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Items: 1 to 50 of 246

1.

Mechanisms of sexually transmitted infection-induced inflammation in women: implications for HIV risk.

Mwatelah R, McKinnon LR, Baxter C, Abdool Karim Q, Abdool Karim SS.

J Int AIDS Soc. 2019 Aug;22 Suppl 6:e25346. doi: 10.1002/jia2.25346.

2.

Diminished HIV Infection of Target CD4+ T Cells in a Toll-Like Receptor 4 Stimulated in vitro Model.

Cromarty R, Sigal A, Liebenberg LJP, McKinnon LR, Abdool Karim SS, Passmore JS, Archary D.

Front Immunol. 2019 Jul 23;10:1705. doi: 10.3389/fimmu.2019.01705. eCollection 2019.

3.

AAV-Mediated Expression of Broadly Neutralizing and Vaccine-like Antibodies Targeting the HIV-1 Envelope V2 Region.

van den Berg FT, Makoah NA, Ali SA, Scott TA, Mapengo RE, Mutsvunguma LZ, Mkhize NN, Lambson BE, Kgagudi PD, Crowther C, Abdool Karim SS, Balazs AB, Weinberg MS, Ely A, Arbuthnot PB, Morris L.

Mol Ther Methods Clin Dev. 2019 Jun 12;14:100-112. doi: 10.1016/j.omtm.2019.06.002. eCollection 2019 Sep 13.

4.

HIV-1 Epidemic Control - Insights from Test-and-Treat Trials.

Abdool Karim SS.

N Engl J Med. 2019 Jul 18;381(3):286-288. doi: 10.1056/NEJMe1907279. No abstract available.

PMID:
31314975
5.

Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised controlled phase I trial.

Mahomed S, Garrett N, Capparelli E, Baxter C, Zuma NY, Gengiah T, Archary D, Moore P, Samsunder N, Barouch DH, Mascola J, Ledgerwood J, Morris L, Abdool Karim S.

BMJ Open. 2019 Jul 3;9(7):e030283. doi: 10.1136/bmjopen-2019-030283.

6.

Frequency of Hepatitis B Virus Resistance Mutations in Women Using Tenofovir Gel as Pre-Exposure Prophylaxis.

Baxter C, Ngcapu S, Blackard JT, Powell EA, Penton PK, Abdool Karim SS.

Viruses. 2019 Jun 19;11(6). pii: E569. doi: 10.3390/v11060569.

7.

Correction to: Addressing challenges in scaling up TB and HIV treatment integration in rural primary healthcare clinics in South Africa (SUTHI): a cluster randomized controlled trial protocol.

Naidoo K, Gengiah S, Yende-Zuma N, Padayatchi N, Barker P, Nunn A, Subrayen P, Abdool Karim SS.

Implement Sci. 2019 Jun 13;14(1):59. doi: 10.1186/s13012-019-0915-1.

8.

The genital tract and rectal microbiomes: their role in HIV susceptibility and prevention in women.

Abdool Karim SS, Baxter C, Passmore JS, McKinnon LR, Williams BL.

J Int AIDS Soc. 2019 May;22(5):e25300. doi: 10.1002/jia2.25300. Review.

9.

Trends in Pretreatment HIV-1 Drug Resistance in Antiretroviral Therapy-naive Adults in South Africa, 2000-2016: A Pooled Sequence Analysis.

Chimukangara B, Lessells RJ, Rhee SY, Giandhari J, Kharsany ABM, Naidoo K, Lewis L, Cawood C, Khanyile D, Ayalew KA, Diallo K, Samuel R, Hunt G, Vandormael A, Stray-Pedersen B, Gordon M, Makadzange T, Kiepiela P, Ramjee G, Ledwaba J, Kalimashe M, Morris L, Parikh UM, Mellors JW, Shafer RW, Katzenstein D, Moodley P, Gupta RK, Pillay D, Abdool Karim SS, de Oliveira T.

