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Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism.

Fumagalli M, Camus SM, Diekmann Y, Burke A, Camus MD, Norman PJ, Joseph A, Abi-Rached L, Benazzo A, Rasteiro R, Mathieson I, Topf M, Parham P, Thomas MG, Brodsky FM.

Elife. 2019 Jun 4;8. pii: e41517. doi: 10.7554/eLife.41517.


HLAIb worldwide genetic diversity: New HLA-H alleles and haplotype structure description.

Paganini J, Abi-Rached L, Gouret P, Pontarotti P, Chiaroni J, Di Cristofaro J.

Mol Immunol. 2019 Aug;112:40-50. doi: 10.1016/j.molimm.2019.04.017. Epub 2019 May 8.


Immune diversity sheds light on missing variation in worldwide genetic diversity panels.

Abi-Rached L, Gouret P, Yeh JH, Di Cristofaro J, Pontarotti P, Picard C, Paganini J.

PLoS One. 2018 Oct 26;13(10):e0206512. doi: 10.1371/journal.pone.0206512. eCollection 2018.


Nomenclature for the KIR of non-human species.

Robinson J, Guethlein LA, Maccari G, Blokhuis J, Bimber BN, de Groot NG, Sanderson ND, Abi-Rached L, Walter L, Bontrop RE, Hammond JA, Marsh SGE, Parham P.

Immunogenetics. 2018 Sep;70(9):571-583. doi: 10.1007/s00251-018-1064-4. Epub 2018 Jun 4.


HLA-G Haplotypes Are Differentially Associated with Asthmatic Features.

Ribeyre C, Carlini F, René C, Jordier F, Picard C, Chiaroni J, Abi-Rached L, Gouret P, Marin G, Molinari N, Chanez P, Paganini J, Gras D, Di Cristofaro J.

Front Immunol. 2018 Feb 23;9:278. doi: 10.3389/fimmu.2018.00278. eCollection 2018.


Evolutionary and expression analyses reveal a pattern of ancient duplications and functional specializations in the diversification of the Downstream of Kinase (DOK) genes.

Guittard G, Pontarotti P, Granjeaud S, Rodrigues M, Abi-Rached L, Nunès JA.

Dev Comp Immunol. 2018 Jul;84:193-198. doi: 10.1016/j.dci.2018.02.011. Epub 2018 Feb 15.


Evolutionary and polymorphism analyses reveal the central role of BTN3A2 in the concerted evolution of the BTN3 gene family.

Afrache H, Pontarotti P, Abi-Rached L, Olive D.

Immunogenetics. 2017 Jun;69(6):379-390. doi: 10.1007/s00251-017-0980-z. Epub 2017 Apr 5.


Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.

Norman PJ, Norberg SJ, Guethlein LA, Nemat-Gorgani N, Royce T, Wroblewski EE, Dunn T, Mann T, Alicata C, Hollenbach JA, Chang W, Shults Won M, Gunderson KL, Abi-Rached L, Ronaghi M, Parham P.

Genome Res. 2017 May;27(5):813-823. doi: 10.1101/gr.213538.116. Epub 2017 Mar 30.


Two Orangutan Species Have Evolved Different KIR Alleles and Haplotypes.

Guethlein LA, Norman PJ, Heijmans CM, de Groot NG, Hilton HG, Babrzadeh F, Abi-Rached L, Bontrop RE, Parham P.

J Immunol. 2017 Apr 15;198(8):3157-3169. doi: 10.4049/jimmunol.1602163. Epub 2017 Mar 6.


Positive selection on sperm ion channels in a brooding brittle star: consequence of life-history traits evolution.

Weber AA, Abi-Rached L, Galtier N, Bernard A, Montoya-Burgos JI, Chenuil A.

Mol Ecol. 2017 Jul;26(14):3744-3759. doi: 10.1111/mec.14024. Epub 2017 Feb 8.


Paleogenetics and Past Infections: the Two Faces of the Coin of Human Immune Evolution.

Abi-Rached L, Raoult D.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.PoH-0018-2015. Review.


Host switching of human lice to new world monkeys in South America.

Drali R, Abi-Rached L, Boutellis A, Djossou F, Barker SC, Raoult D.

