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Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes.

Hsu J, Reilly A, Hayes BJ, Clough CA, Konnick EQ, Torok-Storb B, Gulsuner S, Wu D, Becker PS, Keel SB, Abkowitz JL, Doulatov S.

Blood. 2019 Jul 11;134(2):186-198. doi: 10.1182/blood.2018884338. Epub 2019 Apr 22.


Single-cell analyses demonstrate that a heme-GATA1 feedback loop regulates red cell differentiation.

Doty RT, Yan X, Lausted C, Munday AD, Yang Z, Yi D, Jabbari N, Liu L, Keel SB, Tian Q, Abkowitz JL.

Blood. 2019 Jan 31;133(5):457-469. doi: 10.1182/blood-2018-05-850412. Epub 2018 Dec 10.


Visualizing hematopoiesis as a stochastic process.

Xu J, Wang Y, Guttorp P, Abkowitz JL.

Blood Adv. 2018 Oct 23;2(20):2637-2645. doi: 10.1182/bloodadvances.2018023705.


Confronting the Research Funding Crisis: Medical Societies' Role in Filling the Gap.

Abkowitz JL, Hromas R.

Acad Med. 2018 Jul;93(7):961-962. doi: 10.1097/ACM.0000000000002255. No abstract available.


Approaching the crisis in medical research funding: an important role for nonprofit organizations and medical societies.

Abkowitz JL, Hromas R.

Blood Adv. 2018 Apr 24;2(8):846-847. doi: 10.1182/bloodadvances.2018017947. No abstract available.


Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.

Keel SB, Scott A, Sanchez-Bonilla M, Ho PA, Gulsuner S, Pritchard CC, Abkowitz JL, King MC, Walsh T, Shimamura A.

Haematologica. 2016 Nov;101(11):1343-1350. Epub 2016 Jul 14.


Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome.

Yang Z, Keel SB, Shimamura A, Liu L, Gerds AT, Li HY, Wood BL, Scott BL, Abkowitz JL.

Sci Transl Med. 2016 May 11;8(338):338ra67. doi: 10.1126/scitranslmed.aaf3006.


TLR Stimulation Dynamically Regulates Heme and Iron Export Gene Expression in Macrophages.

Philip M, Chiu EY, Hajjar AM, Abkowitz JL.

J Immunol Res. 2016;2016:4039038. doi: 10.1155/2016/4039038. Epub 2016 Feb 24.


Coordinate expression of heme and globin is essential for effective erythropoiesis.

Doty RT, Phelps SR, Shadle C, Sanchez-Bonilla M, Keel SB, Abkowitz JL.

J Clin Invest. 2015 Dec;125(12):4681-91. doi: 10.1172/JCI83054. Epub 2015 Nov 9.


In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs.

Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC Jr, Bennett JM, Benz EJ Jr, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ Jr, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA.

Mayo Clin Proc. 2015 Aug;90(8):996-1000. doi: 10.1016/j.mayocp.2015.06.001. Epub 2015 Jul 23. No abstract available.


Comparative analysis of flow cytometry and morphology for the detection of acute myeloid leukaemia cells in cerebrospinal fluid.

Loeb KR, Cherian S, Becker PS, Walter RB, Pagel JM, Abkowitz JL, Appelbaum FR, Wood BL, Estey EH.

Br J Haematol. 2016 Jan;172(1):134-6. doi: 10.1111/bjh.13465. Epub 2015 May 26. No abstract available.


Inducing iron deficiency improves erythropoiesis and photosensitivity in congenital erythropoietic porphyria.

Egan DN, Yang Z, Phillips J, Abkowitz JL.

Blood. 2015 Jul 9;126(2):257-61. doi: 10.1182/blood-2014-07-584664. Epub 2015 May 13.


Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver.

Keel SB, Doty R, Liu L, Nemeth E, Cherian S, Ganz T, Abkowitz JL.

Exp Hematol. 2015 Jun;43(6):469-78.e6. doi: 10.1016/j.exphem.2015.03.001. Epub 2015 Mar 14.


Planning for the future workforce in hematology research.

Hoots WK, Abkowitz JL, Coller BS, DiMichele DM.

Blood. 2015 Apr 30;125(18):2745-52. doi: 10.1182/blood-2015-01-617811. Epub 2015 Mar 10.


The role of hematologists in a changing United States health care system.

Wallace PJ, Connell NT, Abkowitz JL.

Blood. 2015 Apr 16;125(16):2467-70. doi: 10.1182/blood-2014-12-615047. Epub 2015 Mar 6.


Relation of clinical response and minimal residual disease and their prognostic impact on outcome in acute myeloid leukemia.

Chen X, Xie H, Wood BL, Walter RB, Pagel JM, Becker PS, Sandhu VK, Abkowitz JL, Appelbaum FR, Estey EH.

J Clin Oncol. 2015 Apr 10;33(11):1258-64. doi: 10.1200/JCO.2014.58.3518. Epub 2015 Mar 2.


Low platelet count reduces subsequent complete remission rate despite marrow with <5% blasts after AML induction therapy.

