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Items: 1 to 50 of 77

1.

Concise Review: Neural Stem Cell-Mediated Targeted Cancer Therapies.

Mooney R, Hammad M, Batalla-Covello J, Abdul Majid A, Aboody KS.

Stem Cells Transl Med. 2018 Oct;7(10):740-747. doi: 10.1002/sctm.18-0003. Epub 2018 Aug 21. Review.

2.

Long-term stability and computational analysis of migration patterns of L-MYC immortalized neural stem cells in the brain.

Rockne RC, Adhikarla V, Tsaturyan L, Li Z, Masihi MB, Aboody KS, Barish ME, Gutova M.

PLoS One. 2018 Aug 2;13(8):e0199967. doi: 10.1371/journal.pone.0199967. eCollection 2018.

3.

Bcl-2 Overexpression Improves Survival and Efficacy of Neural Stem Cell-Mediated Enzyme Prodrug Therapy.

Mooney R, Majid AA, Mota D, He A, Aramburo S, Flores L, Covello-Batalla J, Machado D, Gonzaga J, Aboody KS.

Stem Cells Int. 2018 Jun 20;2018:7047496. doi: 10.1155/2018/7047496. eCollection 2018.

4.

GMP Production and Scale-Up of Adherent Neural Stem Cells with a Quantum Cell Expansion System.

Tirughana R, Metz MZ, Li Z, Hall C, Hsu D, Beltzer J, Annala AJ, Oganesyan D, Gutova M, Aboody KS.

Mol Ther Methods Clin Dev. 2018 Jul 7;10:48-56. doi: 10.1016/j.omtm.2018.05.006. eCollection 2018 Sep 21.

5.

Early Changes in Tumor Perfusion from T1-Weighted Dynamic Contrast-Enhanced MRI following Neural Stem Cell-Mediated Therapy of Recurrent High-Grade Glioma Correlate with Overall Survival.

Sahoo P, Frankel P, Ressler J, Gutova M, Annala AJ, Badie B, Portnow J, Aboody KS, D'Apuzzo M, Rockne RC.

Stem Cells Int. 2018 Mar 14;2018:5312426. doi: 10.1155/2018/5312426. eCollection 2018.

6.

Cell-mediated enzyme prodrug cancer therapies.

Mooney R, Abdul Majid A, Batalla J, Annala AJ, Aboody KS.

Adv Drug Deliv Rev. 2017 Sep 1;118:35-51. doi: 10.1016/j.addr.2017.09.003. Epub 2017 Sep 13. Review.

PMID:
28916493
7.

SLC7A11 Overexpression in Glioblastoma Is Associated with Increased Cancer Stem Cell-Like Properties.

Polewski MD, Reveron-Thornton RF, Cherryholmes GA, Marinov GK, Aboody KS.

Stem Cells Dev. 2017 Sep 1;26(17):1236-1246. doi: 10.1089/scd.2017.0123. Epub 2017 Jul 27.

8.

Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model.

Barish ME, Herrmann K, Tang Y, Argalian Herculian S, Metz M, Aramburo S, Tirughana R, Gutova M, Annala A, Moats RA, Goldstein L, Rockne RC, Gutierrez J, Brown CE, Ghoda L, Aboody KS.

Stem Cells Transl Med. 2017 Jun;6(6):1522-1532. doi: 10.1002/sctm.16-0397. Epub 2017 May 8.

9.

Intraperitoneal Administration of Neural Stem Cell-Nanoparticle Conjugates Targets Chemotherapy to Ovarian Tumors.

Cao P, Mooney R, Tirughana R, Abidi W, Aramburo S, Flores L, Gilchrist M, Nwokafor U, Haber T, Tiet P, Annala AJ, Han E, Dellinger T, Aboody KS, Berlin JM.

Bioconjug Chem. 2017 Jun 21;28(6):1767-1776. doi: 10.1021/acs.bioconjchem.7b00237. Epub 2017 May 18.

10.

Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma.

