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Items: 47

1.

Enzyme structure and function protection from gastrointestinal degradation using enteric coatings.

Gracia R, Yus C, Abian O, Mendoza G, Irusta S, Sebastian V, Andreu V, Arruebo M.

Int J Biol Macromol. 2018 Nov;119:413-422. doi: 10.1016/j.ijbiomac.2018.07.143. Epub 2018 Jul 23.

PMID:
30048728
2.

Thermal liquid biopsy for monitoring melanoma patients under surveillance during treatment: A pilot study.

Velazquez-Campoy A, Vega S, Sanchez-Gracia O, Lanas A, Rodrigo A, Kaliappan A, Hall MB, Nguyen TQ, Brock GN, Chesney JA, Garbett NC, Abian O.

Biochim Biophys Acta Gen Subj. 2018 Aug;1862(8):1701-1710. doi: 10.1016/j.bbagen.2018.04.020. Epub 2018 Apr 26.

PMID:
29705200
3.

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).

Santofimia-Castaño P, Rizzuti B, Abián O, Velázquez-Campoy A, Iovanna JL, Neira JL.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1283-1295. doi: 10.1016/j.bbagen.2018.03.009. Epub 2018 Mar 10.

PMID:
29530795
4.

The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments.

Neira JL, Hornos F, Cozza C, Cámara-Artigas A, Abián O, Velázquez-Campoy A.

Arch Biochem Biophys. 2018 Feb 1;639:26-37. doi: 10.1016/j.abb.2017.12.017. Epub 2017 Dec 27.

PMID:
29288053
5.

A look at ligand binding thermodynamics in drug discovery.

Claveria-Gimeno R, Vega S, Abian O, Velazquez-Campoy A.

Expert Opin Drug Discov. 2017 Apr;12(4):363-377. doi: 10.1080/17460441.2017.1297418. Epub 2017 Mar 1. Review.

PMID:
28276703
6.

The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site.

Claveria-Gimeno R, Lanuza PM, Morales-Chueca I, Jorge-Torres OC, Vega S, Abian O, Esteller M, Velazquez-Campoy A.

Sci Rep. 2017 Jan 31;7:41635. doi: 10.1038/srep41635.

7.

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.

Neira JL, Bintz J, Arruebo M, Rizzuti B, Bonacci T, Vega S, Lanas A, Velázquez-Campoy A, Iovanna JL, Abián O.

Sci Rep. 2017 Jan 5;7:39732. doi: 10.1038/srep39732.

8.

Stevia rebaudiana ethanolic extract exerts better antioxidant properties and antiproliferative effects in tumour cells than its diterpene glycoside stevioside.

López V, Pérez S, Vinuesa A, Zorzetto C, Abian O.

Food Funct. 2016 Apr;7(4):2107-13. doi: 10.1039/c5fo01586c.

PMID:
27071804
9.

Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases.

Velazquez-Campoy A, Sancho J, Abian O, Vega S.

Curr Drug Targets. 2016;17(13):1492-505. Review.

PMID:
26844568
10.

On the link between conformational changes, ligand binding and heat capacity.

Vega S, Abian O, Velazquez-Campoy A.

Biochim Biophys Acta. 2016 May;1860(5):868-878. doi: 10.1016/j.bbagen.2015.10.010. Epub 2015 Oct 22. Review.

PMID:
26476135
11.

Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena sp. PCC 7120.

Botello-Morte L, Pellicer S, Sein-Echaluce VC, Contreras LM, Neira JL, Abián O, Velázquez-Campoy A, Peleato ML, Fillat MF, Bes MT.

Antioxid Redox Signal. 2016 Feb;24(4):173-185. Epub 2015 Oct 9.

12.

Shell Cross-Linked Polymeric Micelles as Camptothecin Nanocarriers for Anti-HCV Therapy.

Jiménez-Pardo I, González-Pastor R, Lancelot A, Claveria-Gimeno R, Velázquez-Campoy A, Abian O, Ros MB, Sierra T.

