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ATR suppresses the pro-tumorigenic functions of breast stromal fibroblasts.

Al-Ansari MM, Aboussekhra A.

Oncotarget. 2018 Oct 5;9(78):34681-34690. doi: 10.18632/oncotarget.26159. eCollection 2018 Oct 5.


Senescent breast luminal cells promote carcinogenesis through IL-8-dependent activation of stromal fibroblasts.

Al-Khalaf HH, Ghebeh H, Inass R, Aboussekhra A.

Mol Cell Biol. 2018 Nov 5. pii: MCB.00359-18. doi: 10.1128/MCB.00359-18. [Epub ahead of print]


IL-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenic and Tumorigenic Promoting Effects.

Al-Khalaf HH, Al-Harbi B, Al-Sayed A, Arafah M, Tulbah A, Jarman A, Al-Mohanna F, Aboussekhra A.

Mol Cell Biol. 2018 Nov 5. pii: MCB.00332-18. doi: 10.1128/MCB.00332-18. [Epub ahead of print]


p16 Controls p53 Protein Expression Through miR-dependent Destabilization of MDM2.

Al-Khalaf HH, Aboussekhra A.

Mol Cancer Res. 2018 Aug;16(8):1299-1308. doi: 10.1158/1541-7786.MCR-18-0017. Epub 2018 May 8.


Let-7b inhibits cancer-promoting effects of breast cancer-associated fibroblasts through IL-8 repression.

Al-Harbi B, Hendrayani SF, Silva G, Aboussekhra A.

Oncotarget. 2018 Apr 3;9(25):17825-17838. doi: 10.18632/oncotarget.24895. eCollection 2018 Apr 3.


The DNA methyl-transferase protein DNMT1 enhances tumor-promoting properties of breast stromal fibroblasts.

Al-Kharashi LA, Al-Mohanna FH, Tulbah A, Aboussekhra A.

Oncotarget. 2017 Dec 18;9(2):2329-2343. doi: 10.18632/oncotarget.23411. eCollection 2018 Jan 5.


Eugenol potentiates cisplatin anti-cancer activity through inhibition of ALDH-positive breast cancer stem cells and the NF-κB signaling pathway.

Islam SS, Al-Sharif I, Sultan A, Al-Mazrou A, Remmal A, Aboussekhra A.

Mol Carcinog. 2018 Mar;57(3):333-346. doi: 10.1002/mc.22758. Epub 2017 Nov 24.


Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity.

Al-Khalaf HH, Amir M, Al-Mohanna F, Tulbah A, Al-Sayed A, Aboussekhra A.

Mol Cell Biol. 2017 Aug 11;37(17). pii: e00101-17. doi: 10.1128/MCB.00101-17. Print 2017 Sep 1.


Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer.

Noman AS, Uddin M, Chowdhury AA, Nayeem MJ, Raihan Z, Rashid MI, Azad AK, Rahman ML, Barua D, Sultana A, Shirin A, Ferdous J, Parag RR, Rahman SM, Mahmud MR, Jerin CS, Jahan N, Siddiqua A, Ara T, Sabur EB, Alam SS, Baidya S, Akther S, Rahman MZ, Banu T, Murugan AK, Sabri S, Islam SMS, Karakas B, Aboussekhra A, Yeger H, Farhat WA, Islam SS.

Sci Rep. 2017 May 11;7(1):1796. doi: 10.1038/s41598-017-01268-4.


p16INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction.

Al-Khalaf HH, Nallar SC, Kalvakolanu DV, Aboussekhra A.

Mol Carcinog. 2017 Jul;56(7):1687-1702. doi: 10.1002/mc.22627. Epub 2017 Mar 6.


p16INK4A induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1.

Al-Khalaf HH, Aboussekhra A.

Mol Carcinog. 2017 Mar;56(3):985-999. doi: 10.1002/mc.22564. Epub 2016 Sep 21.


CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6.

Al-Rakan MA, Hendrayani SF, Aboussekhra A.

BMC Cancer. 2016 Aug 2;16:575. doi: 10.1186/s12885-016-2614-5.


PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells.

Al-Howail HA, Hakami HA, Al-Otaibi B, Al-Mazrou A, Daghestani MH, Al-Jammaz I, Al-Khalaf HH, Aboussekhra A.

BMC Cancer. 2016 Jul 27;16:540. doi: 10.1186/s12885-016-2583-8.


The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts.

Hendrayani SF, Al-Harbi B, Al-Ansari MM, Silva G, Aboussekhra A.

Oncotarget. 2016 Jul 5;7(27):41974-41985. doi: 10.18632/oncotarget.9633.


Overexpression of sonic hedgehog in the triple negative breast cancer: clinicopathological characteristics of high burden breast cancer patients from Bangladesh.

Noman AS, Uddin M, Rahman MZ, Nayeem MJ, Alam SS, Khatun Z, Wahiduzzaman M, Sultana A, Rahman ML, Ali MY, Barua D, Ahmed I, Islam MS, Aboussekhra A, Yeger H, Farhat WA, Islam SS.