Gutova M, Goldstein L, Metz M, Hovsepyan A, Tsurkan LG, Tirughana R, Tsaturyan L, Annala AJ, Synold TW, Wan Z, Seeger R, Anderson C, Moats RA, Potter PM, Aboody KS.

Mol Ther Oncolytics. 2016 Dec 14;4:67-76. doi: 10.1016/j.omto.2016.11.004. eCollection 2017 Mar 17.

11.

Neural Stem Cell-Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients.

Portnow J, Synold TW, Badie B, Tirughana R, Lacey SF, D'Apuzzo M, Metz MZ, Najbauer J, Bedell V, Vo T, Gutova M, Frankel P, Chen M, Aboody KS.

Clin Cancer Res. 2017 Jun 15;23(12):2951-2960. doi: 10.1158/1078-0432.CCR-16-1518. Epub 2016 Dec 15.

12.

Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance.

Polewski MD, Reveron-Thornton RF, Cherryholmes GA, Marinov GK, Cassady K, Aboody KS.

Mol Cancer Res. 2016 Dec;14(12):1229-1242. Epub 2016 Sep 22.

13.

Intranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma.

Dey M, Yu D, Kanojia D, Li G, Sukhanova M, Spencer DA, Pituch KC, Zhang L, Han Y, Ahmed AU, Aboody KS, Lesniak MS, Balyasnikova IV.

Stem Cell Reports. 2016 Sep 13;7(3):471-482. doi: 10.1016/j.stemcr.2016.07.024. Epub 2016 Sep 1.

14.

Gold nanorod-mediated near-infrared laser ablation: in vivo experiments on mice and theoretical analysis at different settings.

Mooney R, Schena E, Saccomandi P, Zhumkhawala A, Aboody K, Berlin JM.

Int J Hyperthermia. 2016 Sep 20:1-10. [Epub ahead of print]

PMID:
27582347
15.

L-MYC Expression Maintains Self-Renewal and Prolongs Multipotency of Primary Human Neural Stem Cells.

Li Z, Oganesyan D, Mooney R, Rong X, Christensen MJ, Shahmanyan D, Perrigue PM, Benetatos J, Tsaturyan L, Aramburo S, Annala AJ, Lu Y, Najbauer J, Wu X, Barish ME, Brody DL, Aboody KS, Gutova M.

Stem Cell Reports. 2016 Sep 13;7(3):483-495. doi: 10.1016/j.stemcr.2016.07.013. Epub 2016 Aug 18.

16.

Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters.

Kim JW, Auffinger B, Spencer DA, Miska J, Chang AL, Kane JR, Young JS, Kanojia D, Qiao J, Mann JF, Zhang L, Wu M, Ahmed AU, Aboody KS, Strong TV, Hébert CD, Lesniak MS.

J Transl Med. 2016 May 16;14(1):134. doi: 10.1186/s12967-016-0895-8.

17.

Internal temperature increase during photothermal tumour ablation in mice using gold nanorods.

Mooney R, Schena E, Zhumkhawala A, Aboody KS, Berlin JM.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:2563-6. doi: 10.1109/EMBC.2015.7318915.

PMID:
26736815
18.

Controlled Payload Release by Magnetic Field Triggered Neural Stem Cell Destruction for Malignant Glioma Treatment.

Muroski ME, Morshed RA, Cheng Y, Vemulkar T, Mansell R, Han Y, Zhang L, Aboody KS, Cowburn RP, Lesniak MS.

PLoS One. 2016 Jan 6;11(1):e0145129. doi: 10.1371/journal.pone.0145129. eCollection 2016.

19.

Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo.

Perrigue PM, Najbauer J, Jozwiak AA, Barciszewski J, Aboody KS, Barish ME.

Pathobiol Aging Age Relat Dis. 2015 Dec 10;5:30052. doi: 10.3402/pba.v5.30052. eCollection 2015.

20.

Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma.

Cheng SH, Yu D, Tsai HM, Morshed RA, Kanojia D, Lo LW, Leoni L, Govind Y, Zhang L, Aboody KS, Lesniak MS, Chen CT, Balyasnikova IV.

