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Bardoxolone-Methyl (CDDO-Me) Suppresses Androgen Receptor and Its Splice-Variant AR-V7 and Enhances Efficacy of Enzalutamide in Prostate Cancer Cells.

Khurana N, Chandra PK, Kim H, Abdel-Mageed AB, Mondal D, Sikka SC.

Antioxidants (Basel). 2020 Jan 12;9(1). pii: E68. doi: 10.3390/antiox9010068.


Ivabradine, the hyperpolarization-activated cyclic nucleotide-gated channel blocker, elicits relaxation of the human corpus cavernosum: a potential option for erectile dysfunction treatment.

Gur S, Alzweri L, Yilmaz-Oral D, Kaya-Sezginer E, Abdel-Mageed AB, Sikka SC, Hellstrom WJG.

Aging Male. 2019 Nov 19:1-10. doi: 10.1080/13685538.2019.1678125. [Epub ahead of print]


A novel gene panel for prediction of lymph-node metastasis and recurrence in patients with thyroid cancer.

Ruiz EML, Niu T, Zerfaoui M, Kunnimalaiyaan M, Friedlander PL, Abdel-Mageed AB, Kandil E.

Surgery. 2020 Jan;167(1):73-79. doi: 10.1016/j.surg.2019.06.058. Epub 2019 Nov 9.


Insulin-Like Growth Factor-1-Loaded Polymeric Poly(Lactic-Co-Glycolic) Acid Microspheres Improved Erectile Function in a Rat Model of Bilateral Cavernous Nerve Injury.

Haney NM, Talwar S, Akula PK, Reddy AG, Pema GS, Ninh TV, Rezk BM, Heidari Z, Bouljihad MT, Sikka SC, John V, Abdel-Mageed AB, Hellstrom WJG.

J Sex Med. 2019 Mar;16(3):383-393. doi: 10.1016/j.jsxm.2018.12.018.


Advances in stem cell therapy for erectile dysfunction.

Gur S, Abdel-Mageed AB, Sikka SC, Hellstrom WJG.

Expert Opin Biol Ther. 2018 Nov;18(11):1137-1150. doi: 10.1080/14712598.2018.1534955. Epub 2018 Oct 21. Review.


Mesenchymal stem cells are attracted to latent HIV-1-infected cells and enable virus reactivation via a non-canonical PI3K-NFκB signaling pathway.

Chandra PK, Gerlach SL, Wu C, Khurana N, Swientoniewski LT, Abdel-Mageed AB, Li J, Braun SE, Mondal D.

Sci Rep. 2018 Oct 2;8(1):14702. doi: 10.1038/s41598-018-32657-y.


Pioglitazone's beneficial effects on erectile function preservation after cavernosal nerve injury in the rat are negated by inhibition of the insulin-like growth factor-1 receptor: a preclinical study.

Heidenberg DJ, Haney NM, Rezk BM, Talwar S, Okpechi SC, Srivastav SK, Honda M, Song B, Swan K, Awadallah S, Anaissie J, Peak T, DeLay KJ, Kadowitz PJ, Sikka SC, Abdel Mageed AB, Hellstrom WJG.

Int J Impot Res. 2019 Jan;31(1):1-8. doi: 10.1038/s41443-018-0054-2. Epub 2018 Aug 2.


Destination Penis? Gene Therapy as a Possible Treatment for Erectile Dysfunction.

Gur S, Abdel-Mageed AB, Sikka SC, Bartolome AR, Hellstrom WJG.

Curr Gene Ther. 2018;18(4):225-239. doi: 10.2174/1566523218666180730110432. Review.


MicroRNAs in prostate cancer: From function to biomarker discovery.

Moustafa AA, Kim H, Albeltagy RS, El-Habit OH, Abdel-Mageed AB.

Exp Biol Med (Maywood). 2018 Jun;243(10):817-825. doi: 10.1177/1535370218775657. Review.


High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer.

Datta A, Kim H, McGee L, Johnson AE, Talwar S, Marugan J, Southall N, Hu X, Lal M, Mondal D, Ferrer M, Abdel-Mageed AB.

Sci Rep. 2018 May 25;8(1):8161. doi: 10.1038/s41598-018-26411-7.


