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Items: 1 to 50 of 80

1.

Overcoming adaptive therapy resistance in AML by targeting immune response pathways.

Melgar K, Walker MM, Jones LM, Bolanos LC, Hueneman K, Wunderlich M, Jiang JK, Wilson KM, Zhang X, Sutter P, Wang A, Xu X, Choi K, Tawa G, Lorimer D, Abendroth J, O'Brien E, Hoyt SB, Berman E, Famulare CA, Mulloy JC, Levine RL, Perentesis JP, Thomas CJ, Starczynowski DT.

Sci Transl Med. 2019 Sep 4;11(508). pii: eaaw8828. doi: 10.1126/scitranslmed.aaw8828.

PMID:
31484791
2.

[Subjectively Experienced Workload during Continuing Education in General Medicine and Demands on a Competence Center: A Cross-Sectional Study from Saxony-Anhalt].

Köhler S, Heise M, Abendroth J, Sommer S, Frese T.

Gesundheitswesen. 2019 Aug 1. doi: 10.1055/a-0905-2921. [Epub ahead of print] German.

PMID:
31370086
3.

Structural characterization of β-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.

Patterson EI, Nanson JD, Abendroth J, Bryan C, Sankaran B, Myler PJ, Forwood JK.

Proteins. 2019 Jun 25. doi: 10.1002/prot.25765. [Epub ahead of print]

PMID:
31237717
4.

Spin Selectivity in Photoinduced Charge-Transfer Mediated by Chiral Molecules.

Abendroth JM, Stemer DM, Bloom BP, Roy P, Naaman R, Waldeck DH, Weiss PS, Mondal PC.

ACS Nano. 2019 May 28;13(5):4928-4946. doi: 10.1021/acsnano.9b01876. Epub 2019 May 7.

PMID:
31016968
5.

Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products.

Sullivan AH, Dranow DM, Horanyi PS, Lorimer DD, Edwards TE, Abendroth J.

Sci Rep. 2019 Mar 13;9(1):4392. doi: 10.1038/s41598-019-40558-x.

6.

Small-Molecule Patterning via Prefunctionalized Alkanethiols.

Cao HH, Nakatsuka N, Deshayes S, Abendroth JM, Yang H, Weiss PS, Kasko AM, Andrews AM.

Chem Mater. 2018 Jun 26;30(12):4017-4030. doi: 10.1021/acs.chemmater.8b00377. Epub 2018 May 22.

7.

Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase.

Milanes JE, Suryadi J, Abendroth J, Van Voorhis WC, Barrett KF, Dranow DM, Phan IQ, Patrick SL, Rozema SD, Khalifa MM, Golden JE, Morris JC.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02410-18. doi: 10.1128/AAC.02410-18. Print 2019 May.

PMID:
30783001
8.

Spin-Dependent Ionization of Chiral Molecular Films.

Abendroth JM, Cheung KM, Stemer DM, El Hadri MS, Zhao C, Fullerton EE, Weiss PS.

J Am Chem Soc. 2019 Mar 6;141(9):3863-3874. doi: 10.1021/jacs.8b08421. Epub 2019 Feb 20.

PMID:
30734553
9.

Ab initio structure solution of a proteolytic fragment using ARCIMBOLDO.

Abendroth J, Sankaran B, Myler PJ, Lorimer DD, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2018 Sep 1;74(Pt 9):530-535. doi: 10.1107/S2053230X18010063. Epub 2018 Aug 29.

10.

Aptamer-field-effect transistors overcome Debye length limitations for small-molecule sensing.

Nakatsuka N, Yang KA, Abendroth JM, Cheung KM, Xu X, Yang H, Zhao C, Zhu B, Rim YS, Yang Y, Weiss PS, Stojanović MN, Andrews AM.

Science. 2018 Oct 19;362(6412):319-324. doi: 10.1126/science.aao6750. Epub 2018 Sep 6.

11.

Crystal structure of chorismate mutase from Burkholderia phymatum.

Asojo OA, Subramanian S, Abendroth J, Exley I, Lorimer DD, Edwards TE, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):187-192. doi: 10.1107/S2053230X18002868. Epub 2018 Mar 22.

12.

The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications.

Helgren TR, Seven ES, Chen C, Edwards TE, Staker BL, Abendroth J, Myler PJ, Horn JR, Hagen TJ.

Bioorg Med Chem Lett. 2018 May 1;28(8):1376-1380. doi: 10.1016/j.bmcl.2018.03.002. Epub 2018 Mar 15.

13.

[57-Year-Old Women: Skin Alteration on Belly].

Fuchs S, Abendroth J.

