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Hedgehog/GLI signaling in tumor immunity - new therapeutic opportunities and clinical implications.

Grund-Gröschke S, Stockmaier G, Aberger F.

Cell Commun Signal. 2019 Dec 26;17(1):172. doi: 10.1186/s12964-019-0459-7. Review.


Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy.

Peer E, Tesanovic S, Aberger F.

Cancers (Basel). 2019 Apr 15;11(4). pii: E538. doi: 10.3390/cancers11040538. Review.


Interplay of transcription factors STAT3, STAT1 and AP-1 mediates activity of the matrix metallo-proteinase-1 promoter in colorectal carcinoma cells.

Muller A, Gasch J, Albring KF, Aberger F, Nivarthi H, Khemeri M, Moriggl R, Friedrich KH.

Neoplasma. 2019 May 23;66(3):357-366. doi: 10.4149/neo_2018_180731N560. Epub 2018 Dec 12.


Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.

Nivarthi H, Gordziel C, Themanns M, Kramer N, Eberl M, Rabe B, Schlederer M, Rose-John S, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S, Friedrich K, Moriggl R.

Oncotarget. 2018 Sep 18;9(73):33865. doi: 10.18632/oncotarget.26156. eCollection 2018 Sep 18.


Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.

Prutsch N, Gurnhofer E, Suske T, Liang HC, Schlederer M, Roos S, Wu LC, Simonitsch-Klupp I, Alvarez-Hernandez A, Kornauth C, Leone DA, Svinka J, Eferl R, Limberger T, Aufinger A, Shirsath N, Wolf P, Hielscher T, Aberger F, Schmoellerl J, Stoiber D, Strobl B, Jäger U, Staber PB, Grebien F, Moriggl R, Müller M, Inghirami GG, Sanda T, Look AT, Turner SD, Kenner L, Merkel O.

Leukemia. 2019 Mar;33(3):696-709. doi: 10.1038/s41375-018-0239-1. Epub 2018 Aug 21.


Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma.

Sternberg C, Gruber W, Eberl M, Tesanovic S, Stadler M, Elmer DP, Schlederer M, Grund S, Roos S, Wolff F, Kaur S, Mangelberger D, Lehrach H, Hache H, Wierling C, Laimer J, Lackner P, Wiederstein M, Kasper M, Risch A, Petzelbauer P, Moriggl R, Kenner L, Aberger F.

Int J Cancer. 2018 Dec 1;143(11):2943-2954. doi: 10.1002/ijc.31724. Epub 2018 Oct 1.


Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia.

Gutjahr JC, Szenes E, Tschech L, Asslaber D, Schlederer M, Roos S, Yu X, Girbl T, Sternberg C, Egle A, Aberger F, Alon R, Kenner L, Greil R, Orian-Rousseau V, Hartmann TN.

Blood. 2018 Mar 22;131(12):1337-1349. doi: 10.1182/blood-2017-08-802462. Epub 2018 Jan 19.


Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance.

Gruber W, Peer E, Elmer DP, Sternberg C, Tesanovic S, Del Burgo P, Coni S, Canettieri G, Neureiter D, Bartz R, Kohlhof H, Vitt D, Aberger F.

Int J Cancer. 2018 Mar 1;142(5):968-975. doi: 10.1002/ijc.31117. Epub 2017 Nov 6.


The sound of tumor cell-microenvironment communication - composed by the Cancer Cluster Salzburg research network.

Wessler S, Aberger F, Hartmann TN.

Cell Commun Signal. 2017 Jun 2;15(1):20. doi: 10.1186/s12964-017-0176-z. No abstract available.


From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases.

Wessler S, Krisch LM, Elmer DP, Aberger F.

Cell Commun Signal. 2017 Apr 20;15(1):15. doi: 10.1186/s12964-017-0171-4. Review.


Understanding cell signaling in cancer stem cells for targeted therapy - can phosphoproteomics help to reveal the secrets?

Gruber W, Scheidt T, Aberger F, Huber CG.

Cell Commun Signal. 2017 Mar 29;15(1):12. doi: 10.1186/s12964-017-0166-1. Review.


Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling.

Aberger F, Hutterer E, Sternberg C, Del Burgo PJ, Hartmann TN.