PRL‑3 increases the aggressive phenotype of prostate cancer cells in vitro and its expression correlates with high-grade prostate tumors in patients.

Edwards DR, Moroz K, Zhang H, Mulholland D, Abdel-Mageed AB, Mondal D.

Int J Oncol. 2018 Feb;52(2):402-412. doi: 10.3892/ijo.2017.4208. Epub 2017 Nov 20.


Downregulation of Bit1 expression promotes growth, anoikis resistance, and transformation of immortalized human bronchial epithelial cells via Erk activation-dependent suppression of E-cadherin.

Yao X, Gray S, Pham T, Delgardo M, Nguyen A, Do S, Ireland SK, Chen R, Abdel-Mageed AB, Biliran H.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):1240-1248. doi: 10.1016/j.bbrc.2017.11.126. Epub 2017 Nov 21.


TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression.

Yao X, Pham T, Temple B, Gray S, Cannon C, Hardy C, Fletcher K, Ireland SK, Hossain A, Chen R, Abdel-Mageed AB, Biliran H.

Oncotarget. 2017 Jul 31;8(42):72235-72249. doi: 10.18632/oncotarget.19703. eCollection 2017 Sep 22.


Multimodal actions of the phytochemical sulforaphane suppress both AR and AR-V7 in 22Rv1 cells: Advocating a potent pharmaceutical combination against castration-resistant prostate cancer.

Khurana N, Kim H, Chandra PK, Talwar S, Sharma P, Abdel-Mageed AB, Sikka SC, Mondal D.

Oncol Rep. 2017 Nov;38(5):2774-2786. doi: 10.3892/or.2017.5932. Epub 2017 Aug 30.


Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.

Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa AA, Jones JC, Mondal D, Ferrer M, Abdel-Mageed AB.

Cancer Lett. 2017 Nov 1;408:73-81. doi: 10.1016/j.canlet.2017.08.020. Epub 2017 Aug 24.


Bilateral Cavernous Nerve Crush Injury in the Rat Model: A Comparative Review of Pharmacologic Interventions.

Haney NM, Nguyen HMT, Honda M, Abdel-Mageed AB, Hellstrom WJG.

Sex Med Rev. 2018 Apr;6(2):234-241. doi: 10.1016/j.sxmr.2017.07.007. Epub 2017 Aug 18. Review.


Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells.

Srivastava A, Amreddy N, Babu A, Panneerselvam J, Mehta M, Muralidharan R, Chen A, Zhao YD, Razaq M, Riedinger N, Kim H, Liu S, Wu S, Abdel-Mageed AB, Munshi A, Ramesh R.

Sci Rep. 2016 Dec 12;6:38541. doi: 10.1038/srep38541.


Identification of microRNA signature and potential pathway targets in prostate cancer.

Moustafa AA, Ziada M, Elshaikh A, Datta A, Kim H, Moroz K, Srivastav S, Thomas R, Silberstein JL, Moparty K, Salem FE, El-Habit OH, Abdel-Mageed AB.

Exp Biol Med (Maywood). 2017 Mar;242(5):536-546. doi: 10.1177/1535370216681554. Epub 2016 Dec 8.


Effect of adipose tissue-derived stem cell injection in a rat model of urethral fibrosis.

Sangkum P, Yafi FA, Kim H, Bouljihad M, Ranjan M, Datta A, Mandava SH, Sikka SC, Abdel-Mageed AB, Hellstrom WJ.

Can Urol Assoc J. 2016 May-Jun;10(5-6):E175-E180. Epub 2016 May 12.


The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells.

Yao X, Pham T, Temple B, Gray S, Cannon C, Chen R, Abdel-Mageed AB, Biliran H.

PLoS One. 2016 Sep 21;11(9):e0163228. doi: 10.1371/journal.pone.0163228. eCollection 2016.


Estradiol-ERβ2 signaling axis confers growth and migration of CRPC cells through TMPRSS2-ETV5 gene fusion.

Kim H, Datta A, Talwar S, Saleem SN, Mondal D, Abdel-Mageed AB.

