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Items: 24


A Triazinone Derivative Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity.

Urano E, Miyauchi K, Kojima Y, Hamatake M, Ablan SD, Fudo S, Freed EO, Hoshino T, Komano J.

ChemMedChem. 2016 Oct 19;11(20):2320-2326. doi: 10.1002/cmdc.201600375. Epub 2016 Sep 16.


Biochemical evidence of a role for matrix trimerization in HIV-1 envelope glycoprotein incorporation.

Tedbury PR, Novikova M, Ablan SD, Freed EO.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E182-90. doi: 10.1073/pnas.1516618113. Epub 2015 Dec 28.


Identification of an HIV-1 Mutation in Spacer Peptide 1 That Stabilizes the Immature CA-SP1 Lattice.

Fontana J, Keller PW, Urano E, Ablan SD, Steven AC, Freed EO.

J Virol. 2015 Nov 4;90(2):972-8. doi: 10.1128/JVI.02204-15. Print 2016 Jan 15.


Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain.

Martins AN, Waheed AA, Ablan SD, Huang W, Newton A, Petropoulos CJ, Brindeiro RD, Freed EO.

J Virol. 2015 Oct 28;90(2):768-79. doi: 10.1128/JVI.01640-15. Print 2016 Jan 15.


Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors.

Urano E, Ablan SD, Mandt R, Pauly GT, Sigano DM, Schneider JP, Martin DE, Nitz TJ, Wild CT, Freed EO.

Antimicrob Agents Chemother. 2015 Oct 19;60(1):190-7. doi: 10.1128/AAC.02121-15. Print 2016 Jan.


TIM-family proteins inhibit HIV-1 release.

Li M, Ablan SD, Miao C, Zheng YM, Fuller MS, Rennert PD, Maury W, Johnson MC, Freed EO, Liu SL.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3699-707. doi: 10.1073/pnas.1404851111. Epub 2014 Aug 18.


MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production.

Chen AK, Sengupta P, Waki K, Van Engelenburg SB, Ochiya T, Ablan SD, Freed EO, Lippincott-Schwartz J.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2676-83. doi: 10.1073/pnas.1408037111. Epub 2014 Jun 17.


Distribution of ESCRT machinery at HIV assembly sites reveals virus scaffolding of ESCRT subunits.

Van Engelenburg SB, Shtengel G, Sengupta P, Waki K, Jarnik M, Ablan SD, Freed EO, Hess HF, Lippincott-Schwartz J.

Science. 2014 Feb 7;343(6171):653-6. doi: 10.1126/science.1247786. Epub 2014 Jan 16.


Global rescue of defects in HIV-1 envelope glycoprotein incorporation: implications for matrix structure.

Tedbury PR, Ablan SD, Freed EO.

PLoS Pathog. 2013;9(11):e1003739. doi: 10.1371/journal.ppat.1003739. Epub 2013 Nov 14.


The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability.

Jiang J, Ablan SD, Derebail S, HercĂ­k K, Soheilian F, Thomas JA, Tang S, Hewlett I, Nagashima K, Gorelick RJ, Freed EO, Levin JG.

Virology. 2011 Dec 20;421(2):253-65. doi: 10.1016/j.virol.2011.09.012. Epub 2011 Oct 26.


Evidence of a role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery in HIV-1 assembly and release.

Joshi A, Garg H, Ablan SD, Freed EO.

J Biol Chem. 2011 Aug 26;286(34):29861-71. doi: 10.1074/jbc.M111.241521. Epub 2011 Jun 16.


Effect of mutations in the human immunodeficiency virus type 1 protease on cleavage of the gp41 cytoplasmic tail.

Waheed AA, Ablan SD, Sowder RC, Roser JD, Schaffner CP, Chertova E, Freed EO.

J Virol. 2010 Mar;84(6):3121-6. doi: 10.1128/JVI.02002-09. Epub 2009 Dec 30.


Functional role of Alix in HIV-1 replication.

Fujii K, Munshi UM, Ablan SD, Demirov DG, Soheilian F, Nagashima K, Stephen AG, Fisher RJ, Freed EO.

Virology. 2009 Sep 1;391(2):284-92. doi: 10.1016/j.virol.2009.06.016.


Evidence that productive human immunodeficiency virus type 1 assembly can occur in an intracellular compartment.

Joshi A, Ablan SD, Soheilian F, Nagashima K, Freed EO.

J Virol. 2009 Jun;83(11):5375-87. doi: 10.1128/JVI.00109-09. Epub 2009 Mar 18.


Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457).

Adamson CS, Waki K, Ablan SD, Salzwedel K, Freed EO.

J Virol. 2009 May;83(10):4884-94. doi: 10.1128/JVI.02659-08. Epub 2009 Mar 11.


Functional replacement of a retroviral late domain by ubiquitin fusion.

Joshi A, Munshi U, Ablan SD, Nagashima K, Freed EO.

Traffic. 2008 Nov;9(11):1972-83. doi: 10.1111/j.1600-0854.2008.00817.x. Epub 2008 Aug 9.


Structure of the myristylated human immunodeficiency virus type 2 matrix protein and the role of phosphatidylinositol-(4,5)-bisphosphate in membrane targeting.

Saad JS, Ablan SD, Ghanam RH, Kim A, Andrews K, Nagashima K, Soheilian F, Freed EO, Summers MF.

J Mol Biol. 2008 Oct 3;382(2):434-47. doi: 10.1016/j.jmb.2008.07.027. Epub 2008 Jul 16.


Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence.

Waheed AA, Ablan SD, Soheilian F, Nagashima K, Ono A, Schaffner CP, Freed EO.

J Virol. 2008 Oct;82(19):9776-81. doi: 10.1128/JVI.00917-08. Epub 2008 Jul 23.


Real-time visualization of HIV-1 GAG trafficking in infected macrophages.

Gousset K, Ablan SD, Coren LV, Ono A, Soheilian F, Nagashima K, Ott DE, Freed EO.

PLoS Pathog. 2008 Mar 7;4(3):e1000015. doi: 10.1371/journal.ppat.1000015.


Photoinduced reactivity of the HIV-1 envelope glycoprotein with a membrane-embedded probe reveals insertion of portions of the HIV-1 Gp41 cytoplasmic tail into the viral membrane.

Viard M, Ablan SD, Zhou M, Veenstra TD, Freed EO, Raviv Y, Blumenthal R.

Biochemistry. 2008 Feb 19;47(7):1977-83. doi: 10.1021/bi701920f. Epub 2008 Jan 17.


HIV-1 escape from the entry-inhibiting effects of a cholesterol-binding compound via cleavage of gp41 by the viral protease.

Waheed AA, Ablan SD, Roser JD, Sowder RC, Schaffner CP, Chertova E, Freed EO.

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8467-71. Epub 2007 May 4.


In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat).

Adamson CS, Ablan SD, Boeras I, Goila-Gaur R, Soheilian F, Nagashima K, Li F, Salzwedel K, Sakalian M, Wild CT, Freed EO.

J Virol. 2006 Nov;80(22):10957-71. Epub 2006 Sep 6.


Inhibition of HIV-1 replication by amphotericin B methyl ester: selection for resistant variants.

Waheed AA, Ablan SD, Mankowski MK, Cummins JE, Ptak RG, Schaffner CP, Freed EO.

J Biol Chem. 2006 Sep 29;281(39):28699-711. Epub 2006 Aug 1.


Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane.

Ono A, Ablan SD, Lockett SJ, Nagashima K, Freed EO.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14889-94. Epub 2004 Oct 1.

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