dermatol. 2011 Oct;131(10):1996-2003. doi: 10.1038/jid.2011.156. Epub 2011 Jun 9.

38.

Development of an in vitro model of myotube ischemia.

Joshi D, Patel H, Baker DM, Shiwen X, Abraham DJ, Tsui JC.

Lab Invest. 2011 Aug;91(8):1241-52. doi: 10.1038/labinvest.2011.79. Epub 2011 May 23.

39.
40.

Endothelin-1 stimulates colon cancer adjacent fibroblasts.

Knowles JP, Shi-Wen X, Haque SU, Bhalla A, Dashwood MR, Yang S, Taylor I, Winslet MC, Abraham DJ, Loizidou M.

Int J Cancer. 2012 Mar 15;130(6):1264-72. doi: 10.1002/ijc.26090. Epub 2011 Jun 9.

41.

mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis.

McCann MR, Monemdjou R, Ghassemi-Kakroodi P, Fahmi H, Perez G, Liu S, Shi-Wen X, Parapuram SK, Kojima F, Denton CP, Abraham DJ, Martel-Pelletier J, Crofford LJ, Leask A, Kapoor M.

Arthritis Res Ther. 2011;13(1):R6. doi: 10.1186/ar3226. Epub 2011 Jan 25. Erratum in: Arthritis Res Ther. 2011;13(2):402.

42.

Perivascular fat-derived leptin: a potential role in improved vein graft performance in coronary artery bypass surgery.

Dashwood MR, Dooley A, Shi-Wen X, Abraham DJ, Dreifaldt M, Souza DS.

Interact Cardiovasc Thorac Surg. 2011 Feb;12(2):170-3. doi: 10.1510/icvts.2010.247874. Epub 2010 Nov 3.

PMID:
21051379
43.

Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo.

Liu S, Xu SW, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A.

J Cell Sci. 2010 Nov 1;123(Pt 21):3674-82. doi: 10.1242/jcs.070672. Epub 2010 Oct 12.

44.

CCN2 is required for bleomycin-induced skin fibrosis in mice.

Liu S, Shi-wen X, Abraham DJ, Leask A.

Arthritis Rheum. 2011 Jan;63(1):239-46. doi: 10.1002/art.30074.

45.

An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor β receptor.

Hoyles RK, Derrett-Smith EC, Khan K, Shiwen X, Howat SL, Wells AU, Abraham DJ, Denton CP.

Am J Respir Crit Care Med. 2011 Jan 15;183(2):249-61. doi: 10.1164/rccm.201002-0279OC. Epub 2010 Aug 13.

PMID:
20709822
46.

Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate.

Dooley A, Shi-Wen X, Aden N, Tranah T, Desai N, Denton CP, Abraham DJ, Bruckdorfer R.

Rheumatology (Oxford). 2010 Nov;49(11):2024-36. doi: 10.1093/rheumatology/keq208. Epub 2010 Jul 13.

PMID:
20627968
47.

Review of the role of erythropoietin in critical leg ischemia.

Joshi D, Tsui J, Ho TK, Selvakumar S, Abraham DJ, Baker DM.

Angiology. 2010 Aug;61(6):541-50. doi: 10.1177/0003319709358697. Epub 2010 May 12. Review.

PMID:
20462898
48.

Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis.

Aden N, Nuttall A, Shiwen X, de Winter P, Leask A, Black CM, Denton CP, Abraham DJ, Stratton RJ.

J Invest Dermatol. 2010 Sep;130(9):2191-200. doi: 10.1038/jid.2010.120. Epub 2010 May 6.

49.

Angiogenic effects of stromal cell-derived factor-1 (SDF-1/CXCL12) variants in vitro and the in vivo expressions of CXCL12 variants and CXCR4 in human critical leg ischemia.

Ho TK, Tsui J, Xu S, Leoni P, Abraham DJ, Baker DM.

J Vasc Surg. 2010 Mar;51(3):689-99. doi: 10.1016/j.jvs.2009.10.044.

50.

Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.

Shi-wen X, Eastwood M, Stratton RJ, Denton CP, Leask A, Abraham DJ.

Rheumatology (Oxford). 2010 Feb;49(2):259-63. doi: 10.1093/rheumatology/kep371. Epub 2009 Dec 9.

PMID:
20007285

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