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Items: 1 to 50 of 119

1.

Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators.

Garai S, Kulkarni PM, Schaffer PC, Leo LM, Brandt AL, Zagzoog A, Black T, Lin X, Hurst DP, Janero DR, Abood ME, Zimmowitch A, Straiker A, Pertwee RG, Kelly M, Szczesniak AM, Denovan-Wright EM, Mackie K, Hohmann AG, Reggio PH, Laprairie RB, Thakur GA.

J Med Chem. 2020 Jan 23;63(2):542-568. doi: 10.1021/acs.jmedchem.9b01142. Epub 2020 Jan 3.

PMID:
31756109
2.

Acute cocaine administration alters permeability of blood-brain barrier in freely-moving rats- Evidence using miniaturized fluorescence microscopy.

Barr JL, Brailoiu GC, Abood ME, Rawls SM, Unterwald EM, Brailoiu E.

Drug Alcohol Depend. 2020 Jan 1;206:107637. doi: 10.1016/j.drugalcdep.2019.107637. Epub 2019 Oct 18.

PMID:
31734036
3.

GPR55-mediated effects on brain microvascular endothelial cells and the blood-brain barrier.

Leo LM, Familusi B, Hoang M, Smith R, Lindenau K, Sporici KT, Brailoiu E, Abood ME, Brailoiu GC.

Neuroscience. 2019 Aug 21;414:88-98. doi: 10.1016/j.neuroscience.2019.06.039. Epub 2019 Jul 4.

PMID:
31279825
4.

Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors.

Brailoiu E, Chakraborty S, Brailoiu GC, Zhao P, Barr JL, Ilies MA, Unterwald EM, Abood ME, Taylor CW.

Cell Rep. 2019 Jan 8;26(2):330-337.e4. doi: 10.1016/j.celrep.2018.12.051.

5.

Understanding the endocannabinoid system as a modulator of the trigeminal pain response to concussion.

Elliott MB, Ward SJ, Abood ME, Tuma RF, Jallo JI.

Concussion. 2017 Oct 4;2(4):CNC49. doi: 10.2217/cnc-2017-0010. eCollection 2017 Dec. Review.

6.

Effects of Platelet-Activating Factor on Brain Microvascular Endothelial Cells.

Brailoiu E, Barlow CL, Ramirez SH, Abood ME, Brailoiu GC.

Neuroscience. 2018 May 1;377:105-113. doi: 10.1016/j.neuroscience.2018.02.039. Epub 2018 Mar 6.

7.

Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.

Bertini S, Chicca A, Gado F, Arena C, Nieri D, Digiacomo M, Saccomanni G, Zhao P, Abood ME, Macchia M, Gertsch J, Manera C.

Bioorg Med Chem. 2017 Dec 15;25(24):6427-6434. doi: 10.1016/j.bmc.2017.10.015. Epub 2017 Oct 16.

8.

Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus.

Brailoiu E, McGuire M, Shuler SA, Deliu E, Barr JL, Abood ME, Brailoiu GC.

Neuroscience. 2017 Dec 4;365:23-32. doi: 10.1016/j.neuroscience.2017.09.034. Epub 2017 Sep 23.

9.

CB1 and CB2 Receptor Pharmacology.

Howlett AC, Abood ME.

Adv Pharmacol. 2017;80:169-206. doi: 10.1016/bs.apha.2017.03.007. Epub 2017 Jun 12. Review.

10.

Protocols and Good Operating Practices in the Study of Cannabinoid Receptors.

Console-Bram LM, Zhao P, Abood ME.

Methods Enzymol. 2017;593:23-42. doi: 10.1016/bs.mie.2017.06.027. Epub 2017 Jul 5.

PMID:
28750805
11.

N-arachidonoyl glycine, another endogenous agonist of GPR55.

Console-Bram L, Ciuciu SM, Zhao P, Zipkin RE, Brailoiu E, Abood ME.

Biochem Biophys Res Commun. 2017 Sep 2;490(4):1389-1393. doi: 10.1016/j.bbrc.2017.07.038. Epub 2017 Jul 8.

12.

Design, synthesis and biological evaluation of GPR55 agonists.