Chen X, Newell LF, Xie H, Walter RB, Pagel JM, Sandhu VK, Becker PS, Hendrie PC, Abkowitz JL, Appelbaum FR, Estey EH.

Leukemia. 2015 Aug;29(8):1779-80. doi: 10.1038/leu.2015.23. Epub 2015 Feb 4. No abstract available.


Heme exporter FLVCR is required for T cell development and peripheral survival.

Philip M, Funkhouser SA, Chiu EY, Phelps SR, Delrow JJ, Cox J, Fink PJ, Abkowitz JL.

J Immunol. 2015 Feb 15;194(4):1677-85. doi: 10.4049/jimmunol.1402172. Epub 2015 Jan 12.


Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.

Zhang MY, Churpek JE, Keel SB, Walsh T, Lee MK, Loeb KR, Gulsuner S, Pritchard CC, Sanchez-Bonilla M, Delrow JJ, Basom RS, Forouhar M, Gyurkocza B, Schwartz BS, Neistadt B, Marquez R, Mariani CJ, Coats SA, Hofmann I, Lindsley RC, Williams DA, Abkowitz JL, Horwitz MS, King MC, Godley LA, Shimamura A.

Nat Genet. 2015 Feb;47(2):180-5. doi: 10.1038/ng.3177. Epub 2015 Jan 12.


G-CSF priming, clofarabine, and high dose cytarabine (GCLAC) for upfront treatment of acute myeloid leukemia, advanced myelodysplastic syndrome or advanced myeloproliferative neoplasm.

Becker PS, Medeiros BC, Stein AS, Othus M, Appelbaum FR, Forman SJ, Scott BL, Hendrie PC, Gardner KM, Pagel JM, Walter RB, Parks C, Wood BL, Abkowitz JL, Estey EH.

Am J Hematol. 2015 Apr;90(4):295-300. doi: 10.1002/ajh.23927. Epub 2015 Jan 30.


Clone wars--the emergence of neoplastic blood-cell clones with aging.

Abkowitz JL.

N Engl J Med. 2014 Dec 25;371(26):2523-5. doi: 10.1056/NEJMe1412902. Epub 2014 Nov 26. No abstract available.


Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity.

Zhang MY, Keel SB, Walsh T, Lee MK, Gulsuner S, Watts AC, Pritchard CC, Salipante SJ, Jeng MR, Hofmann I, Williams DA, Fleming MD, Abkowitz JL, King MC, Shimamura A.

Haematologica. 2015 Jan;100(1):42-8. doi: 10.3324/haematol.2014.113456. Epub 2014 Sep 19.


Sickle cell trait and safe athletic participation: the way forward.

Abkowitz JL, O'Connor FG, Deuster PA, Thompson AA.

Curr Sports Med Rep. 2014 May-Jun;13(3):192-3. doi: 10.1249/JSR.0000000000000054. No abstract available.


Prediction of adverse events during intensive induction chemotherapy for acute myeloid leukemia or high-grade myelodysplastic syndromes.

Buckley SA, Othus M, Vainstein V, Abkowitz JL, Estey EH, Walter RB.

Am J Hematol. 2014 Apr;89(4):423-8. doi: 10.1002/ajh.23661. Epub 2014 Feb 24.


Rapid rate of peripheral blood blast clearance accurately predicts complete remission in acute myeloid leukemia.

Vainstein V, Buckley SA, Shukron O, Estey EH, Abkowitz JL, Wood BL, Walter RB.

Leukemia. 2014 Mar;28(3):713-6. doi: 10.1038/leu.2013.341. Epub 2013 Nov 18. No abstract available.


FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function.

Byon JC, Chen J, Doty RT, Abkowitz JL.

Blood. 2013 Oct 17;122(16):2903-10. doi: 10.1182/blood-2012-10-465104. Epub 2013 Sep 10.


Facing the NIH funding crisis: how professional societies can help.

Hromas R, Abkowitz JL, Keating A.

JAMA. 2012 Dec 12;308(22):2343-4. No abstract available.


Myeloid sarcoma of the heart.

Mawad R, Wu D, Abkowitz JL, Walter RB.

Leuk Lymphoma. 2012 Dec;53(12):2511-4. doi: 10.3109/10428194.2012.685736. Epub 2012 May 21. No abstract available.


Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis.

Keel SB, Phelps S, Sabo KM, O'Leary MN, Kirn-Safran CB, Abkowitz JL.

Exp Hematol. 2012 Apr;40(4):290-4. doi: 10.1016/j.exphem.2011.12.003. Epub 2011 Dec 20.


Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents.

Jaacks LM, Young MF, Essley BV, McNanley TJ, Cooper EM, Pressman EK, McIntyre AW, Orlando MS, Abkowitz JL, Guillet R, O'Brien KO.

J Nutr. 2011 Jul;141(7):1267-72. doi: 10.3945/jn.110.135798. Epub 2011 May 18.


The replication rate of human hematopoietic stem cells in vivo.