J Nucl Med. 2016 Feb;57(2):279-84. doi: 10.2967/jnumed.115.163006. Epub 2015 Nov 12.

21.

MMP14 as a novel downstream target of VEGFR2 in migratory glioma-tropic neural stem cells.

Alexiades NG, Auffinger B, Kim CK, Hasan T, Lee G, Deheeger M, Tobias AL, Kim J, Balyasnikova I, Lesniak MS, Aboody K, Ahmed AU.

Stem Cell Res. 2015 Nov;15(3):598-607. doi: 10.1016/j.scr.2015.10.005. Epub 2015 Oct 22.

22.

Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases.

Kanojia D, Balyasnikova IV, Morshed RA, Frank RT, Yu D, Zhang L, Spencer DA, Kim JW, Han Y, Yu D, Ahmed AU, Aboody KS, Lesniak MS.

Stem Cells. 2015 Oct;33(10):2985-94. doi: 10.1002/stem.2109. Epub 2015 Aug 11.

23.

The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines.

Perrigue PM, Silva ME, Warden CD, Feng NL, Reid MA, Mota DJ, Joseph LP, Tian YI, Glackin CA, Gutova M, Najbauer J, Aboody KS, Barish ME.

Mol Cancer Res. 2015 Apr;13(4):636-50. doi: 10.1158/1541-7786.MCR-13-0268. Epub 2015 Feb 4.

24.

Analysis of glioblastoma tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction.

Morshed RA, Gutova M, Juliano J, Barish ME, Hawkins-Daarud A, Oganesyan D, Vazgen K, Yang T, Annala A, Ahmed AU, Aboody KS, Swanson KR, Moats RA, Lesniak MS.

Cancer Gene Ther. 2015 Jan;22(1):55-61. doi: 10.1038/cgt.2014.72. Epub 2014 Dec 19.

25.

Neural stem cell-mediated intratumoral delivery of gold nanorods improves photothermal therapy.

Mooney R, Roma L, Zhao D, Van Haute D, Garcia E, Kim SU, Annala AJ, Aboody KS, Berlin JM.

ACS Nano. 2014 Dec 23;8(12):12450-60. doi: 10.1021/nn505147w. Epub 2014 Nov 17.

26.

Conjugation of pH-responsive nanoparticles to neural stem cells improves intratumoral therapy.

Mooney R, Weng Y, Garcia E, Bhojane S, Smith-Powell L, Kim SU, Annala AJ, Aboody KS, Berlin JM.

J Control Release. 2014 Oct 10;191:82-9. doi: 10.1016/j.jconrel.2014.06.015. Epub 2014 Jun 18.

27.

Neural stem cells improve intracranial nanoparticle retention and tumor-selective distribution.

Mooney R, Weng Y, Tirughana-Sambandan R, Valenzuela V, Aramburo S, Garcia E, Li Z, Gutova M, Annala AJ, Berlin JM, Aboody KS.

Future Oncol. 2014 Feb;10(3):401-15. doi: 10.2217/fon.13.217.

28.

Human neural stem cells expressing carboxyl esterase target and inhibit tumor growth of lung cancer brain metastases.

Hong SH, Lee HJ, An J, Lim I, Borlongan C, Aboody KS, Kim SU.

Cancer Gene Ther. 2013 Dec;20(12):678-82. doi: 10.1038/cgt.2013.69. Epub 2013 Dec 6.

PMID:
24310061
29.

Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.

Metz MZ, Gutova M, Lacey SF, Abramyants Y, Vo T, Gilchrist M, Tirughana R, Ghoda LY, Barish ME, Brown CE, Najbauer J, Potter PM, Portnow J, Synold TW, Aboody KS.

Stem Cells Transl Med. 2013 Dec;2(12):983-92. doi: 10.5966/sctm.2012-0177. Epub 2013 Oct 28.

30.

Selective antitumor effect of neural stem cells expressing cytosine deaminase and interferon-beta against ductal breast cancer cells in cellular and xenograft models.