Infect Genet Evol. 2016 Apr;39:225-231. doi: 10.1016/j.meegid.2016.02.008. Epub 2016 Feb 8.


Genomic resources and their influence on the detection of the signal of positive selection in genome scans.

Manel S, Perrier C, Pratlong M, Abi-Rached L, Paganini J, Pontarotti P, Aurelle D.

Mol Ecol. 2016 Jan;25(1):170-84. doi: 10.1111/mec.13468. Epub 2015 Dec 17. Review.


Chimpanzee susceptibility to hepatitis C virus infection correlates with presence of Pt-KIR3DS2 and Pt-KIR2DL9: paired activating and inhibitory natural killer cell receptors.

Abi-Rached L, Guethlein LA, Norman PJ, Parham P.

Immunogenetics. 2015 Oct;67(10):625-8. doi: 10.1007/s00251-015-0863-0. Epub 2015 Aug 12.


African relapsing Fever borreliae genomospecies revealed by comparative genomics.

Elbir H, Abi-Rached L, Pontarotti P, Yoosuf N, Drancourt M.

Front Public Health. 2014 May 14;2:43. doi: 10.3389/fpubh.2014.00043. eCollection 2014.


Screening in planarians identifies MORN2 as a key component in LC3-associated phagocytosis and resistance to bacterial infection.

Abnave P, Mottola G, Gimenez G, Boucherit N, Trouplin V, Torre C, Conti F, Ben Amara A, Lepolard C, Djian B, Hamaoui D, Mettouchi A, Kumar A, Pagnotta S, Bonatti S, Lepidi H, Salvetti A, Abi-Rached L, Lemichez E, Mege JL, Ghigo E.

Cell Host Microbe. 2014 Sep 10;16(3):338-50. doi: 10.1016/j.chom.2014.08.002.


Common subclinical hypothyroidism during Whipple's disease.

Lagier JC, Fenollar F, Chiaroni J, Picard C, Oddoze C, Abi-Rached L, Raoult D.

BMC Infect Dis. 2014 Jul 4;14:370. doi: 10.1186/1471-2334-14-370.


The origin and distribution of human lice in the world.

Boutellis A, Abi-Rached L, Raoult D.

Infect Genet Evol. 2014 Apr;23:209-17. doi: 10.1016/j.meegid.2014.01.017. Epub 2014 Feb 11. Review.


Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans.

Norman PJ, Hollenbach JA, Nemat-Gorgani N, Guethlein LA, Hilton HG, Pando MJ, Koram KA, Riley EM, Abi-Rached L, Parham P.

PLoS Genet. 2013 Oct;9(10):e1003938. doi: 10.1371/journal.pgen.1003938. Epub 2013 Oct 31.


Computational analyses of an evolutionary arms race between mammalian immunity mediated by immunoglobulin A and its subversion by bacterial pathogens.

Pinheiro A, Woof JM, Abi-Rached L, Parham P, Esteves PJ.

PLoS One. 2013 Sep 3;8(9):e73934. doi: 10.1371/journal.pone.0073934. eCollection 2013.


Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.

Hilton HG, Vago L, Older Aguilar AM, Moesta AK, Graef T, Abi-Rached L, Norman PJ, Guethlein LA, Fleischhauer K, Parham P.

J Immunol. 2012 Aug 1;189(3):1418-30. doi: 10.4049/jimmunol.1100431. Epub 2012 Jul 6.


Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules.

Parham P, Norman PJ, Abi-Rached L, Guethlein LA.

Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):800-11. doi: 10.1098/rstb.2011.0266. Review.


Review: Immunogenetics of human placentation.

Parham P, Norman PJ, Abi-Rached L, Hilton HG, Guethlein LA.

Placenta. 2012 Feb;33 Suppl:S71-80. doi: 10.1016/j.placenta.2011.11.020. Epub 2011 Dec 15. Review.


The shaping of modern human immune systems by multiregional admixture with archaic humans.

Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, Guethlein LA, Tavoularis S, Little AM, Green RE, Norman PJ, Parham P.

Science. 2011 Oct 7;334(6052):89-94. doi: 10.1126/science.1209202. Epub 2011 Aug 25.


Variable NK cell receptors exemplified by human KIR3DL1/S1.

Parham P, Norman PJ, Abi-Rached L, Guethlein LA.