Oncotarget. 2016 Aug 17;8(38):62820-62833. doi: 10.18632/oncotarget.11355. eCollection 2017 Sep 8.


Sulforaphane increases the efficacy of anti-androgens by rapidly decreasing androgen receptor levels in prostate cancer cells.

Khurana N, Talwar S, Chandra PK, Sharma P, Abdel-Mageed AB, Mondal D, Sikka SC.

Int J Oncol. 2016 Oct;49(4):1609-19. doi: 10.3892/ijo.2016.3641. Epub 2016 Aug 2.


Nanotechnology combined therapy: tyrosine kinase-bound gold nanorod and laser thermal ablation produce a synergistic higher treatment response of renal cell carcinoma in a murine model.

Liu J, Abshire C, Carry C, Sholl AB, Mandava SH, Datta A, Ranjan M, Callaghan C, Peralta DV, Williams KS, Lai WR, Abdel-Mageed AB, Tarr M, Lee BR.

BJU Int. 2017 Feb;119(2):342-348. doi: 10.1111/bju.13590. Epub 2016 Aug 17.


Can Adipose-derived Stem Cells Be Used in the Treatment of Urethral Stricture Disease?

Hellstrom WJ, DeLay KJ, Abdel-Mageed AB.

Eur Urol. 2016 Dec;70(6):1042-1043. doi: 10.1016/j.eururo.2016.05.027. Epub 2016 May 27. No abstract available.


Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor.

Liu S, Zhang Q, Chen C, Ge D, Qu Y, Chen R, Fan YM, Li N, Tang WW, Zhang W, Zhang K, Wang AR, Rowan BG, Hill SM, Sartor O, Abdel-Mageed AB, Myers L, Lin Q, You Z.

Oncotarget. 2016 Mar 22;7(12):13651-66. doi: 10.18632/oncotarget.7296.


Nelfinavir targets multiple drug resistance mechanisms to increase the efficacy of doxorubicin in MCF-7/Dox breast cancer cells.

Chakravarty G, Mathur A, Mallade P, Gerlach S, Willis J, Datta A, Srivastav S, Abdel-Mageed AB, Mondal D.

Biochimie. 2016 May;124:53-64. doi: 10.1016/j.biochi.2016.01.014. Epub 2016 Feb 1.


Pioglitazone Enhances Survival and Regeneration of Pelvic Ganglion Neurons After Cavernosal Nerve Injury.

Katz EG, Moustafa AA, Heidenberg D, Haney N, Peak T, Lasker GF, Knoedler M, Rittenberg D, Rezk BM, Abd Elmageed ZY, Yafi FA, Sikka S, Abdel-Mageed AB, Hellstrom WJ.

Urology. 2016 Mar;89:76-82. doi: 10.1016/j.urology.2015.12.021. Epub 2016 Jan 6.


Adipose Tissue-Derived Stem Cells for the Treatment of Erectile Dysfunction.

Gokce A, Peak TC, Abdel-Mageed AB, Hellstrom WJ.

Curr Urol Rep. 2016 Feb;17(2):14. doi: 10.1007/s11934-015-0569-8. Review.


Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7: Implications for Racial Disparity of Prostate Cancer.

Yang Y, Jia D, Kim H, Abd Elmageed ZY, Datta A, Davis R, Srivastav S, Moroz K, Crawford BE, Moparty K, Thomas R, Hudson RS, Ambs S, Abdel-Mageed AB.

Clin Cancer Res. 2016 Apr 1;22(7):1744-56. doi: 10.1158/1078-0432.CCR-15-1606. Epub 2015 Nov 9.


Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.

Quesenberry PJ, Aliotta J, Camussi G, Abdel-Mageed AB, Wen S, Goldberg L, Zhang HG, Tetta C, Franklin J, Coffey RJ, Danielson K, Subramanya V, Ghiran I, Das S, Chen CC, Pusic KM, Pusic AD, Chatterjee D, Kraig RP, Balaj L, Dooner M.

J Extracell Vesicles. 2015 Aug 28;4:27575. doi: 10.3402/jev.v4.27575. eCollection 2015.


Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.