Cell Commun Signal. 2017 Jan 25;15(1):8. doi: 10.1186/s12964-017-0163-4. Review.


A Double-Hybridization Approach for the Transcription- and Amplification-Free Detection of Specific mRNA on a Microarray.

Haider M, Haselgrübler T, Sonnleitner A, Aberger F, Hesse J.

Microarrays (Basel). 2016 Feb 23;5(1). pii: E5. doi: 10.3390/microarrays5010005.


A microfluidic multiwell chip for enzyme-free detection of mRNA from few cells.

Haider M, Ji B, Haselgrübler T, Sonnleitner A, Aberger F, Hesse J.

Biosens Bioelectron. 2016 Dec 15;86:20-26. doi: 10.1016/j.bios.2016.06.019. Epub 2016 Jun 8.


The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.

Nivarthi H, Gordziel C, Themanns M, Kramer N, Eberl M, Rabe B, Schlederer M, Rose-John S, Knösel T, Kenner L, Freund P, Aberger F, Han X, Kralovics R, Dolznig H, Jennek S, Friedrich K, Moriggl R.

Oncotarget. 2016 Aug 9;7(32):51096-51106. doi: 10.18632/oncotarget.9315. Erratum in: Oncotarget. 2018 Sep 18;9(73):33865.


ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia.

Krenn PW, Hofbauer SW, Pucher S, Hutterer E, Hinterseer E, Denk U, Asslaber D, Ganghammer S, Sternberg C, Neureiter D, Aberger F, Wickström SA, Egle A, Greil R, Hartmann TN.

Cancer Res. 2016 Apr 15;76(8):2186-96. doi: 10.1158/0008-5472.CAN-15-3379. Epub 2016 Feb 2.


DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.

Gruber W, Hutzinger M, Elmer DP, Parigger T, Sternberg C, Cegielkowski L, Zaja M, Leban J, Michel S, Hamm S, Vitt D, Aberger F.

Oncotarget. 2016 Feb 9;7(6):7134-48. doi: 10.18632/oncotarget.6910.


Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis.

Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L.

Nat Commun. 2015 Oct 26;6:8802. doi: 10.1038/ncomms9802. No abstract available.


STAT3 regulated ARF expression suppresses prostate cancer metastasis.

Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L.

Nat Commun. 2015 Jul 22;6:7736. doi: 10.1038/ncomms8736. Erratum in: Nat Commun. 2015;6:8802.


Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation.

Schütz A, Röser K, Klitzsch J, Lieder F, Aberger F, Gruber W, Mueller KM, Pupyshev A, Moriggl R, Friedrich K.

Transl Oncol. 2015 Apr;8(2):97-105. doi: 10.1016/j.tranon.2015.02.002.


Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.

Grabner B, Schramek D, Mueller KM, Moll HP, Svinka J, Hoffmann T, Bauer E, Blaas L, Hruschka N, Zboray K, Stiedl P, Nivarthi H, Bogner E, Gruber W, Mohr T, Zwick RH, Kenner L, Poli V, Aberger F, Stoiber D, Egger G, Esterbauer H, Zuber J, Moriggl R, Eferl R, Győrffy B, Penninger JM, Popper H, Casanova E.

Nat Commun. 2015 Mar 3;6:6285. doi: 10.1038/ncomms7285.


Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.

Kern D, Regl G, Hofbauer SW, Altenhofer P, Achatz G, Dlugosz A, Schnidar H, Greil R, Hartmann TN, Aberger F.

Oncogene. 2015 Oct 16;34(42):5341-51. doi: 10.1038/onc.2014.450. Epub 2015 Feb 2.


An old friend with new skills: Imiquimod as novel inhibitor of Hedgehog signaling in basal cell carcinoma.

Gruber W, Frischauf AM, Aberger F.

Oncoscience. 2014 Sep 16;1(9):567-73. eCollection 2014.


Canonical and non-canonical Hedgehog signalling and the control of metabolism.

Teperino R, Aberger F, Esterbauer H, Riobo N, Pospisilik JA.

Semin Cell Dev Biol. 2014 Sep;33:81-92. doi: 10.1016/j.semcdb.2014.05.007. Epub 2014 May 23. Review.


Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy.

Aberger F, Ruiz I Altaba A.

Semin Cell Dev Biol. 2014 Sep;33:93-104. doi: 10.1016/j.semcdb.2014.05.003. Epub 2014 May 19. Review.


Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance.

Putz EM, Hoelzl MA, Baeck J, Bago-Horvath Z, Schuster C, Reichholf B, Kern D, Aberger F, Sexl V, Hoelbl-Kovacic A.

Cancers (Basel). 2014 Jan 27;6(1):193-210. doi: 10.3390/cancers6010193.


Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation.

Wolff F, Loipetzberger A, Gruber W, Esterbauer H, Aberger F, Frischauf AM.

Oncogene. 2013 Dec 12;32(50):5574-81. doi: 10.1038/onc.2013.343. Epub 2013 Sep 2.


Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.

Götschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, Sonntag J, Rüngeler E, Hache H, Wierling C, Nietfeld W, Lehrach H, Frischauf A, Schwartz-Albiez R, Aberger F, Korf U.

PLoS One. 2013 Jun 10;8(6):e65403. doi: 10.1371/journal.pone.0065403. Print 2013.


Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis.

Chari NS, Romano RA, Koster MI, Jaks V, Roop D, Flores ER, Teglund S, Sinha S, Gruber W, Aberger F, Medeiros LJ, Toftgard R, McDonnell TJ.

Cell Death Differ. 2013 Aug;20(8):1080-8. doi: 10.1038/cdd.2013.41. Epub 2013 May 17.


Expression analysis of multiple myeloma CD138 negative progenitor cells using single molecule microarray readout.

Jacak J, Schnidar H, Muresan L, Regl G, Frischauf A, Aberger F, Schütz GJ, Hesse J.

J Biotechnol. 2013 Apr 15;164(4):525-30. doi: 10.1016/j.jbiotec.2013.01.027. Epub 2013 Feb 14.


Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

Teperino R, Amann S, Bayer M, McGee SL, Loipetzberger A, Connor T, Jaeger C, Kammerer B, Winter L, Wiche G, Dalgaard K, Selvaraj M, Gaster M, Lee-Young RS, Febbraio MA, Knauf C, Cani PD, Aberger F, Penninger JM, Pospisilik JA, Esterbauer H.

Cell. 2012 Oct 12;151(2):414-26. doi: 10.1016/j.cell.2012.09.021.


Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.

Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beissbarth T, Hogendoorn PC, Antonescu CR, Rubin BP, Schulz-Schaeffer W, Aberger F, van den Brink GR, Hahn H.

Gastroenterology. 2013 Jan;144(1):134-144.e6. doi: 10.1053/j.gastro.2012.09.061. Epub 2012 Oct 3.


Use of broad-spectrum antibiotics and the development of irritable bowel syndrome.

Villarreal AA, Aberger FJ, Benrud R, Gundrum JD.

WMJ. 2012 Feb;111(1):17-20.


Canonical and noncanonical Hedgehog/GLI signaling in hematological malignancies.

Aberger F, Kern D, Greil R, Hartmann TN.

Vitam Horm. 2012;88:25-54. doi: 10.1016/B978-0-12-394622-5.00002-X. Review.


Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells.

Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K, Schnidar H, Hache H, Bauer HC, Solca F, Hauser-Kronberger C, Ermilov AN, Verhaegen ME, Bichakjian CK, Dlugosz AA, Nietfeld W, Sibilia M, Lehrach H, Wierling C, Aberger F.

EMBO Mol Med. 2012 Mar;4(3):218-33. doi: 10.1002/emmm.201100201. Epub 2012 Feb 1.


Cooperative Hedgehog-EGFR signaling.

Mangelberger D, Kern D, Loipetzberger A, Eberl M, Aberger F.

Front Biosci (Landmark Ed). 2012 Jan 1;17:90-9. Review.


GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma.

Kuphal S, Shaw-Hallgren G, Eberl M, Karrer S, Aberger F, Bosserhoff AK, Massoumi R.

Oncogene. 2011 Nov 3;30(44):4523-30. doi: 10.1038/onc.2011.163. Epub 2011 May 16.


Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells.

Desch P, Asslaber D, Kern D, Schnidar H, Mangelberger D, Alinger B, Stoecher M, Hofbauer SW, Neureiter D, Tinhofer I, Aberger F, Hartmann TN, Greil R.

Oncogene. 2010 Sep 2;29(35):4885-95. doi: 10.1038/onc.2010.243. Epub 2010 Jul 5.


Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII.

Nitzki F, Zibat A, König S, Wijgerde M, Rosenberger A, Brembeck FH, Carstens PO, Frommhold A, Uhmann A, Klingler S, Reifenberger J, Pukrop T, Aberger F, Schulz-Schaeffer W, Hahn H.

Cancer Res. 2010 Apr 1;70(7):2739-48. doi: 10.1158/0008-5472.CAN-09-3743. Epub 2010 Mar 16.


Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate.

Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, Bayer M, Haschemi A, Puviindran V, Tar K, Orthofer M, Neely GG, Dietzl G, Manoukian A, Funovics M, Prager G, Wagner O, Ferrandon D, Aberger F, Hui CC, Esterbauer H, Penninger JM.

Cell. 2010 Jan 8;140(1):148-60. doi: 10.1016/j.cell.2009.12.027.


Non-consensus GLI binding sites in Hedgehog target gene regulation.

Winklmayr M, Schmid C, Laner-Plamberger S, Kaser A, Aberger F, Eichberger T, Frischauf AM.

BMC Mol Biol. 2010 Jan 13;11:2. doi: 10.1186/1471-2199-11-2.


Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation?

Gore SM, Kasper M, Williams T, Regl G, Aberger F, Cerio R, Neill GW, Philpott MP.

J Pathol. 2009 Sep;219(1):61-8. doi: 10.1002/path.2568.


Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation.

Alinger B, Kiesslich T, Datz C, Aberger F, Strasser F, Berr F, Dietze O, Kaserer K, Hauser-Kronberger C.

Virchows Arch. 2009 Apr;454(4):369-79. doi: 10.1007/s00428-009-0753-7. Epub 2009 Mar 12.


Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway.

Schnidar H, Eberl M, Klingler S, Mangelberger D, Kasper M, Hauser-Kronberger C, Regl G, Kroismayr R, Moriggl R, Sibilia M, Aberger F.

Cancer Res. 2009 Feb 15;69(4):1284-92. doi: 10.1158/0008-5472.CAN-08-2331. Epub 2009 Feb 3.


Array-based profiling of ragweed and mugwort pollen allergens.

Gadermaier G, Wopfner N, Wallner M, Egger M, Didierlaurent A, Regl G, Aberger F, Lang R, Ferreira F, Hawranek T.

Allergy. 2008 Nov;63(11):1543-9. doi: 10.1111/j.1398-9995.2008.01780.x.


GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells.

Eichberger T, Kaser A, Pixner C, Schmid C, Klingler S, Winklmayr M, Hauser-Kronberger C, Aberger F, Frischauf AM.

J Biol Chem. 2008 May 2;283(18):12426-37. doi: 10.1074/jbc.M707117200. Epub 2008 Mar 3.


GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes.

Neill GW, Harrison WJ, Ikram MS, Williams TD, Bianchi LS, Nadendla SK, Green JL, Ghali L, Frischauf AM, O'Toole EA, Aberger F, Philpott MP.

Carcinogenesis. 2008 Apr;29(4):738-46. doi: 10.1093/carcin/bgn037. Epub 2008 Feb 14.


Efficient manipulation of Hedgehog/GLI signaling using retroviral expression systems.

Kasper M, Regl G, Eichberger T, Frischauf AM, Aberger F.

Methods Mol Biol. 2007;397:67-78.


Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth.

Ecke I, Rosenberger A, Obenauer S, Dullin C, Aberger F, Kimmina S, Schweyer S, Hahn H.

Mol Carcinog. 2008 May;47(5):361-72.


Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

Kasper M, Schnidar H, Neill GW, Hanneder M, Klingler S, Blaas L, Schmid C, Hauser-Kronberger C, Regl G, Philpott MP, Aberger F.

Mol Cell Biol. 2006 Aug;26(16):6283-98.

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