EClinicalMedicine. 2019 Mar 18;9:26-34. doi: 10.1016/j.eclinm.2019.03.006. eCollection 2019 Mar.

10.

Evidence for both Intermittent and Persistent Compartmentalization of HIV-1 in the Female Genital Tract.

Mabvakure BM, Lambson BE, Ramdayal K, Masson L, Kitchin D, Allam M, Abdool Karim S, Williamson C, Passmore JA, Martin DP, Scheepers C, Moore PL, Harkins GW, Morris L.

J Virol. 2019 May 1;93(10). pii: e00311-19. doi: 10.1128/JVI.00311-19. Print 2019 May 15.

PMID:
30842323
11.

Positive Selection at Key Residues in the HIV Envelope Distinguishes Broad and Strain-Specific Plasma Neutralizing Antibodies.

Mabvakure BM, Scheepers C, Garrett N, Abdool Karim S, Williamson C, Morris L, Moore PL.

J Virol. 2019 Mar 5;93(6). pii: e01685-18. doi: 10.1128/JVI.01685-18. Print 2019 Mar 15.

12.

Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation.

Johnson EL, Doria-Rose NA, Gorman J, Bhiman JN, Schramm CA, Vu AQ, Law WH, Zhang B, Bekker V, Abdool Karim SS, Ippolito GC, Morris L, Moore PL, Kwong PD, Mascola JR, Georgiou G.

Nat Commun. 2018 Oct 8;9(1):4136. doi: 10.1038/s41467-018-06424-6.

13.

HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth.

Sheward DJ, Marais J, Bekker V, Murrell B, Eren K, Bhiman JN, Nonyane M, Garrett N, Woodman ZL, Abdool Karim Q, Abdool Karim SS, Morris L, Moore PL, Williamson C.

Cell Host Microbe. 2018 Oct 10;24(4):593-599.e3. doi: 10.1016/j.chom.2018.09.001. Epub 2018 Sep 27.

14.

Expert consensus statement on the science of HIV in the context of criminal law.

Barré-Sinoussi F, Abdool Karim SS, Albert J, Bekker LG, Beyrer C, Cahn P, Calmy A, Grinsztejn B, Grulich A, Kamarulzaman A, Kumarasamy N, Loutfy MR, El Filali KM, Mboup S, Montaner JS, Munderi P, Pokrovsky V, Vandamme AM, Young B, Godfrey-Faussett P.

J Int AIDS Soc. 2018 Jul;21(7):e25161. doi: 10.1002/jia2.25161.

15.

Ex vivo HIV entry into blood CD4+ T cells does not predict heterosexual HIV acquisition in women.

Joag V, Sivro A, Yende-Zuma N, Imam H, Samsunder N, Abdool Karim Q, Abdool Karim S, McKinnon L, Kaul R.

PLoS One. 2018 Jul 9;13(7):e0200359. doi: 10.1371/journal.pone.0200359. eCollection 2018.

16.

HIV-No time for complacency.

Abdool Karim Q, Abdool Karim SS.

Science. 2018 Jun 15;360(6394):1153. doi: 10.1126/science.aau2663. No abstract available.

PMID:
29903942
17.

Dolutegravir for first-line antiretroviral therapy in low-income and middle-income countries: uncertainties and opportunities for implementation and research.

Dorward J, Lessells R, Drain PK, Naidoo K, de Oliveira T, Pillay Y, Abdool Karim SS, Garrett N.

Lancet HIV. 2018 Jul;5(7):e400-e404. doi: 10.1016/S2352-3018(18)30093-6. Epub 2018 Jun 5.

18.

Residual T cell activation and skewed CD8+ T cell memory differentiation despite antiretroviral therapy-induced HIV suppression.

Tanko RF, Soares AP, Masson L, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS, Riou C, Burgers WA.

Clin Immunol. 2018 Oct;195:127-138. doi: 10.1016/j.clim.2018.06.001. Epub 2018 Jun 5.

