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Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects.

Ramanjaneya M, Bettahi I, Jerobin J, Chandra P, Abi Khalil C, Skarulis M, Atkin SL, Abou-Samra AB.

Front Endocrinol (Lausanne). 2019 May 31;10:331. doi: 10.3389/fendo.2019.00331. eCollection 2019.


Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.

Ramanjaneya M, Jerobin J, Bettahi I, Bensila M, Aye M, Siveen KS, Sathyapalan T, Skarulis M, Abou-Samra AB, Atkin SL.

Clin Endocrinol (Oxf). 2019 May 7. doi: 10.1111/cen.14007. [Epub ahead of print]


Hepatitis C Virus Treatment with Directly Acting Agents Reduces the Risk of Incident Diabetes - Results from ERCHIVES.

Butt AA, Yan P, Aslam S, Shaikh OS, Abou-Samra AB.

Clin Infect Dis. 2019 Apr 12. pii: ciz304. doi: 10.1093/cid/ciz304. [Epub ahead of print]


Differential effects of gender and patient background diversity on the changes in metabolic and biophysical profiles in people with type-2 diabetes from different ethnicities who fast during Ramadan (H1439); a prospective study from Qatar.

Dabbous Z, Bashir M, Elzouki AN, Ahmed MS, Farouk S, Hassanien M, Malik RA, Abou Samra AB, Elhadd T; PROFAST Study Group.

Diabetes Res Clin Pract. 2019 Jun;152:171-176. doi: 10.1016/j.diabres.2019.03.032. Epub 2019 Mar 28.


Incidence of hypoglycaemia in patients with type-2 diabetes taking multiple glucose lowering therapies during Ramadan: the PROFAST Ramadan Study.

Elhadd T, Dabbous Z, Bashir M, Elzouki A, Ghadban W, Baagar K, Benjamin S, Hassanien M, Saeed AAM, Dukhan K, Malik RA, Abou-Samra AB; PROFAST Study Group.

J Diabetes Metab Disord. 2018 Nov 19;17(2):309-314. doi: 10.1007/s40200-018-0374-2. eCollection 2018 Dec.


DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation.

Arredouani A, Diane A, Khattab N, Bensmail I, Aoude I, Chikri M, Mohammad R, Abou-Samra AB, Dehbi M.

Sci Rep. 2019 Mar 18;9(1):4772. doi: 10.1038/s41598-019-41244-8.


Knowledge and Perception of Diabetes and Available Services among Diabetic Patients in the State of Qatar.

Al-Thani AA, Farghaly A, Akram H, Khalifa S, Vinodson B, Loares A, Abou-Samra AB.

Cent Asian J Glob Health. 2019 Jan 24;8(1):333. doi: 10.5195/cajgh.2019.333. eCollection 2019.


Pregnancy outcomes of early detected gestational diabetes: a retrospective comparison cohort study, Qatar.

Bashir M, Baagar K, Naem E, Elkhatib F, Alshaybani N, Konje JC, Abou-Samra AB.

BMJ Open. 2019 Feb 19;9(2):e023612. doi: 10.1136/bmjopen-2018-023612.


Outcomes of type 1 diabetes mellitus in pregnancy; effect of excessive gestational weight gain and hyperglycaemia on fetal growth.

Bashir M, Naem E, Taha F, Konje JC, Abou-Samra AB.

Diabetes Metab Syndr. 2019 Jan - Feb;13(1):84-88. doi: 10.1016/j.dsx.2018.08.030. Epub 2018 Aug 28.


Type 2 diabetes mellitus in pregnancy: The impact of maternal weight and early glycaemic control on outcomes.

Bashir M, Dabbous Z, Baagar K, Elkhatib F, Ibrahim A, Brich SA, Abdel-Rahman ME, Konje JC, Abou-Samra AB.

Eur J Obstet Gynecol Reprod Biol. 2019 Feb;233:53-57. doi: 10.1016/j.ejogrb.2018.12.008. Epub 2018 Dec 13.


Metformin-treated-GDM has lower risk of macrosomia compared to diet-treated GDM- A retrospective cohort study.

Bashir M, Aboulfotouh M, Dabbous Z, Mokhtar M, Siddique M, Wahba R, Ibrahim A, Al-Houda Brich S, Konje JC, Abou-Samra AB.

