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Items: 1 to 50 of 98

1.

Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1G93A) Mouse Model of ALS.

Zeldich E, Chen CD, Boden E, Howat B, Nasse JS, Zeldich D, Lambert AG, Yuste A, Cherry JD, Mathias RM, Ma Q, Lau NC, McKee AC, Hatzipetros T, Abraham CR.

J Mol Neurosci. 2019 Oct;69(2):264-285. doi: 10.1007/s12031-019-01356-2. Epub 2019 Jun 27.

PMID:
31250273
2.

Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study.

McGrath ER, Himali JJ, Levy D, Conner SC, Pase MP, Abraham CR, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S.

PLoS One. 2019 Mar 4;14(3):e0213321. doi: 10.1371/journal.pone.0213321. eCollection 2019.

3.

Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling.

Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR.

J Alzheimers Dis. 2019;67(3):1089-1106. doi: 10.3233/JAD-180923.

4.

Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.

Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA.

J Neuroimmune Pharmacol. 2018 Jun;13(2):254-264. doi: 10.1007/s11481-018-9781-x. Epub 2018 Mar 7.

5.

Candidate molecular pathways of white matter vulnerability in the brain of normal aging rhesus monkeys.

Robinson AA, Abraham CR, Rosene DL.

Geroscience. 2018 Feb;40(1):31-47. doi: 10.1007/s11357-018-0006-2. Epub 2018 Jan 22.

6.

Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex.

Chen CD, Zeldich E, Li Y, Yuste A, Abraham CR.

J Mol Neurosci. 2018 Feb;64(2):175-184. doi: 10.1007/s12031-017-1011-0. Epub 2018 Jan 19.

7.

[Bilateral calcification of sacrotuberous ligament].

Saal Á, Abraham CR, Dalmasso MV.

Medicina (B Aires). 2016;76(5):316. Spanish. No abstract available.

8.

Klotho Is a Neuroprotective and Cognition-Enhancing Protein.

Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E.

Vitam Horm. 2016;101:215-38. doi: 10.1016/bs.vh.2016.02.004. Epub 2016 Mar 22. Review.

PMID:
27125744
9.

The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination.

Zeldich E, Chen CD, Avila R, Medicetty S, Abraham CR.

J Mol Neurosci. 2015 Oct;57(2):185-96. doi: 10.1007/s12031-015-0598-2. Epub 2015 Jun 12.

PMID:
26067431
10.

Predictors of Hospital Readmission after Bariatric Surgery.

Abraham CR, Werter CR, Ata A, Hazimeh YM, Shah US, Bhakta A, Tafen M, Singh PT, Beyer TD, Stain SC.

J Am Coll Surg. 2015 Jul;221(1):220-7. doi: 10.1016/j.jamcollsurg.2015.02.018. Epub 2015 Feb 28.

PMID:
26047761
11.

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.

Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L.

J Neurosci. 2015 Feb 11;35(6):2358-71. doi: 10.1523/JNEUROSCI.5791-12.2015.

12.

Identification of cleavage sites leading to the shed form of the anti-aging protein klotho.

Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR.

Biochemistry. 2014 Sep 2;53(34):5579-87. doi: 10.1021/bi500409n. Epub 2014 Aug 20.

13.

PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.

Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA.

Ann Neurol. 2014 Sep;76(3):379-92. doi: 10.1002/ana.24219. Epub 2014 Jul 29.

14.

The neuroprotective effect of Klotho is mediated via regulation of members of the redox system.

Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker Zhou TB, Harris DA, Abraham CR.

J Biol Chem. 2014 Aug 29;289(35):24700-15. doi: 10.1074/jbc.M114.567321. Epub 2014 Jul 18.

15.

The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line.

Chen CD, Li H, Liang J, Hixson K, Zeldich E, Abraham CR.

J Mol Neurosci. 2015 Jan;55(1):76-90. doi: 10.1007/s12031-014-0336-1. Epub 2014 Jun 8.

16.

Life extension factor klotho enhances cognition.

Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L.

Cell Rep. 2014 May 22;7(4):1065-76. doi: 10.1016/j.celrep.2014.03.076. Epub 2014 May 10.

17.

A NSQIP risk assessment for thyroid surgery based on comorbidities.

Abraham CR, Ata A, Carsello CB, Chan TL, Stain SC, Beyer TD.

J Am Coll Surg. 2014 Jun;218(6):1231-7. doi: 10.1016/j.jamcollsurg.2014.01.055. Epub 2014 Mar 2.

PMID:
24745620
18.

Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk.

Tucker Zhou TB, King GD, Chen C, Abraham CR.

J Biol Chem. 2013 Dec 20;288(51):36302-11. doi: 10.1074/jbc.M113.490052. Epub 2013 Nov 11.

19.

MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro.

Mehi SJ, Maltare A, Abraham CR, King GD.

Age (Dordr). 2014 Feb;36(1):141-9. doi: 10.1007/s11357-013-9555-6. Epub 2013 Jul 2.

20.

Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants.

So PP, Khodr CE, Chen CD, Abraham CR.

Am J Neurodegener Dis. 2013;2(1):15-28. Epub 2013 Mar 8.

21.

The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.

Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR.

J Neurosci. 2013 Jan 30;33(5):1927-39. doi: 10.1523/JNEUROSCI.2080-12.2013.

22.

The spectrum of disease in chronic traumatic encephalopathy.

McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC.

Brain. 2013 Jan;136(Pt 1):43-64. doi: 10.1093/brain/aws307. Epub 2012 Dec 2. Erratum in: Brain. 2013 Oct;136(Pt 10):e255.

23.

Small-molecule Klotho enhancers as novel treatment of neurodegeneration.