Macromol Biosci. 2015 Oct;15(10):1381-91. doi: 10.1002/mabi.201500094. Epub 2015 Jun 5.

PMID:
26045353
13.

Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier.

Claveria-Gimeno R, Vega S, Grazu V, de la Fuente JM, Lanas A, Velazquez-Campoy A, Abian O.

Int J Nanomedicine. 2015 Mar 19;10:2249-59. doi: 10.2147/IJN.S79480. eCollection 2015.

14.

Deconvolution analysis for classifying gastric adenocarcinoma patients based on differential scanning calorimetry serum thermograms.

Vega S, Garcia-Gonzalez MA, Lanas A, Velazquez-Campoy A, Abian O.

Sci Rep. 2015 Jan 23;5:7988. doi: 10.1038/srep07988.

15.

A unified framework based on the binding polynomial for characterizing biological systems by isothermal titration calorimetry.

Vega S, Abian O, Velazquez-Campoy A.

Methods. 2015 Apr;76:99-115. doi: 10.1016/j.ymeth.2014.09.010. Epub 2014 Oct 8.

PMID:
25305413
16.

Allosteric inhibitors of the NS3 protease from the hepatitis C virus.

Abian O, Vega S, Sancho J, Velazquez-Campoy A.

PLoS One. 2013 Jul 30;8(7):e69773. doi: 10.1371/journal.pone.0069773. Print 2013.

17.

NS3 protease from hepatitis C virus: biophysical studies on an intrinsically disordered protein domain.

Vega S, Neira JL, Marcuello C, Lostao A, Abian O, Velazquez-Campoy A.

Int J Mol Sci. 2013 Jun 26;14(7):13282-306. doi: 10.3390/ijms140713282. Review.

18.

Altering the interfacial activation mechanism of a lipase by solid-phase selective chemical modification.

López-Gallego F, Abian O, Guisán JM.

Biochemistry. 2012 Sep 4;51(35):7028-36. doi: 10.1021/bi300799v. Epub 2012 Aug 23.

PMID:
22876885
19.

Semisynthetic peptide-lipase conjugates for improved biotransformations.

Romero O, Filice M, de las Rivas B, Carrasco-Lopez C, Klett J, Morreale A, Hermoso JA, Guisan JM, Abian O, Palomo JM.

Chem Commun (Camb). 2012 Sep 18;48(72):9053-5. doi: 10.1039/c2cc34816k. Epub 2012 Aug 2.

PMID:
22858661
20.

Studying the allosteric energy cycle by isothermal titration calorimetry.

Martinez-Julvez M, Abian O, Vega S, Medina M, Velazquez-Campoy A.

Methods Mol Biol. 2012;796:53-70. doi: 10.1007/978-1-61779-334-9_4.

PMID:
22052485
21.

Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase.

Abian O, Alfonso P, Velazquez-Campoy A, Giraldo P, Pocovi M, Sancho J.

Mol Pharm. 2011 Dec 5;8(6):2390-7. doi: 10.1021/mp200313e. Epub 2011 Nov 3.

PMID:
21988669
22.

Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity.

Bocanegra R, Nevot M, Doménech R, López I, Abián O, Rodríguez-Huete A, Cavasotto CN, Velázquez-Campoy A, Gómez J, Martínez MÁ, Neira JL, Mateu MG.

PLoS One. 2011;6(9):e23877. doi: 10.1371/journal.pone.0023877. Epub 2011 Sep 8.

23.

Mechanism of FMN Binding to the Apoflavodoxin from Helicobacter pylori.

Ayuso-Tejedor S, Abián O, Velázquez-Campoy A, Sancho J.

Biochemistry. 2011 Oct 11;50(40):8703-11. doi: 10.1021/bi201025y. Epub 2011 Sep 15.

PMID:
21910456
24.

Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis.