Dtsch Med Wochenschr. 2018 Feb;143(4):233-234. doi: 10.1055/s-0043-121538. Epub 2018 Feb 22. German. No abstract available.

PMID:
29471571
14.

Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.

Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C.

Protein Sci. 2018 Feb;27(2):568-572. doi: 10.1002/pro.3343. Epub 2017 Dec 5.

15.

Analyzing Spin Selectivity in DNA-Mediated Charge Transfer via Fluorescence Microscopy.

Abendroth JM, Nakatsuka N, Ye M, Kim D, Fullerton EE, Andrews AM, Weiss PS.

ACS Nano. 2017 Jul 25;11(7):7516-7526. doi: 10.1021/acsnano.7b04165. Epub 2017 Jul 11.

PMID:
28672111
16.

Polymer-Pen Chemical Lift-Off Lithography.

Xu X, Yang Q, Cheung KM, Zhao C, Wattanatorn N, Belling JN, Abendroth JM, Slaughter LS, Mirkin CA, Andrews AM, Weiss PS.

Nano Lett. 2017 May 10;17(5):3302-3311. doi: 10.1021/acs.nanolett.7b01236. Epub 2017 Apr 25.

PMID:
28409640
17.

Structure of acid deoxyribonuclease.

Varela-Ramirez A, Abendroth J, Mejia AA, Phan IQ, Lorimer DD, Edwards TE, Aguilera RJ.

Nucleic Acids Res. 2017 Jun 2;45(10):6217-6227. doi: 10.1093/nar/gkx222.

18.

Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors.

Haft DH, Pierce PG, Mayclin SJ, Sullivan A, Gardberg AS, Abendroth J, Begley DW, Phan IQ, Staker BL, Myler PJ, Marathias VM, Lorimer DD, Edwards TE.

Sci Rep. 2017 Jan 25;7:41074. doi: 10.1038/srep41074.

19.

Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.

Helgren TR, Chen C, Wangtrakuldee P, Edwards TE, Staker BL, Abendroth J, Sankaran B, Housley NA, Myler PJ, Audia JP, Horn JR, Hagen TJ.

Bioorg Med Chem. 2017 Feb 1;25(3):813-824. doi: 10.1016/j.bmc.2016.11.013. Epub 2016 Nov 10.

20.

Structural Basis for the Strict Substrate Selectivity of the Mycobacterial Hydrolase LipW.

McKary MG, Abendroth J, Edwards TE, Johnson RJ.

Biochemistry. 2016 Dec 27;55(51):7099-7111. doi: 10.1021/acs.biochem.6b01057. Epub 2016 Dec 12.

21.

The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 Å resolution.

Cala AR, Nadeau MT, Abendroth J, Staker BL, Reers AR, Weatherhead AW, Dobson RC, Myler PJ, Hudson AO.

Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):885-891. Epub 2016 Nov 25.

22.

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.

Hewitt SN, Dranow DM, Horst BG, Abendroth JA, Forte B, Hallyburton I, Jansen C, Baragaña B, Choi R, Rivas KL, Hulverson MA, Dumais M, Edwards TE, Lorimer DD, Fairlamb AH, Gray DW, Read KD, Lehane AM, Kirk K, Myler PJ, Wernimont A, Walpole C, Stacy R, Barrett LK, Gilbert IH, Van Voorhis WC.

ACS Infect Dis. 2017 Jan 13;3(1):34-44. doi: 10.1021/acsinfecdis.6b00078. Epub 2016 Nov 16.

23.

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.

Klumpp K, Lam AM, Lukacs C, Vogel R, Ren S, Espiritu C, Baydo R, Atkins K, Abendroth J, Liao G, Efimov A, Hartman G, Flores OA.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15196-201. doi: 10.1073/pnas.1513803112. Epub 2015 Nov 23.

24.

Controlling Motion at the Nanoscale: Rise of the Molecular Machines.

Abendroth JM, Bushuyev OS, Weiss PS, Barrett CJ.

ACS Nano. 2015 Aug 25;9(8):7746-68. doi: 10.1021/acsnano.5b03367. Epub 2015 Aug 4. Review.

PMID:
26172380
25.

Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.

Abendroth J, Choi R, Wall A, Clifton MC, Lukacs CM, Staker BL, Van Voorhis W, Myler P, Lorimer DD, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):566-71. doi: 10.1107/S2053230X15001831. Epub 2015 Apr 21.

26.

Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis.

Buchko GW, Abendroth J, Clifton MC, Robinson H, Zhang Y, Hewitt SN, Staker BL, Edwards TE, Van Voorhis WC, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):522-30. doi: 10.1107/S2053230X14028210. Epub 2015 Apr 18.

27.

