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Items: 43


Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis.

Song BJ, Abdelmegeed MA, Cho YE, Akbar M, Rhim JS, Song MK, Hardwick JP.

Adv Exp Med Biol. 2019;1164:73-87. doi: 10.1007/978-3-030-22254-3_6. Review.


Interplay of Oxidative Stress, Inflammation, and Autophagy: Their Role in Tissue Injury of the Heart, Liver, and Kidney.

Mukhopadhyay P, Eid N, Abdelmegeed MA, Sen A.

Oxid Med Cell Longev. 2018 Mar 22;2018:2090813. doi: 10.1155/2018/2090813. eCollection 2018. No abstract available.


Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury.

Cho YE, Yu LR, Abdelmegeed MA, Yoo SH, Song BJ.

J Hepatol. 2018 Jul;69(1):142-153. doi: 10.1016/j.jhep.2018.02.005. Epub 2018 Feb 16.


Enhanced Phosphorylation of Bax and Its Translocation into Mitochondria in the Brains of Individuals Affiliated with Alzheimer's Disease.

Henderson LE, Abdelmegeed MA, Yoo SH, Rhee SG, Zhu X, Smith MA, Nguyen RQ, Perry G, Song BJ.

Open Neurol J. 2017 Nov 16;11:48-58. doi: 10.2174/1874205X01711010048. eCollection 2017.


Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress.

Abdelmegeed MA, Choi Y, Ha SK, Song BJ.

Food Chem Toxicol. 2017 Nov;109(Pt 1):48-59. doi: 10.1016/j.fct.2017.08.022. Epub 2017 Aug 24.


Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress.

Choi Y, Abdelmegeed MA, Song BJ.

Food Chem Toxicol. 2017 May;103:111-121. doi: 10.1016/j.fct.2017.02.039. Epub 2017 Mar 1.


Corrigendum: Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis.

Abdelmegeed MA, Choi Y, Godlewski G, Ha SK, Banerjee A, Jang S, Song BJ.

Sci Rep. 2017 Feb 17;7:42566. doi: 10.1038/srep42566. No abstract available.


Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis.

Abdelmegeed MA, Choi Y, Godlewski G, Ha SK, Banerjee A, Jang S, Song BJ.

Sci Rep. 2017 Jan 4;7:39764. doi: 10.1038/srep39764. Erratum in: Sci Rep. 2017 Feb 17;7:42566.


Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury.

Gao Y, Cao Z, Yang X, Abdelmegeed MA, Sun J, Chen S, Beger RD, Davis K, Salminen WF, Song BJ, Mendrick DL, Yu LR.

Proteomics Clin Appl. 2017 Jan;11(1-2). doi: 10.1002/prca.201600123. Epub 2016 Oct 28.


Preventive effects of dietary walnuts on high-fat-induced hepatic fat accumulation, oxidative stress and apoptosis in mice.

Choi Y, Abdelmegeed MA, Song BJ.

J Nutr Biochem. 2016 Dec;38:70-80. doi: 10.1016/j.jnutbio.2016.08.013. Epub 2016 Sep 22.


Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway.

Chen Y, Singh S, Matsumoto A, Manna SK, Abdelmegeed MA, Golla S, Murphy RC, Dong H, Song BJ, Gonzalez FJ, Thompson DC, Vasiliou V.

Sci Rep. 2016 Jul 12;6:29743. doi: 10.1038/srep29743.


Dietary walnut reduces hepatic triglyceride content in high-fat-fed mice via modulation of hepatic fatty acid metabolism and adipose tissue inflammation.

Choi Y, Abdelmegeed MA, Akbar M, Song BJ.

J Nutr Biochem. 2016 Apr;30:116-25. doi: 10.1016/j.jnutbio.2015.12.005. Epub 2016 Jan 6.


Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress.

Akbar M, Essa MM, Daradkeh G, Abdelmegeed MA, Choi Y, Mahmood L, Song BJ.

Brain Res. 2016 Apr 15;1637:34-55. doi: 10.1016/j.brainres.2016.02.016. Epub 2016 Feb 13. Review.


Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress.

Abdelmegeed MA, Choi Y, Ha SK, Song BJ.

Free Radic Biol Med. 2016 Feb;91:188-202. doi: 10.1016/j.freeradbiomed.2015.12.016. Epub 2015 Dec 17.


Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury.

Jang S, Yu LR, Abdelmegeed MA, Gao Y, Banerjee A, Song BJ.

Redox Biol. 2015 Dec;6:552-564. doi: 10.1016/j.redox.2015.09.040. Epub 2015 Oct 9.


Increased Sensitivity to Binge Alcohol-Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats.

Banerjee A, Abdelmegeed MA, Jang S, Song BJ.

PLoS One. 2015 Oct 20;10(10):e0140498. doi: 10.1371/journal.pone.0140498. eCollection 2015.


Role of CYP2E1 in Mitochondrial Dysfunction and Hepatic Injury by Alcohol and Non-Alcoholic Substances.

Abdelmegeed MA, Ha SK, Choi Y, Akbar M, Song BJ.

Curr Mol Pharmacol. 2017;10(3):207-225. doi: 10.2174/1874467208666150817111114. Review.


Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease.

Song BJ, Akbar M, Jo I, Hardwick JP, Abdelmegeed MA.

Adv Pharmacol. 2015;74:303-72. doi: 10.1016/bs.apha.2015.04.002. Epub 2015 Jun 27. Review.


Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1α-dependent apoptosis pathway in mice and humans.

Yun JW, Son MJ, Abdelmegeed MA, Banerjee A, Morgan TR, Yoo SH, Song BJ.

Free Radic Biol Med. 2014 Dec;77:183-94. doi: 10.1016/j.freeradbiomed.2014.08.030. Epub 2014 Sep 16.