J Matern Fetal Neonatal Med. 2018 Nov 20:1-141. doi: 10.1080/14767058.2018.1550480. [Epub ahead of print]


Direct-Acting Antiviral Therapy for HCV Infection Is Associated With a Reduced Risk of Cardiovascular Disease Events.

Butt AA, Yan P, Shuaib A, Abou-Samra AB, Shaikh OS, Freiberg MS.

Gastroenterology. 2019 Mar;156(4):987-996.e8. doi: 10.1053/j.gastro.2018.11.022. Epub 2018 Nov 13.


Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress.

Bosco G, Vezzani G, Mrakic Sposta S, Rizzato A, Enten G, Abou-Samra A, Malacrida S, Quartesan S, Vezzoli A, Camporesi E.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1501-1505. doi: 10.1080/14756366.2018.1485149.


Prevalence of newly detected diabetes in pregnancy in Qatar, using universal screening.

Bashir M, E Abdel-Rahman M, Aboulfotouh M, Eltaher F, Omar K, Babarinsa I, Appiah-Sakyi K, Sharaf T, Azzam E, Abukhalil M, Boumedjane M, Yousif W, Ahmed W, Khan S, C Konje J, Abou-Samra AB.

PLoS One. 2018 Aug 3;13(8):e0201247. doi: 10.1371/journal.pone.0201247. eCollection 2018.


Public Awareness and Perceptions about Diabetes in the State of Qatar.

Al-Thani AA, Farghaly AH, Akram H, Khalifa SE, Vinodson B, Loares AM, Abou-Samra AB.

Cureus. 2018 May 22;10(5):e2671. doi: 10.7759/cureus.2671.


A pilot study using flash continuous glucose monitoring in patients with type-2 diabetes on multiple anti-diabetic agents during Ramadan.

Bashir M, Elhadd T, Ali H, Baagar K, Abdel Hakam IA, Al-Mohanadi DHS, Naem E, Al Abdulla A, Mohammed K, Abou-Samra AB.

Diabetes Metab Syndr. 2018 Nov;12(6):965-968. doi: 10.1016/j.dsx.2018.06.005. Epub 2018 Jun 7.


Effectiveness, treatment completion and safety of sofosbuvir/ledipasvir and paritaprevir/ritonavir/ombitasvir + dasabuvir in patients with chronic kidney disease: an ERCHIVES study.

Butt AA, Ren Y, Puenpatom A, Arduino JM, Kumar R, Abou-Samra AB.

Aliment Pharmacol Ther. 2018 Jul;48(1):35-43. doi: 10.1111/apt.14799. Epub 2018 May 24.


Diabetes Intervention Accentuating Diet and Enhancing Metabolism (DIADEM-I): a randomised controlled trial to examine the impact of an intensive lifestyle intervention consisting of a low-energy diet and physical activity on body weight and metabolism in early type 2 diabetes mellitus: study protocol for a randomized controlled trial.

Taheri S, Chagoury O, Zaghloul H, Elhadad S, Ahmed SH, Omar O, Payra S, Ahmed S, El Khatib N, Amona RA, El Nahas K, Bolton M, Chaar H, Suleiman N, Jayyousi A, Zirie M, Janahi I, Elhag W, Alnaama A, Zainel A, Hassan D, Cable T, Charlson M, Wells M, Al-Hamaq A, Al-Abdulla S, Abou-Samra AB.

Trials. 2018 May 21;19(1):284. doi: 10.1186/s13063-018-2660-1.


Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A.

Abou Samra A, Robert A, Gov C, Favre L, Eloy L, Jacquet E, Bignon J, Wiels J, Desrat S, Roussi F.

Eur J Med Chem. 2018 Mar 25;148:26-38. doi: 10.1016/j.ejmech.2018.01.100. Epub 2018 Feb 5.


Multiple Evanescent White Dot Syndrome Following Intradermal Influenza Vaccination.

Abou-Samra A, Tarabishy AB.

Ocul Immunol Inflamm. 2018 Jan 25:1-3. doi: 10.1080/09273948.2017.1423334. [Epub ahead of print]


HCV treatment initiation in persons with chronic kidney disease in the directly acting antiviral agents era: Results from ERCHIVES.

Butt AA, Ren Y, Puenpatom A, Arduino JM, Kumar R, Abou-Samra AB.

Liver Int. 2018 Aug;38(8):1411-1417. doi: 10.1111/liv.13672. Epub 2018 Jan 19.


The short-term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct-acting antivirals: An ERCHIVES study.

