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Items: 20


Multi-scale modeling of drug binding kinetics to predict drug efficacy.

Clarelli F, Liang J, Martinecz A, Heiland I, Abel Zur Wiesch P.

Cell Mol Life Sci. 2020 Feb;77(3):381-394. doi: 10.1007/s00018-019-03376-y. Epub 2019 Nov 25. Review.


Quantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiota.

Tepekule B, Abel Zur Wiesch P, Kouyos RD, Bonhoeffer S.

Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23106-23116. doi: 10.1073/pnas.1912188116. Epub 2019 Oct 30.


Reaction Kinetic Models of Antibiotic Heteroresistance.

Martinecz A, Clarelli F, Abel S, Abel Zur Wiesch P.

Int J Mol Sci. 2019 Aug 15;20(16). pii: E3965. doi: 10.3390/ijms20163965.


Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization.

Warr AR, Hubbard TP, Munera D, Blondel CJ, Abel Zur Wiesch P, Abel S, Wang X, Davis BM, Waldor MK.

PLoS Pathog. 2019 Aug 12;15(8):e1007652. doi: 10.1371/journal.ppat.1007652. eCollection 2019 Aug.


Estimating treatment prolongation for persistent infections.

Martinecz A, Abel Zur Wiesch P.

Pathog Dis. 2018 Aug 1;76(6). doi: 10.1093/femspd/fty065.


Deciphering the landscape of host barriers to Listeria monocytogenes infection.

Zhang T, Abel S, Abel Zur Wiesch P, Sasabe J, Davis BM, Higgins DE, Waldor MK.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6334-6339. doi: 10.1073/pnas.1702077114. Epub 2017 May 30.


Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies.

Abel Zur Wiesch P, Clarelli F, Cohen T.

PLoS Comput Biol. 2017 Jan 6;13(1):e1005321. doi: 10.1371/journal.pcbi.1005321. eCollection 2017 Jan.


Smear positivity in paediatric and adult tuberculosis: systematic review and meta-analysis.

Kunkel A, Abel Zur Wiesch P, Nathavitharana RR, Marx FM, Jenkins HE, Cohen T.

BMC Infect Dis. 2016 Jun 13;16:282. doi: 10.1186/s12879-016-1617-9. Review.


Genetic analysis of Vibrio parahaemolyticus intestinal colonization.

Hubbard TP, Chao MC, Abel S, Blondel CJ, Abel Zur Wiesch P, Zhou X, Davis BM, Waldor MK.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):6283-8. doi: 10.1073/pnas.1601718113. Epub 2016 May 16.


The Role of Adherence and Retreatment in De Novo Emergence of MDR-TB.

Cadosch D, Abel Zur Wiesch P, Kouyos R, Bonhoeffer S.

PLoS Comput Biol. 2016 Mar 11;12(3):e1004749. doi: 10.1371/journal.pcbi.1004749. eCollection 2016 Mar.


Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study.

Salvatore PP, Becerra MC, Abel zur Wiesch P, Hinkley T, Kaur D, Sloutsky A, Cohen T.

J Infect Dis. 2016 Jan 1;213(1):149-55. doi: 10.1093/infdis/jiv347. Epub 2015 Jun 19.


Analysis of Bottlenecks in Experimental Models of Infection.

Abel S, Abel zur Wiesch P, Davis BM, Waldor MK.

PLoS Pathog. 2015 Jun 11;11(6):e1004823. doi: 10.1371/journal.ppat.1004823. eCollection 2015 Jun. Review. No abstract available.


Classic reaction kinetics can explain complex patterns of antibiotic action.

Abel Zur Wiesch P, Abel S, Gkotzis S, Ocampo P, Engelstädter J, Hinkley T, Magnus C, Waldor MK, Udekwu K, Cohen T.

Sci Transl Med. 2015 May 13;7(287):287ra73. doi: 10.1126/scitranslmed.aaa8760.


Sequence tag-based analysis of microbial population dynamics.

Abel S, Abel zur Wiesch P, Chang HH, Davis BM, Lipsitch M, Waldor MK.

Nat Methods. 2015 Mar;12(3):223-6, 3 p following 226. doi: 10.1038/nmeth.3253. Epub 2015 Jan 19.


The path of least resistance: aggressive or moderate treatment?

Kouyos RD, Metcalf CJ, Birger R, Klein EY, Abel zur Wiesch P, Ankomah P, Arinaminpathy N, Bogich TL, Bonhoeffer S, Brower C, Chi-Johnston G, Cohen T, Day T, Greenhouse B, Huijben S, Metlay J, Mideo N, Pollitt LC, Read AF, Smith DL, Standley C, Wale N, Grenfell B.

Proc Biol Sci. 2014 Nov 7;281(1794):20140566. doi: 10.1098/rspb.2014.0566.


Cycling empirical antibiotic therapy in hospitals: meta-analysis and models.

Abel zur Wiesch P, Kouyos R, Abel S, Viechtbauer W, Bonhoeffer S.

PLoS Pathog. 2014 Jun 26;10(6):e1004225. doi: 10.1371/journal.ppat.1004225. eCollection 2014 Jun.


Antagonism between bacteriostatic and bactericidal antibiotics is prevalent.

Ocampo PS, Lázár V, Papp B, Arnoldini M, Abel zur Wiesch P, Busa-Fekete R, Fekete G, Pál C, Ackermann M, Bonhoeffer S.

Antimicrob Agents Chemother. 2014 Aug;58(8):4573-82. doi: 10.1128/AAC.02463-14. Epub 2014 May 27.


Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle.

Abel S, Bucher T, Nicollier M, Hug I, Kaever V, Abel Zur Wiesch P, Jenal U.

PLoS Genet. 2013;9(9):e1003744. doi: 10.1371/journal.pgen.1003744. Epub 2013 Sep 5.


On being the right size: the impact of population size and stochastic effects on the evolution of drug resistance in hospitals and the community.

Kouyos RD, Abel Zur Wiesch P, Bonhoeffer S.

PLoS Pathog. 2011 Apr;7(4):e1001334. doi: 10.1371/journal.ppat.1001334. Epub 2011 Apr 14.


Informed switching strongly decreases the prevalence of antibiotic resistance in hospital wards.

Kouyos RD, Abel Zur Wiesch P, Bonhoeffer S.

PLoS Comput Biol. 2011 Mar;7(3):e1001094. doi: 10.1371/journal.pcbi.1001094. Epub 2011 Mar 3.

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