Yi BR, Hwang KA, Aboody KS, Jeung EB, Kim SU, Choi KC.

Stem Cell Res. 2014 Jan;12(1):36-48. doi: 10.1016/j.scr.2013.09.010. Epub 2013 Oct 1.

31.

Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells: studies leading to clinical use.

Gutova M, Frank JA, D'Apuzzo M, Khankaldyyan V, Gilchrist MM, Annala AJ, Metz MZ, Abramyants Y, Herrmann KA, Ghoda LY, Najbauer J, Brown CE, Blanchard MS, Lesniak MS, Kim SU, Barish ME, Aboody KS, Moats RA.

Stem Cells Transl Med. 2013 Oct;2(10):766-75. doi: 10.5966/sctm.2013-0049. Epub 2013 Sep 6.

32.

Intranasal delivery of mesenchymal stem cells significantly extends survival of irradiated mice with experimental brain tumors.

Balyasnikova IV, Prasol MS, Ferguson SD, Han Y, Ahmed AU, Gutova M, Tobias AL, Mustafi D, Rincón E, Zhang L, Aboody KS, Lesniak MS.

Mol Ther. 2014 Jan;22(1):140-8. doi: 10.1038/mt.2013.199. Epub 2013 Sep 3.

33.

The timing of neural stem cell-based virotherapy is critical for optimal therapeutic efficacy when applied with radiation and chemotherapy for the treatment of glioblastoma.

Tobias AL, Thaci B, Auffinger B, Rincón E, Balyasnikova IV, Kim CK, Han Y, Zhang L, Aboody KS, Ahmed AU, Lesniak MS.

Stem Cells Transl Med. 2013 Sep;2(9):655-66. doi: 10.5966/sctm.2013-0039. Epub 2013 Aug 7.

34.

Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy.

Cheng Y, Morshed R, Cheng SH, Tobias A, Auffinger B, Wainwright DA, Zhang L, Yunis C, Han Y, Chen CT, Lo LW, Aboody KS, Ahmed AU, Lesniak MS.

Small. 2013 Dec 20;9(24):4123-9. doi: 10.1002/smll.201301111. Epub 2013 Jul 21.

35.

A preclinical evaluation of neural stem cell-based cell carrier for targeted antiglioma oncolytic virotherapy.

Ahmed AU, Thaci B, Tobias AL, Auffinger B, Zhang L, Cheng Y, Kim CK, Yunis C, Han Y, Alexiades NG, Fan X, Aboody KS, Lesniak MS.

J Natl Cancer Inst. 2013 Jul 3;105(13):968-77. doi: 10.1093/jnci/djt141.

36.

Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies.

Aboody KS, Najbauer J, Metz MZ, D'Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA, Blanchard S, Moats RA, Garcia E, Aramburo S, Valenzuela VV, Frank RT, Barish ME, Brown CE, Kim SU, Badie B, Portnow J.

Sci Transl Med. 2013 May 8;5(184):184ra59. doi: 10.1126/scitranslmed.3005365.

37.

Gold nanoparticle-loaded neural stem cells for photothermal ablation of cancer.

Schnarr K, Mooney R, Weng Y, Zhao D, Garcia E, Armstrong B, Annala AJ, Kim SU, Aboody KS, Berlin JM.

Adv Healthc Mater. 2013 Jul;2(7):976-82. doi: 10.1002/adhm.201300003. Epub 2013 Apr 17. No abstract available.

PMID:
23592703
38.

Researchers and the translational reality. Interview with Karen Aboody.

Aboody K.

Regen Med. 2012 Nov;7(6 Suppl):64-6. doi: 10.2217/rme.12.85.

PMID:
23210812
39.

Contact and encirclement of glioma cells in vitro is an intrinsic behavior of a clonal human neural stem cell line.

Khosh N, Brown CE, Aboody KS, Barish ME.

PLoS One. 2012;7(12):e51859. doi: 10.1371/journal.pone.0051859. Epub 2012 Dec 11.

40.

TWIST1 associates with NF-κB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production.