PMID:
29883708
19.

Beyond syndromic management: Opportunities for diagnosis-based treatment of sexually transmitted infections in low- and middle-income countries.

Garrett NJ, Osman F, Maharaj B, Naicker N, Gibbs A, Norman E, Samsunder N, Ngobese H, Mitchev N, Singh R, Abdool Karim SS, Kharsany ABM, Mlisana K, Rompalo A, Mindel A.

PLoS One. 2018 Apr 24;13(4):e0196209. doi: 10.1371/journal.pone.0196209. eCollection 2018.

20.

Correction for Anthony et al., "Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope".

Anthony C, York T, Bekker V, Matten D, Selhorst P, Ferreria RC, Garrett NJ, Abdool Karim SS, Morris L, Wood NT, Moore PL, Williamson C.

J Virol. 2018 Apr 13;92(9). pii: e00243-18. doi: 10.1128/JVI.00243-18. Print 2018 May 1. No abstract available.

21.

HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies.

Richardson SI, Chung AW, Natarajan H, Mabvakure B, Mkhize NN, Garrett N, Abdool Karim S, Moore PL, Ackerman ME, Alter G, Morris L.

PLoS Pathog. 2018 Apr 9;14(4):e1006987. doi: 10.1371/journal.ppat.1006987. eCollection 2018 Apr.

22.

Case report: mechanisms of HIV elite control in two African women.

Moosa Y, Tanko RF, Ramsuran V, Singh R, Madzivhandila M, Yende-Zuma N, Abrahams MR, Selhorst P, Gounder K, Moore PL, Williamson C, Abdool Karim SS, Garrett NJ, Burgers WA.

BMC Infect Dis. 2018 Jan 25;18(1):54. doi: 10.1186/s12879-018-2961-8.

23.

Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes.

Sivro A, Schuetz A, Sheward D, Joag V, Yegorov S, Liebenberg LJ, Yende-Zuma N, Stalker A, Mwatelah RS, Selhorst P, Garrett N, Samsunder N, Balgobin A, Nawaz F, Cicala C, Arthos J, Fauci AS, Anzala AO, Kimani J, Bagaya BS, Kiwanuka N, Williamson C, Kaul R, Passmore JS, Phanuphak N, Ananworanich J, Ansari A, Abdool Karim Q, Abdool Karim SS, McKinnon LR; CAPRISA004 and RV254 study groups.

Sci Transl Med. 2018 Jan 24;10(425). pii: eaam6354. doi: 10.1126/scitranslmed.aam6354.

PMID:
29367348
24.

Addressing challenges in scaling up TB and HIV treatment integration in rural primary healthcare clinics in South Africa (SUTHI): a cluster randomized controlled trial protocol.

Naidoo K, Gengiah S, Yende-Zuma N, Padayatchi N, Barker P, Nunn A, Subrayen P, Abdool Karim SS.

Implement Sci. 2017 Nov 13;12(1):129. doi: 10.1186/s13012-017-0661-1. Erratum in: Implement Sci. 2019 Jun 13;14(1):59.

25.

The microbiome and HIV prevention strategies in women.

Abdool Karim SS, Passmore JS, Baxter C.

Curr Opin HIV AIDS. 2018 Jan;13(1):81-87. doi: 10.1097/COH.0000000000000431. Review.

PMID:
29059077
26.

Plasma Cytokine Predictors of Tuberculosis Recurrence in Antiretroviral-Treated Human Immunodeficiency Virus-infected Individuals from Durban, South Africa.

Sivro A, McKinnon LR, Yende-Zuma N, Gengiah S, Samsunder N, Abdool Karim SS, Naidoo K.

Clin Infect Dis. 2017 Sep 1;65(5):819-826. doi: 10.1093/cid/cix357.

27.

Protocol for a randomised controlled implementation trial of point-of-care viral load testing and task shifting: the Simplifying HIV TREAtment and Monitoring (STREAM) study.