Fakhouri L, Cook CD, Al-Huniti MH, Console-Bram LM, Hurst DP, Spano MBS, Nasrallah DJ, Caron MG, Barak LS, Reggio PH, Abood ME, Croatt MP.

Bioorg Med Chem. 2017 Aug 15;25(16):4355-4367. doi: 10.1016/j.bmc.2017.06.016. Epub 2017 Jun 13.

13.

CB1 allosteric modulator Org27569 is an antagonist/inverse agonist of ERK1/2 signaling.

Gamage TF, Anderson JC, Abood ME.

Cannabis Cannabinoid Res. 2016 Dec;1(1):272-280. doi: 10.1089/can.2016.0028. Erratum in: Cannabis Cannabinoid Res. 2019 Dec 09;4(4):285-286.

14.

HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens.

Brailoiu GC, Deliu E, Barr JL, Console-Bram LM, Ciuciu AM, Abood ME, Unterwald EM, Brailoiu E.

Drug Alcohol Depend. 2017 Sep 1;178:7-14. doi: 10.1016/j.drugalcdep.2017.04.015. Epub 2017 Jun 8.

15.

Effects of VPAC1 activation in nucleus ambiguus neurons.

Gherghina FL, Tica AA, Deliu E, Abood ME, Brailoiu GC, Brailoiu E.

Brain Res. 2017 Feb 15;1657:297-303. doi: 10.1016/j.brainres.2016.12.026. Epub 2016 Dec 30.

16.

Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor.

Lingerfelt MA, Zhao P, Sharir HP, Hurst DP, Reggio PH, Abood ME.

Biochemistry. 2017 Jan 24;56(3):473-486. doi: 10.1021/acs.biochem.6b01013. Epub 2017 Jan 11.

17.

Mechanisms of modulation of brain microvascular endothelial cells function by thrombin.

Brailoiu E, Shipsky MM, Yan G, Abood ME, Brailoiu GC.

Brain Res. 2017 Feb 15;1657:167-175. doi: 10.1016/j.brainres.2016.12.011. Epub 2016 Dec 18.

18.

Structure-activity relationships of benzothiazole GPR35 antagonists.

Abdalhameed MM, Zhao P, Hurst DP, Reggio PH, Abood ME, Croatt MP.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):612-615. doi: 10.1016/j.bmcl.2016.12.012. Epub 2016 Dec 5.

19.

Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.

Meza-Aviña ME, Lingerfelt MA, Console-Bram LM, Gamage TF, Sharir H, Gettys KE, Hurst DP, Kotsikorou E, Shore DM, Caron MG, Rao N, Barak LS, Abood ME, Reggio PH, Croatt MP.

Bioorg Med Chem Lett. 2016 Apr 1;26(7):1827-1830. doi: 10.1016/j.bmcl.2016.02.030. Epub 2016 Feb 16.

20.

Allosteric Modulators: A Side Door.

Abood ME.

J Med Chem. 2016 Jan 14;59(1):42-3. doi: 10.1021/acs.jmedchem.5b01824. Epub 2015 Dec 8.

PMID:
26645411
21.

Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors.

Brailoiu GC, Deliu E, Console-Bram LM, Soboloff J, Abood ME, Unterwald EM, Brailoiu E.

Biochem J. 2016 Jan 1;473(1):1-5. doi: 10.1042/BJ20150934. Epub 2015 Oct 14.

22.

Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways.

Barr JL, Deliu E, Brailoiu GC, Zhao P, Yan G, Abood ME, Unterwald EM, Brailoiu E.

Cell Calcium. 2015 Aug;58(2):196-207. doi: 10.1016/j.ceca.2015.05.001. Epub 2015 May 27.

23.

The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray.

Deliu E, Sperow M, Console-Bram L, Carter RL, Tilley DG, Kalamarides DJ, Kirby LG, Brailoiu GC, Brailoiu E, Benamar K, Abood ME.

Mol Pharmacol. 2015 Aug;88(2):265-72. doi: 10.1124/mol.115.099333. Epub 2015 May 13.

24.

HIV-gp120 and physical dependence to buprenorphine.

Palma J, Abood ME, Benamar K.

Drug Alcohol Depend. 2015 May 1;150:175-8. doi: 10.1016/j.drugalcdep.2015.02.021. Epub 2015 Feb 26.