Li DK, Ren Y, Fierer DS, Rutledge S, Shaikh OS, Lo Re V 3rd, Simon T, Abou-Samra AB, Chung RT, Butt AA.

Hepatology. 2018 Jun;67(6):2244-2253. doi: 10.1002/hep.29707. Epub 2018 Apr 19.


Hepatitis B reactivation and outcomes in persons treated with directly acting antiviral agents against hepatitis C virus: results from ERCHIVES.

Butt AA, Yan P, Shaikh OS, Abou-Samra AB.

Aliment Pharmacol Ther. 2018 Feb;47(3):412-420. doi: 10.1111/apt.14426. Epub 2017 Nov 27.


(+)- and (-)-Ecarlottones, Uncommon Chalconoids from Fissistigma latifolium with Pro-Apoptotic Activity.

Gény C, Abou Samra A, Retailleau P, Iorga BI, Nedev H, Awang K, Roussi F, Litaudon M, Dumontet V.

J Nat Prod. 2017 Dec 22;80(12):3179-3185. doi: 10.1021/acs.jnatprod.7b00494. Epub 2017 Nov 21.


Pathways governing development of stem cell-derived pancreatic β cells: lessons from embryogenesis.

Al-Khawaga S, Memon B, Butler AE, Taheri S, Abou-Samra AB, Abdelalim EM.

Biol Rev Camb Philos Soc. 2018 Feb;93(1):364-389. doi: 10.1111/brv.12349. Epub 2017 Jun 22. Review.


Risk of Acute Myocardial Infarction Among Hepatitis C Virus (HCV)-Positive and HCV-Negative Men at Various Lipid Levels: Results From ERCHIVES.

Butt AA, Yan P, Chew KW, Currier J, Corey K, Chung RT, Shuaib A, Abou-Samra AB, Butler J, Freiberg MS.

Clin Infect Dis. 2017 Aug 15;65(4):557-565. doi: 10.1093/cid/cix359.


Antibiotic prescription patterns for upper respiratory tract infections in the outpatient Qatari population in the private sector.

Butt AA, Navasero CS, Thomas B, Marri SA, Katheeri HA, Thani AA, Khal AA, Khan T, Abou-Samra AB.

Int J Infect Dis. 2017 Feb;55:20-23. doi: 10.1016/j.ijid.2016.12.004. Epub 2016 Dec 9.


Cholesterol Depletion Alters Cardiomyocyte Subcellular Signaling and Increases Contractility.

Haque MZ, McIntosh VJ, Abou Samra AB, Mohammad RM, Lasley RD.

PLoS One. 2016 Jul 21;11(7):e0154151. doi: 10.1371/journal.pone.0154151. eCollection 2016.


Measurement of 1,5-anhydroglucitol in blood and saliva: from non-targeted metabolomics to biochemical assay.

Halama A, Kulinski M, Kader SA, Satheesh NJ, Abou-Samra AB, Suhre K, Mohammad RM.

J Transl Med. 2016 May 18;14(1):140. doi: 10.1186/s12967-016-0897-6.


Changes in circulating lipids level over time after acquiring HCV infection: results from ERCHIVES.

Butt AA, Yan P, Simon TG, Chung RT, Abou-Samra AB; ERCHIVES study team.

BMC Infect Dis. 2015 Nov 11;15:510. doi: 10.1186/s12879-015-1268-2.


Beneficial Effects of Implementing Stroke Protocols Require Establishment of a Geographically Distinct Unit.

Akhtar N, Kamran S, Singh R, Cameron P, D'Souza A, Imam Y, Bourke P, Joseph S, Khan R, Santos M, Deleu D, El-Zouki A, Abou-Samra A, Butt AA, Shuaib A.

Stroke. 2015 Dec;46(12):3494-501. doi: 10.1161/STROKEAHA.115.010552. Epub 2015 Oct 22.


Plasma Lactate Levels Increase during Hyperinsulinemic Euglycemic Clamp and Oral Glucose Tolerance Test.

Berhane F, Fite A, Daboul N, Al-Janabi W, Msallaty Z, Caruso M, Lewis MK, Yi Z, Diamond MP, Abou-Samra AB, Seyoum B.

J Diabetes Res. 2015;2015:102054. doi: 10.1155/2015/102054. Epub 2015 Apr 19.


Effect of addition of statins to antiviral therapy in hepatitis C virus-infected persons: Results from ERCHIVES.