Catlin SN, Busque L, Gale RE, Guttorp P, Abkowitz JL.

Blood. 2011 Apr 28;117(17):4460-6. doi: 10.1182/blood-2010-08-303537. Epub 2011 Feb 22.


Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin.

Yang Z, Philips JD, Doty RT, Giraudi P, Ostrow JD, Tiribelli C, Smith A, Abkowitz JL.

J Biol Chem. 2010 Sep 10;285(37):28874-82. doi: 10.1074/jbc.M110.119131. Epub 2010 Jul 7.


Feline leukemia virus integrase and capsid packaging functions do not change the insertion profile of standard Moloney retroviral vectors.

Métais JY, Topp S, Doty RT, Borate B, Nguyen AD, Wolfsberg TG, Abkowitz JL, Dunbar CE.

Gene Ther. 2010 Jun;17(6):799-804. doi: 10.1038/gt.2010.24. Epub 2010 Mar 18.


An all-feline retroviral packaging system for transduction of human cells.

Doty RT, Sabo KM, Chen J, Miller AD, Abkowitz JL.

Hum Gene Ther. 2010 Aug;21(8):1019-27. doi: 10.1089/hum.2010.032.


The microcytic red cell and the anemia of inflammation.

Keel SB, Abkowitz JL.

N Engl J Med. 2009 Nov 5;361(19):1904-6. doi: 10.1056/NEJMcibr0906391. No abstract available.


In utero transplantation of monocytic cells in cats with alpha-mannosidosis.

Abkowitz JL, Sabo KM, Yang Z, Vite CH, Shields LE, Haskins ME.

Transplantation. 2009 Aug 15;88(3):323-9. doi: 10.1097/TP.0b013e3181b0d264.


The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells.

Oehler VG, Guthrie KA, Cummings CL, Sabo K, Wood BL, Gooley T, Yang T, Epping MT, Shou Y, Pogosova-Agadjanyan E, Ladne P, Stirewalt DL, Abkowitz JL, Radich JP.

Blood. 2009 Oct 8;114(15):3299-308. doi: 10.1182/blood-2008-07-170282. Epub 2009 Jul 22.


A heme export protein is required for red blood cell differentiation and iron homeostasis.

Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL.

Science. 2008 Feb 8;319(5864):825-8. doi: 10.1126/science.1151133.


Hematopoietic stem-cell behavior in nonhuman primates.

Shepherd BE, Kiem HP, Lansdorp PM, Dunbar CE, Aubert G, LaRochelle A, Seggewiss R, Guttorp P, Abkowitz JL.

Blood. 2007 Sep 15;110(6):1806-13. Epub 2007 May 25.


Mobilization as a preparative regimen for hematopoietic stem cell transplantation.

Chen J, Larochelle A, Fricker S, Bridger G, Dunbar CE, Abkowitz JL.

Blood. 2006 May 1;107(9):3764-71. Epub 2006 Jan 26.


The kinetics of clonal dominance in myeloproliferative disorders.

Catlin SN, Guttorp P, Abkowitz JL.

Blood. 2005 Oct 15;106(8):2688-92. Epub 2005 Jul 7.


Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia.

Quigley JG, Gazda H, Yang Z, Ball S, Sieff CA, Abkowitz JL.

Blood Cells Mol Dis. 2005 Sep-Oct;35(2):189-92.


Improved transduction of human sheep repopulating cells by retrovirus vectors pseudotyped with feline leukemia virus type C or RD114 envelopes.

Lucas ML, Seidel NE, Porada CD, Quigley JG, Anderson SM, Malech HL, Abkowitz JL, Zanjani ED, Bodine DM.

Blood. 2005 Jul 1;106(1):51-8. Epub 2005 Mar 17.


Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths.

Shepherd BE, Guttorp P, Lansdorp PM, Abkowitz JL.

Exp Hematol. 2004 Nov;32(11):1040-50.


Identification of a human heme exporter that is essential for erythropoiesis.

Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL.

Cell. 2004 Sep 17;118(6):757-66.


Strategies to expand transduced hematopoietic stem cells in vivo.

Abkowitz JL, Golinelli D, Guttorp P.

Mol Ther. 2004 Apr;9(4):566-76.


Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure.

Abkowitz JL, Robinson AE, Kale S, Long MW, Chen J.

Blood. 2003 Aug 15;102(4):1249-53. Epub 2003 Apr 24.


Expression from second-generation feline immunodeficiency virus vectors is impaired in human hematopoietic cells.

Price MA, Case SS, Carbonaro DA, Yu XJ, Petersen D, Sabo KM, Curran MA, Engel BC, Margarian H, Abkowitz JL, Nolan GP, Kohn DB, Crooks GM.

Mol Ther. 2002 Nov;6(5):645-52.


Longitudinal studies of telomere length in feline blood cells: implications for hematopoietic stem cell turnover in vivo.

Brümmendorf TH, Mak J, Sabo KM, Baerlocher GM, Dietz K, Abkowitz JL, Lansdorp PM.

Exp Hematol. 2002 Oct;30(10):1147-52.


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