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Items: 1 to 50 of 58

1.

Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma.

Santofimia-Castaño P, Xia Y, Peng L, Velázquez-Campoy A, Abián O, Lan W, Lomberk G, Urrutia R, Rizzuti B, Soubeyran P, Neira JL, Iovanna J.

Cells. 2019 Nov 17;8(11). pii: E1453. doi: 10.3390/cells8111453. Review.

2.

Targeting intrinsically disordered proteins involved in cancer.

Santofimia-Castaño P, Rizzuti B, Xia Y, Abian O, Peng L, Velázquez-Campoy A, Neira JL, Iovanna J.

Cell Mol Life Sci. 2019 Oct 30. doi: 10.1007/s00018-019-03347-3. [Epub ahead of print] Review.

PMID:
31667555
3.

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2.

Martínez de Paz A, Khajavi L, Martin H, Claveria-Gimeno R, Tom Dieck S, Cheema MS, Sanchez-Mut JV, Moksa MM, Carles A, Brodie NI, Sheikh TI, Freeman ME, Petrotchenko EV, Borchers CH, Schuman EM, Zytnicki M, Velazquez-Campoy A, Abian O, Hirst M, Esteller M, Vincent JB, Malnou CE, Ausió J.

Epigenetics Chromatin. 2019 Oct 10;12(1):63. doi: 10.1186/s13072-019-0298-1.

4.

Site-selective modification of tryptophan and protein tryptophan residues through PdNP bionanohybrid-catalysed C-H activation in aqueous media.

Perez-Rizquez C, Abian O, Palomo JM.

Chem Commun (Camb). 2019 Oct 24;55(86):12928-12931. doi: 10.1039/c9cc06971b.

PMID:
31599273
5.

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm.

Santofimia-Castaño P, Rizzuti B, Xia Y, Abian O, Peng L, Velázquez-Campoy A, Iovanna JL, Neira JL.

Mol Cell Oncol. 2019 May 16;6(5):e1612678. doi: 10.1080/23723556.2019.1612678. eCollection 2019.

PMID:
31528692
6.

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors.

Felix J, Weinhäupl K, Chipot C, Dehez F, Hessel A, Gauto DF, Morlot C, Abian O, Gutsche I, Velazquez-Campoy A, Schanda P, Fraga H.

Sci Adv. 2019 Sep 4;5(9):eaaw3818. doi: 10.1126/sciadv.aaw3818. eCollection 2019 Sep.

7.

Thermal Liquid Biopsy (TLB): A Predictive Score Derived from Serum Thermograms as a Clinical Tool for Screening Lung Cancer Patients.

Rodrigo A, Ojeda JL, Vega S, Sanchez-Gracia O, Lanas A, Isla D, Velazquez-Campoy A, Abian O.

Cancers (Basel). 2019 Jul 19;11(7). pii: E1012. doi: 10.3390/cancers11071012.

8.

Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1.

Neira JL, Correa J, Rizzuti B, Santofimia-Castaño P, Abian O, Velázquez-Campoy A, Fernandez-Megia E, Iovanna JL.

Biomacromolecules. 2019 Jul 8;20(7):2567-2576. doi: 10.1021/acs.biomac.9b00378. Epub 2019 Jun 24.

PMID:
31181156
9.

Tinkering with Binding Polynomials in Isothermal Titration Calorimetry.

Claveria-Gimeno R, Vega S, Abian O, Velazquez-Campoy A.

Methods Mol Biol. 2019;1964:185-213. doi: 10.1007/978-1-4939-9179-2_14.

PMID:
30929244
10.

Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position.

Gálvez JA, Clavería-Gimeno R, Galano-Frutos JJ, Sancho J, Velázquez-Campoy A, Abian O, Díaz-de-Villegas MD.

Eur J Med Chem. 2019 Jun 1;171:401-419. doi: 10.1016/j.ejmech.2019.03.019. Epub 2019 Mar 12.

PMID:
30928711
11.

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.

Santofimia-Castaño P, Xia Y, Lan W, Zhou Z, Huang C, Peng L, Soubeyran P, Velázquez-Campoy A, Abián O, Rizzuti B, Neira JL, Iovanna J.

J Clin Invest. 2019 Mar 28;129(6):2500-2513. doi: 10.1172/JCI127223.

12.

Enzyme structure and function protection from gastrointestinal degradation using enteric coatings.