Dorward J, Garrett N, Quame-Amaglo J, Samsunder N, Ngobese H, Ngomane N, Moodley P, Mlisana K, Schaafsma T, Donnell D, Barnabas R, Naidoo K, Abdool Karim S, Celum C, Drain PK.

BMJ Open. 2017 Sep 27;7(9):e017507. doi: 10.1136/bmjopen-2017-017507.

28.

Serum glycan-binding IgG antibodies in HIV-1 infection and during the development of broadly neutralizing responses.

Scheepers C, Chowdhury S, Wright WS, Campbell CT, Garrett NJ, Abdool Karim Q, Abdool Karim SS, Moore PL, Gildersleeve JC, Morris L.

AIDS. 2017 Oct 23;31(16):2199-2209. doi: 10.1097/QAD.0000000000001643.

29.

High mortality rates in men initiated on anti-retroviral treatment in KwaZulu-Natal, South Africa.

Naidoo K, Hassan-Moosa R, Yende-Zuma N, Govender D, Padayatchi N, Dawood H, Adams RN, Govender A, Chinappa T, Abdool-Karim S, Abdool-Karim Q.

PLoS One. 2017 Sep 13;12(9):e0184124. doi: 10.1371/journal.pone.0184124. eCollection 2017.

30.

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge.

Julg B, Tartaglia LJ, Keele BF, Wagh K, Pegu A, Sok D, Abbink P, Schmidt SD, Wang K, Chen X, Joyce MG, Georgiev IS, Choe M, Kwong PD, Doria-Rose NA, Le K, Louder MK, Bailer RT, Moore PL, Korber B, Seaman MS, Abdool Karim SS, Morris L, Koup RA, Mascola JR, Burton DR, Barouch DH.

Sci Transl Med. 2017 Sep 6;9(406). pii: eaal1321. doi: 10.1126/scitranslmed.aal1321.

31.

A38 Diversity analyses of HIV-1 envelope glycoproteins in HIV-infected individuals with and without broadly neutralizing antibodies.

Mabvakure B, Scheepers C, Nonyane M, Lambson B, Madzorera S, Kitchin D, Bhiman J, Wibmer K, Abdool Karim S, Williamson C, Morris L, Moore PL.

Virus Evol. 2017 Mar 5;3(Suppl 1). pii: vew036.037. doi: 10.1093/ve/vew036.037. eCollection 2017 Mar. No abstract available.

32.

Brief Report: Selection of HIV-1 Variants With Higher Transmission Potential by 1% Tenofovir Gel Microbicide.

Ngandu NK, Carlson JM, Chopera DR, Ndabambi N, Abdool Karim Q, Abdool Karim S, Williamson C.

J Acquir Immune Defic Syndr. 2017 Sep 1;76(1):43-47. doi: 10.1097/QAI.0000000000001458.

33.

Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.

Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noël-Romas L, Grobler A, Westmacott G, Xie IY, Butler J, Mansoor L, McKinnon LR, Passmore JS, Abdool Karim Q, Abdool Karim SS, Burgener AD.

Science. 2017 Jun 2;356(6341):938-945. doi: 10.1126/science.aai9383.

PMID:
28572388
34.

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

Alam SM, Aussedat B, Vohra Y, Meyerhoff RR, Cale EM, Walkowicz WE, Radakovich NA, Anasti K, Armand L, Parks R, Sutherland L, Scearce R, Joyce MG, Pancera M, Druz A, Georgiev IS, Von Holle T, Eaton A, Fox C, Reed SG, Louder M, Bailer RT, Morris L, Abdool-Karim SS, Cohen M, Liao HX, Montefiori DC, Park PK, Fernández-Tejada A, Wiehe K, Santra S, Kepler TB, Saunders KO, Sodroski J, Kwong PD, Mascola JR, Bonsignori M, Moody MA, Danishefsky S, Haynes BF.