A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.

Clifton MC, Dranow DM, Leed A, Fulroth B, Fairman JW, Abendroth J, Atkins KA, Wallace E, Fan D, Xu G, Ni ZJ, Daniels D, Van Drie J, Wei G, Burgin AB, Golub TR, Hubbard BK, Serrano-Wu MH.

PLoS One. 2015 Apr 24;10(4):e0125010. doi: 10.1371/journal.pone.0125010. eCollection 2015.

28.

Crystal structures of Mycobacterial MeaB and MMAA-like GTPases.

Edwards TE, Baugh L, Bullen J, Baydo RO, Witte P, Thompkins K, Phan IQ, Abendroth J, Clifton MC, Sankaran B, Van Voorhis WC, Myler PJ, Staker BL, Grundner C, Lorimer DD.

J Struct Funct Genomics. 2015 Jun;16(2):91-9. doi: 10.1007/s10969-015-9197-2. Epub 2015 Apr 2.

29.

Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.

Hecker SJ, Reddy KR, Totrov M, Hirst GC, Lomovskaya O, Griffith DC, King P, Tsivkovski R, Sun D, Sabet M, Tarazi Z, Clifton MC, Atkins K, Raymond A, Potts KT, Abendroth J, Boyer SH, Loutit JS, Morgan EE, Durso S, Dudley MN.

J Med Chem. 2015 May 14;58(9):3682-92. doi: 10.1021/acs.jmedchem.5b00127. Epub 2015 Mar 17.

PMID:
25782055
30.

Increasing the structural coverage of tuberculosis drug targets.

Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ.

Tuberculosis (Edinb). 2015 Mar;95(2):142-8. doi: 10.1016/j.tube.2014.12.003. Epub 2014 Dec 19.

31.

Tyrosine aminotransferase from Leishmania infantum: A new drug target candidate.

Moreno MA, Alonso A, Alcolea PJ, Abramov A, de Lacoba MG, Abendroth J, Zhang S, Edwards T, Lorimer D, Myler PJ, Larraga V.

Int J Parasitol Drugs Drug Resist. 2014 Jul 30;4(3):347-54. doi: 10.1016/j.ijpddr.2014.06.001. eCollection 2014 Dec.

32.

Clerkship in primary care: a cross-sectional study about expectations and experiences of undergraduates in medicine.

Fuchs S, Klement A, Lichte T, Abendroth J.

GMS Z Med Ausbild. 2014 Nov 17;31(4):Doc44. doi: 10.3205/zma000936. eCollection 2014.

33.

Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1.

Moen SO, Abendroth J, Fairman JW, Baydo RO, Bullen J, Kirkwood JL, Barnes SR, Raymond AC, Begley DW, Henkel G, McCormack K, Tam VC, Phan I, Staker BL, Stacy R, Myler PJ, Lorimer D, Edwards TE.

Sci Rep. 2014 Aug 4;4:5944. doi: 10.1038/srep05944.

34.

Inhibition of plasma kallikrein by a highly specific active site blocking antibody.

Kenniston JA, Faucette RR, Martik D, Comeau SR, Lindberg AP, Kopacz KJ, Conley GP, Chen J, Viswanathan M, Kastrapeli N, Cosic J, Mason S, DiLeo M, Abendroth J, Kuzmic P, Ladner RC, Edwards TE, TenHoor C, Adelman BA, Nixon AE, Sexton DJ.

J Biol Chem. 2014 Aug 22;289(34):23596-608. doi: 10.1074/jbc.M114.569061. Epub 2014 Jun 26.

35.

Structure of tyrosine aminotransferase from Leishmania infantum.

Moreno MA, Abramov A, Abendroth J, Alonso A, Zhang S, Alcolea PJ, Edwards T, Lorimer D, Myler PJ, Larraga V.

Acta Crystallogr F Struct Biol Commun. 2014 May;70(Pt 5):583-7. doi: 10.1107/S2053230X14007845. Epub 2014 Apr 25.

36.

Structure of the Reston ebolavirus VP30 C-terminal domain.

Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO.

Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi: 10.1107/S2053230X14003811. Epub 2014 Mar 25.

37.

Motives of former interns in general practice for speciality-choice--results of a cross-sectional study among graduates 2007 to 2012.

Abendroth J, Schnell U, Lichte T, Oemler M, Klement A.

GMS Z Med Ausbild. 2014 Feb 17;31(1):Doc11. doi: 10.3205/zma000903. eCollection 2014.

38.

A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.

Begley DW, Fox D 3rd, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, Barnes SR, Moen SO, Raymond AC, Stacy R, Myler PJ, Staker BL, Harmer NJ, Norville IH, Holzgrabe U, Sarkar-Tyson M, Edwards TE, Lorimer DD.