J Immunol. 2011 Jul 1;187(1):11-9. doi: 10.4049/jimmunol.0902332. Review.


Natural variation at position 45 in the D1 domain of lineage III killer cell immunoglobulin-like receptors (KIR) has major effects on the avidity and specificity for MHC class I.

Older Aguilar AM, Guethlein LA, Abi-Rached L, Parham P.

Immunogenetics. 2011 Aug;63(8):543-7. doi: 10.1007/s00251-011-0527-7. Epub 2011 May 4.


Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires.

Gleimer M, Wahl AR, Hickman HD, Abi-Rached L, Norman PJ, Guethlein LA, Hammond JA, Draghi M, Adams EJ, Juo S, Jalili R, Gharizadeh B, Ronaghi M, Garcia KC, Hildebrand WH, Parham P.

J Immunol. 2011 Feb 1;186(3):1575-88. doi: 10.4049/jimmunol.1002990. Epub 2011 Jan 5.


Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.

Pyo CW, Guethlein LA, Vu Q, Wang R, Abi-Rached L, Norman PJ, Marsh SG, Miller JS, Parham P, Geraghty DE.

PLoS One. 2010 Dec 29;5(12):e15115. doi: 10.1371/journal.pone.0015115.


Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells.

Abi-Rached L, Moesta AK, Rajalingam R, Guethlein LA, Parham P.

PLoS Genet. 2010 Nov 4;6(11):e1001192. doi: 10.1371/journal.pgen.1001192.


Coevolution of killer cell Ig-like receptors with HLA-C to become the major variable regulators of human NK cells.

Older Aguilar AM, Guethlein LA, Adams EJ, Abi-Rached L, Moesta AK, Parham P.

J Immunol. 2010 Oct 1;185(7):4238-51. doi: 10.4049/jimmunol.1001494. Epub 2010 Aug 30.


Humans differ from other hominids in lacking an activating NK cell receptor that recognizes the C1 epitope of MHC class I.

Moesta AK, Graef T, Abi-Rached L, Older Aguilar AM, Guethlein LA, Parham P.

J Immunol. 2010 Oct 1;185(7):4233-7. doi: 10.4049/jimmunol.1001951. Epub 2010 Aug 27.


Primate-specific regulation of natural killer cells.

Parham P, Abi-Rached L, Matevosyan L, Moesta AK, Norman PJ, Older Aguilar AM, Guethlein LA.

J Med Primatol. 2010 Aug;39(4):194-212. doi: 10.1111/j.1600-0684.2010.00432.x. Review.


A small, variable, and irregular killer cell Ig-like receptor locus accompanies the absence of MHC-C and MHC-G in gibbons.

Abi-Rached L, Kuhl H, Roos C, ten Hallers B, Zhu B, Carbone L, de Jong PJ, Mootnick AR, Knaust F, Reinhardt R, Parham P, Walter L.

J Immunol. 2010 Feb 1;184(3):1379-91. doi: 10.4049/jimmunol.0903016. Epub 2009 Dec 21.


KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.

Graef T, Moesta AK, Norman PJ, Abi-Rached L, Vago L, Older Aguilar AM, Gleimer M, Hammond JA, Guethlein LA, Bushnell DA, Robinson PJ, Parham P.

J Exp Med. 2009 Oct 26;206(11):2557-72. doi: 10.1084/jem.20091010.


Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands.

Gendzekhadze K, Norman PJ, Abi-Rached L, Graef T, Moesta AK, Layrisse Z, Parham P.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18692-7. doi: 10.1073/pnas.0906051106. Epub 2009 Oct 16.


A novel system of polymorphic and diverse NK cell receptors in primates.

Averdam A, Petersen B, Rosner C, Neff J, Roos C, Eberle M, Aujard F, Münch C, Schempp W, Carrington M, Shiina T, Inoko H, Knaust F, Coggill P, Sehra H, Beck S, Abi-Rached L, Reinhardt R, Walter L.

PLoS Genet. 2009 Oct;5(10):e1000688. doi: 10.1371/journal.pgen.1000688. Epub 2009 Oct 16.


Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes.