Laurent LC, Abdel-Mageed AB, Adelson PD, Arango J, Balaj L, Breakefield X, Carlson E, Carter BS, Majem B, Chen CC, Cocucci E, Danielson K, Courtright A, Das S, Abd Elmageed ZY, Enderle D, Ezrin A, Ferrer M, Freedman J, Galas D, Gandhi R, Huentelman MJ, Van Keuren-Jensen K, Kalani Y, Kim Y, Krichevsky AM, Lai C, Lal-Nag M, Laurent CD, Leonardo T, Li F, Malenica I, Mondal D, Nejad P, Patel T, Raffai RL, Rubio R, Skog J, Spetzler R, Sun J, Tanriverdi K, Vickers K, Wang L, Wang Y, Wei Z, Weiner HL, Wong D, Yan IK, Yeri A, Gould S.

J Extracell Vesicles. 2015 Aug 28;4:26533. doi: 10.3402/jev.v4.26533. eCollection 2015.


Differential expression of novel biomarkers (TLR-2, TLR-4, COX-2, and Nrf-2) of inflammation and oxidative stress in semen of leukocytospermia patients.

Hagan S, Khurana N, Chandra S, Abdel-Mageed AB, Mondal D, Hellstrom WJ, Sikka SC.

Andrology. 2015 Sep;3(5):848-55. doi: 10.1111/andr.12074. Epub 2015 Jul 30.


Collagenase Clostridium histolyticum (Xiaflex) for the Treatment of Urethral Stricture Disease in a Rat Model of Urethral Fibrosis.

Sangkum P, Yafi FA, Kim H, Bouljihad M, Ranjan M, Datta A, Mandava SH, Sikka SC, Abdel-Mageed AB, Moparty K, Hellstrom WJ.

Urology. 2015 Sep;86(3):647.e1-6. doi: 10.1016/j.urology.2015.06.013. Epub 2015 Jun 27.


Intratunical Injection of Genetically Modified Adipose Tissue-Derived Stem Cells with Human Interferon α-2b for Treatment of Erectile Dysfunction in a Rat Model of Tunica Albugineal Fibrosis.

Gokce A, Abd Elmageed ZY, Lasker GF, Bouljihad M, Braun SE, Kim H, Kadowitz PJ, Abdel-Mageed AB, Sikka SC, Hellstrom WJ.

J Sex Med. 2015 Jul;12(7):1533-44. doi: 10.1111/jsm.12916. Epub 2015 Jun 10.


Selective targeting of FAK-Pyk2 axis by alpha-naphthoflavone abrogates doxorubicin resistance in breast cancer cells.

Datta A, Bhasin N, Kim H, Ranjan M, Rider B, Abd Elmageed ZY, Mondal D, Agrawal KC, Abdel-Mageed AB.

Cancer Lett. 2015 Jun 28;362(1):25-35. doi: 10.1016/j.canlet.2015.03.009. Epub 2015 Mar 18.


Transforming Growth Factor-β1 Induced Urethral Fibrosis in a Rat Model.

Sangkum P, Gokce A, Tan RB, Bouljihad M, Kim H, Mandava SH, Saleem SN, Lasker GF, Yafi FA, Abd Elmageed ZY, Moparty K, Sikka SC, Abdel-Mageed AB, Hellstrom WJ.

J Urol. 2015 Sep;194(3):820-7. doi: 10.1016/j.juro.2015.02.014. Epub 2015 Feb 10.


Cystine dimethyl ester induces apoptosis through regulation of PKC-δ and PKC-ε in prostate cancer cells.

Gurbuz N, Park MA, Dent P, Abdel Mageed AB, Sikka SC, Baykal A.

Anticancer Agents Med Chem. 2015;15(2):217-27.


Active surveillance of prostate cancer in African American men.

Silberstein JL, Feibus AH, Maddox MM, Abdel-Mageed AB, Moparty K, Thomas R, Sartor O.

Urology. 2014 Dec;84(6):1255-61. doi: 10.1016/j.urology.2014.06.064. Epub 2014 Oct 3. Review.


Tumor-derived exosomes in oncogenic reprogramming and cancer progression.

Saleem SN, Abdel-Mageed AB.