Antimicrob Agents Chemother. 2014;58(3):1458-67. doi: 10.1128/AAC.01875-13. Epub 2013 Dec 23.

39.

Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution.

Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C.

J Biol Chem. 2014 Jan 24;289(4):2139-47. doi: 10.1074/jbc.M113.525683. Epub 2013 Dec 4.

40.

Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia.

Buchko GW, Abendroth J, Robinson H, Zhang Y, Hewitt SN, Edwards TE, Van Voorhis WC, Myler PJ.

J Struct Funct Genomics. 2013 Jun;14(2):47-57. doi: 10.1007/s10969-013-9155-9. Epub 2013 May 25.

41.

Structure and function of a cyanophage-encoded peptide deformylase.

Frank JA, Lorimer D, Youle M, Witte P, Craig T, Abendroth J, Rohwer F, Edwards RA, Segall AM, Burgin AB Jr.

ISME J. 2013 Jun;7(6):1150-60. doi: 10.1038/ismej.2013.4. Epub 2013 Feb 14.

42.

Combining functional and structural genomics to sample the essential Burkholderia structome.

Baugh L, Gallagher LA, Patrapuvich R, Clifton MC, Gardberg AS, Edwards TE, Armour B, Begley DW, Dieterich SH, Dranow DM, Abendroth J, Fairman JW, Fox D 3rd, Staker BL, Phan I, Gillespie A, Choi R, Nakazawa-Hewitt S, Nguyen MT, Napuli A, Barrett L, Buchko GW, Stacy R, Myler PJ, Stewart LJ, Manoil C, Van Voorhis WC.

PLoS One. 2013;8(1):e53851. doi: 10.1371/journal.pone.0053851. Epub 2013 Jan 31.

43.

Structure of the cystathionine γ-synthase MetB from Mycobacterium ulcerans.

Clifton MC, Abendroth J, Edwards TE, Leibly DJ, Gillespie AK, Ferrell M, Dieterich SH, Exley I, Staker BL, Myler PJ, Van Voorhis WC, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1154-8. doi: 10.1107/S1744309111029575. Epub 2011 Aug 16.

44.

Structure of 3-ketoacyl-(acyl-carrier-protein) reductase from Rickettsia prowazekii at 2.25 Å resolution.

Subramanian S, Abendroth J, Phan IQ, Olsen C, Staker BL, Napuli A, Van Voorhis WC, Stacy R, Myler PJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1118-22. doi: 10.1107/S1744309111030673. Epub 2011 Aug 16.

45.

Structure of aldose reductase from Giardia lamblia.

Ferrell M, Abendroth J, Zhang Y, Sankaran B, Edwards TE, Staker BL, Van Voorhis WC, Stewart LJ, Myler PJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1113-7. doi: 10.1107/S1744309111030879. Epub 2011 Aug 16.

46.

BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a 'putative β-lactamase-like protein' from Brucella melitensis.

Abendroth J, Sankaran B, Edwards TE, Gardberg AS, Dieterich S, Bhandari J, Napuli AJ, Van Voorhis WC, Staker BL, Myler PJ, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1106-12. doi: 10.1107/S1744309111010220. Epub 2011 Aug 16.

47.

Structure of triosephosphate isomerase from Cryptosporidium parvum.

Nguyen TN, Abendroth J, Leibly DJ, Le KP, Guo W, Kelley A, Stewart L, Myler PJ, Van Voorhis WC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1095-9. doi: 10.1107/S1744309111019178. Epub 2011 Aug 16.

48.

Structure of thymidylate kinase from Ehrlichia chaffeensis.

Leibly DJ, Abendroth J, Bryan CM, Sankaran B, Kelley A, Barrett LK, Stewart L, Van Voorhis WC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1090-4. doi: 10.1107/S174430911101493X. Epub 2011 Aug 16.

49.

Structure of a cyclin-dependent kinase from Giardia lamblia.

Leibly DJ, Newling PA, Abendroth J, Guo W, Kelley A, Stewart LJ, Van Voorhis W.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1084-9. doi: 10.1107/S1744309111018070. Epub 2011 Aug 16.

50.

Structure of a Nudix hydrolase (MutT) in the Mg(2+)-bound state from Bartonella henselae, the bacterium responsible for cat scratch fever.

Buchko GW, Edwards TE, Abendroth J, Arakaki TL, Law L, Napuli AJ, Hewitt SN, Van Voorhis WC, Stewart LJ, Staker BL, Myler PJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1078-83. doi: 10.1107/S1744309111011559. Epub 2011 Aug 16.

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