Sci Transl Med. 2017 Mar 15;9(381). pii: eaai7521. doi: 10.1126/scitranslmed.aai7521.

35.

Genital-Systemic Chemokine Gradients and the Risk of HIV Acquisition in Women.

Liebenberg LJ, Masson L, Arnold KB, Mckinnon LR, Werner L, Proctor E, Archary D, Mansoor LE, Lauffenburger DA, Abdool Karim Q, Abdool Karim SS, Passmore JS.

J Acquir Immune Defic Syndr. 2017 Mar 1;74(3):318-325. doi: 10.1097/QAI.0000000000001218.

36.

Replication Capacity of Viruses from Acute Infection Drives HIV-1 Disease Progression.

Selhorst P, Combrinck C, Ndabambi N, Ismail SD, Abrahams MR, Lacerda M, Samsunder N, Garrett N, Abdool Karim Q, Abdool Karim SS, Williamson C.

J Virol. 2017 Mar 29;91(8). pii: e01806-16. doi: 10.1128/JVI.01806-16. Print 2017 Apr 15.

37.

Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.

Wibmer CK, Gorman J, Ozorowski G, Bhiman JN, Sheward DJ, Elliott DH, Rouelle J, Smira A, Joyce MG, Ndabambi N, Druz A, Asokan M, Burton DR, Connors M, Abdool Karim SS, Mascola JR, Robinson JE, Ward AB, Williamson C, Kwong PD, Morris L, Moore PL.

PLoS Pathog. 2017 Jan 11;13(1):e1006074. doi: 10.1371/journal.ppat.1006074. eCollection 2017 Jan.

38.

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting.

Doria-Rose NA, Altae-Tran HR, Roark RS, Schmidt SD, Sutton MS, Louder MK, Chuang GY, Bailer RT, Cortez V, Kong R, McKee K, O'Dell S, Wang F, Abdool Karim SS, Binley JM, Connors M, Haynes BF, Martin MA, Montefiori DC, Morris L, Overbaugh J, Kwong PD, Mascola JR, Georgiev IS.

PLoS Pathog. 2017 Jan 4;13(1):e1006148. doi: 10.1371/journal.ppat.1006148. eCollection 2017 Jan.

39.

Effect of Antiretroviral Therapy on the Memory and Activation Profiles of B Cells in HIV-Infected African Women.

Tanko RF, Soares AP, Müller TL, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS, Riou C, Burgers WA.

J Immunol. 2017 Feb 1;198(3):1220-1228. doi: 10.4049/jimmunol.1601560. Epub 2016 Dec 30.

40.

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site.

Wibmer CK, Gorman J, Anthony CS, Mkhize NN, Druz A, York T, Schmidt SD, Labuschagne P, Louder MK, Bailer RT, Abdool Karim SS, Mascola JR, Williamson C, Moore PL, Kwong PD, Morris L.

J Virol. 2016 Oct 28;90(22):10220-10235. doi: 10.1128/JVI.01357-16. Print 2016 Nov 15.

41.

Metabolic Syndrome After HIV Acquisition in South African Women.

Sobieszczyk ME, Werner L, Mlisana K, Naicker N, Feinstein A, Gray CM, Masson L, Passmore JS, Williamson C, Abdool Karim Q, Abdool Karim SS, Garrett NJ.

J Acquir Immune Defic Syndr. 2016 Dec 1;73(4):438-445.

PMID:
27391387
42.

Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.

Bradley T, Trama A, Tumba N, Gray E, Lu X, Madani N, Jahanbakhsh F, Eaton A, Xia SM, Parks R, Lloyd KE, Sutherland LL, Scearce RM, Bowman CM, Barnett S, Abdool-Karim SS, Boyd SD, Melillo B, Smith AB 3rd, Sodroski J, Kepler TB, Alam SM, Gao F, Bonsignori M, Liao HX, Moody MA, Montefiori D, Santra S, Morris L, Haynes BF.

