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Items: 27

1.

Polarized AAVR expression determines infectivity by AAV gene therapy vectors.

Hamilton BA, Li X, Pezzulo AA, Abou Alaiwa MH, Zabner J.

Gene Ther. 2019 Jun;26(6):240-249. doi: 10.1038/s41434-019-0078-3. Epub 2019 Apr 8.

PMID:
30962536
2.

Mucus strands from submucosal glands initiate mucociliary transport of large particles.

Fischer AJ, Pino-Argumedo MI, Hilkin BM, Shanrock CR, Gansemer ND, Chaly AL, Zarei K, Allen PD, Ostedgaard LS, Hoffman EA, Stoltz DA, Welsh MJ, Abou Alaiwa MH.

JCI Insight. 2019 Jan 10;4(1). pii: 124863. doi: 10.1172/jci.insight.124863. [Epub ahead of print]

3.

Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways.

Xie Y, Ostedgaard L, Abou Alaiwa MH, Lu L, Fischer AJ, Stoltz DA.

Ann Am Thorac Soc. 2018 Nov;15(Supplement_3):S171-S176. doi: 10.1513/AnnalsATS.201805-308AW.

PMID:
30431346
4.

Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis.

Abou Alaiwa MH, Launspach JL, Grogan B, Carter S, Zabner J, Stoltz DA, Singh PK, McKone EF, Welsh MJ.

JCI Insight. 2018 Aug 9;3(15). pii: 121468. doi: 10.1172/jci.insight.121468. eCollection 2018 Aug 9.

5.

The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity.

Reznikov LR, Meyerholz DK, Abou Alaiwa M, Kuan SP, Liao YJ, Bormann NL, Bair TB, Price M, Stoltz DA, Welsh MJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L133-L148. doi: 10.1152/ajplung.00557.2017. Epub 2018 Apr 5.

6.

Solitary Cholinergic Stimulation Induces Airway Hyperreactivity and Transcription of Distinct Pro-inflammatory Pathways.

Reznikov LR, Meyerholz DK, Kuan SP, Guevara MV, Atanasova KR, Abou Alaiwa MH.

Lung. 2018 Apr;196(2):219-229. doi: 10.1007/s00408-018-0091-0. Epub 2018 Jan 29.

7.

Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling.

Mao S, Shah AS, Moninger TO, Ostedgaard LS, Lu L, Tang XX, Thornell IM, Reznikov LR, Ernst SE, Karp PH, Tan P, Keshavjee S, Abou Alaiwa MH, Welsh MJ.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1370-1375. doi: 10.1073/pnas.1719177115. Epub 2018 Jan 22.

8.

Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid.

Vargas Buonfiglio LG, Mudunkotuwa IA, Abou Alaiwa MH, Vanegas Calderón OG, Borcherding JA, Gerke AK, Zabner J, Grassian VH, Comellas AP.

Environ Health Perspect. 2017 Jul 5;125(7):077003. doi: 10.1289/EHP876.

9.

Postnatal airway growth in cystic fibrosis piglets.

Adam RJ, Abou Alaiwa MH, Bouzek DC, Cook DP, Gansemer ND, Taft PJ, Powers LS, Stroik MR, Hoegger MJ, McMenimen JD, Hoffman EA, Zabner J, Welsh MJ, Meyerholz DK, Stoltz DA.

J Appl Physiol (1985). 2017 Sep 1;123(3):526-533. doi: 10.1152/japplphysiol.00263.2017. Epub 2017 Jun 15.

10.

Gel-forming mucins form distinct morphologic structures in airways.

Ostedgaard LS, Moninger TO, McMenimen JD, Sawin NM, Parker CP, Thornell IM, Powers LS, Gansemer ND, Bouzek DC, Cook DP, Meyerholz DK, Abou Alaiwa MH, Stoltz DA, Welsh MJ.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6842-6847. doi: 10.1073/pnas.1703228114. Epub 2017 Jun 12.

11.

Monocyte derived macrophages from CF pigs exhibit increased inflammatory responses at birth.

Paemka L, McCullagh BN, Abou Alaiwa MH, Stoltz DA, Dong Q, Randak CO, Gray RD, McCray PB Jr.

J Cyst Fibros. 2017 Jul;16(4):471-474. doi: 10.1016/j.jcf.2017.03.007. Epub 2017 Apr 1.

12.

Mounier-Kuhn syndrome: a case of tracheal smooth muscle remodeling.

Cook DP, Adam RJ, Abou Alaiwa MH, Eberlein M, Klesney-Tait JA, Parekh KR, Meyerholz DK, Stoltz DA.

Clin Case Rep. 2016 Dec 29;5(2):93-96. doi: 10.1002/ccr3.794. eCollection 2017 Feb.

13.

Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice.

Reznikov LR, Meyerholz DK, Adam RJ, Abou Alaiwa M, Jaffer O, Michalski AS, Powers LS, Price MP, Stoltz DA, Welsh MJ.

PLoS One. 2016 Nov 7;11(11):e0166089. doi: 10.1371/journal.pone.0166089. eCollection 2016.

14.

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.

Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Abou Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, Welsh MJ, Sinn PL, Schaffer DV, Zabner J.

JCI Insight. 2016 Sep 8;1(14):e88728. doi: 10.1172/jci.insight.88728.

15.

Lentiviral-mediated phenotypic correction of cystic fibrosis pigs.