Abraham CR, Chen C, Cuny GD, Glicksman MA, Zeldich E.

Future Med Chem. 2012 Sep;4(13):1671-9. doi: 10.4155/fmc.12.134.

24.

Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization.

So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR.

Am J Neurodegener Dis. 2012;1(1):75-87.

25.

Identification of novel small molecules that elevate Klotho expression.

King GD, Chen C, Huang MM, Zeldich E, Brazee PL, Schuman ER, Robin M, Cuny GD, Glicksman MA, Abraham CR.

Biochem J. 2012 Jan 1;441(1):453-61. doi: 10.1042/BJ20101909.

26.

Promoter methylation and age-related downregulation of Klotho in rhesus monkey.

King GD, Rosene DL, Abraham CR.

Age (Dordr). 2012 Dec;34(6):1405-19. doi: 10.1007/s11357-011-9315-4. Epub 2011 Sep 16.

27.

Detection of amyloid-β protein precursor homo-interactions using beta-galactosidase enzyme fragment complementation.

So PP, Chen CD, Abraham CR.

J Alzheimers Dis. 2011;26(4):647-55. doi: 10.3233/JAD-2011-110323.

PMID:
21694460
28.

Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.

Erlich PM, Lunetta KL, Cupples LA, Abraham CR, Green RC, Baldwin CT, Farrer LA.

Neurobiol Aging. 2012 May;33(5):1015.e7-23. doi: 10.1016/j.neurobiolaging.2010.08.003. Epub 2010 Oct 27.

29.

Cell-type dependent modulation of Notch signaling by the amyloid precursor protein.

Oh SY, Chen CD, Abraham CR.

J Neurochem. 2010 Apr;113(1):262-74. doi: 10.1111/j.1471-4159.2010.06603.x. Epub 2010 Jan 20.

30.

Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide.

Yamin R, Zhao C, O'Connor PB, McKee AC, Abraham CR.

Mol Neurodegener. 2009 Jul 23;4:33. doi: 10.1186/1750-1326-4-33.

31.

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein.

Zerbinatti CV, Cordy JM, Chen CD, Guillily M, Suon S, Ray WJ, Seabrook GR, Abraham CR, Wolozin B.

Mol Neurodegener. 2008 Mar 18;3:5. doi: 10.1186/1750-1326-3-5.

32.

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17.

Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19796-801. Epub 2007 Dec 3.

33.

Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts.

Hinman JD, Chen CD, Oh SY, Hollander W, Abraham CR.

Glia. 2008 Jan 1;56(1):118-33.

PMID:
17963267
34.

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey.

Duce JA, Podvin S, Hollander W, Kipling D, Rosene DL, Abraham CR.

Glia. 2008 Jan 1;56(1):106-17.

PMID:
17963266
35.

What's behind the decline? The role of white matter in brain aging.

Hinman JD, Abraham CR.

Neurochem Res. 2007 Dec;32(12):2023-31. Epub 2007 Apr 20. Review.

PMID:
17447140
36.

Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide.

Yamin R, Bagchi S, Hildebrant R, Scaloni A, Widom RL, Abraham CR.

J Neurochem. 2007 Jan;100(2):458-67.

37.
38.

Age-related molecular reorganization at the node of Ranvier.

Hinman JD, Peters A, Cabral H, Rosene DL, Hollander W, Rasband MN, Abraham CR.

J Comp Neurol. 2006 Apr 1;495(4):351-62.

39.

Amyloid precursor protein interacts with notch receptors.

Oh SY, Ellenstein A, Chen CD, Hinman JD, Berg EA, Costello CE, Yamin R, Neve RL, Abraham CR.

J Neurosci Res. 2005 Oct 1;82(1):32-42.

PMID:
16118793
40.

Activation of early components of complement targets myelin and oligodendrocytes in the aged rhesus monkey brain.

Duce JA, Hollander W, Jaffe R, Abraham CR.

Neurobiol Aging. 2006 Apr;27(4):633-44. Epub 2005 Jun 29.

PMID:
15992964
41.

Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey.

Hinman JD, Duce JA, Siman RA, Hollander W, Abraham CR.

J Neurochem. 2004 Apr;89(2):430-41.

42.

The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation.

York IA, Mo AX, Lemerise K, Zeng W, Shen Y, Abraham CR, Saric T, Goldberg AL, Rock KL.

Immunity. 2003 Mar;18(3):429-40.

43.
44.

Reactive astrocytes and alpha1-antichymotrypsin in Alzheimer's disease.

Abraham CR.

Neurobiol Aging. 2001 Nov-Dec;22(6):931-6. Review.

PMID:
11755001
45.

Alpha 1-antichymotrypsin inhibits A beta degradation in vitro and in vivo.

Abraham CR, McGraw WT, Slot F, Yamin R.

Ann N Y Acad Sci. 2000;920:245-8.

PMID:
11193158
46.

Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice.

Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E.

Am J Pathol. 2000 Dec;157(6):2003-10.

47.

Amyloid beta peptide: a century of discoveries.

Abraham CR.

Amyloid. 2000 Mar;7(1):7-9. Review. No abstract available.

PMID:
10842695
48.

Astrocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey.

Sloane JA, Hollander W, Rosene DL, Moss MB, Kemper T, Abraham CR.

Brain Res. 2000 Apr 17;862(1-2):1-10.

PMID:
10799662
49.

Increased microglial activation and protein nitration in white matter of the aging monkey.

Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR.

Neurobiol Aging. 1999 Jul-Aug;20(4):395-405.

PMID:
10604432
50.

Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation.

Yamin R, Malgeri EG, Sloane JA, McGraw WT, Abraham CR.

J Biol Chem. 1999 Jun 25;274(26):18777-84.

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