Sci Rep. 2016 Jan 5;6:18830. doi: 10.1038/srep18830.


miR-146b-5p mediates p16-dependent repression of IL-6 and suppresses paracrine procarcinogenic effects of breast stromal fibroblasts.

Al-Ansari MM, Aboussekhra A.

Oncotarget. 2015 Oct 6;6(30):30006-16. doi: 10.18632/oncotarget.4933.


p16(INK4A) inhibits the pro-metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF-β1.

Silva G, Aboussekhra A.

Mol Carcinog. 2016 May;55(5):525-36. doi: 10.1002/mc.22299. Epub 2015 Mar 1.


PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition.

Al-Qasem A, Al-Howail HA, Al-Swailem M, Al-Mazrou A, Al-Otaibi B, Al-Jammaz I, Al-Khalaf HH, Aboussekhra A.

Mol Carcinog. 2016 Mar;55(3):233-44. doi: 10.1002/mc.22271. Epub 2015 Jan 16.


The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females.

Al-Moghrabi N, Nofel A, Al-Yousef N, Madkhali S, Bin Amer SM, Alaiya A, Shinwari Z, Al-Tweigeri T, Karakas B, Tulbah A, Aboussekhra A.

BMC Cancer. 2014 Nov 17;14:830. doi: 10.1186/1471-2407-14-830.


Obesity is a significant risk factor for breast cancer in Arab women.

Elkum N, Al-Tweigeri T, Ajarim D, Al-Zahrani A, Amer SM, Aboussekhra A.

BMC Cancer. 2014 Oct 29;14:788. doi: 10.1186/1471-2407-14-788.


The cytokine IL-6 reactivates breast stromal fibroblasts through transcription factor STAT3-dependent up-regulation of the RNA-binding protein AUF1.

Hendrayani SF, Al-Khalaf HH, Aboussekhra A.

J Biol Chem. 2014 Nov 7;289(45):30962-76. doi: 10.1074/jbc.M114.594044. Epub 2014 Sep 17.


Caffeine mediates sustained inactivation of breast cancer-associated myofibroblasts via up-regulation of tumor suppressor genes.

Al-Ansari MM, Aboussekhra A.

PLoS One. 2014 Mar 3;9(3):e90907. doi: 10.1371/journal.pone.0090907. eCollection 2014.


Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation.

Al-Sharif I, Remmal A, Aboussekhra A.

BMC Cancer. 2013 Dec 13;13:600. doi: 10.1186/1471-2407-13-600.


Breast stromal fibroblasts from histologically normal surgical margins are pro-carcinogenic.

Al-Rakan MA, Colak D, Hendrayani SF, Al-Bakheet A, Al-Mohanna FH, Kaya N, Al-Malik O, Aboussekhra A.

J Pathol. 2013 Dec;231(4):457-65. doi: 10.1002/path.4256.


Prevalence of PIK3CA mutations and the SNP rs17849079 in Arab breast cancer patients.

Karakas B, Colak D, Kaya N, Ghebeh H, Al-Qasem A, Hendrayani F, Toulimat M, Al-Tweigeri T, Park BH, Aboussekhra A.

Cancer Biol Ther. 2013 Oct 1;14(10):888-96. doi: 10.4161/cbt.25945. Epub 2013 Aug 12.


p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.

Al-Khalaf HH, Aboussekhra A.

PLoS One. 2013 Jul 23;8(7):e70133. doi: 10.1371/journal.pone.0070133. Print 2013.


ATR controls the UV-related upregulation of the CDKN1A mRNA in a Cdk1/HuR-dependent manner.

Al-Khalaf HH, Aboussekhra A.

Mol Carcinog. 2014 Dec;53(12):979-87. doi: 10.1002/mc.22066. Epub 2013 Jun 29.


p16INK4A represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition.

Al-Ansari MM, Hendrayani SF, Tulbah A, Al-Tweigeri T, Shehata AI, Aboussekhra A.

Neoplasia. 2012 Dec;14(12):1269-77.


Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells.

Elamin MH, Daghestani MH, Omer SA, Elobeid MA, Virk P, Al-Olayan EM, Hassan ZK, Mohammed OB, Aboussekhra A.

Food Chem Toxicol. 2013 Mar;53:310-6. doi: 10.1016/j.fct.2012.12.009. Epub 2012 Dec 20.


Camel urine components display anti-cancer properties in vitro.

Al-Yousef N, Gaafar A, Al-Otaibi B, Al-Jammaz I, Al-Hussein K, Aboussekhra A.

J Ethnopharmacol. 2012 Oct 11;143(3):819-25. doi: 10.1016/j.jep.2012.07.042. Epub 2012 Aug 16.


p16(INK4A) represses the paracrine tumor-promoting effects of breast stromal fibroblasts.

Al-Ansari MM, Hendrayani SF, Shehata AI, Aboussekhra A.

Oncogene. 2013 May 2;32(18):2356-64. doi: 10.1038/onc.2012.270. Epub 2012 Jul 2. Erratum in: Oncogene. 2013 May 2;32(18):2372.


The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women.