EBioMedicine. 2016 Oct;12:196-207. doi: 10.1016/j.ebiom.2016.08.045. Epub 2016 Aug 31.

43.

Early evolution of human leucocyte antigen-associated escape mutations in variable Gag proteins predicts CD4+ decline in HIV-1 subtype C-infected women.

Chopera DR, Ntale R, Ndabambi N, Garrett N, Gray CM, Matten D, Abdool Karim Q, Abdool Karim S, Williamson C.

AIDS. 2017 Jan 14;31(2):191-197. doi: 10.1097/QAD.0000000000001298.

44.

Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.

Selhorst P, Masson L, Ismail SD, Samsunder N, Garrett N, Mansoor LE, Abdool Karim Q, Abdool Karim SS, Passmore JS, Williamson C.

Clin Infect Dis. 2017 Jan 1;64(1):79-82. Epub 2016 Sep 29.

45.

Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization.

Rademeyer C, Korber B, Seaman MS, Giorgi EE, Thebus R, Robles A, Sheward DJ, Wagh K, Garrity J, Carey BR, Gao H, Greene KM, Tang H, Bandawe GP, Marais JC, Diphoko TE, Hraber P, Tumba N, Moore PL, Gray GE, Kublin J, McElrath MJ, Vermeulen M, Middelkoop K, Bekker LG, Hoelscher M, Maboko L, Makhema J, Robb ML, Abdool Karim S, Abdool Karim Q, Kim JH, Hahn BH, Gao F, Swanstrom R, Morris L, Montefiori DC, Williamson C.

PLoS Pathog. 2016 Jul 19;12(7):e1005742. doi: 10.1371/journal.ppat.1005742. eCollection 2016 Jul. Erratum in: PLoS Pathog. 2017 Sep 25;13(9):e1006641.

46.

Combination HIV prevention options for young women in Africa.

Baxter C, Abdool Karim S.

Afr J AIDS Res. 2016 Jul;15(2):109-21. doi: 10.2989/16085906.2016.1196224. Review.

PMID:
27399041
47.

Modulation of Female Genital Tract-Derived Dendritic Cell Migration and Activation in Response to Inflammatory Cytokines and Toll-Like Receptor Agonists.

Shey MS, Maharaj N, Archary D, Ngcapu S, Garrett N, Abdool Karim S, Passmore JA.

PLoS One. 2016 May 12;11(5):e0155668. doi: 10.1371/journal.pone.0155668. eCollection 2016.

48.

Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel.

Archary D, Seaton KE, Passmore JS, Werner L, Deal A, Dunphy LJ, Arnold KB, Yates NL, Lauffenburger DA, Bergin P, Liebenberg LJ, Samsunder N, Mureithi MW, Altfeld M, Garrett N, Abdool Karim Q, Abdool Karim SS, Morris L, Tomaras GD.

Mucosal Immunol. 2016 May;9(3):834. doi: 10.1038/mi.2016.21. No abstract available.

PMID:
27116933
49.

Association of Polymorphisms in the Regulatory Region of the Cyclophilin a Gene (PPIA) with Gene Expression and HIV/AIDS Disease Progression.

Madlala P, Singh R, An P, Werner L, Mlisana K, Abdool Karim SS, Winkler CA, Ndungʼu T.

J Acquir Immune Defic Syndr. 2016 Aug 15;72(5):465-73. doi: 10.1097/QAI.0000000000001028.

50.

Corrigendum to "oral and injectable contraceptive use and HIV acquisition risk among women in four African countries: a secondary analysis of data from a microbicide trial" [Contraception 2016; 93 (1): 25-31].

Balkus JE, Brown ER, Hillier SL, Coletti A, Ramjee G, Mgodi N, Makanani B, Reid C, Martinson F, Soto-Torres L, Abdool Karim SS, Chirenje ZM.

Contraception. 2016 Jul;94(1):95. doi: 10.1016/j.contraception.2016.03.018. Epub 2016 Apr 14. No abstract available.

PMID:
27085419

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