Li S, Kendall SE, Raices R, Finlay J, Covarrubias M, Liu Z, Lowe G, Lin YH, Teh YH, Leigh V, Dhillon S, Flanagan S, Aboody KS, Glackin CA.

BMC Biol. 2012 Aug 14;10:73. doi: 10.1186/1741-7007-10-73.

41.

Pharmacokinetic study of neural stem cell-based cell carrier for oncolytic virotherapy: targeted delivery of the therapeutic payload in an orthotopic brain tumor model.

Thaci B, Ahmed AU, Ulasov IV, Tobias AL, Han Y, Aboody KS, Lesniak MS.

Cancer Gene Ther. 2012 Jun;19(6):431-42. doi: 10.1038/cgt.2012.21. Epub 2012 May 4.

42.

Cellular host responses to gliomas.

Najbauer J, Huszthy PC, Barish ME, Garcia E, Metz MZ, Myers SM, Gutova M, Frank RT, Miletic H, Kendall SE, Glackin CA, Bjerkvig R, Aboody KS.

PLoS One. 2012;7(4):e35150. doi: 10.1371/journal.pone.0035150. Epub 2012 Apr 23.

43.

Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma.

Gutova M, Shackleford GM, Khankaldyyan V, Herrmann KA, Shi XH, Mittelholtz K, Abramyants Y, Blanchard MS, Kim SU, Annala AJ, Najbauer J, Synold TW, D'Apuzzo M, Barish ME, Moats RA, Aboody KS.

Gene Ther. 2013 Feb;20(2):143-50. doi: 10.1038/gt.2012.12. Epub 2012 Mar 8.

44.

Human neural stem cell tropism to metastatic breast cancer.

Zhao D, Najbauer J, Annala AJ, Garcia E, Metz MZ, Gutova M, Polewski MD, Gilchrist M, Glackin CA, Kim SU, Aboody KS.

Stem Cells. 2012 Feb;30(2):314-25. doi: 10.1002/stem.784.

45.

Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer.

Seol HJ, Jin J, Seong DH, Joo KM, Kang W, Yang H, Kim J, Shin CS, Kim Y, Kim KH, Kong DS, Lee JI, Aboody KS, Lee HJ, Kim SU, Nam DH.

Cancer Lett. 2011 Dec 8;311(2):152-9. doi: 10.1016/j.canlet.2011.07.001. Epub 2011 Jul 14.

PMID:
21868150
46.

Strategies for enhancing antibody delivery to the brain.

Frank RT, Aboody KS, Najbauer J.

Biochim Biophys Acta. 2011 Dec;1816(2):191-8. doi: 10.1016/j.bbcan.2011.07.002. Epub 2011 Jul 8. Review.

PMID:
21767610
47.

Neural stem cell-based cell carriers enhance therapeutic efficacy of an oncolytic adenovirus in an orthotopic mouse model of human glioblastoma.

Ahmed AU, Thaci B, Alexiades NG, Han Y, Qian S, Liu F, Balyasnikova IV, Ulasov IY, Aboody KS, Lesniak MS.

Mol Ther. 2011 Sep;19(9):1714-26. doi: 10.1038/mt.2011.100. Epub 2011 May 31.

48.

Translating stem cell studies to the clinic for CNS repair: current state of the art and the need for a Rosetta stone.

Aboody K, Capela A, Niazi N, Stern JH, Temple S.

Neuron. 2011 May 26;70(4):597-613. doi: 10.1016/j.neuron.2011.05.007. Review.

49.

Concise review: stem cells as an emerging platform for antibody therapy of cancer.

Frank RT, Najbauer J, Aboody KS.

Stem Cells. 2010 Nov;28(11):2084-7. doi: 10.1002/stem.513. Review.

50.

Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies.

Frank RT, Edmiston M, Kendall SE, Najbauer J, Cheung CW, Kassa T, Metz MZ, Kim SU, Glackin CA, Wu AM, Yazaki PJ, Aboody KS.

PLoS One. 2009 Dec 15;4(12):e8314. doi: 10.1371/journal.pone.0008314.

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