Pérez-Llarena FJ, Kerff F, Abián O, Mallo S, Fernández MC, Galleni M, Sancho J, Bou G.

Antimicrob Agents Chemother. 2011 Sep;55(9):4361-8. doi: 10.1128/AAC.00298-11. Epub 2011 Jul 5.

25.

Protein-cation interactions: structural and thermodynamic aspects.

Arias-Moreno X, Abian O, Vega S, Sancho J, Velazquez-Campoy A.

Curr Protein Pept Sci. 2011 Jun;12(4):325-38. Review.

PMID:
21401523
26.

Conformational stability of hepatitis C virus NS3 protease.

Abian O, Vega S, Neira JL, Velazquez-Campoy A.

Biophys J. 2010 Dec 1;99(11):3811-20. doi: 10.1016/j.bpj.2010.10.037.

27.

Underexposed polar residues and protein stabilization.

Ayuso-Tejedor S, Abián O, Sancho J.

Protein Eng Des Sel. 2011 Jan;24(1-2):171-7. doi: 10.1093/protein/gzq072. Epub 2010 Oct 11.

PMID:
20937603
28.

Dendrimers as potential inhibitors of the dimerization of the capsid protein of HIV-1.

Doménech R, Abian O, Bocanegra R, Correa J, Sousa-Herves A, Riguera R, Mateu MG, Fernandez-Megia E, Velázquez-Campoy A, Neira JL.

Biomacromolecules. 2010 Aug 9;11(8):2069-78. doi: 10.1021/bm100432x.

PMID:
20690715
29.

Design and structure of an equilibrium protein folding intermediate: a hint into dynamical regions of proteins.

Ayuso-Tejedor S, Angarica VE, Bueno M, Campos LA, Abián O, Bernadó P, Sancho J, Jiménez MA.

J Mol Biol. 2010 Jul 23;400(4):922-34. doi: 10.1016/j.jmb.2010.05.050. Epub 2010 May 27.

PMID:
20553732
30.

Thermodynamics of zinc binding to hepatitis C virus NS3 protease: a folding by binding event.

Abian O, Neira JL, Velazquez-Campoy A.

Proteins. 2009 Nov 15;77(3):624-36. doi: 10.1002/prot.22475.

PMID:
19536779
31.

Defining the epitope region of a peptide from the Streptomyces coelicolor phosphoenolpyruvate:sugar phosphotransferase system able to bind to the enzyme I.

Hurtado-Gómez E, Abián O, Muñoz FJ, Hernáiz MJ, Velázquez-Campoy A, Neira JL.

Biophys J. 2008 Aug;95(3):1336-48. doi: 10.1529/biophysj.107.126664. Epub 2008 May 2.

32.

Stabilization of enzymes by multipoint immobilization of thiolated proteins on new epoxy-thiol supports.

Grazú V, Abian O, Mateo C, Batista-Viera F, Fernández-Lafuente R, Guisán JM.

Biotechnol Bioeng. 2005 Jun 5;90(5):597-605.

PMID:
15818562
33.

Determination of protein-protein interactions through aldehyde-dextran intermolecular cross-linking.

Fuentes M, Segura RL, Abian O, Betancor L, Hidalgo A, Mateo C, Fernandez-Lafuente R, Guisan JM.

Proteomics. 2004 Sep;4(9):2602-7.

PMID:
15352235
34.

Reversible and strong immobilization of proteins by ionic exchange on supports coated with sulfate-dextran.

Fuentes M, Pessela BC, Maquiese JV, Ortiz C, Segura RL, Palomo JM, Abian O, Torres R, Mateo C, Fernández-Lafuente R, Guisán JM.

Biotechnol Prog. 2004 Jul-Aug;20(4):1134-9.

PMID:
15296440
35.

Enantioselective synthesis of phenylacetamides in the presence of high organic cosolvent concentrations catalyzed by stabilized penicillin G acylase. Effect of the acyl donor.