Gracia R, Yus C, Abian O, Mendoza G, Irusta S, Sebastian V, Andreu V, Arruebo M.

Int J Biol Macromol. 2018 Nov;119:413-422. doi: 10.1016/j.ijbiomac.2018.07.143. Epub 2018 Jul 23.

PMID:
30048728
13.

Thermal liquid biopsy for monitoring melanoma patients under surveillance during treatment: A pilot study.

Velazquez-Campoy A, Vega S, Sanchez-Gracia O, Lanas A, Rodrigo A, Kaliappan A, Hall MB, Nguyen TQ, Brock GN, Chesney JA, Garbett NC, Abian O.

Biochim Biophys Acta Gen Subj. 2018 Aug;1862(8):1701-1710. doi: 10.1016/j.bbagen.2018.04.020. Epub 2018 Apr 26.

14.

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).

Santofimia-Castaño P, Rizzuti B, Abián O, Velázquez-Campoy A, Iovanna JL, Neira JL.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1283-1295. doi: 10.1016/j.bbagen.2018.03.009. Epub 2018 Mar 10.

PMID:
29530795
15.

The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments.

Neira JL, Hornos F, Cozza C, Cámara-Artigas A, Abián O, Velázquez-Campoy A.

Arch Biochem Biophys. 2018 Feb 1;639:26-37. doi: 10.1016/j.abb.2017.12.017. Epub 2017 Dec 27.

PMID:
29288053
16.

A look at ligand binding thermodynamics in drug discovery.

Claveria-Gimeno R, Vega S, Abian O, Velazquez-Campoy A.

Expert Opin Drug Discov. 2017 Apr;12(4):363-377. doi: 10.1080/17460441.2017.1297418. Epub 2017 Mar 1. Review.

PMID:
28276703
17.

The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site.

Claveria-Gimeno R, Lanuza PM, Morales-Chueca I, Jorge-Torres OC, Vega S, Abian O, Esteller M, Velazquez-Campoy A.

Sci Rep. 2017 Jan 31;7:41635. doi: 10.1038/srep41635.

18.

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.

Neira JL, Bintz J, Arruebo M, Rizzuti B, Bonacci T, Vega S, Lanas A, Velázquez-Campoy A, Iovanna JL, Abián O.

Sci Rep. 2017 Jan 5;7:39732. doi: 10.1038/srep39732.

19.

Stevia rebaudiana ethanolic extract exerts better antioxidant properties and antiproliferative effects in tumour cells than its diterpene glycoside stevioside.

López V, Pérez S, Vinuesa A, Zorzetto C, Abian O.

Food Funct. 2016 Apr;7(4):2107-13. doi: 10.1039/c5fo01586c.

PMID:
27071804
20.

Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases.

Velazquez-Campoy A, Sancho J, Abian O, Vega S.

Curr Drug Targets. 2016;17(13):1492-505. Review.

PMID:
26844568
21.

On the link between conformational changes, ligand binding and heat capacity.

Vega S, Abian O, Velazquez-Campoy A.

Biochim Biophys Acta. 2016 May;1860(5):868-878. doi: 10.1016/j.bbagen.2015.10.010. Epub 2015 Oct 22. Review.

PMID:
26476135
22.

Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena sp. PCC 7120.

Botello-Morte L, Pellicer S, Sein-Echaluce VC, Contreras LM, Neira JL, Abián O, Velázquez-Campoy A, Peleato ML, Fillat MF, Bes MT.

Antioxid Redox Signal. 2016 Feb;24(4):173-185. Epub 2015 Oct 9.

23.

Shell Cross-Linked Polymeric Micelles as Camptothecin Nanocarriers for Anti-HCV Therapy.

Jiménez-Pardo I, González-Pastor R, Lancelot A, Claveria-Gimeno R, Velázquez-Campoy A, Abian O, Ros MB, Sierra T.

Macromol Biosci. 2015 Oct;15(10):1381-91. doi: 10.1002/mabi.201500094. Epub 2015 Jun 5.

PMID:
26045353
24.

Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier.

Claveria-Gimeno R, Vega S, Grazu V, de la Fuente JM, Lanas A, Velazquez-Campoy A, Abian O.

Int J Nanomedicine. 2015 Mar 19;10:2249-59. doi: 10.2147/IJN.S79480. eCollection 2015.

25.