25.

G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells.

Altmann JB, Yan G, Meeks JF, Abood ME, Brailoiu E, Brailoiu GC.

J Neurochem. 2015 Jun;133(5):629-39. doi: 10.1111/jnc.13066. Epub 2015 Mar 2.

26.

Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.

Rahman T, Cai X, Brailoiu GC, Abood ME, Brailoiu E, Patel S.

Sci Signal. 2014 Nov 18;7(352):ra109. doi: 10.1126/scisignal.2005450.

27.

CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.

Lucchesi V, Hurst DP, Shore DM, Bertini S, Ehrmann BM, Allarà M, Lawrence L, Ligresti A, Minutolo F, Saccomanni G, Sharir H, Macchia M, Di Marzo V, Abood ME, Reggio PH, Manera C.

J Med Chem. 2014 Nov 13;57(21):8777-91. doi: 10.1021/jm500807e. Epub 2014 Oct 15.

28.

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation.

Lin-Moshier Y, Keebler MV, Hooper R, Boulware MJ, Liu X, Churamani D, Abood ME, Walseth TF, Brailoiu E, Patel S, Marchant JS.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13087-92. doi: 10.1073/pnas.1407004111. Epub 2014 Aug 25.

29.

Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.

Joshi YB, Giannopoulos PF, Chu J, Sperow M, Kirby LG, Abood ME, Praticò D.

Hum Mol Genet. 2014 Dec 20;23(25):6894-902. doi: 10.1093/hmg/ddu412. Epub 2014 Aug 13.

30.

Differential activation of intracellular versus plasmalemmal CB2 cannabinoid receptors.

Brailoiu GC, Deliu E, Marcu J, Hoffman NE, Console-Bram L, Zhao P, Madesh M, Abood ME, Brailoiu E.

Biochemistry. 2014 Aug 5;53(30):4990-9. doi: 10.1021/bi500632a. Epub 2014 Jul 24.

31.

Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.

Console-Bram L, Brailoiu E, Brailoiu GC, Sharir H, Abood ME.

Br J Pharmacol. 2014 Aug;171(16):3908-17. doi: 10.1111/bph.12746.

32.

Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling.

Shore DM, Baillie GL, Hurst DH, Navas F 3rd, Seltzman HH, Marcu JP, Abood ME, Ross RA, Reggio PH.

J Biol Chem. 2014 Feb 28;289(9):5828-45. doi: 10.1074/jbc.M113.478495. Epub 2013 Dec 23.

33.

Crucial positively charged residues for ligand activation of the GPR35 receptor.

Zhao P, Lane TR, Gao HG, Hurst DP, Kotsikorou E, Le L, Brailoiu E, Reggio PH, Abood ME.

J Biol Chem. 2014 Feb 7;289(6):3625-38. doi: 10.1074/jbc.M113.508382. Epub 2013 Dec 17.

34.

Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.

Kotsikorou E, Sharir H, Shore DM, Hurst DP, Lynch DL, Madrigal KE, Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak LS, Croatt MP, Abood ME, Reggio PH.

Biochemistry. 2013 Dec 31;52(52):9456-69. doi: 10.1021/bi4008885. Epub 2013 Dec 17.

35.

Functional interaction between HIV-gp120 and opioid system in the preoptic anterior hypothalamus.

Palma J, Abood ME, Barbe MF, Benamar K.

Drug Alcohol Depend. 2014 Jan 1;134:383-386. doi: 10.1016/j.drugalcdep.2013.09.015. Epub 2013 Sep 26.

36.

Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55.

Yu J, Deliu E, Zhang XQ, Hoffman NE, Carter RL, Grisanti LA, Brailoiu GC, Madesh M, Cheung JY, Force T, Abood ME, Koch WJ, Tilley DG, Brailoiu E.

J Biol Chem. 2013 Aug 2;288(31):22481-92. doi: 10.1074/jbc.M113.456178. Epub 2013 Jun 27.

37.

Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2.

Marcu J, Shore DM, Kapur A, Trznadel M, Makriyannis A, Reggio PH, Abood ME.

