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Items: 21

1.

Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.

Ablain J, Xu M, Rothschild H, Jordan RC, Mito JK, Daniels BH, Bell CF, Joseph NM, Wu H, Bastian BC, Zon LI, Yeh I.

Science. 2018 Nov 30;362(6418):1055-1060. doi: 10.1126/science.aau6509. Epub 2018 Nov 1.

2.

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.

Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH.

J Biol Chem. 2018 Dec 21;293(51):19797-19811. doi: 10.1074/jbc.RA118.002742. Epub 2018 Oct 26.

3.

Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion.

McConnell AM, Mito JK, Ablain J, Dang M, Formichella L, Fisher DE, Zon LI.

Dev Biol. 2019 May 15;449(2):107-114. doi: 10.1016/j.ydbio.2018.05.026. Epub 2018 Jun 5.

PMID:
29883661
4.

Tissue-specific gene targeting using CRISPR/Cas9.

Ablain J, Zon LI.

Methods Cell Biol. 2016;135:189-202. doi: 10.1016/bs.mcb.2016.03.004. Epub 2016 Apr 23.

5.

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI.

Mol Cell. 2016 Apr 7;62(1):34-46. doi: 10.1016/j.molcel.2016.03.013.

6.

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.

Kaufman CK, Mosimann C, Fan ZP, Yang S, Thomas AJ, Ablain J, Tan JL, Fogley RD, van Rooijen E, Hagedorn EJ, Ciarlo C, White RM, Matos DA, Puller AC, Santoriello C, Liao EC, Young RA, Zon LI.

Science. 2016 Jan 29;351(6272):aad2197. doi: 10.1126/science.aad2197. Epub 2016 Jan 28.

7.

p53 as an Effector or Inhibitor of Therapy Response.

Ablain J, Poirot B, Esnault C, Lehmann-Che J, de Thé H.

Cold Spring Harb Perspect Med. 2015 Dec 4;6(1):a026260. doi: 10.1101/cshperspect.a026260. Review.

8.

Adenosine signaling promotes hematopoietic stem and progenitor cell emergence.

Jing L, Tamplin OJ, Chen MJ, Deng Q, Patterson S, Kim PG, Durand EM, McNeil A, Green JM, Matsuura S, Ablain J, Brandt MK, Schlaeger TM, Huttenlocher A, Daley GQ, Ravid K, Zon LI.

J Exp Med. 2015 May 4;212(5):649-63. doi: 10.1084/jem.20141528. Epub 2015 Apr 13.

9.

A CRISPR/Cas9 vector system for tissue-specific gene disruption in zebrafish.

Ablain J, Durand EM, Yang S, Zhou Y, Zon LI.

Dev Cell. 2015 Mar 23;32(6):756-64. doi: 10.1016/j.devcel.2015.01.032. Epub 2015 Mar 5.

10.

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation.

Vitaliano-Prunier A, Halftermeyer J, Ablain J, de Reynies A, Peres L, Le Bras M, Metzger D, de Thé H.

Blood. 2014 Dec 11;124(25):3772-80. doi: 10.1182/blood-2014-03-561852. Epub 2014 Sep 25.

PMID:
25258343
11.

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia.

Ablain J, de Thé H.

Int J Cancer. 2014 Nov 15;135(10):2262-72. doi: 10.1002/ijc.29081. Epub 2014 Aug 14. Review.

12.

Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392.

De Bellis F, Carafa V, Conte M, Rotili D, Petraglia F, Matarese F, Françoijs KJ, Ablain J, Valente S, Castellano R, Goubard A, Collette Y, Mandoli A, Martens JH, de Thé H, Nebbioso A, Mai A, Stunnenberg HG, Altucci L.

Cancer Res. 2014 Apr 15;74(8):2328-39. doi: 10.1158/0008-5472.CAN-13-2568. Epub 2014 Feb 24.

13.

Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure.

Ablain J, Rice K, Soilihi H, de Reynies A, Minucci S, de Thé H.

Nat Med. 2014 Feb;20(2):167-74. doi: 10.1038/nm.3441. Epub 2014 Jan 12.

PMID:
24412926
14.

Of fish and men: using zebrafish to fight human diseases.

Ablain J, Zon LI.

Trends Cell Biol. 2013 Dec;23(12):584-6. doi: 10.1016/j.tcb.2013.09.009.

15.

Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies.

Ablain J, Leiva M, Peres L, Fonsart J, Anthony E, de Thé H.

J Exp Med. 2013 Apr 8;210(4):647-53. doi: 10.1084/jem.20122337. Epub 2013 Mar 18.

16.

How animal models of leukaemias have already benefited patients.

Ablain J, Nasr R, Zhu J, Bazarbachi A, Lallemand-Breittenbach V, de Thé H.

Mol Oncol. 2013 Apr;7(2):224-31. doi: 10.1016/j.molonc.2013.01.006. Epub 2013 Feb 11. Review.

17.

8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation.

Jiao B, Ren ZH, Liu P, Chen LJ, Shi JY, Dong Y, Ablain J, Shi L, Gao L, Hu JP, Ren RB, de Thé H, Chen Z, Chen SJ.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3495-500. doi: 10.1073/pnas.1222863110. Epub 2013 Feb 4.

18.

The drug-induced degradation of oncoproteins: an unexpected Achilles' heel of cancer cells?

Ablain J, Nasr R, Bazarbachi A, de Thé H.

Cancer Discov. 2011 Jul;1(2):117-27. doi: 10.1158/2159-8290.CD-11-0087. Review.

19.

Revisiting the differentiation paradigm in acute promyelocytic leukemia.

Ablain J, de The H.

Blood. 2011 Jun 2;117(22):5795-802. doi: 10.1182/blood-2011-02-329367. Epub 2011 Mar 28.

PMID:
21444912
20.

Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia.

El Hajj H, El-Sabban M, Hasegawa H, Zaatari G, Ablain J, Saab ST, Janin A, Mahfouz R, Nasr R, Kfoury Y, Nicot C, Hermine O, Hall W, de Thé H, Bazarbachi A.

J Exp Med. 2010 Dec 20;207(13):2785-92. doi: 10.1084/jem.20101095. Epub 2010 Dec 6.

21.

Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.

Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD.

Blood. 2009 Dec 24;114(27):5499-511. doi: 10.1182/blood-2009-03-206524. Epub 2009 Oct 23.

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