Butt AA, Yan P, Bonilla H, Abou-Samra AB, Shaikh OS, Simon TG, Chung RT, Rogal SS; ERCHIVES (Electronically Retrieved Cohort of HCV Infected Veterans) Study Team.

Hepatology. 2015 Aug;62(2):365-74. doi: 10.1002/hep.27835. Epub 2015 May 23.


Prevalence of Diabetes in an Urban Hospital Emergency Room Serving Predominantly Indigenous Population.

Araia M, Roxas R, Abou-Samra AB, Seyoum B.

J Natl Med Assoc. 2015 Feb;107(1):11-6. doi: 10.1016/S0027-9684(15)30004-3. Epub 2015 Dec 2.


A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy.

Zhang R, Abou-Samra AB.

Cardiovasc Diabetol. 2014 Sep 13;13:133. doi: 10.1186/s12933-014-0133-8. Review.


Macrophages inhibit insulin signalling in adipocytes: role of inducible nitric oxide synthase and nitric oxide.

Fite A, Abou-Samra AB, Seyoum B.

Can J Diabetes. 2015 Feb;39(1):36-43. doi: 10.1016/j.jcjd.2014.02.023. Epub 2014 Aug 30.


An explanation for recent discrepancies in levels of human circulating betatrophin.

Fu Z, Abou-Samra AB, Zhang R.

Diabetologia. 2014 Oct;57(10):2232-4. doi: 10.1007/s00125-014-3346-1. Epub 2014 Aug 7. No abstract available.


Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer.

Gao J, Azmi AS, Aboukameel A, Kauffman M, Shacham S, Abou-Samra AB, Mohammad RM.

Oncotarget. 2014 Jun 15;5(11):3444-54.


Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity.

Fu Z, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R.

Sci Rep. 2014 May 23;4:5013. doi: 10.1038/srep05013.


Increased interaction with insulin receptor substrate 1, a novel abnormality in insulin resistance and type 2 diabetes.

Caruso M, Ma D, Msallaty Z, Lewis M, Seyoum B, Al-janabi W, Diamond M, Abou-Samra AB, Højlund K, Tagett R, Draghici S, Zhang X, Horowitz JF, Yi Z.

Diabetes. 2014 Jun;63(6):1933-47. doi: 10.2337/db13-1872. Epub 2014 Feb 28.


Resolution of diabetes after bariatric surgery among predominantly African-American patients: race has no effect in remission of diabetes after bariatric surgery.

Araia M, Wood M, Kroll J, Abou-Samra A, Seyoum B.

Obes Surg. 2014 Jun;24(6):835-40. doi: 10.1007/s11695-014-1187-0.


Nuclear export mediated regulation of microRNAs: potential target for drug intervention.

Muqbil I, Bao B, Abou-Samra AB, Mohammad RM, Azmi AS.

Curr Drug Targets. 2013 Sep;14(10):1094-100. Review.


Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH.

Maeda A, Okazaki M, Baron DM, Dean T, Khatri A, Mahon M, Segawa H, Abou-Samra AB, Jüppner H, Bloch KD, Potts JT Jr, Gardella TJ.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5864-9. doi: 10.1073/pnas.1301674110. Epub 2013 Mar 26.


Emerging roles of Lipasin as a critical lipid regulator.

Zhang R, Abou-Samra AB.

Biochem Biophys Res Commun. 2013 Mar 15;432(3):401-5. doi: 10.1016/j.bbrc.2013.01.129. Epub 2013 Feb 13. Review.


Ahsg-fetuin blocks the metabolic arm of insulin action through its interaction with the 95-kD β-subunit of the insulin receptor.

Goustin AS, Derar N, Abou-Samra AB.

Cell Signal. 2013 Apr;25(4):981-8. doi: 10.1016/j.cellsig.2012.12.011. Epub 2013 Jan 11.


Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family.

Fu Z, Yao F, Abou-Samra AB, Zhang R.

Biochem Biophys Res Commun. 2013 Jan 18;430(3):1126-31. doi: 10.1016/j.bbrc.2012.12.025. Epub 2012 Dec 19.


MKP1-dependent PTH modulation of bone matrix mineralization in female mice is osteoblast maturation stage specific and involves P-ERK and P-p38 MAPKs.

Mahalingam CD, Sampathi BR, Sharma S, Datta T, Das V, Abou-Samra AB, Datta NS.

J Endocrinol. 2013 Feb 25;216(3):315-29. doi: 10.1530/JOE-12-0372. Print 2013 Mar.

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