Cooney AL, Abou Alaiwa MH, Shah VS, Bouzek DC, Stroik MR, Powers LS, Gansemer ND, Meyerholz DK, Welsh MJ, Stoltz DA, Sinn PL, McCray PB Jr.

JCI Insight. 2016 Sep 8;1(14). pii: 88730. doi: 10.1172/jci.insight.88730.

16.

Repurposing tromethamine as inhaled therapy to treat CF airway disease.

Abou Alaiwa MH, Launspach JL, Sheets KA, Rivera JA, Gansemer ND, Taft PJ, Thorne PS, Welsh MJ, Stoltz DA, Zabner J.

JCI Insight. 2016 Jun 2;1(8). pii: 87535. doi: 10.1172/jci.insight.87535.

17.

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

Shah VS, Meyerholz DK, Tang XX, Reznikov L, Abou Alaiwa M, Ernst SE, Karp PH, Wohlford-Lenane CL, Heilmann KP, Leidinger MR, Allen PD, Zabner J, McCray PB Jr, Ostedgaard LS, Stoltz DA, Randak CO, Welsh MJ.

Science. 2016 Jan 29;351(6272):503-7. doi: 10.1126/science.aad5589.

18.

Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense.

Li X, Tang XX, Vargas Buonfiglio LG, Comellas AP, Thornell IM, Ramachandran S, Karp PH, Taft PJ, Sheets K, Abou Alaiwa MH, Welsh MJ, Meyerholz DK, Stoltz DA, Zabner J.

Am J Physiol Lung Cell Mol Physiol. 2016 Apr 1;310(7):L670-9. doi: 10.1152/ajplung.00422.2015. Epub 2016 Jan 22.

19.

Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility.

Cook DP, Rector MV, Bouzek DC, Michalski AS, Gansemer ND, Reznikov LR, Li X, Stroik MR, Ostedgaard LS, Abou Alaiwa MH, Thompson MA, Prakash YS, Krishnan R, Meyerholz DK, Seow CY, Stoltz DA.

Am J Respir Crit Care Med. 2016 Feb 15;193(4):417-26. doi: 10.1164/rccm.201508-1562OC.

20.

pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37.

Abou Alaiwa MH, Reznikov LR, Gansemer ND, Sheets KA, Horswill AR, Stoltz DA, Zabner J, Welsh MJ.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18703-8. doi: 10.1073/pnas.1422091112. Epub 2014 Dec 15.

21.

Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor.

Chang EH, Tang XX, Shah VS, Launspach JL, Ernst SE, Hilkin B, Karp PH, Abou Alaiwa MH, Graham SM, Hornick DB, Welsh MJ, Stoltz DA, Zabner J.

Int Forum Allergy Rhinol. 2015 Feb;5(2):178-81. doi: 10.1002/alr.21440. Epub 2014 Oct 31.

22.

Antibacterial properties of the CFTR potentiator ivacaftor.

Reznikov LR, Abou Alaiwa MH, Dohrn CL, Gansemer ND, Diekema DJ, Stoltz DA, Welsh MJ.

J Cyst Fibros. 2014 Sep;13(5):515-9. doi: 10.1016/j.jcf.2014.02.004. Epub 2014 Mar 5.

23.

Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.

Abou Alaiwa MH, Beer AM, Pezzulo AA, Launspach JL, Horan RA, Stoltz DA, Starner TD, Welsh MJ, Zabner J.

J Cyst Fibros. 2014 Jul;13(4):373-7. doi: 10.1016/j.jcf.2013.12.006. Epub 2014 Jan 11.

24.

Early airway structural changes in cystic fibrosis pigs as a determinant of particle distribution and deposition.

Awadalla M, Miyawaki S, Abou Alaiwa MH, Adam RJ, Bouzek DC, Michalski AS, Fuld MK, Reynolds KJ, Hoffman EA, Lin CL, Stoltz DA.

Ann Biomed Eng. 2014 Apr;42(4):915-27. doi: 10.1007/s10439-013-0955-7. Epub 2013 Dec 6.

25.

Air trapping and airflow obstruction in newborn cystic fibrosis piglets.

Adam RJ, Michalski AS, Bauer C, Abou Alaiwa MH, Gross TJ, Awadalla MS, Bouzek DC, Gansemer ND, Taft PJ, Hoegger MJ, Diwakar A, Ochs M, Reinhardt JM, Hoffman EA, Beichel RR, Meyerholz DK, Stoltz DA.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1434-41. doi: 10.1164/rccm.201307-1268OC.

26.

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.

Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH, Samuel MS, Reznikov LR, Rector MV, Gansemer ND, Bouzek DC, Abou Alaiwa MH, Hoegger MJ, Ludwig PS, Taft PJ, Wallen TJ, Wohlford-Lenane C, McMenimen JD, Chen JH, Bogan KL, Adam RJ, Hornick EE, Nelson GA 4th, Hoffman EA, Chang EH, Zabner J, McCray PB Jr, Prather RS, Meyerholz DK, Welsh MJ.

J Clin Invest. 2013 Jun;123(6):2685-93. doi: 10.1172/JCI68867. Epub 2013 May 8.

27.

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung.

Pezzulo AA, Tang XX, Hoegger MJ, Abou Alaiwa MH, Ramachandran S, Moninger TO, Karp PH, Wohlford-Lenane CL, Haagsman HP, van Eijk M, Bánfi B, Horswill AR, Stoltz DA, McCray PB Jr, Welsh MJ, Zabner J.

Nature. 2012 Jul 4;487(7405):109-13. doi: 10.1038/nature11130.

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