Al-Qasem A, Toulimat M, Tulbah A, Elkum N, Al-Tweigeri T, Aboussekhra A.

Oncol Lett. 2012 Apr 1;3(4):875-878. Epub 2012 Jan 24.


Survivin expression increases during aging and enhances the resistance of aged human fibroblasts to genotoxic stress.

Al-Khalaf HH, Aboussekhra A.

Age (Dordr). 2013 Jun;35(3):549-62. doi: 10.1007/s11357-011-9378-2. Epub 2012 Jan 15.


Role of cancer-associated fibroblasts in breast cancer development and prognosis.

Aboussekhra A.

Int J Dev Biol. 2011;55(7-9):841-9. doi: 10.1387/ijdb.113362aa. Review.


ATR controls the p21(WAF1/Cip1) protein up-regulation and apoptosis in response to low UV fluences.

Al-Khalaf HH, Hendrayani SF, Aboussekhra A.

Mol Carcinog. 2012 Dec;51(12):930-8. doi: 10.1002/mc.20864. Epub 2011 Oct 4.


p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.

Al-Khalaf HH, Colak D, Al-Saif M, Al-Bakheet A, Hendrayani SF, Al-Yousef N, Kaya N, Khabar KS, Aboussekhra A.

PLoS One. 2011;6(7):e21111. doi: 10.1371/journal.pone.0021111. Epub 2011 Jul 20.


Response of medulloblastoma cells to vincristine and lomustine: role of TRKC, CTNNB1 and STK15.

Shinwari Z, Al-Hindi H, Al-Shail E, Khafaga Y, Al-Kofide A, El-Kum N, Aboussekhra A.

Anticancer Res. 2011 May;31(5):1721-33.


Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women.

Al-Moghrabi N, Al-Qasem AJ, Aboussekhra A.

Int J Oncol. 2011 Jul;39(1):129-35. doi: 10.3892/ijo.2011.1021. Epub 2011 Apr 29.


TP53 genetic alterations in Arab breast cancer patients: Novel mutations, pattern and distribution.

Al-Qasem AJ, Toulimat M, Eldali AM, Tulbah A, Al-Yousef N, Al-Daihan SK, Al-Tassan N, Al-Tweigeri T, Aboussekhra A.

Oncol Lett. 2011 Mar;2(2):363-369. Epub 2011 Jan 18.


The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation.

Al-Khalaf HH, Hendrayani SF, Aboussekhra A.

Mol Cancer Res. 2011 Mar;9(3):311-9. doi: 10.1158/1541-7786.MCR-10-0506. Epub 2011 Jan 26.


PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells.

Al-Hujaily EM, Mohamed AG, Al-Sharif I, Youssef KM, Manogaran PS, Al-Otaibi B, Al-Haza'a A, Al-Jammaz I, Al-Hussein K, Aboussekhra A.

Breast Cancer Res Treat. 2011 Jul;128(1):97-107. doi: 10.1007/s10549-010-1089-3. Epub 2010 Aug 1.


Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule.

Ghebeh H, Lehe C, Barhoush E, Al-Romaih K, Tulbah A, Al-Alwan M, Hendrayani SF, Manogaran P, Alaiya A, Al-Tweigeri T, Aboussekhra A, Dermime S.

Breast Cancer Res. 2010;12(4):R48. doi: 10.1186/bcr2605. Epub 2010 Jul 13.


Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells.

Elamin MH, Shinwari Z, Hendrayani SF, Al-Hindi H, Al-Shail E, Khafaga Y, Al-Kofide A, Aboussekhra A.

Mol Carcinog. 2010 Mar;49(3):302-14. doi: 10.1002/mc.20604.


The RAD9-dependent gene trans-activation is required for excision repair of active genes but not for repair of non-transcribed DNA.

Al-Moghrabi NM, Al-Sharif IS, Aboussekhra A.

Mutat Res. 2009 Apr 26;663(1-2):60-8. doi: 10.1016/j.mrfmmm.2009.01.008. Epub 2009 Feb 4.


Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes.

Hawsawi NM, Ghebeh H, Hendrayani SF, Tulbah A, Al-Eid M, Al-Tweigeri T, Ajarim D, Alaiya A, Dermime S, Aboussekhra A.

Cancer Res. 2008 Apr 15;68(8):2717-25. doi: 10.1158/0008-5472.CAN-08-0192.


Vincristine and lomustine induce apoptosis and p21(WAF1) up-regulation in medulloblastoma and normal human epithelial and fibroblast cells.

Shinwari Z, Manogaran PS, Alrokayan SA, Al-Hussein KA, Aboussekhra A.

J Neurooncol. 2008 Apr;87(2):123-32. Epub 2007 Dec 6.


Expression of survivin and p16(INK4a)/Cdk6/pRB proteins and induction of apoptosis in response to radiation and cisplatin in meningioma cells.

Al-Khalaf HH, Lach B, Allam A, Hassounah M, Alkhani A, Elkum N, Alrokayan SA, Aboussekhra A.

Brain Res. 2008 Jan 10;1188:25-34. Epub 2007 Nov 4.


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