Cell Mol Life Sci. 2015 Jan;72(1):1-10. doi: 10.1007/s00018-014-1710-4. Epub 2014 Aug 26. Review.


Subverting ER-stress towards apoptosis by nelfinavir and curcumin coexposure augments docetaxel efficacy in castration resistant prostate cancer cells.

Mathur A, Abd Elmageed ZY, Liu X, Kostochka ML, Zhang H, Abdel-Mageed AB, Mondal D.

PLoS One. 2014 Aug 14;9(8):e103109. doi: 10.1371/journal.pone.0103109. eCollection 2014.


Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37.

Kim H, Abd Elmageed ZY, Davis C, El-Bahrawy AH, Naura AS, Ekaidi I, Abdel-Mageed AB, Boulares AH.

Mol Med. 2014 Jul 14;20:270-9. doi: 10.2119/molmed.2013.00166.


Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.

Abd Elmageed ZY, Yang Y, Thomas R, Ranjan M, Mondal D, Moroz K, Fang Z, Rezk BM, Moparty K, Sikka SC, Sartor O, Abdel-Mageed AB.

Stem Cells. 2014 Apr;32(4):983-97. doi: 10.1002/stem.1619.


Adipose tissue-derived stem cell therapy for prevention and treatment of erectile dysfunction in a rat model of Peyronie's disease.

Gokce A, Abd Elmageed ZY, Lasker GF, Bouljihad M, Kim H, Trost LW, Kadowitz PJ, Abdel-Mageed AB, Sikka SC, Hellstrom WJ.

Andrology. 2014 Mar;2(2):244-51. doi: 10.1111/j.2047-2927.2013.00181.x.


Molecular characterization of exosome-like vesicles from breast cancer cells.

Kruger S, Abd Elmageed ZY, Hawke DH, Wörner PM, Jansen DA, Abdel-Mageed AB, Alt EU, Izadpanah R.

BMC Cancer. 2014 Jan 27;14:44. doi: 10.1186/1471-2407-14-44.


Nrf1 and Nrf2 transcription factors regulate androgen receptor transactivation in prostate cancer cells.

Schultz MA, Hagan SS, Datta A, Zhang Y, Freeman ML, Sikka SC, Abdel-Mageed AB, Mondal D.

PLoS One. 2014 Jan 22;9(1):e87204. doi: 10.1371/journal.pone.0087204. eCollection 2014.


Imatinib mesylate (Gleevec) induces human corpus cavernosum relaxation by inhibiting receptor tyrosine kinases (RTKs): identification of new RTK targets.

Gur S, Sikka SC, Abdel-Mageed AB, Abd Elmageed ZY, Rezk B, Pankey E, Kadowitz PJ, Hellstrom WJ.

Urology. 2013 Sep;82(3):745.e11-6. doi: 10.1016/j.urology.2013.04.030. Epub 2013 Jul 13.


PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth.

Kim H, Abd Elmageed ZY, Ju J, Naura AS, Abdel-Mageed AB, Varughese S, Paul D, Alahari S, Catling A, Kim JG, Boulares AH.

Mol Med. 2013 Aug 28;19:253-62. doi: 10.2119/molmed.2011.00001.


High circulating estrogens and selective expression of ERβ in prostate tumors of Americans: implications for racial disparity of prostate cancer.

Abd Elmageed ZY, Moroz K, Srivastav SK, Fang Z, Crawford BE, Moparty K, Thomas R, Abdel-Mageed AB.

Carcinogenesis. 2013 Sep;34(9):2017-23. doi: 10.1093/carcin/bgt156. Epub 2013 May 8.


Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways.

Kandil E, Tsumagari K, Ma J, Abd Elmageed ZY, Li X, Slakey D, Mondal D, Abdel-Mageed AB.

J Surg Res. 2013 Oct;184(2):898-906. doi: 10.1016/j.jss.2013.03.052. Epub 2013 Apr 2.


The nuclear factor kappa-B signaling pathway as a therapeutic target against thyroid cancers.

Li X, Abdel-Mageed AB, Mondal D, Kandil E.

Thyroid. 2013 Feb;23(2):209-18. doi: 10.1089/thy.2012.0237. Epub 2012 Dec 28. Review.


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