Norman PJ, Abi-Rached L, Gendzekhadze K, Hammond JA, Moesta AK, Sharma D, Graef T, McQueen KL, Guethlein LA, Carrington CV, Chandanayingyong D, Chang YH, Crespí C, Saruhan-Direskeneli G, Hameed K, Kamkamidze G, Koram KA, Layrisse Z, Matamoros N, Milà J, Park MH, Pitchappan RM, Ramdath DD, Shiau MY, Stephens HA, Struik S, Tyan D, Verity DH, Vaughan RW, Davis RW, Fraser PA, Riley EM, Ronaghi M, Parham P.

Genome Res. 2009 May;19(5):757-69. doi: 10.1101/gr.085738.108.


Chimpanzees use more varied receptors and ligands than humans for inhibitory killer cell Ig-like receptor recognition of the MHC-C1 and MHC-C2 epitopes.

Moesta AK, Abi-Rached L, Norman PJ, Parham P.

J Immunol. 2009 Mar 15;182(6):3628-37. doi: 10.4049/jimmunol.0803401.


Evolution and survival of marine carnivores did not require a diversity of killer cell Ig-like receptors or Ly49 NK cell receptors.

Hammond JA, Guethlein LA, Abi-Rached L, Moesta AK, Parham P.

J Immunol. 2009 Mar 15;182(6):3618-27. doi: 10.4049/jimmunol.0803026.


Evolutionary analysis and molecular dissection of caveola biogenesis.

Kirkham M, Nixon SJ, Howes MT, Abi-Rached L, Wakeham DE, Hanzal-Bayer M, Ferguson C, Hill MM, Fernandez-Rojo M, Brown DA, Hancock JF, Brodsky FM, Parton RG.

J Cell Sci. 2008 Jun 15;121(Pt 12):2075-86. doi: 10.1242/jcs.024588. Epub 2008 May 27.


Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans.

Norman PJ, Abi-Rached L, Gendzekhadze K, Korbel D, Gleimer M, Rowley D, Bruno D, Carrington CV, Chandanayingyong D, Chang YH, Crespí C, Saruhan-Direskeneli G, Fraser PA, Hameed K, Kamkamidze G, Koram KA, Layrisse Z, Matamoros N, Milà J, Park MH, Pitchappan RM, Ramdath DD, Shiau MY, Stephens HA, Struik S, Verity DH, Vaughan RW, Tyan D, Davis RW, Riley EM, Ronaghi M, Parham P.

Nat Genet. 2007 Sep;39(9):1092-9. Epub 2007 Aug 12.


Episodes of natural selection shaped the interactions of IgA-Fc with FcalphaRI and bacterial decoy proteins.

Abi-Rached L, Dorighi K, Norman PJ, Yawata M, Parham P.

J Immunol. 2007 Jun 15;178(12):7943-54. Erratum in: J Immunol. 2007 Aug 15;179(4):2658.


The expanded cattle KIR genes are orthologous to the conserved single-copy KIR3DX1 gene of primates.

Guethlein LA, Abi-Rached L, Hammond JA, Parham P.

Immunogenetics. 2007 Jun;59(6):517-22. Epub 2007 Apr 21.


High KIR diversity in Amerindians is maintained using few gene-content haplotypes.

Gendzekhadze K, Norman PJ, Abi-Rached L, Layrisse Z, Parham P.

Immunogenetics. 2006 Jun;58(5-6):474-80. Epub 2006 May 5.


Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution.

Wakeham DE, Abi-Rached L, Towler MC, Wilbur JD, Parham P, Brodsky FM.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7209-14. Epub 2005 May 9.


Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primates.

Sambrook JG, Bashirova A, Palmer S, Sims S, Trowsdale J, Abi-Rached L, Parham P, Carrington M, Beck S.

Genome Res. 2005 Jan;15(1):25-35.


Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors.

Rajalingam R, Parham P, Abi-Rached L.

J Immunol. 2004 Jan 1;172(1):356-69.


Evolution of the proto-MHC ancestral region: more evidence for the plesiomorphic organisation of human chromosome 9q34 region.

Vienne A, Shiina T, Abi-Rached L, Danchin E, Vitiello V, Cartault F, Inoko H, Pontarotti P.

Immunogenetics. 2003 Oct;55(7):429-36. Epub 2003 Oct 3. Erratum in: Immunogenetics. 2004 Mar;55(12):878.


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