Deconvolution analysis for classifying gastric adenocarcinoma patients based on differential scanning calorimetry serum thermograms.

Vega S, Garcia-Gonzalez MA, Lanas A, Velazquez-Campoy A, Abian O.

Sci Rep. 2015 Jan 23;5:7988. doi: 10.1038/srep07988.

26.

A unified framework based on the binding polynomial for characterizing biological systems by isothermal titration calorimetry.

Vega S, Abian O, Velazquez-Campoy A.

Methods. 2015 Apr;76:99-115. doi: 10.1016/j.ymeth.2014.09.010. Epub 2014 Oct 8.

PMID:
25305413
27.

Allosteric inhibitors of the NS3 protease from the hepatitis C virus.

Abian O, Vega S, Sancho J, Velazquez-Campoy A.

PLoS One. 2013 Jul 30;8(7):e69773. doi: 10.1371/journal.pone.0069773. Print 2013.

28.

NS3 protease from hepatitis C virus: biophysical studies on an intrinsically disordered protein domain.

Vega S, Neira JL, Marcuello C, Lostao A, Abian O, Velazquez-Campoy A.

Int J Mol Sci. 2013 Jun 26;14(7):13282-306. doi: 10.3390/ijms140713282. Review.

29.

Altering the interfacial activation mechanism of a lipase by solid-phase selective chemical modification.

López-Gallego F, Abian O, Guisán JM.

Biochemistry. 2012 Sep 4;51(35):7028-36. doi: 10.1021/bi300799v. Epub 2012 Aug 23.

PMID:
22876885
30.

Semisynthetic peptide-lipase conjugates for improved biotransformations.

Romero O, Filice M, de las Rivas B, Carrasco-Lopez C, Klett J, Morreale A, Hermoso JA, Guisan JM, Abian O, Palomo JM.

Chem Commun (Camb). 2012 Sep 18;48(72):9053-5. doi: 10.1039/c2cc34816k. Epub 2012 Aug 2.

PMID:
22858661
31.

Studying the allosteric energy cycle by isothermal titration calorimetry.

Martinez-Julvez M, Abian O, Vega S, Medina M, Velazquez-Campoy A.

Methods Mol Biol. 2012;796:53-70. doi: 10.1007/978-1-61779-334-9_4.

PMID:
22052485
32.

Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase.

Abian O, Alfonso P, Velazquez-Campoy A, Giraldo P, Pocovi M, Sancho J.

Mol Pharm. 2011 Dec 5;8(6):2390-7. doi: 10.1021/mp200313e. Epub 2011 Nov 3.

PMID:
21988669
33.

Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity.

Bocanegra R, Nevot M, Doménech R, López I, Abián O, Rodríguez-Huete A, Cavasotto CN, Velázquez-Campoy A, Gómez J, Martínez MÁ, Neira JL, Mateu MG.

PLoS One. 2011;6(9):e23877. doi: 10.1371/journal.pone.0023877. Epub 2011 Sep 8.

34.

Mechanism of FMN Binding to the Apoflavodoxin from Helicobacter pylori.

Ayuso-Tejedor S, Abián O, Velázquez-Campoy A, Sancho J.

Biochemistry. 2011 Oct 11;50(40):8703-11. doi: 10.1021/bi201025y. Epub 2011 Sep 15.

PMID:
21910456
35.

Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis.

Pérez-Llarena FJ, Kerff F, Abián O, Mallo S, Fernández MC, Galleni M, Sancho J, Bou G.

Antimicrob Agents Chemother. 2011 Sep;55(9):4361-8. doi: 10.1128/AAC.00298-11. Epub 2011 Jul 5.

36.

Protein-cation interactions: structural and thermodynamic aspects.

Arias-Moreno X, Abian O, Vega S, Sancho J, Velazquez-Campoy A.

Curr Protein Pept Sci. 2011 Jun;12(4):325-38. Review.

PMID:
21401523
37.

Conformational stability of hepatitis C virus NS3 protease.

Abian O, Vega S, Neira JL, Velazquez-Campoy A.

Biophys J. 2010 Dec 1;99(11):3811-20. doi: 10.1016/j.bpj.2010.10.037.

38.

Underexposed polar residues and protein stabilization.

Ayuso-Tejedor S, Abián O, Sancho J.

Protein Eng Des Sel. 2011 Jan;24(1-2):171-7. doi: 10.1093/protein/gzq072. Epub 2010 Oct 11.