J Pharmacol Exp Ther. 2013 May;345(2):189-97. doi: 10.1124/jpet.112.201046. Epub 2013 Feb 20.

38.

CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.

Baillie GL, Horswill JG, Anavi-Goffer S, Reggio PH, Bolognini D, Abood ME, McAllister S, Strange PG, Stephens GJ, Pertwee RG, Ross RA.

Mol Pharmacol. 2013 Feb;83(2):322-38. doi: 10.1124/mol.112.080879. Epub 2012 Nov 15.

39.

Selective GPR35 Antagonists - Probe 3.

Heynen-Genel S, Dahl R, Shi S, Sauer M, Hariharan S, Sergienko E, Dad S, Chung TDY, Stonich D, Su Y, Zhao P, Caron MG, Abood ME, Barak LS.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Mar 29 [updated 2011 Nov 21].

40.

GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors.

Zhao P, Abood ME.

Life Sci. 2013 Mar 19;92(8-9):453-7. doi: 10.1016/j.lfs.2012.06.039. Epub 2012 Jul 20. Review.

PMID:
22820167
41.

The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55.

Sharir H, Console-Bram L, Mundy C, Popoff SN, Kapur A, Abood ME.

J Neuroimmune Pharmacol. 2012 Dec;7(4):856-65. doi: 10.1007/s11481-012-9351-6. Epub 2012 Mar 28.

42.

Cannabinoid receptors: nomenclature and pharmacological principles.

Console-Bram L, Marcu J, Abood ME.

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jul 2;38(1):4-15. doi: 10.1016/j.pnpbp.2012.02.009. Epub 2012 Feb 28. Review.

43.

Screening for Selective Ligands for GPR55 - Antagonists.

Heynen-Genel S, Dahl R, Shi S, Milan L, Hariharan S, Sergienko E, Hedrick M, Dad S, Stonich D, Su Y, Vicchiarelli M, Mangravita-Novo A, Smith LH, Chung TDY, Sharir H, Caron MG, Barak LS, Abood ME.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Oct 30 [updated 2011 May 26].

44.

Screening for Selective Ligands for GPR55 - Agonists.

Heynen-Genel S, Dahl R, Shi S, Milan L, Hariharan S, Bravo Y, Sergienko E, Hedrick M, Dad S, Stonich D, Su Y, Vicchiarelli M, Mangravita-Novo A, Smith LH, Chung TDY, Sharir H, Barak LS, Abood ME.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Sep 29 [updated 2011 May 26].

45.

Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide.

Brailoiu GC, Oprea TI, Zhao P, Abood ME, Brailoiu E.

J Biol Chem. 2011 Aug 19;286(33):29166-74. doi: 10.1074/jbc.M110.217463. Epub 2011 Jun 30.

46.

Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.

Kotsikorou E, Madrigal KE, Hurst DP, Sharir H, Lynch DL, Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak L, Abood ME, Reggio PH.

Biochemistry. 2011 Jun 28;50(25):5633-47. doi: 10.1021/bi200010k. Epub 2011 Jun 1.

47.

Selective GPR35 Antagonists - Probes 1 & 2.

Heynen-Genel S, Dahl R, Shi S, Sauer M, Hariharan S, Sergienko E, Dad S, Chung TDY, Stonich D, Su Y, Caron M, Zhao P, Abood ME, Barak LS.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Feb 28 [updated 2010 Oct 4].

48.

HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions.

Persidsky Y, Ho W, Ramirez SH, Potula R, Abood ME, Unterwald E, Tuma R.

Brain Behav Immun. 2011 Jun;25 Suppl 1:S61-70. doi: 10.1016/j.bbi.2011.03.001. Epub 2011 Mar 21. Review.

49.

Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55.

Kotsikorou E, Lynch DL, Abood ME, Reggio PH.

Chem Phys Lipids. 2011 Feb;164(2):131-43. doi: 10.1016/j.chemphyslip.2010.12.003. Epub 2010 Dec 24.

50.

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂.

Pertwee RG, Howlett AC, Abood ME, Alexander SP, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS, Kunos G, Mackie K, Mechoulam R, Ross RA.

Pharmacol Rev. 2010 Dec;62(4):588-631. doi: 10.1124/pr.110.003004. Review.

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