Functional roles of protein nitration in acute and chronic liver diseases.

Abdelmegeed MA, Song BJ.

Oxid Med Cell Longev. 2014;2014:149627. doi: 10.1155/2014/149627. Epub 2014 Apr 30. Review.


Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice.

Kwon HJ, Won YS, Park O, Chang B, Duryee MJ, Thiele GE, Matsumoto A, Singh S, Abdelmegeed MA, Song BJ, Kawamoto T, Vasiliou V, Thiele GM, Gao B.

Hepatology. 2014 Jul;60(1):146-57. doi: 10.1002/hep.27036. Epub 2014 May 28.


Zidovudine (AZT) and hepatic lipid accumulation: implication of inflammation, oxidative and endoplasmic reticulum stress mediators.

Banerjee A, Abdelmegeed MA, Jang S, Song BJ.

PLoS One. 2013 Oct 11;8(10):e76850. doi: 10.1371/journal.pone.0076850. eCollection 2013.


CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.

Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ, Keshavarzian A, Song BJ.

Free Radic Biol Med. 2013 Dec;65:1238-1245. doi: 10.1016/j.freeradbiomed.2013.09.009. Epub 2013 Sep 21.


Activation of PPARα by Wy-14643 ameliorates systemic lipopolysaccharide-induced acute lung injury.

Yoo SH, Abdelmegeed MA, Song BJ.

Biochem Biophys Res Commun. 2013 Jul 5;436(3):366-71. doi: 10.1016/j.bbrc.2013.05.073. Epub 2013 May 29.


Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic fatty liver disease.

Song BJ, Abdelmegeed MA, Henderson LE, Yoo SH, Wan J, Purohit V, Hardwick JP, Moon KH.

Oxid Med Cell Longev. 2013;2013:781050. doi: 10.1155/2013/781050. Epub 2013 Apr 3. Review.


Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury.

Abdelmegeed MA, Jang S, Banerjee A, Hardwick JP, Song BJ.

Free Radic Biol Med. 2013 Jul;60:211-22. doi: 10.1016/j.freeradbiomed.2013.02.018. Epub 2013 Feb 27.


Eicosanoids in metabolic syndrome.

Hardwick JP, Eckman K, Lee YK, Abdelmegeed MA, Esterle A, Chilian WM, Chiang JY, Song BJ.

Adv Pharmacol. 2013;66:157-266. doi: 10.1016/B978-0-12-404717-4.00005-6. Review.


Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis.

Abdelmegeed MA, Banerjee A, Yoo SH, Jang S, Gonzalez FJ, Song BJ.

J Hepatol. 2012 Oct;57(4):860-6. doi: 10.1016/j.jhep.2012.05.019. Epub 2012 Jun 2.


Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.

Song BJ, Abdelmegeed MA, Yoo SH, Kim BJ, Jo SA, Jo I, Moon KH.

J Proteomics. 2011 Nov 18;74(12):2691-702. doi: 10.1016/j.jprot.2011.05.013. Epub 2011 May 15. Review.


PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver.

Abdelmegeed MA, Yoo SH, Henderson LE, Gonzalez FJ, Woodcroft KJ, Song BJ.

J Nutr. 2011 Apr 1;141(4):603-10. doi: 10.3945/jn.110.135210. Epub 2011 Feb 23.


Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress.

Yoo SH, Park O, Henderson LE, Abdelmegeed MA, Moon KH, Song BJ.

Toxicol Lett. 2011 Apr 10;202(1):23-9. doi: 10.1016/j.toxlet.2011.01.013. Epub 2011 Jan 22.


Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity.

Abdelmegeed MA, Moon KH, Chen C, Gonzalez FJ, Song BJ.

Biochem Pharmacol. 2010 Jan 1;79(1):57-66. doi: 10.1016/j.bcp.2009.07.016. Epub 2009 Aug 4.


Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress.

Abdelmegeed MA, Moon KH, Hardwick JP, Gonzalez FJ, Song BJ.

Free Radic Biol Med. 2009 Sep 15;47(6):767-78. doi: 10.1016/j.freeradbiomed.2009.06.017. Epub 2009 Jun 17.


PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease.

Hardwick JP, Osei-Hyiaman D, Wiland H, Abdelmegeed MA, Song BJ.

PPAR Res. 2009;2009:952734. doi: 10.1155/2009/952734. Epub 2010 Mar 16.


Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion.

Moon KH, Hood BL, Mukhopadhyay P, Rajesh M, Abdelmegeed MA, Kwon YI, Conrads TP, Veenstra TD, Song BJ, Pacher P.

Gastroenterology. 2008 Oct;135(4):1344-57. doi: 10.1053/j.gastro.2008.06.048. Epub 2008 Jun 25.


Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver.

Moon KH, Abdelmegeed MA, Song BJ.

FEBS Lett. 2007 Aug 21;581(21):3967-72. Epub 2007 Jul 25.


Role of mechanical and redox stress in activation of mitogen-activated protein kinases in primary cultured rat hepatocytes.

Kim SK, Woodcroft KJ, Oh SJ, Abdelmegeed MA, Novak RF.

Biochem Pharmacol. 2005 Dec 5;70(12):1785-95. Epub 2005 Oct 20.


Acetoacetate induces CYP2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes.

Abdelmegeed MA, Carruthers NJ, Woodcroft KJ, Kim SK, Novak RF.

J Pharmacol Exp Ther. 2005 Oct;315(1):203-13. Epub 2005 Jun 24.


Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: role of oxidative stress.

Abdelmegeed MA, Kim SK, Woodcroft KJ, Novak RF.

J Pharmacol Exp Ther. 2004 Aug;310(2):728-36. Epub 2004 Mar 29.


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