PMID:
20937603
39.

Dendrimers as potential inhibitors of the dimerization of the capsid protein of HIV-1.

Doménech R, Abian O, Bocanegra R, Correa J, Sousa-Herves A, Riguera R, Mateu MG, Fernandez-Megia E, Velázquez-Campoy A, Neira JL.

Biomacromolecules. 2010 Aug 9;11(8):2069-78. doi: 10.1021/bm100432x.

PMID:
20690715
40.

Design and structure of an equilibrium protein folding intermediate: a hint into dynamical regions of proteins.

Ayuso-Tejedor S, Angarica VE, Bueno M, Campos LA, Abián O, Bernadó P, Sancho J, Jiménez MA.

J Mol Biol. 2010 Jul 23;400(4):922-34. doi: 10.1016/j.jmb.2010.05.050. Epub 2010 May 27.

PMID:
20553732
41.

Thermodynamics of zinc binding to hepatitis C virus NS3 protease: a folding by binding event.

Abian O, Neira JL, Velazquez-Campoy A.

Proteins. 2009 Nov 15;77(3):624-36. doi: 10.1002/prot.22475.

PMID:
19536779
42.

Defining the epitope region of a peptide from the Streptomyces coelicolor phosphoenolpyruvate:sugar phosphotransferase system able to bind to the enzyme I.

Hurtado-Gómez E, Abián O, Muñoz FJ, Hernáiz MJ, Velázquez-Campoy A, Neira JL.

Biophys J. 2008 Aug;95(3):1336-48. doi: 10.1529/biophysj.107.126664. Epub 2008 May 2.

43.

Stabilization of enzymes by multipoint immobilization of thiolated proteins on new epoxy-thiol supports.

Grazú V, Abian O, Mateo C, Batista-Viera F, Fernández-Lafuente R, Guisán JM.

Biotechnol Bioeng. 2005 Jun 5;90(5):597-605.

PMID:
15818562
44.

Determination of protein-protein interactions through aldehyde-dextran intermolecular cross-linking.

Fuentes M, Segura RL, Abian O, Betancor L, Hidalgo A, Mateo C, Fernandez-Lafuente R, Guisan JM.

Proteomics. 2004 Sep;4(9):2602-7.

PMID:
15352235
45.

Reversible and strong immobilization of proteins by ionic exchange on supports coated with sulfate-dextran.

Fuentes M, Pessela BC, Maquiese JV, Ortiz C, Segura RL, Palomo JM, Abian O, Torres R, Mateo C, Fernández-Lafuente R, Guisán JM.

Biotechnol Prog. 2004 Jul-Aug;20(4):1134-9.

PMID:
15296440
46.

Enantioselective synthesis of phenylacetamides in the presence of high organic cosolvent concentrations catalyzed by stabilized penicillin G acylase. Effect of the acyl donor.

Abian O, Mateo C, Palomo JM, Fernández-Lorente G, Guisán JM, Fernández-Lafuente R.

Biotechnol Prog. 2004 May-Jun;20(3):984-8.

PMID:
15176909
47.

Co-aggregation of penicillin g acylase and polyionic polymers: an easy methodology to prepare enzyme biocatalysts stable in organic media.

Wilson L, Illanes A, Abián O, Pessela BC, Fernández-Lafuente R, Guisán JM.

Biomacromolecules. 2004 May-Jun;5(3):852-7.

PMID:
15132672
48.

Encapsulation of crosslinked penicillin G acylase aggregates in lentikats: evaluation of a novel biocatalyst in organic media.

Wilson L, Illanes A, Pessela BC, Abian O, Fernández-Lafuente R, Guisán JM.

Biotechnol Bioeng. 2004 Jun 5;86(5):558-62.

PMID:
15129439
49.

Stabilization of penicillin G acylase from Escherichia coli: site-directed mutagenesis of the protein surface to increase multipoint covalent attachment.

Abian O, Grazú V, Hermoso J, González R, García JL, Fernández-Lafuente R, Guisán JM.

Appl Environ Microbiol. 2004 Feb;70(2):1249-51.

50.

New cationic exchanger support for reversible immobilization of proteins.

Fuentes M, Maquiese JV, Pessela BC, Abian O, Fernández-Lafuente R, Mateo C, Guisán JM.

Biotechnol Prog. 2004 Jan-Feb;20(1):284-8.

PMID:
14763854

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