Abian O, Mateo C, Palomo JM, Fernández-Lorente G, Guisán JM, Fernández-Lafuente R.

Biotechnol Prog. 2004 May-Jun;20(3):984-8.

PMID:
15176909
36.

Co-aggregation of penicillin g acylase and polyionic polymers: an easy methodology to prepare enzyme biocatalysts stable in organic media.

Wilson L, Illanes A, Abián O, Pessela BC, Fernández-Lafuente R, Guisán JM.

Biomacromolecules. 2004 May-Jun;5(3):852-7.

PMID:
15132672
37.

Encapsulation of crosslinked penicillin G acylase aggregates in lentikats: evaluation of a novel biocatalyst in organic media.

Wilson L, Illanes A, Pessela BC, Abian O, Fernández-Lafuente R, Guisán JM.

Biotechnol Bioeng. 2004 Jun 5;86(5):558-62.

PMID:
15129439
38.

Stabilization of penicillin G acylase from Escherichia coli: site-directed mutagenesis of the protein surface to increase multipoint covalent attachment.

Abian O, Grazú V, Hermoso J, González R, García JL, Fernández-Lafuente R, Guisán JM.

Appl Environ Microbiol. 2004 Feb;70(2):1249-51.

39.

New cationic exchanger support for reversible immobilization of proteins.

Fuentes M, Maquiese JV, Pessela BC, Abian O, Fernández-Lafuente R, Mateo C, Guisán JM.

Biotechnol Prog. 2004 Jan-Feb;20(1):284-8.

PMID:
14763854
40.

Thermodynamically controlled synthesis of amide bonds catalyzed by highly organic solvent-resistant penicillin acylase derivatives.

Abian O, Mateo C, Fernández-Lorente G, Guisán JM, Fernández-Lafuente R.

Biotechnol Prog. 2004 Jan-Feb;20(1):117-21.

PMID:
14763832
41.

Improving the industrial production of 6-APA: enzymatic hydrolysis of penicillin G in the presence of organic solvents.

Abian O, Mateo C, Fernández-Lorente G, Guisán JM, Fernández-Lafuente R.

Biotechnol Prog. 2003 Nov-Dec;19(6):1639-42.

PMID:
14656134
42.

Novel bifunctional epoxy/thiol-reactive support to immobilize thiol containing proteins by the epoxy chemistry.

Grazú V, Abian O, Mateo C, Batista-Viera F, Fernández-Lafuente R, Guisán JM.

Biomacromolecules. 2003 Nov-Dec;4(6):1495-501.

PMID:
14606872
43.

Epoxy-amino groups: a new tool for improved immobilization of proteins by the epoxy method.

Mateo C, Torres R, Fernández-Lorente G, Ortiz C, Fuentes M, Hidalgo A, López-Gallego F, Abian O, Palomo JM, Betancor L, Pessela BC, Guisan JM, Fernández-Lafuente R.

Biomacromolecules. 2003 May-Jun;4(3):772-7.

PMID:
12741797
44.

Epoxy sepabeads: a novel epoxy support for stabilization of industrial enzymes via very intense multipoint covalent attachment.

Mateo C, Abian O, Fernández-Lorente G, Pedroche J, Fernández-Lafuente R, Guisan JM, Tam A, Daminati M.

Biotechnol Prog. 2002 May-Jun;18(3):629-34.

PMID:
12052083
45.
46.

Increase in conformational stability of enzymes immobilized on epoxy-activated supports by favoring additional multipoint covalent attachment*

Mateo C, Abian O, Fernandez-Lafuente R, Guisan JM.

Enzyme Microb Technol. 2000 Apr 1;26(7):509-515.

PMID:
10771054
47.

Reversible enzyme immobilization via a very strong and nondistorting ionic adsorption on support-polyethylenimine composites.

Mateo C, Abian O, Fernandez-Lafuente R, Guisan JM.

Biotechnol Bioeng. 2000 Apr 5;68(1):98-105.

PMID:
10699877

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